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Yu Yue,Shen Liangliang,Xie Xiaoyun,Zhao Jingjun,Jiang Miao 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.1
BACKGROUND: Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective treatments. However, exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs)-Ex have been regarded as potential treatments for various autoimmune diseases, and may also act as candidates for treating scleroderma. METHODS: Mice with scleroderma received a single 50 lg HUMSCs-Ex. HUMSCs-Ex was characterized using transmission electron microscopy, nanoparticle tracking analysis and nanoflow cytometry. The therapeutic efficacy was assessed using histopathology, immunohistochemistry, immunofluorescence, quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay and western blot. RESULTS: HUMSCs-Ex ameliorated the deposition of extracellular matrix and suppressed the epithelial-mesenchymal transition process, and the effects lasted at least three weeks. In addition, HUMSCs-Ex promoted M1 macrophage polarization and inhibited M2 macrophage polarization, leading to the restoration of the balance of M1/M2 macrophages. CONCLUSION: We investigated the potential antifibrotic and anti-inflammatory effects of HUMSCs-Ex in a bleomycininduced mouse model of scleroderma. So HUMSCs-Ex could be considered as a candidate therapy for scleroderma.
Liangliang Wang,Shuangying Li,Da Zhu,Yu Qin,Xiaoli Wang,Zhenya Hong,Zhiqiang Han 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4
Objective: To evaluate the effectiveness and safety of nab-paclitaxel plus platinum as first-line chemotherapy for ovarian cancer (OC). Methods: Patients administered platinum combined with nab-paclitaxel as first-line chemotherapy for epithelial OC, fallopian tube cancer, or primary peritoneal cancer from July 2018 to December 2021 were retrospectively evaluated. The primary outcome was progression-free survival (PFS). Adverse events (AEs) were examined. Subgroup analysis was performed. Results: Seventy-two patients (median age, 54.5 years; range, 20.0–79.0 years) were evaluated, including 12 and 60 administered neoadjuvant therapy and primary surgery with subsequent chemotherapy, respectively. The median follow-up duration was 25.6 months, and the median PFS was 26.7 (95% confidence interval [CI]=24.0–29.3) months in the whole patient population. In the neoadjuvant subgroup, the median PFS was 26.7 (95% CI=22.9–30.5) months vs. 30.1 (95% CI=23.1–37.1) months in the primary surgery subgroup. Twenty-seven patients were administered nab-paclitaxel plus carboplatin and had a median PFS of 30.3 (95% CI=not available [NA]–NA) months. The commonest grade 3–4 AEs included anemia (15.3%), white blood cell decreased (11.1%), and neutrophil count decreased (20.8%). No drug-related hypersensitivity reactions occurred. Conclusion: Nab-paclitaxel plus platinum as first-line treatment in OC was associated with a favorable prognosis and was tolerable in patients with OC.
A green route for esterification of kraft lignin with long-chain fatty acid in water
Liangliang An,Chuanlign Si,Guanhua Wang,Cheol-Soon Choi,Yong-Ho Yu,Jin-Ho Bae,Soo-Min Lee,Yong-Sik Kim 강원대학교 산림과학연구소 2019 강원대학교 산림과학연구소 학술대회 Vol.2019 No.09
Water, as a reaction solvent, has received considerable attention in synthetic organic chemistry due to being low-cost and green. In this study, green esterification of Kraft lignin and oleic acid at room temperature was investigated, and only water was used as a reaction solvent. A surfactant-combined system (p-toluenesulfonic acid/4-dodecylbenzenesulfonic acid) was designed to simultaneously solubilize lignin and disperse oleic acid, producing microreactors for esterification. After the reaction, adding water into the reaction mixture could easily precipitate the lignin ester. Its yield was 30.3 ± 0.9%. The lignin ester was characterized by 1H NMR, FT-IR, GPC, TGA, DSC, PSA, and contact angle analyzer. The results showed the successful esterification of lignin and oleic acid, indicating the effectiveness and feasibility of esterification of macromolecules in water. Due to long oleyl chains substituting hydroxyl groups of lignin, the lignin ester showed a significant decrease in glass transition temperature, an obvious increase in contact angle, and exhibited excellent thermoplasticity and hydrophobicity. Additionally, the result of PSA showed some lignin-ester particles fell in the nano-size range.
( Liangliang Wang ),( Jiajun Wang ),( Hao Shi ),( Huaxiang Gu ),( Yu Zhang ),( Xun Li ),( Fei Wang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.6
Glycerol dehydrogenases (GlyDHs) are essential for glycerol metabolism in vivo, catalyzing its reversible reduction to 1,3-dihydroxypropranone (DHA). The gldA gene encoding a putative GlyDH was cloned from Thermoanaerobacterium thermosaccharolyticum DSM 571 (TtGlyDH) and expressed in Escherichia coli. The presence of Mn(2+) enhanced its enzymatic activity by 79.5%. Three highly conserved residues (Asp(171), His(254), and His(271)) in TtGlyDH were associated with metal ion binding. Based on an investigation of glycerol oxidation and DHA reduction, TtGlyDH showed maximum activity towards glycerol at 60°C and pH 8.0 and towards DHA at 60°C and pH 6.0. DHA reduction was the dominant reaction, with a lower Km(DHA) of 1.08 ± 0.13 mM and Vmax of 0.0053 ± 0.0001 mM/s, compared with glycerol oxidation, with a Km(glycerol) of 30.29 ± 3.42 mM and Vmax of 0.042 ± 0.002 mM/s. TtGlyDH had an apparent activation energy of 312.94 kJ/mol. The recombinant TtGlyDH was thermostable, maintaining 65% of its activity after a 2-h incubation at 60°C. Molecular modeling and site-directed mutagenesis analyses demonstrated that TtGlyDH had an atypical dinucleotide binding motif (GGG motif) and a basic residue Arg(43), both related to dinucleotide binding.
RCS Numerical Simulation of Stealth Modified Three-Surface Aircraft
Cheng Liangliang,Yue Kuizhi,Xing CuiFang,Yu Dazhao 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.1
The RCS characteristics of stealth modified three-surface aircraft are analyzed in this paper. Prototype A is built with CATIA software and the three-dimensional digital models of modified stealth three-surface B and C are also designed based on carrier-based aircraft Su-33; the numerical simulation of RCS characteristics of three-surface aircraft is conducted with RCSAnsys software based on physical optics method and the method of equivalent currents; The following results are obtained by comparative analysis and mathematical statistics: (1) by the use of physical optics method and equivalent electromagnetic current method, the scattering intensity for each part of the model and RCS characteristic of the aircraft can be analyzed efficiently and accurately; (2) compared with model A, the mean RCS value of model B is reduced to 14.1% in forward direction and 48.1% in lateral direction; (3) compared with model A, the mean RCS value of model C decreases to 11.4% in forward direction and 21.6% in lateral direction. The results are expected to provide theoretical basis and technical support to the conceptual design of aircraft and stealth technology research.
Li Liangliang,Zhang Yanan,Chen Yang,Guo Yi,Wang Yinghui,Hu Gengwang,Kang Chengtao,Jiangfeng Wang,Wang Yu 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2
Sarcophaga peregrina Robineau-Desvoidy, 1830 (Diptera: Sarcophagidae) is a widely distributed species in the Palearctic, Oriental and Australian regions. Numerous studies and case reports have confirmed the value of this species in forensic investigations, but methods for estimating the age of the intrapuparial period of this species are lacking. In this study, S. peregrina pupae were sampled at 16 ◦ C, 19 ◦ C, 22 ◦ C, 25 ◦ C, 28 ◦ C, 31 ◦ C, and 34 ◦ C. Morphological changes within the puparium were observed under a stereomicroscope. The results of the study showed that S. peregrina could complete its intrapuparial development at each of the seven tested constant temperatures. As the temperature increased, the average minimum duration of the intrapuparial period of S. peregrina decreased from 706.7 ± 28.1 h at 16 ◦ C to 170.7 ± 4.6 h at 34 ◦ C. The intrapuparial morphological changes of S. peregrina can be divided into 12 sub-stages. While some structures such as the compound eyes, mouthparts, antennae, thorax, legs, wings, and abdomen can be used individually to estimate intrapuparial age, we observed all these structures with local magnification photographs and classified the developmental process of these structures into 6–11 stages. The time range for the appearance of each sub-stage or structure was recorded in detail. The results of this study provide important basic data for estimating the minimum postmortem interval using the intrapuparial morphology of S. peregrina.