Nocturia is the Lower Urinary Tract Symptom With Greatest Impact on Quality of Life of Men From a Community Setting

Eduardo de Paula Miranda,Cristiano Mendes Gomes,Fábio César Miranda Torricelli,José de Bessa Júnior,José Everton de Castro,Bruno Roberto da Silva Ferreira,Ariel Gustavo Scafuri,Homero Bruschini,Miguel 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.2

Purpose: Lower urinary tract symptoms are numerous, but the specific impact of each of these symptoms on the quality of life (QoL) has not been evaluated in community-dwelling men. An assessment of these symptoms and their effects on QoL was the focus of this study. Methods: We performed a cross-sectional study with 373 men aged >50 years from a community setting. Patients completed the International Prostate Symptom Score questionnaire, which includes questions on each of the specific urinary symptoms and a question addressing health-related QoL that are graded from 0 to 5. We used the Pearson correlation test to assess the impact of each symptom on QoL. Results: Nocturia (58.9%) was the most prevalent urinary symptom. The mean score was 0.9±1.4 for incomplete emptying, 1.0±1.5 for frequency, 0.9±1.3 for intermittency, 0.8±1.3 for urgency, 1.0±1.5 for weak stream, 0.5±1.0 for straining, and 2.0±1.6 for nocturia. Nocturia and frequency were the only symptoms associated with poorer QoL, with nocturia showing a stronger association. Conclusions: Nocturia affects 50% of community dwelling men aged >50 years, and is the lower urinary tract symptom with the greatest negative impact on QoL.

환경보호, 기술혁신 및 녹색 일자리 - 독일식 모델을 중심으로 한 고찰

Miranda Schreurs 한국노동연구원 2008 국제노동브리프 Vol.6 No.12

Study of Mechanical Properties of an LM24 Composite Alloy Reinforced with Cu-CNT Nanofillers, Processed Using Ultrasonic Cavitation

Miranda, Alberto,Alba-Baena, Noe,McKay, Brian J.,Eskin, Dmitry G.,Ko, Se Hyun,Shin, J.S. Trans Tech Publications, Ltd. 2013 Materials science forum Vol.765 No.-

<P>This study investigates the effect of Cu-Carbon Nanotube (Cu-CNT´s) composite powders on the mechanical properties of an Al-Si9.5-Cu4-Fe1.3 wt.% (LM24) aluminium matrix composite (AMC). Carbon nanotubes (CNT’s) can exhibit exceptional mechanical properties, e.g. stiffness up to 1000 GPa and strength in the order of 100 GPa. In recent years there has been significant scientific interest in improving properties in conventional alloys, via fabricating CNT metal matrix composites in order to attempt to harness their extraordinary attributes. In this study mechanically alloyed Cu-CNTS powders were added to molten LM24. The melt was processed using ultrasonic cavitation and subsequently high pressure die casting to form as-cast tensile specimens. SEM results indicate that CNT’s can be successfully introduced into the melt using this method. Compared to the unreinforced alloy, the CNT additions resulted in an increment (~20±10 MPa) to both ultimate tensile strength and yield strength, with a corresponding decline (~1±0.5l %) in elongation. This observed increase in strengthening may be attributed to the CNT’s pinning and hindering both grain boundary and dislocation migration during applied loading. Interestingly, no significant difference in properties were found with an increase in the CNT content (from 0.05 to 0.1 wt.%) potentially indicating a saturation limit.</P>

Factors influencing decision-making around opportunistic salpingectomy: a nationwide survey

Miranda P. Steenbeek,Laura A.M. van Lieshout,Johanna W.M. Aarts,Jurgen M.J. Piek,Sjors F.P.J. Coppus,Leon FAG Massuger,Rosella P.M.G. Hermens,Joanne A. de Hullu 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.1

Objective: To explore current practice and influencing factors on adoption of the opportunistic salpingectomy (OS), particularly regarding the decision making, to eventually enhance the development and implementation of clear guidelines. Methods: This nationwide cross-sectional survey study was conducted in all hospitals in the Netherlands. An anonymous online survey was sent to gynecologists with special interest in gynecological oncology, gynecological endoscopy or urogynecology and all Dutch gynecology trainees. The survey mainly focused on current practice regarding OS and identification of influencing factors on the level of innovation, organization, healthcare professional and individual patient. Results: The response rate was 348 out of 597 gynecologists (58.3%) and 142 out of 340 trainees (41.8%). Current practice of discussing and performing the OS varied widely, with ovarian cancer (OC) risk reduction as most important supportive factor on innovation level. Supportive factors on the level of organization and healthcare provider were; working in a non-training hospital, knowledge of current literature and extensive work experience (in years and annual number of hysterectomies). On individual patient level, a vaginal approach of hysterectomy, negative family history for OC and the presence of firm adhesions were suppressive factors for the OS. Conclusion: In this study we evaluated the current practice regarding the opportunistic salpingectomy in the Netherlands and identified influencing factors on different levels to raise awareness and attribute to development of a targeted implementation strategy, on both national and international level.

Charlotte’s Web: Reproduction and Subversion of American 1950s Gender Ideology

Miranda Kerkhove 한국영미문학교육학회 2018 영미문학교육 Vol.22 No.3

This essay analyses ambivalent perspectives on E. B. White’s Charlotte’s Web. The book shows how one human girl character and an anthropomorphised animal character conform to heteronormative behavioural expectations of women, particularly in Charlotte’s taking care of a male piglet who is about to be culled. Such a literary representation closely corresponded to the gender ideology of the United States for middle-class white women in the 1950s. White seems to prepare the little girl Fern to live up to the 1950s’ standards of becoming a caring mother. Spider Charlotte seemingly has the same function within the narrative, showing girl readers what Fern’s life is likely to develop into. At the same time, however, the narrative presents an alternative subversive message with its liminal characters. On a deeper level and with a focus on morality according to ethics-of-care theories, we cannot but notice how minor characters are deployed to oppose the restricting societal norms and values in terms of gender and social class. The insight and success of those deviant characters tell a different tale of exclusion and how to empower oneself. With the main character Charlotte who faithfully follows the societal expectation and the few minor animal characters who open up the subversive potentials, White succeeds in epitomizing the marginalised in society as well as the mainstream ideal of America through the successful portrayal of fantasy-reality mixture. By focusing the dialectic aspects of the novel, I will try to explain the ways in which White has encouraged the child reader to look beyond the obvious and create a space for oneself in a heteronormative world.

Effects of Recombination on the Pathogenicity and Evolution of Pepper mottle virus

Miranda Gilda Jonson,서장균,최홍수,김정수,김국형 한국식물병리학회 2009 Plant Pathology Journal Vol.25 No.4

The analysis of the full length genome of Korean isolates of Pepper mottle virus (PepMoV) in previous study showed molecular variations and are found to be related to symptom variation and pathogenicity (Kim et al., 2009, Virus Res. 144:83-88). To fully understand the molecular variation of PepMoV in Korea, we further assessed the role of RNA recombination to biological variation and evolution of PepMoV. Full-length genome of a total of 17 Korean-PepMoV and 2 American (CA and FL) isolates were examined for possible detection of genetic recombination using different recombination detections programs and detected 5 and 8 tentative recombination events using RDP3 and Splits Tree4 programs, respectively. Interestingly, tentative recombinants detected such as isolates 57, 134 and 217 were previously identified as severe isolates and 205135 and 205136 as differentiating isolates (Kim et al., 2009, Virus Res. 144:83-88). In addition, recombination was frequently detected in the Vb isolate, the first PepMoV isolate reported in Korea, suggesting significant involvement in the evolution of PepMoV in Korea. These initial results of our recombination analyses among PepMoV isolates in Korea may serve as clues to further investigate the biological variations and evolution of PepMoV brought about by recombination.

Complete Genome Sequence of the RNAs 3 and 4 Segments of Rice stripe virus Isolates in Korea and their Phylogenetic Relationships with Japan and China Isolates

Miranda Gilda Jonson,최홍수,김정수,최일영,김국형 한국식물병리학회 2009 Plant Pathology Journal Vol.25 No.2

The complete genome sequences of RNA3 and RNA4 of the 13 different Rice stripe virus (RSV) isolates were determined and characterized in this study to address the possible causes of the recent re-emergence of RSV that affected many rice fields in Korea. The genome size of each RNA segment varied among isolates and significant differences were observed in the intergenic region. There was up to 4% average divergence in the RNA4 nucleotide sequence among 13 Korean isolates and only 1.4% in the RNA3. Phylogenetic relationships among different Korean isolates revealed that there were at least 2 types of RNA3 and 4 distinct types of RNA4 genomes present in Korea. However, Korean isolates with one type of RNA3 predominate over the other while the occurrences of the RSV Korean isolates with the 4 types of RNA4 genome were not correlated to specific geographical areas. Results further indicate that RNA4 had diverged more than RNA3 and these differences in accumulation of mutations in the individual RNA segments indicate that genetic reassortment were likely to contribute to the genetic divergence in the 13 Korean isolates. All of the Korean-RNA3 sequences except for one isolate grouped with Chinese isolates (JY and Z). In contrast, the RNA 4 sequences segregated together with either Chinese (JY and Z) and Japanese (M and T) isolates but genetic relationships of Korean isolates- RNAs 3 and 4 segments to Chinese-Y isolate were low. Altogether, these results suggest that the occurrence of mixtures of RNAs 3 and 4 genotypes in the natural population of RSV may have contributed to the sudden outbreak in Korea.

Genetic Reassortment of Rice stripe virus RNA Segments Detected by RT-PCR Restriction Enzyme Analysis-based Method

Miranda Gilda Jonson,Sen Lian,최홍수,이관석,김창석,김국형 한국식물병리학회 2011 Plant Pathology Journal Vol.27 No.2

Our previous sequence and phylogenetic analyses of the Korean Rice stripe virus (RSV) suggested possible genetic reassortment of RNA segments, but whether this RNA variation contributed to the recent RSV outbreaks in Korea is yet unclear. To further clarify these RSVRNA segment variations, we developed a reverse transcription-polymerase reaction/restriction enzyme (RTPCR/RE) analysis-based method. We identified five REs, including DraI, EcoR1, NdeI/AseI, and SpeI, that could differentiate RSV RNA 1–4 subtypes, respectively. Our RT-PCR/RE results provided a clear pattern of RNA reassortment, i.e., different groups of isolates having their RNA segments derived from two to three different RSV ancestors, such as from Eastern and Southwestern Chinese or Japanese M and T isolates. We also found that the migratory small brown planthopper from Eastern China caught by aerial net traps that possesses RSVRNA3genotypes corresponds mainly to Eastern China,with a few for Southwestern China based on RT-PCR/RE, sequence and phylogenetic analyses, indicating that RSV populations in Eastern China may also have strong RNA variation. The development of an RE analysisbased method proved a useful epidemiological tool for rapid genotyping and identification of mixed infections by RSV strain and by different subtype.

The Photocycle and Proton Translocation Pathway in a Cyanobacterial Ion-Pumping Rhodopsin

Miranda, M.R.M.,Choi, A.R.,Shi, L.,Bezerra, A.G.,Jung, K.H.,Brown, L.S. Biophysical Society ; Published for the Biophysica 2009 Biophysical journal Vol.96 No.4

The genome of thylakoidless cyanobacterium Gloeobacter violaceus encodes a fast-cycling rhodopsin capable of light-driven proton transport. We characterize the dark state, the photocycle, and the proton translocation pathway of GR spectroscopically. The dark state of GR contains predominantly all-trans-retinal and, similar to proteorhodopsin, does not show the light/dark adaptation. We found an unusually strong coupling between the conformation of the retinal and the site of Glu<SUP>132</SUP>, the homolog of Asp<SUP>96</SUP> of BR. Although the photocycle of GR is similar to that of proteorhodopsin in general, it differs in accumulating two intermediates typical for BR, the L-like and the N-like states. The latter state has a deprotonated cytoplasmic proton donor and is spectrally distinct from the strongly red-shifted N intermediate known for proteorhodopsin. The proton uptake precedes the release and occurs during the transition to the O intermediate. The proton translocation pathway of GR is similar to those of other proton-pumping rhodopsins, involving homologs of BR Schiff base proton acceptor and donor Asp<SUP>85</SUP> and Asp<SUP>96</SUP> (Asp<SUP>121</SUP> and Glu<SUP>132</SUP>). We assigned a pair of FTIR bands (positive at 1749 cm<SUP>-1</SUP> and negative at 1734 cm<SUP>-1</SUP>) to the protonation and deprotonation, respectively, of these carboxylic acids.

The lived experience of CrossFit as a context for the development of women’s body image and appearance management practices

Miranda Podmore,Jennifer Paff Ogle 한국의류학회 2018 Fashion and Textiles Vol.5 No.1

The purpose of this interpretive study was to explore how women’s participation in the sport of CrossFit sets a context for the development of their body images—including their thoughts and feelings about the body and their lived experiences of embodiment—as well as their perceptions of culturally constructed ideals of beauty and gender. Analyses were informed by feminist cultural studies. In-depth, face-to-face interviews were conducted with 16 women who regularly participate in CrossFit. Data were analyzed using constant comparison processes. Findings illuminate how women experienced the culture of a male-owned, co-ed, CrossFit gym and how their immersion and participation in that gym culture gave rise to varied bodily experiences and practices, including body/appearance ideals, bodily appraisals, appetites and diets, physical fitness ideologies, appearance management routines, perspectives on gender, and identity development. Participant narratives revealed diverse lived realities across accounts as well as some evidence of contradiction or ambivalence within individual accounts. Implications for professionals who work in the body image area (e.g., nutritionists, counselors/therapists, sports psychologists), for the apparel and merchandising industry, for the sport of CrossFit, and for future work in the area are discussed.