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- 저자 : Kwon Hyuk-Sang (검색결과 1,524 건)
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Kwon, Ok-Seon,Kwon, Soo-Jung,Kim, Jin Sang,Lee, Gunbong,Maeng, Han-Joo,Lee, Jeongmi,Hwang, Gwi Seo,Cha, Hyuk-Jin,Chun, Kwang-Hoon The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker skin tone. Tyrosinase is a key enzyme in melanin synthesis, which regulates the rate-limiting step during conversion of tyrosine into DOPA and dopaquinone. To develop effective RNA interference therapeutics, we designed a melanin siRNA pool by applying multiple prediction programs to reduce human tyrosinase levels. First, 272 siRNAs passed the target accessibility evaluation using the RNAxs program. Then we selected 34 siRNA sequences with ${\Delta}G{\geq}-34.6kcal/mol$, i-Score value ${\geq}65$, and siRNA scales score ${\leq}30$. siRNAs were designed as 19-bp RNA duplexes with an asymmetric 3' overhang at the 3' end of the antisense strand. We tested if these siRNAs effectively reduced tyrosinase gene expression using qRT-PCR and found that 17 siRNA sequences were more effective than commercially available siRNA. Three siRNAs further tested showed an effective visual color change in MNT-1 human cells without cytotoxic effects, indicating these sequences are anti-melanogenic. Our study revealed that human tyrosinase siRNAs could be efficiently designed using multiple prediction algorithms.
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Dimensional Change of Carbonized Woods at Low Temperatures
Kwon, Sung-Min,Jang, Jae-Hyuk,Kim, Nam-Hun Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.2
To understand transition characteristics from wood to charcoal the dimensional changes of carbonized woods at low temperature from $300^{\circ}C$ to $350^{\circ}C$ at the intervals of $10^{\circ}C$ were investigated. Three species of hardwoods and two species of softwoods were used in this study. Measurements of dimensional changes of cells were observed by stereoscopic microscope and an image analyzer. The apparent volume of each specimen decreased greatly with increasing temperature. Severe cracks and collapse were observed frequently in hardwoods and hardly in softwoods. Vessel diameter and tracheid cell wall thickness of the wood samples were decreased with increasing carbonization temperature. Contraction of vessel diameter in tangential direction was greater than that in radial direction. Cell wall thickness of tracheids decreased with increasing carbonization temperature. Consequently, even though it was small range of carbonization temperature, dimensions of wood components were changed considerably.
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Prevalence and Clinical Characteristics of the Metabolic Syndrome in Middle-Aged Korean Adults
( Hyuk Sang Kwon ),( Yong Moon Park ),( Hye Jung Lee ),( Jin Hee Lee ),( Yoon Hee Choi ),( Seung Hyun Ko ),( Jung Min Lee ),( Sung Rae Kim ),( So Young Kang ),( Won Chul Lee ),( Myung Sook Ahn ),( Jae 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.4
Background : The aim of this study was to analyze the prevalence and clinical characteristic of the metabolic syndrome of adults, over 40 years old, living in Korea. Methods : This study was carried out for 2 years, 2003-2004, on total 5,330 individuals (2,197 men and 3,133 women) selected by the stratified random cluster sampling among adults over 40 years old. Metabolic syndrome was defined based on both the NCEP-ATP III criteria and Modified ATP III criteria applying the WHO-APR (Asian Pacific Region)`s abdominal obesity criteria (waist circumference > 90 cm in men, 80 cm in women) instead of NCEP-ATP III criteria. Results : Using NCEP-ATP III criteria, the age-adjusted overall prevalence of metabolic syndrome was 24.8% (17.6% in men, 30.0% in women). Age-adjusted overall prevalence of metabolic syndrome as defined by modified-ATP III criteria was 34.3% (26.3% in men, 40.1% in women). The prevalence of metabolic syndrome for each age group (40-49, 50-59, 60-69, ≥ 70) in men was as follows: 18.8%, 17.4%, 18.3%, 14.5%. In women: 22.3%, 32.7%, 39.9%, 39.3%. The prevalence of hypertriglyceridemia (triglycerides ≥ 1.7 mmol/l) was well correlated with the changing pattern of the prevalence of metabolic syndrome both in men and women. Conclusions : The peak age of metabolic syndrome in men was age 40 through 49, and the prevalence decreased with aging. Therefore, early intervention for risk factors of metabolic syndrome might be required in men. On the other hand, prevention for cardiovascular disease will be needed for perimenopausal women due to considerably increased prevalence in the age 50 through 59.
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Winding Factor of Vernier Permanent Magnet Motor
Kwon Hyuk-Sung,Yeo Han-Kyeol,Seo Jangho 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4
Several studies have been reported on vernier permanent magnet synchronous motors (VPMSMs) using spatial harmonics in air-gap fl ux density owing to their low-speed high-torque characteristics. However, coeffi cients that can predict the performance of VPMSMs in motor design processes have not been extensively researched. The gear ratio indicates the degree of amplifi cation of the spatial harmonics, but there is a big diff erence between the performances predicted using the gear ratio and the actual performance of VPMSMs. The winding factor can estimate the magnitude of the electromotive force (EMF) of the motor. Although the winding factor is suitable for conventional motors, it cannot be applied to VPMSM, which amplifi es EMF through spatial harmonics. In this study, we investigated the winding factor of VPMSMs and proposed a winding factor calculation method suitable for VPMSMs. Based on the analytical method, the proposed calculation method could instantly and accurately estimate the winding factor of VPMSMs. With this method, the EMF performance of VPMSMs can be predicted according to the pole–slot combination. To verify the validity of the proposed method, we compared the gear ratio, the proposed winding factor, and the magnitude of the EMF obtained by the fi nite element method.
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Hyuk-Sung Kwon,이창하,Eunyong Chung,Junse Oh,안익성 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.1
Manganese peroxidase (MnP) is a key enzyme involved in the lignolysis of white-rot fungi. The purpose of this study is to investigate the effect of immobilization and culture conditions on MnP production in cultures of Phanerochaete chrysosporium grown on polyurethane foam. Higher concentrations of foam and lower levels of spore inoculums resulted in the formation of scattered mycelial pellets, increased autolysis of chlamydospore-like cells (a reservoir of MnP), and a higher activity of MnP. Even though MnP was a secondary metabolite, the addition of 5 times more glucose and diammonium tartrate, as carbon and nitrogen sources, resulted in a 4 fold increase in the dry cell mass. However, MnP activity decreased under these conditions to less than half, due to the formation of increasingly dense pellets and the inhibited lysis of chlamydospore-like cells.
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Experimental Investigations of Pulse-Power-Modulated Inductive Discharges
Sang-Hun Seo,Dong-Ho Kim,장홍영,Jae-Hyun Nam,Joon-Hyuk Kwon,Sung-Jin Moon,Woong-Cheol Yang,Yoon-Young Kim 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.3
Time-resolved probe measurements are carried out using the boxcar measurement method in a pulsed, low-pressure inductively coupled plasma. The characteristics of the transient behavior of the electron energy distribution function (EEDF) and of the plasma parameters such as the electron density, the electron temperature, and the plasma and floating potentials, are presented and analyzed with the global model of a pulsed discharge. From the relaxation behavior of the EEDF and the analysis of the characteristic relaxation times of the electron density and temperature, the initial fast relaxation of high-energy electrons just after the power is turned off is found to be dominated by electron-atom inelastic collisions rather than the diffusive cooling effect at low pressure. A revised global model in which the effect of electron-atom inelastic collisions is included is presented. After the power is turned on, an initial very sharp rise in electron temperature followed by a decay of electron temperature is observed, and the peak electron temperature is found to increase with reducing duty cycle of the power pulse. A comparison of the measured EEDFs shows that the increase in the peak electron temperature under a shorter duty cycle pulse is caused by the depopulation of low-energy electrons, not by the overpopulation of high-energy electrons.
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Hyuk-Min Kwon,In-Shik Han,Jung-Deuk Bok,Sang-Uk Park,Yi-Jung Jung,Ga-Won Lee,Yi-Sun Chung,Jung-Hwan Lee,Chang Yong Kang,Kirsch, P,Jammy, R,Hi-Deok Lee IEEE 2011 IEEE electron device letters Vol.32 No.5
<P>The behavior of I<SUB>D</SUB> random telegraph signal (RTS) noise of a p-MOSFET with an advanced gate stack of HfO<SUB>2</SUB>/TaN is experimentally investigated and discussed. The I<SUB>D</SUB>-RTS noise is evaluated on a wafer level (100 sites) for statistical evaluation. The observed ratio of I<SUB>D</SUB>-RTS noise on a wafer is quite similar to that of a p-MOSFET with the conventional plasma-SiON dielectric, which means that the noise distribution on a wafer level is independent of the gate oxide structure and/or material. However, the relative magnitude of change of the drain current to the applied current (ΔI<SUB>D</SUB>/I<SUB>D</SUB>) of the p-MOSFETs with high-k (HK) dielectrics is greater than that of p-MOSFETs with conventional plasma-SiON dielectrics by about six times due to the greater number of preexisting bulk traps in the HK dielectric. Therefore, I<SUB>D</SUB>-RTS noise and its associated 1/f noise can present a serious issue to the CMOSFET with an advanced HK dielectric for low-power analog and mixed-signal applications.</P>
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( Sung Joon Park ),( Yoon Soo Jang ),( Tae Hyuk Koh ),( Young A Kwon ),( Sang Wroul Song ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.6
This research focuses on four cases of patients having undergone eximer laser photorefractive surgery who were diagnosed with adenoviral keratoconjunctivitis during the postoperative period and who later developed epidemic keratoconjunctivitis (EKC)-like keratitis. Two of the patients had undergone laser-assisted subepithelial keratectomy (LASEK), one had undergone laser in situ keratomileusis and one had photorefractive keratectomy. After the surgery adenoviral keratoconjunctivitis and recurrent late-developing EKC-like keratitis were observed in the patients. Recurrent late-developing EKC-like keratitis occurred in one of the patients, who had received LASEK as many as three times. The others had only one or two episodes.The corneal infiltrates of keratitis mainly occurred in the central cornea. Successful resolution of recurrent late-developing EKC-like keratitis was achieved through the use of topical steroids without sequelae and the final best-corrected visual acuity was as good as the base line. These keratitis infiltrates have been presumed to represent an immune response to the suspected adenoviral antigens deposited in corneal stroma during the primary adenoviral infection. Previous reports argued that patients with a history of adenoviral ketatoconjunctivitis were succeptible to adenoviral keratoconjunctivitis becoming reactivated; however, in our research, our patients had their first adenoviral infections after the eximer laser photorefractive surgery and reactivation was confirmed. We recommend that attention be paid to adenoviral infection after laser refractive operations, because these patients seem to have more frequent recurrences.
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Hyuk Woo KWON,Min Woo Hyun,Jun Yong Kim,Junsang Oh,Gi-Ho Sung,Seong Hwan Kim 한국버섯학회 2011 버섯 Vol.15 No.2
Beauveria bassiana is one of universal insect pathogenic fungi that have been used for biocontrol agent against insect pests. This fungus has also been studied for medicinal use. To meet for commercial use, the artificial production of the fruit body of this fungus has been established by the Mushtech Co in Korea. This study was carried out to define the morphological features of the fruit body of B. bassiana developed through artificial cultivation. For the observation of mycelia growth, B. bassiana was cultured on the Sabouraud Dextrose agar plus Yeast Extract(SDAY), nut-supplemented medium, and Fe ion-supplemented SDAY at 25℃ for 15 days. The variation of colony color was observed between the different media. Strong pigmentation was observed on Fe ion-supplemented SDAY. To investigate morphological characteristics of fruit body, geminating ascospores and vegetative hyphae were observed though light microscopy and scanning microscope. During seven weeks of cultivation period, the development process of apical fertile part of stromata can be separated by the development stage of perithecia. To understand the developing process of fruit body at the transcript level, investigating process of distinct gene expression according to cultural condition and developmental stage was discussed.
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