An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib

Kwon, Taeho,Kyung Rho, Jin,Cheol Lee, Jae,Park, Young-Ho,Shin, Hye-Jun,Cho, Sunwha,Kang, Yong-Kook,Kim, Bo-Yeon,Yoon, Do-Young,Yu, Dae-Yeul Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.5

<P>Redox adaptation is an important concept that explains the mechanisms by which cancer cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this concept, we determined the expression levels of peroxiredoxins (Prxs), antioxidant enzymes in drug-resistant non-small cell lung carcinoma cells. Prx II was remarkably increased only in A549/GR (gefitinib-resistant) cells compared with A549 cells, consistent with methylation/demethylation. Prx II was highly methylated in the A549 cells but was demethylated in the A549/GR cells. The elevated expression of Prx II resulted in the downregulation of reactive oxygen species (ROS) and cell death and upregulation of cell cycle progression in the A549/GR cells. When Prx II mRNA in the A549/GR cells was knocked down, the levels of ROS and apoptosis were significantly recovered to the levels of the controls. In addition, signaling molecules involved in apoptosis were increased in the A549/GR-shPrx II cells. There was no difference in the expression of MAPK/ERK between the A549/GR cells and A549/GR-shPrx II cells, but the phosphorylation of JNK was increased in the A549/GR cells and was markedly decreased in the A549/GR-shPrx II cells. Colony number and tumor growth were significantly decreased in the A549/GR-shPrx II cells compared with the A549/GR cells. Our findings suggest that Prx II has an important role in cancer cell survival via the modulation of signaling molecules involved in apoptosis and the phosphorylation of JNK by the downregulation of ROS levels in A549/GR cells.</P>

Industrialization of useful proteins derived from transgenic rice

Taeho KWON 한국생물공학회 2016 한국생물공학회 학술대회 Vol.2016 No.4

Informal Settlements under the Impact of Globalization in Southeast Asian Megacities : The Case of Bangkok

Taeho Kwon 서울시립대학교 도시과학연구원 2006 International journal of urban sciences (IJUS) Vol. No.

Globalization studies in Asia tend to highlight the positive influences or impacts that the mega-cities could benefit from in economic development, thereby gearing up to join ‘global cities’within the world city system. Micro-level observation within a mega-city, however, brings up the issue of unequal effects of globalization among the citizens. Economic globalization, in terms of its essential attribute, tends to converge on the key centers of production, distribution, services and finance, and thus their benefits are subjected to a preoccupation by ‘the haves’, rather than ‘the have-nots’. Paying attention to this likelihood of an ‘unequal world’, the paper attempts to examine the influence of economic globalization on the informal settlements in Bangkok and its vicinity. For this purpose, Section II analyzes changes in size and spatial distribution of informal settlements, followed by a discussion on globalization impacts on informal settlements from economic, social and physical perspectives in Section III. The last section includes conclusions and policy recommendations to promote a‘ trickle down’of the benefits of economic globalization to the urban poor.

빅데이터 기반 교통상황 예측기술 동향 및 활용방안

권태호(Taeho Kwon),김광석(Gwangseok Kim) 대한공간정보학회 2019 한국지형공간정보학회 학술대회 Vol.2019 No.11

아시아 도시의 재난취약성과 인도주의 건축의 역할

권태호(Kwon, Taeho) 한국아시아학회 2017 아시아연구 Vol.20 No.4

아시아의 (대)도시는 경제성장의 엔진역할을 해 왔지만, 동시에 과도한 인구집중과 산업화로 빈곤과 양극화, 주택․기반시설 부족, 환경오염과 교통문제 등이 고착되면서 홍수, 태풍, 지진, 쓰나미 등 재난발생 시 많은 인적, 물적 피해를 경험하여왔다. 특히 최근에는 이러한 도시화의 부작용과 기후변화가 결합되면서 자연재난이 빈번해지면서 취약계층의 어려움은 가중되고 있다. 학제적이고 시론적인 본 논문은 도시화와 불평등한 취약성에 주목하고, 협력적 거버넌스 프레임을 참조하면서 최근 부상하고 있는 인도주의 건축 개념을 설명하고 건축가의 역할을 탐색하는데 목적이 있다. 논문의 주된 내용은 다음과 같다. 먼저 급속한 도시화 결과의 양면성과 빈곤층의 재난취약성에 대하여 논의한 다음(2장), 주민의 현장지식과 참여그룹 간 협력을 기반으로 하는 재난관리단계별 주요활동을 설명하고(3장), 협력적 거버넌스를 위한 건축가의 사회적 책임과 인도주의 건축의 개념을 정리한 후, 인도주의 건축의 역할을 주도적 역할과 참여적 역할로 나누어 단계별로 제시한다(4장). Many cities of Asian region play leading roles of national economic development measured typically by their proportion of Gross Domestic Product(GDP). Nonetheless, these cities also expose such problems as poverty and polarization, shortage of housing and infrastructure, environmental pollution and traffic congestion due to excessive concentration of population and production facilities. Frequent occurrence of large-scale natural disasters including typhoon, flooding, earthquake, tsunami tend to further aggravate extent of vulnerability of disaster-prone areas and people in Asian cities. Focusing on the unequal vulnerability and referring to collaborative governance framework, this exploratory paper discusses and suggests the concept and role of humanitarian architecture recently emerging among academic arena as well as disaster areas. The remaining parts of the paper are organized following. Chapter II discusses double-edges of rapid urbanization and disaster vulnerability of the poor. Based upon people"s local knowledge and collaborative efforts among participants, stepwise activities required for disaster management are explained in Chapter III. The first half of Chapter IV discusses the issue of architect"s social responsibility, and provides an operational definition of the concept of humanitarian architecture. The second half explores/suggests possible role of architects in the humanitarian space.

가스 안전 플랫폼을 이용한 공간정보를 활용한 사고예방 분석 연구

권태호(TAEHO KWON) 한국가스학회 2018 한국가스학회 학술대회논문집 Vol.2018 No.5

Vector model에 근거한 지리정보의 디스플레이에 관한 연구

권태호(Taeho Kwon),이태승(Taiseung Lee),최윤철(Yoonchul Choy) 한국정보과학회 1992 한국정보과학회 학술발표논문집 Vol.19 No.2

지리정보를 다루는 GIS는 크게 데이타 입력/저장, 공간분석, 디스플레이의 세부분으로 구성되어있다. 본 논문에서는 지리정보를 구성하는 공간자료와 속성자료가 유기적으로 통합되어 디스플레이 될 수 있는 디스플레이 시스템을 윈도우상 에서 설계하였다. 시스템의 기본적인 구조와 각종 지리요소의 디스플레이 기법을 기술한다.

주거가능성과 형평성을 위한 지방정부의 주택정책 : 호주 뉴 사우스 웨이즐주의 적정주거정책을 중심으로

권태호(TaeHo Kwon) 한국지역개발학회 2000 韓國地域開發學會誌 Vol.12 No.2

시장경제 체제에서 공적개입의 정당성은 공급자와 수요자간의 여러 불균형 요인의 작동으로 시장메커니즘이 불완전한 상태로 되어 결국 자원의 최적배분을 어렵게 한다는 인식에 근거를 두고 있다. 주택시장의 경우에도 수요자, 특히 저소득층 및 소외계층의 제한된 구매력의 문제는 주거 형평성 및 주거수준의 질적 재고를 어렵게 하는 일차적 요인이 되며, 이것이 호주를 포함한 대부분의 선진국에서 주택정책의 목표를 형평성 및 거주가능성 또는 주택구매능력 (Affordability)에 두는 이유이기도 하다. `90년대 초반까지 호주의 주택정책은 연방 및 주정부가 견인차 역할을 하면서 공급위주의 프로그램 실행에 주력하였다. 하지만 `90년대 중반 이후에는 연방 및 주 정부의 재정악화 및 정책선회로 주택공급을 위한 전략과 계획 수립에 있어서의 지방정부의 역할이 강조되기 시작하였고, 특히 저소득층 및 소외계층을 위한 창의적인 주택공급 프로그램을 개발하고 있다. 본 논문은, 뉴 사우스 웨일즈주의 사례를 중심으로 하여, 관련문헌을 고찰함으로써, i) 호주의 주택정책에 있어서 증대되고 있는 지방정부 역할 및 주요 정책프로그램을 소개하고, ii) 주택정책에서의 거주가능성, 형평성의 문제 및 지방정부의 주거전략계획의 세 가지 기본 원칙 - Variety, Diversity, Choice - 을 논의하며, iii) 적정주거(Affordable Housing)의 공급확대를 위한 전략계획의 주요 내용을 분석한다. 결론에서는 중앙정부 주택정책 관련 권한의 지방자치단체로의 위임, 지방정부의 주거전략 계획수립, 민간부문 및 비정부단체와의 협력 등을 중심으로 우리 나라 지방정부의 주택정책 수립에 유용한 몇 가지 시사점을 제시하였다.

자전거를 이용하는 항만근로자들의 안전을 위한 파손 도로 탐지 딥러닝 디바이스, “Safe Bike(Sabi)”

권기연 ( Giyeon Kwon ),박기현 ( Gihyun Park ),이유빈 ( Yubin Lee ),이은지 ( Eunji Lee ),권태호 ( Taeho Kwon ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2

자전거를 이용해 출퇴근하는 항만 근로자들은 대형화물이 만들어낸 포트홀과 같은 파손된 도로에 의해 위협받는다. 이러한 문제를 해결하기 위해 센서와 카메라로 파손 도로를 탐지하는 디바이스를 구상하였다. Port workers commuting by bicycle are threatened by damaged roads such as port halls created by large cargo. To solve this problem, a device was designed to detect broken roads with sensors and a camera.

Shelter material and shape preferences of the sea cucumber, <i>Apostichopus japonicus</i>

Kwon, Inyeong,Lee, Kyounghoon,Kim, Taeho Elsevier 2019 Aquaculture Vol.508 No.-

<P><B>Abstract</B></P> <P>The purpose of this study was to determine the physical properties of shelter design that could enhance sea cucumber cultivation. The structural material (PVC, cement mortar, and porous cement mortar), hole shape (triangle, square, and circle), and hole size (0.0014, 0.0025, and 0.0079 m<SUP>2</SUP>) of shelters were analyzed to determine sea cucumber preferences. Ninety sea cucumbers were used (30 individuals per body size group) and the initial weights were 20.56 ± 4.97 g, 60.80 ± 6.05 g, and 115.80 ± 9.13 g for small, medium, and large sea cucumbers, respectively. Changes in behavioral characteristics in relation to body weight at 10, 15, and 20 °C were also analyzed. Additionally, movement characteristics on surfaces of varying degrees of roughness (a. PVC [0.68–0.9 mm], b. cement mortar [1.5–1.8 mm], and c. porous cement mortar [2.0–2.2 mm]) were determined using particle image velocimetry (PIV) and 2D velocity fields. By day, we observed that sea cucumbers were attached to the inside of circular holes (<I>P</I> < 0.05). Sea cucumbers were attached to shelters made of cement mortar (average 10) > porous cement mortar (average 8) > PVC (average 6), regardless of water temperature or body weight. The preference for sheltering was higher in the small- and medium-size sea cucumber groups than in the group of large-size sea cucumbers. Most sea cucumbers attached to the shelters were in the weight range 20–60 g. The average distances moved by the small, medium, and large sea cucumbers were 1.501, 1.475, and 1.310 m, respectively, and their movement speeds (×10<SUP>−3</SUP> m/s) were 0.181, 0.289, and 0.269, respectively, regardless of water temperature. The movement speed of the sea cucumbers was the fastest (0.373 × 10<SUP>−3</SUP> m/s) at 20 °C. The PIV measurements showed that different velocities and forces were generated when the sea cucumbers moved to shelter materials of varying degrees of surface roughness (force: PVC > porous cement mortar > cement mortar). The sea cucumbers produced the greatest amount of force when moving over smooth surfaces, such as PVC. The smaller the sea cucumber, the less they were affected by temperature change.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effects of different shelter properties on the behavior of sea cucumbers were investigated. </LI> <LI> The movement distance and speed of sea cucumbers were measured using cameras, software, and particle image velocimetry. </LI> <LI> The shelter preference was higher for small and medium sea cucumbers than for large ones. </LI> <LI> Different forces were generated when the sea cucumbers moved over shelter materials of varying roughness. </LI> </UL> </P>