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      • KCI등재SCOPUS

        Transcriptional and Mycolic Acid Profiling in Mycobacterium bovis BCG In Vitro Show an Effect for c-di-GMP and Overlap between Dormancy and Biofilms

        Miguel,A.,De,la,Cruz,Miguel,A.,Ares,Diana,Rodríguez-Valverde,Alba,Adriana,Vallejo-Cardona,Mario,Alberto,Flores-Valdez,Iris,Denisse,Cota,Núñez,Michel,de,Jesús,Aceves-Sánchez,Jonahtan,Lira-Chávez,Jacobo 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.6

        Mycobacterium tuberculosis produces mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled by diguanylate cyclases (DGC) and phosphodiesterases (PDE). The transcriptional regulator dosR, is involved in response to low oxygen, a condition likely happening to a subset of cells within biofilms. Here, we found that in M. bovis BCG, expression of both BCG1416c and BCG1419c genes, which code for a DGC and a PDE, respectively, decreased in both stationary phase and during biofilm production. The kasA, kasB, and fas genes, which are involved in mycolic acid biosynthesis, were induced in biofilm cultures, as was dosR, therefore suggesting an inverse correlation in their expression compared with that of genes involved in c-di-GMP metabolism. The relative abundance within trehalose dimycolate (TDM) of α- mycolates decreased during biofilm maturation, with methoxy mycolates increasing over time, and keto species remaining practically stable. Moreover, addition of synthetic c-di-GMP to mid-log phase BCG cultures reduced methoxy mycolates, increased keto species and practically did not affect α-mycolates, showing a differential effect of c-di-GMP on keto- and methoxy-mycolic acid metabolism.

      • KCI등재후보
      • KCI등재후보
      • KCI등재

        Nonsurgical endodontic retreatment of fused teeth with transposition: a case report

        Miguel,Agostinho,Beco,Pinto,Cardoso,Rita,Brandao,Noites,Miguel,Andre,Duarte,Martins,Manuel,Pedro,da,Fonseca,Paulo 대한치과보존학회 2016 Restorative Dentistry & Endodontics Vol.41 No.2

        Tooth transposition is a disorder in which a permanent tooth develops and erupts in the normal position of another permanent tooth. Fusion and gemination are developmental disturbances presenting as the union of teeth. This article reports the nonsurgical retreatment of a very rare case of fused teeth with transposition. A patient was referred for endodontic treatment of her maxillary left first molar in the position of the first premolar, which was adjacent to it on the distobuccal side. Orthopantomography and periapical radiography showed two crowns sharing the same root, with a root canal treatment and an associated periapical lesion. Tooth fusion with transposition of a maxillary molar and a premolar was diagnosed. Nonsurgical endodontic retreatment was performed. At four yr follow-up, the tooth was asymptomatic and the radiolucency around the apical region had decreased, showing the success of our intervention. The diagnosis and treatment of fused teeth require special attention. The canal system should be carefully explored to obtain a full understanding of the anatomy, allowing it to be fully cleaned and obturated. Thermoplastic techniques were useful in obtaining hermetic obturation. A correct anatomical evaluation improves the set of treatment options under consideration, leading to a higher likelihood of esthetically and functionally successful treatment.

      • SCIESCOPUSKCI등재후보

        Damage detection in truss structures using a flexibility based approach with noise influence consideration

        Miguel,,Leandro,Fleck,Fadel,Miguel,,Leticia,Fleck,Fadel,Riera,,Jorge,Daniel,Menezes,,Ruy,Carlos,Ramos,De Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.5

        The damage detection process may appear difficult to be implemented for truss structures because not all degrees of freedom in the numerical model can be experimentally measured. In this context, the damage locating vector (DLV) method, introduced by Bernal (2002), is a useful approach because it is effective when operating with an arbitrary number of sensors, a truncated modal basis and multiple damage scenarios, while keeping the calculation in a low level. In addition, the present paper also evaluates the noise influence on the accuracy of the DLV method. In order to verify the DLV behavior under different damages intensities and, mainly, in presence of measurement noise, a parametric study had been carried out. Different excitations as well as damage scenarios are numerically tested in a continuous Warren truss structure subjected to five noise levels with a set of limited measurement sensors. Besides this, it is proposed another way to determine the damage locating vectors in the DLV procedure. The idea is to contribute with an alternative option to solve the problem with a more widespread algebraic method. The original formulation via singular value decomposition (SVD) is replaced by a common solution of an eigenvector-eigenvalue problem. The final results show that the DLV method, enhanced with the alternative solution proposed in this paper, was able to correctly locate the damaged bars, using an output-only system identification procedure, even considering small intensities of damage and moderate noise levels.

      • Quality of Life and Psychological Well-Being in Obesity Management

        Miguel,Á,ngel,Rojo,Tirado 계명대학교 간호과학연구소 2017 계명간호과학 Vol.20 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: The purpose of this study was to review the Quality of Life and Psychological Well-Being in Obesity Management. Methods: Literature on psychological and behavioral issues in obesity treatment was explored. Results: Obesity is rapidly becoming one of the most important health concerns in developed countries worldwide. The increasing prevalence of obesity places significant burdens on individuals and healthcare systems. In addition to its clear clinical effects, obesity carries a substantial burden in personal terms, as measured by reduced daily functioning, and by general, health-related and obesity-specific quality-of- life (QoL) metrics. QoL has been defined as the effect of medical conditions on well being and physical and mental function, reflecting the functional effects of a disease as perceived by the patient. Hence, individuals living with obesity are subject to considerable stigma, which they may internalize and experience as shame, depression and anxiety. The negative impact of obesity on the four main domains of QOL(physical health, mental health, social functioning, and vocational functioning) largely outweighs physical symptoms and its associated co-morbidities, such as diabetes mellitus, hypertension, and coronary heart disease. Obesity per se is a cause of discrimination in several areas of social life. Psychological disturbances, frequently observed in obese people, are likely to further impair the perceived health status. Conclusion: A quantitative measurement of QOL (including the physical and mental dimensions) is critical in defining strategies to improve patients' reported outcomes.

      • KCI등재

        Clinical Efficacy in the Treatment of Overactive Bladder Refractory to Anticholinergics by Posterior Tibial Nerve Stimulation

        Miguel,Angel,Arrabal-Polo,Francisco,Palao-Yago,Iluminada,Campon-Pacheco,Maribel,Martinez-Sanchez,Armando,Zuluaga-Gomez,Miguel,Arrabal-Martin 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.7

        Purpose: Overactive bladder (OAB) is a clinical syndrome that is currently treated initially with anticholinergics, although some other therapeutic alternatives exist, such as neuromodulation, botulinum toxin, and posterior tibial nerve stimulation (PTNS). The purpose of this study was to assess the efficacy of PTNS in patients with OAB refractory to anticholinergics. Materials and Methods: We present a cohort study of 14 women with OAB to whom we applied PTNS. We assessed (before and after the treatment) the diurnal micturitional frequency, the nocturnal micturitional frequency, urgency episodes, and urge incontinence episodes. Results were analyzed by using the Wilcoxon test for nonparametric samples. Results: We observed statistically significant improvement in the diurnal micturitional frequency (p=0.05), in episodes of micturitional urgency (p=0.03), and in episodes of urge incontinence (p=0.004). A total of 50% of the patients felt subjective improvement from their pathology. Conclusions: PTNS is a valid, minimally invasive treatment option with minimum morbidity for patients with OAB refractory to treatment with anticholinergics. Purpose: Overactive bladder (OAB) is a clinical syndrome that is currently treated initially with anticholinergics, although some other therapeutic alternatives exist, such as neuromodulation, botulinum toxin, and posterior tibial nerve stimulation (PTNS). The purpose of this study was to assess the efficacy of PTNS in patients with OAB refractory to anticholinergics. Materials and Methods: We present a cohort study of 14 women with OAB to whom we applied PTNS. We assessed (before and after the treatment) the diurnal micturitional frequency, the nocturnal micturitional frequency, urgency episodes, and urge incontinence episodes. Results were analyzed by using the Wilcoxon test for nonparametric samples. Results: We observed statistically significant improvement in the diurnal micturitional frequency (p=0.05), in episodes of micturitional urgency (p=0.03), and in episodes of urge incontinence (p=0.004). A total of 50% of the patients felt subjective improvement from their pathology. Conclusions: PTNS is a valid, minimally invasive treatment option with minimum morbidity for patients with OAB refractory to treatment with anticholinergics.

      • KCI등재

        Bone and Metabolic Markers in Women With Recurrent Calcium Stones

        Miguel,Angel,Arrabal-Polo,Miguel,Arrabal-Martin,Salvador,Arias-Santiago 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.3

        Purpose: The target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis. Materials and Methods: We conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis,and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry. Results: Patients in group 3 showed statistically significantly elevated calciuria (15.4mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups. Conclusions: Recurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.

      • KCI등재

        Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases.

        José,Miguel,Campos,Ana,Catarina,Sousa,Pedro,Olivério,Pinto,Jorge,Ribeiro,Miguel,Lacueva,França,Ana,Rita,Caseiro,Mariana,Vieira,Branquinho,Sílvia,Santos,Pedrosa,Carla,Mendonça,Ana,Brandão,José,Domingos 한국생체재료학회 2019 생체재료학회지 Vol.23 No.1

        Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P2O5-CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals' quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.

      • SCIESCOPUSKCI등재

        Transcriptional and Mycolic Acid Profiling in Mycobacterium bovis BCG In Vitro Show an Effect for c-di-GMP and Overlap between Dormancy and Biofilms

        Cruz,,Miguel,A.,De,la,Ares,,Miguel,A.,Rodriguez-Valverde,,Diana,Vallejo-Cardona,,Alba,Adriana,Flores-Valdez,,Mario,Alberto,Nunez,,Iris,Denisse,Cota,Aceves-Sanchez,,Michel,de,Jesus,Lira-Chavez,,Jonahta The Korean Society for Microbiology and Biotechnol 2020 Journal of microbiology and biotechnology Vol.30 No.6

        Mycobacterium tuberculosis produces mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled by diguanylate cyclases (DGC) and phosphodiesterases (PDE). The transcriptional regulator dosR, is involved in response to low oxygen, a condition likely happening to a subset of cells within biofilms. Here, we found that in M. bovis BCG, expression of both BCG1416c and BCG1419c genes, which code for a DGC and a PDE, respectively, decreased in both stationary phase and during biofilm production. The kasA, kasB, and fas genes, which are involved in mycolic acid biosynthesis, were induced in biofilm cultures, as was dosR, therefore suggesting an inverse correlation in their expression compared with that of genes involved in c-di-GMP metabolism. The relative abundance within trehalose dimycolate (TDM) of α-mycolates decreased during biofilm maturation, with methoxy mycolates increasing over time, and keto species remaining practically stable. Moreover, addition of synthetic c-di-GMP to mid-log phase BCG cultures reduced methoxy mycolates, increased keto species and practically did not affect α-mycolates, showing a differential effect of c-di-GMP on keto- and methoxy-mycolic acid metabolism.

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