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Inhibitory Effects of Dicaffeoylquinic Acids from Artemisia dubia on Aldo-keto Reductase Family 1B10
Lee, Hee-Ju,Lee, Joo-Young,Kim, Sang-Min,Nho, Chu-Won,Jung, Sang-Hoon,Song, Dae-Geun,Kim, Chul-Young,Pan, Cheol-Ho The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.6
The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant hnman AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dibydroxybenzoic acid (1), quercetin 3-O-${\beta}$-glucose (2), 3,4-DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of $IC_{50}$ $1.24-2.29\;{\mu}M$, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-${\beta}$-glucose showed no inhibitory activity on rhAKR1B10.
Lee, Chu,Chun, Wonjoo,Zhao, Rongjie,Kim, Young Dae,Nam, Myung Mo,Jung, Dae Hwa,Cho, Il Je,Jegal, Kyung Hwan,Lee, Tae Hoon,Kim, Young Woo,Park, Sang Mi,Ju, Seong A.,Lee, Chul Won,Kim, Sang Chan,An, Won D.A. Spandidos 2017 Oncology letters Vol.14 No.2
<P><I>Patinopecten yessoensis</I>, is a species of scallop and a marine bivalve mollusk. In traditional East Asian medicine, scallop meat is used as a drug for the treatment of diabetes, pollakisuria, and indigestion. The present study was conducted in order to examine the potential anticancer effects of scallop flesh extract (SE) on MCF-7 human breast cancer cells. An MTT assay was used to evaluate cell viability and flow cytometry was used for the assessment of cell cycle distribution and apoptosis. The alteration in protein expression level was determined by western blot analysis, and the amounts of docosahexaenoic acid and eicosapentaenoic acid in the SE were measured by gas chromatography. SE inhibited the growth of MCF-7 human breast cancer cells in a dose-dependent manner by inducing G0/G1 phase arrest. The cell cycle arrest was associated with the upregulation of p53 and p21, and downregulation of G1 phase-associated cyclin D1/cyclin-dependent kinase (Cdk) 4 and cyclin E1/Cdk 2. In addition, SE-mediated cell cycle arrest was associated with the promotion of apoptosis, as indicated by the expression of apoptosis-associated proteins and changes in nuclear morphology. SE appeared to induce the mitochondrial apoptotic cascade, as indicated by a decreased expression of Bcl-2, activation of Bcl-2 associated X protein, release of cytochrome c, decrease in procaspase-3, and an increase in cleaved-poly (ADP-ribose) polymerase (PARP). Furthermore, the expression levels of Fas-associated via death domain and cleaved caspase-8 were increased in a SE dose-dependent manner. Taken together, these results suggest that the intrinsic and extrinsic pathways of apoptosis are associated with the anticancer effects of SE on MCF-7 cells. Thus, SE may be a suitable candidate for the treatment and prevention of human breast cancer.</P>
Lee, Won‐,Mo,Sung, Ji Ho,Chu, Kanghyun,Moya, Xavier,Lee, Donghun,Kim, Cheol‐,Joo,Mathur, Neil D.,Cheong, S.‐,W.,Yang, C.‐,H.,Jo, Moon‐,Ho WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.10
<P>On page OP49, M.‐H. Jo and co‐workers describe a method of control over photocurrent detection by manipulating ferroelectric domain configurations. The magnitude is spectrally centered around charged domain walls that are associated with oxygen vacancy migration in BiFeO<SUB>3</SUB>, where potential gradients caused by spontaneous polarization yield asymmetric and nonlinear photocarrier dynamics. </P>
Chu Mi Ae,Jang Yoon Young,Lee Dong Won,Kim Sung Hoon,류남희,박성균,Lee Jae Hee,Chung Hai Lee 대한소아청소년과학회 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.12
Background: Viral load and shedding duration are highly associated with the transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, limited studies have reported on viral load or shedding in children and adolescents infected with sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Purpose: This study aimed to investigate the natural course of viral load in asymptomatic or mild pediatric cases.Methods: Thirty-one children (<18 years) with confirmed SARS-CoV-2 infection were hospitalized and enrolled in this study. Viral loads were evaluated in nasopharyngeal swab samples using real-time reverse transcription polymerase chain reaction (E, RdRp, N genes). cycle threshold (Ct) values were measured when patients met the clinical criteria to be released from quarantine.Results: The mean age of the patients was 9.8 years, 18 (58%) had mild disease, and 13 (42%) were asymptomatic. Most children were infected by adult family members, most commonly by their mothers. The most common symptoms were fever and sputum (26%), followed by cough and runny nose. Nine patients (29%) had a high or intermediate viral load (Ct value≤30) when they had no clinical symptoms. Viral load showed no difference between symptomatic and asymptomatic patients. Viral rebounds were found in 15 cases (48%), which contributed to prolonged viral detection. The mean duration of viral detection was 25.6 days. Viral loads were significantly lower in patients with viral rebounds than in those with no rebound (E, P=0.003; RdRp, P=0.01; N, P=0.02).Conclusion: Our study showed that many pediatric patients with coronavirus disease 2019 (COVID-19) experienced viral rebound and showed viral detection for more than 3 weeks. Further studies are needed to investigate the relationship between viral rebound and infectiousness in COVID-19.
Chu, Sang Hui,Baek, Ji Won,Kim, Eun Sook,Stefani, Katherine M.,Lee, Won Joon,Park, Yeong-Ran,Youm, Yoosik,Kim, Hyeon Chang The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1
Objectives: Controlling blood pressure is a key step in reducing cardiovascular mortality in older adults. Gender differences in patients' attitudes after disease diagnosis and their management of the disease have been identified. However, it is unclear whether gender differences exist in hypertension management among older adults. We hypothesized that gender differences would exist among factors associated with hypertension diagnosis and control among community-dwelling, older adults. Methods: This cross-sectional study analyzed data from 653 Koreans aged ${\geq}60years$ who participated in the Korean Social Life, Health, and Aging Project. Multiple logistic regression was used to compare several variables between undiagnosed and diagnosed hypertension, and between uncontrolled and controlled hypertension. Results: Diabetes was more prevalent in men and women who had uncontrolled hypertension than those with controlled hypertension or undiagnosed hypertension. High body mass index was significantly associated with uncontrolled hypertension only in men. Multiple logistic regression analysis indicated that in women, awareness of one's blood pressure level (odds ratio [OR], 2.86; p=0.003) and the number of blood pressure checkups over the previous year (OR, 1.06; p=0.011) might influence the likelihood of being diagnosed with hypertension. More highly educated women were more likely to have controlled hypertension than non-educated women (OR, 5.23; p=0.013). Conclusions: This study suggests that gender differences exist among factors associated with hypertension diagnosis and control in the study population of community-dwelling, older adults. Education-based health promotion strategies for hypertension control might be more effective in elderly women than in elderly men. Gender-specific approaches may be required to effectively control hypertension among older adults.
The Chemopreventive Effect of Taxifolin Is Exerted through ARE-Dependent Gene Regulation
Lee, Saet Byoul,Cha, Kwang Hyun,Selenge, Dangaa,Solongo, Amgalan,Nho, Chu Won Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.6
<P>Phase II detoxification enzymes are responsible for the detoxification and elimination of activated carcinogens, and thus act as important biomarkers for chemoprevention. In this study, we tested the chemopreventive activity of taxifolin, a flavanon compound purified from a mongolian medicinal plant, by measuring quinone reductase (QR) activity in HCT 116 cells. Taxifolin induced significant QR activity, but displayed relatively low cytotoxicity in cells (chemoprevention index=5.75). To identify the target genes regulated by taxifolin, DNA microarray was performed with a 3K human cancer chip containing 3096 human genes associated with carcinogenesis. Significant analysis of microarray (SAM) revealed 428 differentially expressed (DE) genes as statistically significant, with a false discovery rate (FDR) of 57.2% (delta=0.3366). Sixty-five genes, including a few detoxification enzymes (<I>NQO1</I>, <I>GSTM1</I>) and an antioxidant enzyme (<I>TXNRD1</I>), were up-regulated and 363 genes were down-regulated in the presence of 60 μ<SMALL>M</SMALL> taxifolin. In view of the finding that selected genes of interest contained antioxidant response element (ARE), we hypothesize that taxifolin modulates chemopreventive genes through activation of the ARE. Transient transfection experiments using the ARE QR-CAT construct demonstrate that taxifolin significantly activates ARE, but not xenobiotic response element (XRE). In conclusion, taxifolin acts as a potential chemopreventive agent by regulating genes <I>via</I> an ARE-dependent mechanism.</P>