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데이컴 직무분석 기법을 이용한 수술실 간호사의 직무분석
조경숙(Cho Kyung-Sook),손행미(Son Haeng-Mi),강현숙(Kang Hyun-Sook),김주현(Kim Joo-Hyun),임난영(Lim Nan-Young),윤계숙(Yoon Kye-Sook),한혜자(Han Hye-Ja) 기본간호학회 2008 기본간호학회지 Vol.15 No.4
Purpose: Developing a curriculum(DACUM) is a method of analyzing job focused competency, which is obtained from the data of an expert belonging to a certain career. In this study the DACUM method was used to analyze the jobs of operating room nurses. Method: Through the DACUM workshop which was arranged by two DACUM facillitators, a definition of the role of operating room nurses was developed and then duties and tasks of operating room nurses' were identified. For the workshop, a DACUM committee with 10 operating room nurses was organized. Finally, the duties and tasks which were identified were validated by 422 nurses for importance, difficulty, and frequency. Results: Thirteen duties and 105 tasks were identified on the DACUM chart, where importance, difficulty, and frequency of tasks were represented by alphabet letters A, B, and C as higher degree of importance. The determinant coefficient(DC) showed that the most important duty was assisting with operations(DC=6.61), and the least, managing operating materials(DC=4.22). For tasks, the most important ones were assisting in orthostatic surgery(DC=7.60), and assisting in thoracic surgery(DC=7.38), and the least important making gauze ball(DC=2.39), and saving of operation site((DC=3.27). Conclusion: The results suggest a need to develop an education program using the DACUM chart as a basis for the development and as a clinical career ladder and for curriculum of operating room nursing.
Proteomic analysis of injured rat spinal cords after transplantation of human embryonic stem cells
Hye Sook Hwang,Bae Hwan Lee,Kwang Sik Kim,Kun Ho Choi,Sae Jin Oh,Kyung Jin Roh,Se Jin Hwang,Jeong Bok Lee,Hyun Soo Yun,Kye Seong Kim,Yeo Sung Yoon,Je Kyung Seong 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-
Weak response of porcine C5a receptor towards human C5a in miniature pig endothelial cells and PMNs
Yi, Kye Sook,Lee, Sukmook,Kang, Yoon-Ho,Bae, Yoe-Sik,Hwang, Seung Yong,Ha, Insu,Kim, Hyori,Kim, Min Soo,Cho, Bumrae,Kang, Hee Jung,Bang, Ki Tae,Kim, Jae Yong,Yang, Jaeseok,Chung, Junho,Ahn, Curie Blackwell Publishing Ltd 2007 Xenotransplantation Vol.14 No.6
<P>Abstract: Background: </P><P>The anaphylatoxin C5a is a potent inflammatory molecule generated during complement activation. Although some reports have implicated C5a in xenograft rejection, to date, the molecular compatibility between human C5a and porcine C5a receptor (C5aR) has been little studied. To examine the need for pC5aR-deficient pig in xenotransplantaion, we aimed to look at the degree of direct interaction between human C5a (recipient side) and porcine endothelial cells (PECs) and porcine polymorphonuclear neutrophils (PMNs) (donor side).</P><P>Methods: </P><P>Following the treatment of human C5a to isolated porcine PMNs, transmigration of PMNs was measured by Transwell system and superoxide generation by cytochrome <I>c</I> reduction assay. Next, the effects of human C5a on several intracellular signaling pathways were further checked; actin cytoskeletal change was observed under a confocal microscope after staining with Alexa Fluor-546-phalloidin, intracellular calcium mobilization was measured by spectrofluorophotometer. The degree of direct effect of human C5a on porcine PMNs was compared with that in human PMNs. Finally, microarray was performed to monitor the effect of human C5a on gene expression of PEC and the expression of several candidate proteins was checked by flow cytometry.</P><P>Results: </P><P>We found that human C5a was able to induce chemotaxis, superoxide generation, actin cytoskeletal change, and intracellular calcium mobilization in porcine PMNs. However, higher concentration of human C5a was required to stimulate porcine PMNs in comparison with activating human PMNs. The amino acid sequences of porcine C5aR with those of human C5aR showed a sequence homology of only 67%. To elucidate the effect of human C5a to PECs, microarray analysis following the treatment of PECs with human C5a was performed. These data showed that human C5a did not significantly affect gene transcription patterns in PECs. Additionally, treatment of PECs with human C5a also did not induce protein expression of several cell adhesion molecules, including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, P-selectin, and E-selectin, or secretion of interleukin-8 from PECs.</P><P>Conclusions: </P><P>These results suggest that human C5a may play a minor role on PEC activation possibly due to molecular incompatibility across the species barrier.</P>
Hyung Yoon Kim,Sung-A Chang,Kye Hun Kim,Jae-Young Kim,Woo-Keun Seo,Hyung Seop Kim,Jeong-Sook Seo,Sung Hee Shin,Sang Jae Rhee,Sun Hwa Lee,Jung Sun Cho 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.3
BACKGROUND: The annual incidence of venous thromboembolism (VTE) is increasing, and the treatment pattern of oral anticoagulants (OACs) has changed with introduction of new oral anticoagulants (NOACs). The aims of this study were to assess the annual incidence of VTE in a Korean population and the change of treatment pattern with availability of NOACs using a population-based database. METHODS: Using the Korean National Health Insurance Services database, we identified patients diagnosed with VTE between 2009 and 2016. The annual prevalence of VTE and clinical characteristics and treatment pattern were investigated. The annual incidence of VTE was calculated using direct and indirect methods using the estimated Korean population in 2009 as the reference. RESULTS: The annual incidence of VTE in Korean has increased yearly from 23.9 per 100,000 in 2009 to 42.2 in 2016. The overall rate of OAC prescription for VTE treatment increased from 55.9% to 68% in the same time period. The rate of initiation of NOAC treatment greatly increased, particularly from 2013 onwards, with a 20-fold increase from 2009 to 2016 (2.1% vs. 54.3%). CONCLUSIONS: The annual incidence of VTE in Korea increased by almost two-fold from 2009 to 2016. The rate of initiation of NOAC treatment has increased substantially since 2013, and these agents have surpassed VKAs as the anticoagulant of choice for VTE. This temporal pattern of OAC prescription is consistent with the current clinical guidelines, which indicate NOACs over the warfarin in patients with VTE.
Characterization of an Elastase Inhibitor Produced by Streptomyces lavendulae SMF11
Lee, Hyun Sook,Jin, Wook,Kang, Sung Gyun,Hwang, Yoon Sook,Kho, Yung Hee,Lee, Kye Joon 한국미생물 · 생명공학회 2000 Journal of microbiology and biotechnology Vol.10 No.1
An elastase inhibitor, SMFEI02, was isolated from culture broth of Streptomyces lavendulae SMF11. The inhibitor was purified by ultrafiltration followed by XAD-7 column and Dowex-1 anion-exchange chromatographies, and preparative HPLC. The molecular formula was determined to be C_14H_16N_2O_2 (MW 244) by HRFAB-MS analysis. The inhibitor was identified to be a diketopiperazine cyclo(S-Phe-S-Pro) by the optical rotation value and NMR spectral data, and showed inhibitory activities for trypsin, chymotrypsin, cathepsin B, and papain as well as elastase with the K_i values ranging from 1.78mM to 2.86μM. The inhibition showed a competitive mode for elastase, chymotrypsin, and cathepsin B, whereas it showed a noncompetitive mode for trypsin and papain.
( Hyeon Jeong Suh ),( Sook-In Jung ),( Kyoung-Ho Song ),( Wan Beom Park ),( Yee Gyung Kwak ),( Kye-Hyung Kim ),( Jeong-Hwan Hwang ),( Nara Yoon ),( Hee-Chang Jang ),( Young Keun Kim ),( Kyung-Hwa Park 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Background: Increasing methicillin-resistance among the community-onset Staphylococcus aureus infection is growing concern. We tried to identify demographic and clinical risk factors for methicillin-resistance in community-onset S. aureus bacteremia (CO-SAB) and developed a clinical risk score system. Methods: We reviewed the medical records of three multicenter, prospective cohort studies: the cohort from July, 2009 to June, 2011 at 9 hospitals, from May to December, 2012 at 16 hospitals, and from September, 2013 to March, 2015 at 13 hospitals. Using these data, we developed a risk score system. Point allocation in the methicillin-resistance was based on beta-coefficient in the final regression model. Results: We gathered a total of 1,802 cases of CO-SAB, 752 (41.7%) of which were methicillin-resistant S. aureus (MRSA) infections. MRSA bacteremia cases were significantly older, and more likely to have a history of MRSA infection or colonization within six months [Odds ratio(OR), 4.456; 95% confidence interval(CI), 2.974-6.677; 1.5 point], hospitalization or surgery (OR 2.050; 95% CI 1.640-2.563; 0.5 point), residence in a long term care facility (OR 1.679; 95% CI 1.297-2.173; 0.5 point) and dialysis (OR 1.475; 95% CI 1.075-2.024; 0.5 point) within the past year. On the other hand, they were less likely to have hematologic disease (OR 0.445; 95% CI 0.234-0.847; -1 point) and skin and soft tissue infection (OR 0.570; 95% CI 0.410-0.793; -0.5 point), bone and joint infection (OR 0.650; 95% CI 0.481-0.878; -0.5 point), or endovascular infection (OR 0.456; 95% CI 0.263-0.790; -1 point) as a primary site of infection. The area under the curve (AUC) was 0.684 and cut-off value was 0.75. The sensitivity, specificity, positive predictive value and negative predictive value were 0.543, 0.751, 0.610 and 0.696, respectively. Conclusions: We developed a clinical risk score system to predict methicillin-resistance in CO-SAB in this study. However, it was not possible to make a distinguishable system only based on demographic and clinical factors in spite of a large scale of cases. Other tools such as rapid microorganism identification technology will be necessary for early adequate antibiotic therapy in CO-SAB.
Baek, Jae-Min,Yoon, Na-Young,Kim, Yeon-Kye,Lee, Doo-Seog,Yoon, Ho-Dong,Park, Jeung-Sook The Korean Society of Fisheries and Aquatic Scienc 2011 Fisheries and Aquatic Sciences Vol.14 No.2
We investigated the antioxidant and cholinesterase inhibitory activities of the aqueous extract of rainbow trout Oncorhynchus mykiss. The antioxidant activity of O. mykiss aqueous extract was determined by in vitro peroxynitrite scavenging activity and reducing power assays. The aqueous extract of O. mykiss showed potent peroxynitrite radical scavenging activity ($IC_{50}=0.12{\pm}0.001\;mg/mL$) and reducing power (absorbance=$0.47{\pm}0.001$) at the concentration of 1 mg/mL. The in vitro cholinesterase inhibitory activity of O. mykiss aqueous extract was examined using spectrophotometric analyses of acetyl- and butyrylcholinesterase. The aqueous extract of O. mykiss showed acetylcholinesterase inhibitory activity ($IC_{50}=1.61{\pm}0.13\;mg/mL$), but did not exhibit inhibitory activity against butyrylcholinesterase. These results suggest that O. mykiss possesses antioxidant and acetylcholinesterase inhibitory activities and provide scientific evidence for the health benefits of O. mykiss aqueous extract.