A Study of the Content Validity of Reading Comprehension Tests in NMET II

Zhen-Jie Liu,Ming-Hao Jin 대한언어학회 2018 언어학 Vol.26 No.4

Liu, Zhen-Jie & Jin, Ming-Hao. (2018). A study of the content validity of reading comprehension tests in NMET II. The Linguistic Association of Korea Journal, 26(4), 103-124. Based on Bachman and Palmer’s (1996) framework of task characteristics, this paper aims to compare the reading comprehension tests of the 2013-2017 National Matriculation English Test II (NMET II) with the requirements of the New Curriculum Standards and Testing Syllabus, in particular, concerning the content validity of the tests in terms of the characteristics of input and expected responses. The implications of this study are discussed for test designers, teachers, and students. The results show that reading comprehension tests from 2013 to 2017 basically meet the requirements of the New Curriculum Standard and Testing Syllabus and have a high content validity. In terms of the characteristics of input, the length, reading speed, and readability of comprehension passages are appropriate for students; however, the distribution of topics and genres in each year is uneven. In terms of the characteristics of expected responses, the wordings of questions and the design of question items are reasonable. However, the response type is mainly restricted to selected response questions (multiple-choice), and the measure of reading skills coverage is unbalanced.

물류 유통을 최적화하기 위한 네트워크-유통 알고리즘의 설계

김명하, 이충세 충북대학교 컴퓨터정보통신연구소 2008 컴퓨터정보통신연구 Vol.16 No.1

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HYPER 빔창주위의 열유동 해석에 의한 안전성 평가에 관한 연구

송민근,최진호,주은선,송태영 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-

A spent fuel problem has prevented the nuclear power from claiming to be a completely clean energy source. The nuclear transmutation technology to incinerate the long lived radioactive nuclides and produce energy during the incineration process is believed to be one or the best solutions. HYPER(Hybrid Power Extraction Reactor)is the accelerator driven transmutation system which is being developed by KAERI(Korea Atomic Energy Research Institute). Some major feature of HYPER have been developed and employed. On-power fueling concepts are employed to keep system power constant with minimum variation of accelerator power. A hollow cylinder-type metal fuel is designed for the on-line refueling concept. Lead-bismuth(Pb-Bi) is adopted as a coolant and Spallation target material. One of the issues related to the HYPER target system is the thermal and mechanical loads imposed on the Pb-Bi and the beam window. FLUENT is used for thermal-hydraulic calculation, and finally stress calculation is performed by ANSYS. A beam condition such as current is varied. The initial velocity of Pb-Bi is also varied.

비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

A Rapid Scheme for Acquisition of Pseudonoise Signals

Ming Lu Jin,Kyu Young Rhee,Gi Young Lim,Ming Xue Jin,Kyung S. Kwak 대한전자공학회 1996 ITC-CSCC :International Technical Conference on Ci Vol.- No.-

KIOM-79에 의한 p65 단백질의 핵내 이동 및 iNOS 발현 억제

김진숙(Jin-Sook Kim),장대식(Dae-Sik Jang),전영진(Young-Jin Jeon),유호진(Ho-Jin You),박경한(Kyeong Han Park),김 명(Jin Ming),문형윤(Hyung-Yoon Moon),윤상필(Sang-Pil Yoon),장인엽(In-Youb Chang) 대한해부학회 2006 Anatomy & Cell Biology Vol.39 No.2

후박 (Magnolia officinalis), 갈근 (Pueraria lobata), 감초 (Glycyrrhiza uralensis) 및 대극(Euphorbia pekinensis)은 염증성질병을 포함한 다양한 질병을 치료하기 위해 사용되었다. 본 실험에서는 각각의 천연물의 복합추출물인 KIOM-79가 큰포식세포에서 inducible NO synthase (iNOS) 유전자의 발현을 억제시키는 기전을 밝혀내기 위하여 면역형광염색, RT-PCR, electrophoretic mobility shift assay (EMSA) 등을 실시하였다. 면역형광염색 소견을 보면 RAW 264.7 세포에 lipopolysaccharide (LPS)에 의해 유도된 iNOS 단백질의 발현이 KIOM-79에 의해 억제되는 것을 알 수 있다. Western blot과 RT-PCR 분석에 의하면 KIOM-79가 LPS에 의한 iNOS의 발현을 억제함을 확인 할 수 있다. LPS와 KIOM-79를 처리한 RAW 264.7 세포에서 nuclear extract를 추출하여 EMSA로 분석한 결과, LPS에 의해 유도된 NF-κB/Rel의 DNA 결합이 KIOM-79에 의해 억제됨을 확인하였다. 면역형광염색 소견을 보면 NF-κB/Rel의 구성단백질 중의 하나인 p65단백질은 세포질에서 발현되고 있으며, LPS를 처리하면 p65가 핵으로 이동함을 알 수 있다. 이때 KIOM-79를 처리하면 LPS에 의한 p65의 핵 내 이동이 억제됨을 확인할 수 있다. 결론적으로, KIOM-79는 큰포식세포에 작용해 iNOS 유전자의 발현을 억제하며, 이러한 큰포식세포의 활성억제는 p65 단백질의 핵 내 이동 억제를 통해서 유도되는 것으로 사료된다. We demonstrate that KIOM-79, combined extracts isolated from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, inhibits LPS-induced expression of iNOS gene in RAW 264.7 cells. Treatment of RAW 264.7 cells with KIOM-79 inhibited LPS-stimulated nitric oxide production in a doserelated manner. Immunohisto-chemical staining of iNOS and RT-PCR analysis showed that the decrease of NO was due to the inhibition of iNOS gene expression. Immunostaining of p65 and EMSA showed that KIOM-79 inhibited NF-κ/Rel nuclear translocation and DNA binding, respectively. Collectively, this series of experiments indicates that KIOM inhibits iNOS gene expression by blocking NF-κ/Rel. Due to the critical role that NO release plays in mediating inflammatory responses, the inhibitory effects of KIOM-79 on iNOS suggest that KIOM-79 may represent a useful anti-inflammatory agent.

Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review

Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.

Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.

Jin, Ming Ji,Kim, Unyong,Kim, In Sook,Kim, Yuri,Kim, Dong-Hyun,Han, Sang Beom,Kim, Dong-Hyun,Kwon, Oh-Seung,Yoo, Hye Hyun Taylor Francis 2010 Journal of toxicology and environmental health. Pa Vol.73 No.21

<P>Hesperidin is a biologically active flavanone glycoside occurring abundantly in citrus fruits. In the present study, effects of intestinal microflora on pharmacokinetics of hesperidin were investigated using a pseudo-germ-free rat model treated with antibiotics. After administration of hesperidin to rats, hesperetin, hesperetin glucuronides, and metabolites postulated to be eriodictyol, hemoeriodictyol, and their glucuronides were detected in urine while hesperetin glucuronide was predominantly found in plasma. The plasma concentration-time profile of hesperetin was compared between non-antibiotic-exposed and pseudo-germ-free rats administered this compound. The maximal concentration (C(max)) values of hesperetin in non-antibiotic-exposed and pseudo-germ-free rats were 0.58 and 0.20 관g/ml, respectively, and area under the curve (AUC) values were 6.3 and 2.8 관g-h/ml, respectively. Thus, systemic exposure as evidenced by AUC and C(max) was significantly higher in normal compared to pseudo-germ-free rats. Fecal 관-glucosidase activities of non-antibiotic-exposed and pseudo-germ-free rats were 0.21 and 0.11 nmol/min/mg, while fecal 관-rhamnosidase activities were 0.37 and 0.12 nmol/min/mg, respectively. The rate of hesperidin transformation to hesperetin was 6.9 and 2.9 nmol/min/g in fecal samples in non-antibiotic-exposed and pseudo-germ-free rats, respectively. Taken together, these results showed that pharmacokinetic differences between non-antibiotic-exposed and pseudo-germ-free rats may be attributed to differing hesperidin uptake, as well as alterations in metabolic activities of intestinal flora.</P>

Indoline-Based Molecular Engineering for Optimizing the Performance of Photoactive Thin Films

Ming Yu Jin,Byung-Man Kim,Hyun Sil Jung,Jun-Hyeok Park,Deok-Ho Roh,Dong Guk Nam,Tae-Hyuk Kwon,Do Hyun Ryu 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2