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      • FEM analysis of the modular prefabricated steel-concrete composite beam-column internal joint under reciprocating action

        Cheng Long Wu,Jian Cheng Kan,Qi Hui Wang,Ji Ming Liu,Zun Qiang Li 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1

        Prefabricated steel-concrete composite structure has the advantages of large bearing capacity, reliable connection, and good durability, which is of great significance to the development of building industrialization. In this paper, a finite element model (FEM) of the modular prefabricated SRC column-steel beam composite joint is established and verified its accuracy through ABAQUS. The effects of various parameter variables on the hysteresis curve, skeleton curve, ductility, energy consumption, and performance deterioration are investigated. The results show that as the axial compression ratio increases, the joint bearing capacity first increases and then decreases, the strength and stiffness have relatively stable degradation characteristics. However, the hysteresis curve has a certain “pinch” phenomenon, which reduces the energy consumption performance. Different column end bolts margin and apertures have little effect on the bearing capacity, strength and stiffness degradation performance, but affect energy consumption and ductility. The width-to-thickness ratio of the square steel tube has a greater impact on the bearing capacity, energy consumption and ductility, and has less impact on the strength and stiffness degradation performance. As the thickness of the joint cover plate increases, the bearing capacity, energy consumption and initial stiffness of the joint gradually increase, the ductility first increases and then decreases.

      • KCI등재

        Surf points based Moving Target Detection and Long-term Tracking in Aerial Videos

        ( Juan-juan Zhu ),( Wei Sun ),( Bao-long Guo ),( Cheng Li ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11

        A novel method based on Surf points is proposed to detect and lock-track single ground target in aerial videos. Videos captured by moving cameras contain complex motions, which bring difficulty in moving object detection. Our approach contains three parts: moving target template detection, search area estimation and target tracking. Global motion estimation and compensation are first made by grids-sampling Surf points selecting and matching. And then, the single ground target is detected by joint spatial-temporal information processing. The temporal process is made by calculating difference between compensated reference and current image and the spatial process is implementing morphological operations and adaptive binarization. The second part improves KALMAN filter with surf points scale information to predict target position and search area adaptively. Lastly, the local Surf points of target template are matched in this search region to realize target tracking. The long-term tracking is updated following target scaling, occlusion and large deformation. Experimental results show that the algorithm can correctly detect small moving target in dynamic scenes with complex motions. It is robust to vehicle dithering and target scale changing, rotation, especially partial occlusion or temporal complete occlusion. Comparing with traditional algorithms, our method enables real time operation, processing 520×390 frames at around 15fps.

      • KCI등재

        Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

        An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

        Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

      • KCI등재

        Mechanical and Tribological Properties of Short Basalt Fiber-reinforced Polyoxymethylene Composites

        Chenghe Liu,Chunguang Long,Lei Chen,Junpeng Liu,Taishan Cao,Jian Zhang 한국고분자학회 2016 폴리머 Vol.40 No.6

        In this paper, short basalt fiber-reinforced polyoxymethylene (POM) composites were prepared by melt blending and injection molding. The mechanical and tribological properties of the composites were studied by an orthogonal experiment. It was found that the optimal combination of fiber length 4 mm, fiber content 20 wt% and treated with KH550 would result in a comprehensive property which is 27.45% higher tensile strength, 9.65% higher impact strength and 18.11% higher flexural strength with compared to that of pure POM. But its tribological properties would be worse with the addition of the basalt fibers. After incorporating 10 wt% of polytetrafluoroethylene (PTFE) into the composites, the tribological properties of the composites was improved, closed to that of pure POM, with an insignificant decrease to their mechanical properties. Moreover, the morphology of fracture surfaces and worn surfaces evaluated by scanning electron microscopy showed good agreement with the results of the literature.

      • SCISCIESCOPUS

        Anaerobic membrane bioreactors for antibiotic wastewater treatment: Performance and membrane fouling issues

        Cheng, Dongle,Ngo, Huu Hao,Guo, Wenshan,Liu, Yiwen,Chang, Soon Woong,Nguyen, Dinh Duc,Nghiem, Long Duc,Zhou, Junliang,Ni, Bingjie Elsevier 2018 Bioresource technology Vol.267 No.-

        <P><B>Abstract</B></P> <P>Antibiotic wastewater has become a major concern due to the toxicity and recalcitrance of antibiotics. Anaerobic membrane bioreactors (AnMBRs) are considered alternative technology for treating antibiotic wastewater because of their advantages over the conventional anaerobic processes and aerobic MBRs. However, membrane fouling remains the most challenging issue in the AnMBRs’ operation and this limits their application. This review critically discusses: (i) antibiotics removal and antibiotic resistance genes (ARGs) in different types of AnMBRs and the impact of antibiotics on membrane fouling and (ii) the integrated AnMBRs systems for fouling control and removal of antibiotics. The presence of antibiotics in AnMBRs could aggravate membrane fouling by influencing fouling-related factors (i.e., sludge particle size, extracellular polymeric substances (EPS), soluble microbial products (SMP), and fouling-related microbial communities). Conclusively, integrated AnMBR systems can be a practical technology for antibiotic wastewater treatment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Removal of antibiotics and their effects on membrane fouling in AnMBRs are reviewed. </LI> <LI> AnMBRs are efficient for treating antibiotic wastewater mainly by biodegradation. </LI> <LI> The presence of antibiotics in AnMBRs will aggravate membrane fouling. </LI> <LI> Integrating AnMBRs with biofilm carriers and BES is efficient in fouling control. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • An Isolated Multi-Port Converter with Hybrid Power Flow Control

        Cheng-Yu Tang,Yu-Long Wei,Sheng-Yuan Ou 전력전자학회 2023 ICPE(ISPE)논문집 Vol.2023 No.-

        An isolated multi-port converter (IMPC) with hybrid power flow control is proposed in this paper. Three input/output ports are included in the IMPC. The first input of the IMPC can be connected to PV array or other dc sources. The second input will be connected to the battery, whereas the second input can be acted as the load according to different operating scenarios. The output will be connected to the load. Besides, the hybrid power flow control will be developed and realized by the digital signal processor (DSP). With this proposed circuit and control strategy, the energy between the PV array, the battery and the load can effectively be regulated. If the demanded load power is greater than the supplied power from the PV array, the inadequate power can be provided by the battery. On the contrary, if the demanded load power is lower than the PV power, the battery will be charged. Hardware experiments are presented to verify the feasibility of the proposed IMPC. Finally, a 150W prototype circuit is designed and implemented. The voltage/current of the first and the second input ports are set as 60V/2.5A and 100V/1.5A, respectively. The output voltage and current are set as 100V/1.5A.

      • Changes in Markers of Liver Function in HCV 1b Patients with Compensated Cirrhosis Treated with Ombitasvir/Paritaprevir/ Ritonavir plus Dasabuvir with Ribavirin

        ( Jeong Heo ),( Yan Luo ),( Wan-long Chuang ),( Jidong Jia ),( Kwang-hyub Han ),( Ming-lung Yu ),( Hong Tang ),( Young-suk Lim ),( Cheng-yuan Peng ),( Min Xu ),( Maorong Wang ),( Bo Fu ),( Niloufar Mo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Patients chronically infected with HCV are at risk of developing extrahepatic manifestations of HCV as well as progressing to compensated or decompensated cirrhosis and HCC. Although current treatments have high rates of SVR, relatively little is known about possible regression of liver fibrosis after achieving an SVR. The ONYX-II trial examined the efficacy and safety of ombitasvir/paritaprevir/ritonavir plus dasabuvir + ribavirin (RBV) in Asian patients with HCV genotype 1b infection and compensated cirrhosis. Here we report changes in key markers of liver fibrosis and function. Methods: Patients with chronic HCV GT1b infection and compensated cirrhosis were enrolled in China, South Korea and Taiwan and received 12 weeks of OBV/PTV/r (25 mg/150 mg/100 mg once daily) and DSV (250 mg twice daily) with weight-based RBV. The primary objective of ONYX-II was to assess efficacy (SVR12) and safety of the regimen. Changes in markers of liver fibrosis and function between baseline (BL) and post-treatment week (PTW) 12 are presented. Results: Overall, 104 patients were enrolled and treated in ONYX-II. All patients (104/104, 100%) achieved SVR12. BL and PTW12 data for FibroTest score, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, platelet count and alpha fetoprotein (AFP) are shown in Table 1. All selected parameters showed numerical improvements between BL and PTW12. Mean ALT and AST levels returned to within normal range and FibroTest scores demonstrated a numerical improvement, suggesting improvement in liver status. The complete set of data between BL and PTW12 will be presented for these parameters and other liver composite parameters at the conference. Conclusions: Measurement of key liver function markers during the ONYX-II trial showed a numerical improvement within 12 weeks of completion of treatment in HCV GT1b-infected patients with compensated cirrhosis. Further follow-up of these patients will determine the long-term durability of these changes.

      • Small activating RNA induced expression of VHL gene in renal cell carcinoma

        Kang, Moo Rim,Park, Ki Hwan,Lee, Chang Woo,Lee, Myeong Youl,Han, Sang-Bae,Li, Long-Cheng,Kang, Jong Soon Elsevier 2018 The international journal of biochemistry & cell b Vol.97 No.-

        <P><B>Abstract</B></P> <P>Recent studies have reported that chemically synthesized double-stranded RNAs (dsRNAs), also known as small activating RNA (saRNAs), can specifically induce gene expression by targeting promoter sequences by a mechanism termed RNA activation (RNAa). In the present study, we designed 4 candidate saRNAs targeting the Von Hippel-Lindau (VHL) gene promoter. Among these saRNAs, dsVHL-821 significantly inhibited cell growth by up-regulating VHL at both the mRNA and protein levels in renal cell carcinoma 769-P cells. Functional analysis showed that dsVHL-821 induced apoptosis by increasing p53, decreasing Bcl-xL, activating caspase 3/7 and poly-ADP-ribose polymerase in a dose-dependent manner. Chromatin immunoprecipitation analysis revealed that dsVHL-821 increased the enrichment of Ago2 and RNA polymerase II at the dsVHL-821 target site. In addition, Ago2 depletion significantly suppressed dsVHL-821-induced up-regulation of VHL gene expression and related effects. Single transfection of dsVHL-821 caused long-lasting (14 days) VHL up-regulation. Furthermore, the activation of VHL by dsVHL-821 was accompanied by an increase in dimethylation of histone 3 at lysine 4 (H3K4me2) and acetylation of histone 4 (H4ac) and a decrease in dimethylation of histone 3 at lysine 9 (H3K9me2) and lysine 27 (H3K27me2) in the dsVHL-821 target region. Taken together, these results demonstrate that dsVHL-821, a novel saRNA for VHL, induces the expression of the VHL gene by epigenetic changes, leading to inhibition of cell growth and induction of apoptosis, and suggest that targeted activation of VHL by dsVHL-821 may be explored as a novel treatment of renal cell carcinoma.</P>

      • Identification of Prostate Cancer LncRNAs by RNA-Seq

        Hu, Cheng-Cheng,Gan, Ping,Zhang, Rui-Ying,Xue, Jin-Xia,Ran, Long-Ke Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

        Purpose: To identify prostate cancer lncRNAs using a pipeline proposed in this study, which is applicable for the identification of lncRNAs that are differentially expressed in prostate cancer tissues but have a negligible potential to encode proteins. Materials and Methods: We used two publicly available RNA-Seq datasets from normal prostate tissue and prostate cancer. Putative lncRNAs were predicted using the biological technology, then specific lncRNAs of prostate cancer were found by differential expression analysis and co-expression network was constructed by the weighted gene co-expression network analysis. Results: A total of 1,080 lncRNA transcripts were obtained in the RNA-Seq datasets. Three genes (PCA3, C20orf166-AS1 and RP11-267A15.1) showed a significant differential expression in the prostate cancer tissues, and were thus identified as prostate cancer specific lncRNAs. Brown and black modules had significant negative and positive correlations with prostate cancer, respectively. Conclusions: The pipeline proposed in this study is useful for the prediction of prostate cancer specific lncRNAs. Three genes (PCA3, C20orf166-AS1, and RP11-267A15.1) were identified to have a significant differential expression in prostate cancer tissues. However, there have been no published studies to demonstrate the specificity of RP11-267A15.1 in prostate cancer tissues. Thus, the results of this study can provide a new theoretic insight into the identification of prostate cancer specific genes.

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