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        A Novel Nonlinear Link Element for Direct Second-Order Analysis of Trusses Assembled by Weak Shear Stiffness Members

        Ruijie Zhu,Feng Li,Zhiqin Zhao,Xingzhong Wang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11

        The transverse shear effect and initial imperfection have significant influence on the post-buckling performance of weak shear stiffness struts such as pultruded fiber reinforced polyester (FRP) members and lattice column. A novel nonlinear link (NNL) element was proposed to perform direct second-order analysis of trusses assembled by such members. Adopting the Engesser approach to account for shear deformability, the expressions of transverse deflection under tensile and compressive load were obtained respectively. Taking the linear tension-compression deformation and bowing effect into account, the correction coefficients of axial stiffness for FRP truss member under tension and compression were obtained. Combined with ANSYS UPFs -user programmable features, the user-defined NNL element was established. Both pultruded FRP profiles and lattice column were modeled separately by standard commercial elements and the proposed NNL element. The comparison of the obtained results verified the convenience of the NNL element in modeling and computing. Moreover, the NNL element was adopted to model and calculate two FRP plane truss structures, and the calculation result was compared with test result. It demonstrated that the NNL element can accurately predict structural stiffness change and change points during successive buckling of certain truss members, showing the promising usage of NNL element in structural design of other FRP truss structures.

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        Pharmacokinetic difference of berberine between normal and chronic visceral hypersensitivity irritable bowel syndrome rats and its mechanism

        Zipeng Gong,Ying Chen,Ruijie Zhang,Qing Yang,Yajie Wang,Yan Guo,Bingbing Zhou,Xiaogang Weng,Xuchen Liu,Yujie Li,Xiaoxin Zhu,Yu Dong 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

        Berberine is one of active alkaloids from Rhizomacoptidis in traditional Chinese medicine. The pharmacokineticsof berberine in rat plasma were compared betweennormal and chronic visceral hypersensitivity irritable bowelsyndrome rats (CVH-IBS) established by mechanical colonirritation using angioplasty balloons for 2 weeks after oraladministration of berberine hydrochloride (25 mg/kg) withthe equivalent dose of 22 mg/kg for berberine according tobody weight. Immunohistochemical analysis of c-fos andmyosin light chain kinase (MLCK) and immunofluorescenceanalysis of MLCK in rat colon were conducted. Quantificationof berberine in rat plasma was achieved by using a sensitiveand rapidUPLC-MS/MSmethod. Plasma samples werecollected at 15 different points in time and the pharmacokineticparameters were analyzed by WinNonlin software. Thegreat different pharmacokinetic behavior of berberine wasobserved between normal and CVH-IBS model rats. Compared with normal group, T1/2 and AUC(0–t) of berberinein the model group were significantly increased, respectively(573.21 ± 127.53 vs 948.22 ± 388.57 min; 8,657.19 ±1,562.54 vs 11,415.12 ± 1,670.72 min.ng/ml). Cl/F of berberinein the model group significantly decreased, respectively(13.89 ± 1.69 vs 9.19 ± 2.91 L/h/kg). Additionally,the expressions of c-fos and MLCK in model group werehigher than those in normal group. The pharmacokinetic behaviorof berberine was significantly altered in CVH-IBSpathological conditions, which indicated the dosage modificationof berberine hydrochloride in CVH-IBS were necessary. Especially, improved exposure to berberine in ratplasma inCVH-IBSmodel rats was attributed to increased theexpression of MLCK.

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        Static performance of a new GFRP–metal string truss bridge subjected to unsymmetrical loads

        Dongdong Zhang,Jiaxin Yuan,Qilin Zhao,Feng Li,Yifeng Gao,Ruijie Zhu,Zhiqin Zhao 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.35 No.5

        A unique lightweight string truss deployable bridge assembled by thin-walled fiber reinforced polymer (FRP) and metal profiles was designed for emergency applications. As a new structure, investigations into the static structural performance under the serviceability limit state are desired for examining the structural integrity of the developed bridge when subjected to unsymmetrical loadings characterized by combined torsion and bending. In this study, a full-scale experimental inspection was conducted on a fabricated bridge, and the combined flexural–torsional behavior was examined in terms of displacement and strains. The experimental structure showed favorable strength and rigidity performances to function as deployable bridge under unsymmetrical loading conditions and should be designed in accordance with the stiffness criterion, the same as that under symmetrical loads. In addition, a finite element model (FEM) with a simple modeling process, which considered the multi segments of the FRP members and realistic nodal stiffness of the complex unique hybrid nodal joints, was constructed and compared against experiments, demonstrating good agreement. A FEM-based numerical analysis was thereafter performed to explore the effect of the change in elastic modulus of different FRP elements on the static deformation of the bridge. The results confirmed that the change in elastic modulus of different types of FRP element members caused remarkable differences on the bending and torsional stiffness of the hybrid bridge. The global stiffness of such a unique bridge can be significantly enhanced by redesigning the critical lower string pull bars using designable FRP profiles with high elastic modulus.

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