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Inhibitory effects of bee venom and its components against viruses in vitro and in vivo
Md Bashir Uddin,이병훈,NIKAPITIYACHAMILANI LALANTHI,김재훈,김태환,이현철,김철구,이종수,김철중 한국미생물학회 2016 The journal of microbiology Vol.54 No.12
Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties of BV and its component against a broad panel of viruses. Co-incubation of non-cytotoxic amounts of BV and MLT, the main component of BV, significantly inhibited the replication of enveloped viruses such as Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV). Additionally, BV and MLT also inhibited the replication of non-enveloped viruses such as Enterovirus-71 (EV-71) and Coxsackie Virus (H3). Such antiviral properties were mainly explained by virucidal mechanism. Moreover, MLT protected mice which were challenged with lethal doses of pathogenic influenza A H1N1 viruses. Therefore, these results provides the evidence that BV and MLT could be a potential source as a promising antiviral agent, especially to develop as a broad spectrum antiviral agent.
Low frequency stability study of a three-phase induction motor
M. Bashir Uddin,Md. Nuruzzaman Pramanik,Sheikh Abu Reza 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
A suitable volt/㎐ control strategy is proposed for stability improvement in low frequency operation of induction motors fed from variable voltage and variable frequency supply. The analysis is based on small scale perturbation method applied to the linearized model of state-space equations. Stability analyses are carried out through evaluation of eigen values of the linear model characteristic equation. Stability investigation shows that the simultaneous adjustment of stator voltage and frequency provides a convenient means for maintaining stability of induction motor. The results are verified by standard transient analysis method and demonstrate a very close agreement.
Weeratunga, Prasanna,Uddin, Md Bashir,Kim, Myun Soo,Lee, Byeong-Hoon,Kim, Tae-Hwan,Yoon, Ji-Eun,Ma, Jin Yeul,Kim, Hongik,Lee, Jong-Soo Springer-Verlag 2016 The journal of microbiology Vol.54 No.1
<P>Angelica tenuissima Nakai is a widely used commodity in traditional medicine. Nevertheless, no study has been conducted on the antiviral and immune-modulatory properties of an aqueous extract of Angelica tenuissima Nakai. In the present study, we evaluated the antiviral activities and the mechanism of action of an aqueous extract of Angelica tenuissima Nakai both in vitro and in vivo. In vitro, an effective dose of Angelica tenuissima Nakai markedly inhibited the replication of Influenza A virus (PR8), Vesicular stomatitis virus (VSV), Herpes simplex virus (HSV), Coxsackie virus, and Enterovirus (EV-71) on epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. Such inhibition can be described by the induction of the antiviral state in cells by antiviral, IFN-related gene induction and secretion of IFNs and pro-inflammatory cytokines. In vivo, Angelica tenuissima Nakai treated BALB/c mice displayed higher survivability and lower lung viral titers when challenged with lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3, and H9N2). We also found that Angelica tenuissima Nakai can induce the secretion of IL-6, IFN-lambda, and local IgA in bronchoalveolar lavage fluid (BALF) of Angelica tenuissima Nakai treated mice, which correlating with the observed prophylactic effects. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we evaluated antiviral properties of ferulic acid. Therefore, an extract of Angelica tenuissima Nakai and its components, including ferulic acid, play roles as immunomodulators and may be potential candidates for novel anti-viral/anti-influenza agents.</P>
Serological prevalence of brucellosis of cattle in selected dairy farms in Bangladesh
Hassan, Abdullah Al,Uddin, M. Bashir,Islam, Md. Rafiqul,Cho, Ho-Seong,Hossain, Md. Mukter The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.4
This study was conducted to investigate the status of brucellosis in dairy cattle from five selected dairy farms in the Mohammadpur Beribadh area of Bangladesh. A cross-sectional study was carried out from October 2010 to March 2011 in which a total of 334 serum samples from cattle in five herds were screened by the Rose-Bengal plate-agglutination test (RBPT) and the positives were confirmed using an indirect enzyme-linked immunosorbent assay (I-ELISA). A structured questionnaire was used to collect epidemiological information describing the animals. Overall, 4.20% of the animals were RBPT positive, while subsequent confirmatory tests with I-ELISA revealed that the overall animal-level prevalence derived from the samples was 1.20%. Additionally, the prevalence was relatively higher in females than in males. A significant association was found between abortion, age of the animals, and the occurrence of brucellosis (p < 0.05). Considering the overall low prevalence of brucellosis in the selected farms in the present study, a brucellosis eradication program for dairy farms using a test-and-slaughter policy would be possible.
이병훈,Kiramage Chathuranga,Md Bashir Uddin,Prasanna Weeratunga,김면수,조원경,김홍익,마진열,이종수 한국미생물학회 2017 The journal of microbiology Vol.55 No.6
Coptidis Rhizoma is derived from the dried rhizome of Ranunculaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respiratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death. This antiviral activity against RSV was through the induction of type I interferon- related signaling and the antiviral state in HEp2 cells. More importantly, oral administration of CRE exhibited prophylactic effects in BALB/c mice against RSV. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we confirmed that palmatine was related to the antiviral properties and immunemodulation effect. Taken together, an extract of Coptidis Rhizoma and its components play roles as immunomodulators and could be a potential source as promising natural antivirals that can confer protection to RSV. These outcomes should encourage further allied studies in other natural products.
Chowdhury, Mohammed Y.E.,Kim, Tae-Hwan,Uddin, Md Bashir,Kim, Jae-Hoon,Hewawaduge, C.Y.,Ferdowshi, Zannatul,Sung, Moon-Hee,Kim, Chul-Joong,Lee, Jong-Soo Elsevier 2017 Veterinary microbiology Vol.201 No.-
<P><B>Abstract</B></P> <P>To develop a safe and effective mucosal vaccine that broad cross protection against seasonal or emerging influenza A viruses, we generated a mucosal influenza vaccine system combining the highly conserved matrix protein-2 (sM2), fusion peptide of hemagglutinin (HA<SUB>2</SUB>), the well-known mucosal adjuvant cholera toxin subunit A1 (CTA1) and poly-γ-glutamic acid (γ-PGA)-chitosan nanoparticles (PC NPs), which are safe, natural materials that are able to target the mucosal membrane as a mucosal adjuvant. The mucosal administration of sM2HA2CTA1/PC NPs could induce a high degree of systemic immunity (IgG and IgA) at the site of inoculation as well as at remote locations and also significantly increase the levels of sM2- or HA2-specific cell-mediated immune response. In challenge tests in BALB/c mice with 10 MLD<SUB>50</SUB> of A/EM/Korea/W149/06(H5N1), A/Puerto Rico/8/34(H1N1), A/Aquatic bird/Korea/W81/2005(H5N2), A/Aquatic bird/Korea/W44/2005 (H7N3) or A/Chicken/Korea/116/2004(H9N2) viruses, the recombinant sM2HA2CTA1/PC NPs provided cross protection against divergent lethal influenza subtypes and also the protection was maintained up to six months after vaccination. Thus, sM2HA2CTA1/PC NPs could be a promising strategy for a universal influenza vaccine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Construction of poly-γ-glutamic acid (γ-PGA)-chitosan nanoparticles (PC NPs) containing conserved antigens of Influenza virus and mucosal adjuvant cholera toxin subunit A1 (CTA1) as a safe and effective mucosal vaccine against emerging influenza A viruses. </LI> <LI> The mucosal administration of sM2HA2CTA1/PC NPs could induce a high degree of systemic, mucosal and cell-mediated immune response. </LI> <LI> Induced immune responses could protect mice against 10MLD<SUB>50</SUB> of divergent influenza subtypes. </LI> <LI> The immune response and efficacy of protection was maintained up to six months after final inoculation. </LI> </UL> </P>
Kim, Jae-Hoon,Park, Min-Eun,Nikapitiya, Chamilani,Kim, Tae-Hwan,Uddin, Md Bashir,Lee, Hyun-Cheol,Kim, Eunhee,Ma, Jin Yeul,Jung, Jae U.,Kim, Chul-Joong,Lee, Jong-Soo Public Library of Science 2017 PLoS pathogens Vol.13 No.5
<▼1><P>FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1<SUP>gt/gt</SUP> mice, which deficient in FAF1, and FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. FAF1 was bound competitively to NLRX1 and positively regulated type I IFN signaling by interfering with the interaction between NLRX1 and MAVS, thereby freeing MAVS to bind RIG-I, which switched on the MAVS-RIG-I-mediated antiviral signaling cascade. These results highlight a critical role of FAF1 in antiviral responses against RNA virus infection.</P></▼1><▼2><P><B>Author summary</B></P><P>Type I interferon-mediated antiviral response is critical for controlling virus infections. However, interferon-mediated immune responses need to be tightly regulated to maintain host immune homeostasis. Recently, molecules involved in regulating interferon-mediated innate immune response are the subject of much research. Among these, the first protein to be identified as a negative regulator of MAVS was the nucleotide-binding domain and leucine-rich repeat containing family member, NLRX1. NLRX1 associates with MAVS to inhibit antiviral signaling by interrupting virus-induced RLR-MAVS interactions. Interestingly, we found that FAF1 interacts with NLRX1 in response to RNA virus infection and this interaction inhibits binding of MAVS to NLRX1, which in turn switches on RIG-I mediated antiviral immune responses. As results, we showed that FAF1<SUP>gt/gt</SUP> mice, which deficient in FAF1, and FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. Our findings suggest that FAF1 is a crucial regulator that induces the antiviral innate immune responses against RNA virus infection.</P></▼2>