Does openness to innovation matter? The moderating role of open innovation between organizational ambidexterity and innovation performance

Li Ruijie,Fu Lihua,Liu Zhiying 기술경영경제학회 2020 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.28 No.2

Based on organizational ambidexterity theory and knowledge-based view, this study presents a conceptual framework that links organizational ambidexterity, open innovation and innovation performance together and tested this framework by distributing questionnaires to senior managers in East and Mid-China to assess related variables. The empirical study analysis based on 274 returned questionnaires finds a non-linear relationship between organizational ambidexterity and innovation performance and the moderating effects of inbound and outbound open innovation on the ambidexterity-performance relationship. To effectively use organizational ambidexterity, firms need open innovation to use external ideas as well as internal ideas, and to take advantage of both internal and external paths to market.

A Novel Nonlinear Link Element for Direct Second-Order Analysis of Trusses Assembled by Weak Shear Stiffness Members

Ruijie Zhu,Feng Li,Zhiqin Zhao,Xingzhong Wang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11

The transverse shear effect and initial imperfection have significant influence on the post-buckling performance of weak shear stiffness struts such as pultruded fiber reinforced polyester (FRP) members and lattice column. A novel nonlinear link (NNL) element was proposed to perform direct second-order analysis of trusses assembled by such members. Adopting the Engesser approach to account for shear deformability, the expressions of transverse deflection under tensile and compressive load were obtained respectively. Taking the linear tension-compression deformation and bowing effect into account, the correction coefficients of axial stiffness for FRP truss member under tension and compression were obtained. Combined with ANSYS UPFs -user programmable features, the user-defined NNL element was established. Both pultruded FRP profiles and lattice column were modeled separately by standard commercial elements and the proposed NNL element. The comparison of the obtained results verified the convenience of the NNL element in modeling and computing. Moreover, the NNL element was adopted to model and calculate two FRP plane truss structures, and the calculation result was compared with test result. It demonstrated that the NNL element can accurately predict structural stiffness change and change points during successive buckling of certain truss members, showing the promising usage of NNL element in structural design of other FRP truss structures.

Pharmacokinetic difference of berberine between normal and chronic visceral hypersensitivity irritable bowel syndrome rats and its mechanism

Zipeng Gong,Ying Chen,Ruijie Zhang,Qing Yang,Yajie Wang,Yan Guo,Bingbing Zhou,Xiaogang Weng,Xuchen Liu,Yujie Li,Xiaoxin Zhu,Yu Dong 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

Berberine is one of active alkaloids from Rhizomacoptidis in traditional Chinese medicine. The pharmacokineticsof berberine in rat plasma were compared betweennormal and chronic visceral hypersensitivity irritable bowelsyndrome rats (CVH-IBS) established by mechanical colonirritation using angioplasty balloons for 2 weeks after oraladministration of berberine hydrochloride (25 mg/kg) withthe equivalent dose of 22 mg/kg for berberine according tobody weight. Immunohistochemical analysis of c-fos andmyosin light chain kinase (MLCK) and immunofluorescenceanalysis of MLCK in rat colon were conducted. Quantificationof berberine in rat plasma was achieved by using a sensitiveand rapidUPLC-MS/MSmethod. Plasma samples werecollected at 15 different points in time and the pharmacokineticparameters were analyzed by WinNonlin software. Thegreat different pharmacokinetic behavior of berberine wasobserved between normal and CVH-IBS model rats. Compared with normal group, T1/2 and AUC(0–t) of berberinein the model group were significantly increased, respectively(573.21 ± 127.53 vs 948.22 ± 388.57 min; 8,657.19 ±1,562.54 vs 11,415.12 ± 1,670.72 min.ng/ml). Cl/F of berberinein the model group significantly decreased, respectively(13.89 ± 1.69 vs 9.19 ± 2.91 L/h/kg). Additionally,the expressions of c-fos and MLCK in model group werehigher than those in normal group. The pharmacokinetic behaviorof berberine was significantly altered in CVH-IBSpathological conditions, which indicated the dosage modificationof berberine hydrochloride in CVH-IBS were necessary. Especially, improved exposure to berberine in ratplasma inCVH-IBSmodel rats was attributed to increased theexpression of MLCK.

Observation and characterization of the effect of electron cyclotron waves on toroidal rotation in EAST L-mode discharges

CHEN, Jun,HU, Ruiji,LYU, Bo,WANG, Fudi,WANG, Xiaojie,XU, Handong,LI, Yingying,FU, Jia,YIN, Xianghui,WU, Dajun,LIU, Fukun,ZANG, Qing,LIU, Haiqing,SHI, Yuejiang,MAO, Shifeng,YU, Yi,WAN, Baonian,YE, Miny IOP Publishing 2017 Plasma science & technology Vol.19 No.10

Slipchip Device Development in Molecular Diagnostics

Qingtian Yin,Huiwen Bai,Ruijie Li,석영웅 한국재료학회 2024 한국재료학회지 Vol.34 No.2

Slipchip offers advantages such as high-throughout, low cost, and simple operation, and therefore, it is one of the technologies with the greatest potential for high-throughput, single-cell, and single-molecule analyses. Slipchip devices have achieved remarkable advances over the past decades, with its simplified molecular diagnostics gaining particular attention, especially during the COVID-19 pandemic and in various infectious diseases scenarios. Medical testing based on nucleic acid amplification in the Slipchip has become a promising alternative simple and rapid diagnostic tool in field situations. Herein, we present a comprehensive review of Slipchip device advances in molecular diagnostics, highlighting its use in digital recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), and polymerase chain reaction (PCR). Slipchip technology allows users to conduct reliable droplet transfers with high-throughput potential for single-cell and molecule analyses. This review explores the device’s versatility in miniaturized and rapid molecular diagnostics. A complete Slipchip device can be operated without special equipment or skilled handling, and provides high-throughput results in minimum settings. This review focuses on recent developments and Slipchip device challenges that need to be addressed for further advancements in microfluidics technology.

Static performance of a new GFRP–metal string truss bridge subjected to unsymmetrical loads

Dongdong Zhang,Jiaxin Yuan,Qilin Zhao,Feng Li,Yifeng Gao,Ruijie Zhu,Zhiqin Zhao 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.35 No.5

A unique lightweight string truss deployable bridge assembled by thin-walled fiber reinforced polymer (FRP) and metal profiles was designed for emergency applications. As a new structure, investigations into the static structural performance under the serviceability limit state are desired for examining the structural integrity of the developed bridge when subjected to unsymmetrical loadings characterized by combined torsion and bending. In this study, a full-scale experimental inspection was conducted on a fabricated bridge, and the combined flexural–torsional behavior was examined in terms of displacement and strains. The experimental structure showed favorable strength and rigidity performances to function as deployable bridge under unsymmetrical loading conditions and should be designed in accordance with the stiffness criterion, the same as that under symmetrical loads. In addition, a finite element model (FEM) with a simple modeling process, which considered the multi segments of the FRP members and realistic nodal stiffness of the complex unique hybrid nodal joints, was constructed and compared against experiments, demonstrating good agreement. A FEM-based numerical analysis was thereafter performed to explore the effect of the change in elastic modulus of different FRP elements on the static deformation of the bridge. The results confirmed that the change in elastic modulus of different types of FRP element members caused remarkable differences on the bending and torsional stiffness of the hybrid bridge. The global stiffness of such a unique bridge can be significantly enhanced by redesigning the critical lower string pull bars using designable FRP profiles with high elastic modulus.

Upgrades of poloidal and tangential x-ray imaging crystal spectrometers for temperature and rotation measurements on EAST

Wang, Fudi,Chen, Jun,Hu, Ruiji,Lyu, Bo,Colledani, Gilles,Fu, Jia,Li, Yingying,Bitter, Manfred,Hill, Kenneth,Lee, Sangon,Ye, Minyou,Shi, Yuejiang,Wan, Baonian American Institute of Physics 2016 Review of scientific instruments Vol.87 No.11

Effects of Hydrodynamic Disturbance on Vegetation Development in Coastal Salt Marshes: A Model Study in Jiangsu, China

Chen Zhipeng,Luo Feng,Zeng Jingwei,Dai Jiancheng,Zhou Guanghuai,Li Ruijie 한국해양과학기술원 2023 Ocean science journal Vol.58 No.1

Salt marshes are now known to improve coastal safety by attenuating waves and stabilizing the bed. Meanwhile, for salt marsh conservatin and restoration, a great deal of research has been done on the establishment mechanism of vegetation in salt marshes. However, research on the efects of hydrodynamic disturbance on the development of salt marsh vegetation is limited. The purpose of this paper is to investigate how the hydro-morphodynamic process afects the establishment and expansion of plants in salt marshes and to simulate the establishment process. First, we used a 2D fnite-element model to simulate hydro-morphodynamics in the selected tidal fat in Jiangsu, China. We then defned the variables describing the frequency and magnitude of hydrodynamic disturbance and quantifed the efects of disturbance on plant establishment using Spearman correlation coefcients. Finally, the vegetation development process was further analyzed using a logistic regression model, and the vegetation development in the study area was simulated from 2017 to 2021. The results show that salt marsh vegetation colonization has a relatively high correlation with fooding time and bed shear stress (ρ>0.6), and bed shear stress is the main hydrodynamic disturbance parameter limiting further expansion of salt marsh vegetation. The method combining hydrodynamic modeling and logistic regression has the potential to be used to identify hydrodynamic disturbances in future salt marsh restoration and management processes and to help design appropriate restoration measures.