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임한철(Han-Cheol Lim),변영화(Young-Hwa Byun),권원태(Won-Tae Kwon),전종갑(Jong-Ghap Jhun) 한국기상학회 2008 대기 Vol.18 No.1
This study provides an impact assessment of climate change on energy consumption, based on ‘active-deal scenario'. This approach assumes that the amount of electric energy consumption depends on human spontaneous acts against local temperature change. In this study, a statistical model for estimation of the Residential Electric Energy Consumption (REEC) has been developed by using monthly mean temperature and monthly amount of electric energy consumption in the 6 major cities over the 1999-2005 period. The statistical model is utilized to estimate the past and future REEC, and to assess the economic benefits and damage in energy consumption sector. For an estimation of the future REEC, climate change scenario, which is generated by National Institute of Meteorological Research, is utilized in this study. According to the model, it is estimated that over the standard period (1999~2005), there might be economic benefits of about 31 billion Won/year in Seoul due to increasing temperature than in the 1980s. The REEC is also predicted to be gradually reduced across the Korean peninsula since the 2020s. These results suggest that Korea will gain economic benefits in the REEC sector during the 21st century as temperature increases under global warming scenarios.
P247 : A study on use of complementary and alternative medicine for acne
( Sook Kyung Lee ),( Taek Geun Lee ),( Hyun Hwang Bo ),( Tae Gwang Kwon ),( Se Won Jung ),( Young Seok Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Complementary and alternative medicine (CAM) is any practice that has healing effects, but is not based on evidence demonstrated by scientific method. Recently, CAM has been used in various diseases including acne. However, there have been no studies on CAM for acne in Korea. Objectives: The purpose of this study was to analyze the use of CAM in acne patients. Methods: A total of 159 patients with acne were enrolled on the study, and filled out a questionnaire about use of CAM. Results: Overall 87.4% (139/159) of the patients reported the previous or current use of at least one more type of CAM. Cosmetics for acne (100, 22.9%) was most frequently used, followed by diet therapy (81, 18.5%), spa and bath therapies (77, 17.6%), health food supplement (67, 15.3%), skin care shop (64, 14.6%), oriental medicine (38, 8.7%), and aromatherapy (9, 2.1%). The most common reason for using CAM was ``wish to try everything`` (28.6%), and the most common source of information was internet (40.5%). The therapeutic effect of CAM was best with diet therapy (32.1%). The most common side effect of CAM was aggravation of symptoms. The most common monthly cost for CAM was between 50,000 and 100,000 won/person. Conclusion: As our results, we can predict that the use of various types of CAM for acne will become more common. Therefore, dermatologists need to study about benefits and adverse effects of CAM for acne.
Tae-Woo Kim,Hyuk-Min Kwon,Seung Heon Shin,Chan-Soo Shin,Won-Kyu Park,Chiu, Eddie,Rivera, Manny,Lew, Jae Ik,Veksler, Dmitry,Orzali, Tommaso,Dae-Hyun Kim IEEE 2015 IEEE electron device letters Vol.36 No.7
<P>We report on the impact of H-2 high-pressure annealing (HPA) onto In0.7Ga0.3As MOSCAPs and quantum-well (QW) MOSFETs with Al2O3/HfO2 gate-stack. After HPA with process condition of 300 degrees C, H-2 ambient and pressure of 20 atm, we observed notable improvements of the capacitance-voltage (CV) characteristics in InGaAs MOSCAPs with Al2O3/HfO2 gate-stack, such as reduction of equivalent-oxide-thickness and less frequency dispersion in the accumulation region. There was 20% improvement of the interfacial trap density (D-it). Then, we incorporated the HPA process into the fabrication of sub-100-nm In0.7Ga0.3As QW MOSFETs, to investigate the impact of HPA process. After HPA process, the device with L-g = 50 nm exhibits improved subthreshold-swing (SS) = 105 mV/decade, in comparison with SS = 130 mV/decade for the reference device without HPA process. Finally, we carried out reliability assessment under a constant-voltage-stress (CVS), and it turns out that the HPA process was effective in mitigating a shift of threshold voltage (Delta V-T) during the CVS. These are attributed to the effective passivation of oxide traps in the high-k dielectric layer and interfacial traps, after HPA process in the H-2 ambient.</P>
Identification of SNPs Affecting Porcine Carcass Weight with the 60K SNP Chip
( Kwon Kang ),( Dong Won Seo ),( Jae Bong Lee ),( Eun Ji Jung ),( Hee Bok Park ),( In Cheol Cho ),( Hyun Tae Lim ),( Jun Heon Lee ) 한국동물자원과학회(구 한국축산학회) 2013 한국축산학회지 Vol.55 No.4
Carcass weight (CW) is one of the most important economic traits in pigs, directly affecting the income of farmers. In this study, a genome wide association study was performed to detect significant single nucleotide polymorphisms (SNPs) affecting CW in pigs derived from a F2 intercross between Landrace and Korean native pig (KNP). Using high-density porcine SNP chips, highly significant SNPs were identified on SSC12. Two candidate genes, LOC100523510 and LOC100621652, were subsequently selected within this region and further investigated. Within these candidate genes, five SNPs were identified and genotyped using the VeraCode GoldenGate assay. The results revealed that one SNP in the LOC100621652 gene and four SNPs in the LOC100523510 gene are highly associated with CW. These SNP markers can thus have significant applications for improving CW in KNP. However, the functions of these candidate genes are not fully understood and require further study.
Bacillus sp. HJ 57에 의한 버섯 병원균주의 생육억제
Kwon-Il Seo(서권일),Sang-Won Gal(갈상완),Sung-Tae Yee(이성태),Kyung-Wuk Park(박경욱),Sang-Won Lee(이상원) 한국생명과학회 2012 생명과학회지 Vol.22 No.6
발효된 버섯배지 및 부엽토 등으로부터 80여 종의 균주를 1차 분리하여 CMCase, amylase 및 protease활성이 높고 버섯질병균주에 대한 항균활성이 높으면서 표고버섯 및 팽이버섯의 생육에는 전혀 영향을 미치지 않는 HJ-57 항균미생물을 최종 분리균주로 선정하였다. 최종 선정한 HJ-57 항균미생물을 동정한 결과 Bacillus sp. HJ-57로 밝혀졌으며, 배양을 위한 배지의 초기 pH는 pH 7, 배양온도는 35℃가 최적인 것으로 나타났다. Bacillus sp. HJ-57균주는 12 hr 배양하였을 때는 약간의 항균활성을 나타내었지만, 배양 36~48 hr 배양하였을 때는 비교적 높은 항균활성을 나타내었다. Bacillus sp. HJ-57 항균미생물은 팽이버섯 재배농가에서 사용하는 콘코프 함유배지상에서도 버섯질병균주인 세균 및 곰팡이에 대하여 매우 높은 항균활성을 나타내었다. Approximately 80 species of bacteria were isolated from the fermented mushroom first and the HJ-57 antibacterial micro-organism was selected to the final isolation bacteria. It has a high degree of CMCase, amylase, and protease activity as well as high antibacterial activity against mushroom pathogenic bacteria without affecting the growth and development of Flammulina velutipes and Lentinus edodes mushrooms. The finally selected HJ-57 antibacterial micro-organism was identified as Bacillus sp. HJ-57. The initial pH for culture was pH7 and its optimum culture temperature was 35 ℃. The antibacterial material produced by Bacillus sp. HJ-57 showed a little antibacterial activity even in the 12 hr of culture, but showed the highest antibacterial activity in the 36~48 hr of culture. The HJ-57 antibacterial micro-organism also showed a high antibacterial activity against mushroom pathogenic bacteria and molds in the corn cob contained culture medium is used in Flammulina velutipes cultivators.
Won, Suk-Hyun,Lee, Hyo-Jeong,Jeong, Soo-Jin,Lee, Hyo-Jung,Lee, Eun-Ok,Jung, Deok-Beom,Shin, Ji-Min,Kwon, Tae-Rin,Yun, Sun-Mi,Lee, Min-Ho,Choi, Seung-Hoon,Lü,, Junxuan,Kim, Sung-Hoon Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.11
<P>Tanshinone IIA (Tan IIA; 14,16-epoxy-20-nor-5(10),6,8,13,15-abietapentaene-11,12-dione), a phytochemical derived from the roots of <I>Salvia miltiorrhiza</I> B<SMALL>UNGE</SMALL>, has been reported to posses anti-angiogenic, anti-oxidant, anti-inflammatory and apoptotic activities. However, the cancer growth inhibitory/cytocidal effects and molecular mechanisms in prostate cancer cells have not been well studied. In the present study, we demonstrate that Tan IIA significantly decreased the viable cell number of LNCaP (phosphate and tensin homolog (PTEN) mutant, high AKT, wild type p53) prostate cancer cells more sensitively than against the PC-3 (PTEN null, high AKT, p53 null) prostate cancer cells. Tan IIA significantly increased TdT-mediated dUTP nick-end labeling (TUNEL) positive index and sub-G1 DNA contents of treated cells, consistent with apoptosis. Tan IIA treatment led to cleavage activation of pro-caspases-9 and 3, but not pro-caspase-8, and cleavage of poly (ADP ribose) polymerase (PARP), a caspase-3 substrate. Additionally, Tan IIA treatment induced cytochrome <I>c</I> release from the mitochondria into the cytosol and reduced mitochondrial membrane potential and suppressed the expression of mitochondria protective Bcl-2 family protein Mcl-1<SUB>L</SUB>. Tan IIA reduced the expression of phosphoinositide 3-kinase (PI3K) p85 subunit, and the phosphorylation of AKT and mammalian target of rapamycin (mTOR) in a concentration-dependent manner. Moreover, the combination of Tan IIA and LY294002, a specific PI3K inhibitor, enhanced PARP cleavage of LNCaP and PC-3, but not in MDA-MB-231 breast cancer cells which do not contain detectable active AKT. The findings suggest that Tan IIA-induced apoptosis involves mitochondria intrinsic caspase activation cascade and an inhibition of the PI3K/AKT survival pathway.</P>
Oxidation of Rosmarinic Acid Catalyzed by Mushroom Tyrosinase
Tae Joung Ha,Myoung-Hee Lee,Hyun Sook Kwon,Byeong Won Lee,Chang-Hwan Park,Suk-Bok Pae,Chan-Sik Jung,Keum-Yong Park 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Rosmarinic acid isolated from the Perilla frutescens (L.) was found to possess mushroom tyrosinase (EC 1.14.18.1) inhibitory activities with an IC50 of 4.0 μM. However, rosmarinic acid was oxidized as a substrate catalyzed by tyrosinase. The oxidation kinetics of mushroom tyrosinase by rosmarinic acid measured by spectrophotometic and polarographic methods showed Km=166.8 μM, 225.1 μM and Vmax=16.26 μM/min, 3.05 mg O2/L/min, respectively.
Detection of Enterovirus, Cytomegalovirus, and Chlamydia pneumoniae in Atheromas
Tae Won Kwon,Do Kyun Kim,Jeong Sook Ye,Won Joo Lee,Mi Sun Moon,Chul Hyun Joo,Heuiran Lee,Yoo Kyum Kim 한국미생물학회 2004 The journal of microbiology Vol.42 No.4
To investigate the presence of infectious agents in human atherosclerotic arterial tissues. Atherosclerotic plaques were removed from 128 patients undergoing carotid endarterectomy or other bypass procedures for occlusive disease, and from twenty normal arterial wall samples, obtained from transplant donors with no history of diabetes, hypertension, smoking, or hyperlipidemia. Using the polymerase chain reaction (PCR) or reverse transcription-PCR, these samples were analyzed for the presence of Chlamydia pneumoniae, cytomegalovirus, enterovirus, adenovirus, herpes simplex viruses types 1 and 2, and Epstein-Barr virus. The amplicons were then sequenced, and phylogenetic analyses were performed. Enteroviral RNA was found in 22 of 128 atherosclerotic vascular lesions (17.2%), and C. pneumoniae and cytomegalovirus were each found in 2 samples (1.6%). In contrast, adenovirus, herpes simplex viruses, and Epstein-Barr virus were not identified in any of the atherosclerotic samples. Enterovirus was detected in 6/24 (25.0%) aortas, 7/33 (21.2%) carotid arteries, 6/40 (15.0%) femoral arteries, and 3/31 (9.7%) radial arteries of patients with chronic renal failure. There were no infectious agents detected in any of the control specimens. Using phylogenetic analysis, the enterovirus isolates were clustered into 3 groups, arranged as echovirus 9 and coxsackieviruses B1 and B3. Enteroviral RNA was detected in 17.2% of atherosclerotic plaques, but was not observed in any of the control specimens. This suggests a connection between enteroviral infection and atherosclerosis. These findings differ from those of other studies, which found more frequent incidence of C. pneumoniae and cytomegalovirus infection in atherosclerotic plaques.