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Haibing He,Xing Tang,Bo Shi,Cuifang Cai 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
The poorly water-soluble drug lovastatin (LVA) is an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase and has a slow dissolution rate. In this study, a microcrystal dispersion (MCD) technique was used in the preparation of LVA to increase its dissolution rate and then combining with an extrusion-spheronization method, microcrystalline cellulose (MCC) matrix sustained-release pellets containing LVA-MCD were developed and characterized in vitro. Photomicrographs indicated that LVA-MCD existed as fine crystals, of which the mean particle size was reduced from 65.75 μm to 3.97 μm and the dried LVA-MCD powders released completely within 2 hours. SEM results during the release process showed that pellets possessed a matrix structure and after the dissolution test, this matrix structure became loose and porous. The release of LVA was fast and complete, and accumulated release by the optimal formulation was: 0.5 h (20.23 ± 3.40%), 2 h (56.87 ± 2.85%), 4 h (78.71 ± 3.42%), and 8 h (96.81 ± 3.30%). The 3 months accelerating test at 40^oC and 75% RH demonstrated that drug release of pellets was not changed and drug degradation was less than 1%. Thus, a novel MCD process with MCC matrix was feasible and effective to get complete release without a lag time for the poorly water soluble drug, LVA, with high stability.
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RCS Numerical Simulation of Stealth Modified Three-Surface Aircraft
Cheng Liangliang,Yue Kuizhi,Xing CuiFang,Yu Dazhao 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.1
The RCS characteristics of stealth modified three-surface aircraft are analyzed in this paper. Prototype A is built with CATIA software and the three-dimensional digital models of modified stealth three-surface B and C are also designed based on carrier-based aircraft Su-33; the numerical simulation of RCS characteristics of three-surface aircraft is conducted with RCSAnsys software based on physical optics method and the method of equivalent currents; The following results are obtained by comparative analysis and mathematical statistics: (1) by the use of physical optics method and equivalent electromagnetic current method, the scattering intensity for each part of the model and RCS characteristic of the aircraft can be analyzed efficiently and accurately; (2) compared with model A, the mean RCS value of model B is reduced to 14.1% in forward direction and 48.1% in lateral direction; (3) compared with model A, the mean RCS value of model C decreases to 11.4% in forward direction and 21.6% in lateral direction. The results are expected to provide theoretical basis and technical support to the conceptual design of aircraft and stealth technology research.
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