간찰 부위에서 발생한 전신형 고리 육아종 1예

허규 ( Gyoo Huh ),이현주 ( Heun-joo Lee ),최영준 ( Young-jun Choi ),김원석 ( Won-serk Kim ),이가영 ( Ga-young Lee ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.10

Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

Elderly Patients Exhibit Stronger Inflammatory Responses during Gout Attacks

Lee, Jae Hyun,Yang, Ji Ae,Shin, Kichul,Lee, Ga Hye,Lee, Won-Woo,Lee, Eun Young,Song, Yeong Wook,Lee, Eun Bong,Park, Jin Kyun KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.12

<P>Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Patients in three age groups were compared in terms of presence of fever (> 37.8°C), C-reactive protein (CRP) levels, and erythrocyte sedimentation ratio (ESR) at the gout attacks. Monocytes, which were isolated from 10 consecutive patients who previously experienced gout attacks, were stimulated with monosodium urate (MSU) crystals and cytokine production was measured by flow cytometry. Among 254 patients analyzed in this study, 48 were young, 65 were middle-aged, and 141 were elderly. The elderly patients were more likely to have fever (51.1%) during the attack than the young (20.8%) and middle-aged (30.8%) patients (<I>P</I> < 0.001 by χ<SUP>2</SUP> test). They were also more likely to have higher ESR and CRP levels than the young patients (<I>P</I> = 0.002 for ESR, <I>P</I> < 0.001 for CRP). Patients' age correlated significantly with CRP and ESR levels (both <I>P</I> < 0.001). After stimulation with MSU, the production of interleukin-1β by monocytes increased with patients' age (<I>r</I> = 0.670, <I>P</I> = 0.03). In conclusion, gout attacks in elderly patients are associated with fever and higher ESR and CRP levels, often resembling a septic arthritis.</P>

XPC polymorphisms and lung cancer risk

Lee, Ga Young,Jang, Jin-Sung,Lee, Sin Yeob,Jeon, Hyo-Sung,Kim, Kyung Mee,Choi, Jin Eun,Park, Jung Min,Chae, Myung Hwa,Lee, Won Kee,Kam, Sin,Kim, In-San,Lee, Jae-Tae,Jung, Tae Hoon,Park, Jae Yong Wiley Subscription Services, Inc., A Wiley Company 2005 International journal of cancer: Journal internati Vol.115 No.5

<P>Polymorphisms in DNA repair genes may be associated with differences in the capacity to repair DNA damage and thereby influence an individual's susceptibility to smoking-related cancer. To test this hypothesis, we investigated the potential association of 7 XPC polymorphisms (–449G→C, –371G→A, –27G→C, Val499Arg, PAT–/+, IVS11-5C→A and Lys939Gln) and their haplotypes with lung cancer risk in a Korean population. XPC genotypes were determined in 432 lung cancer patients and 432 healthy controls frequency-matched for age and sex. XPC haplotypes were predicted using a Bayesian algorithm in the Phase program. The combined –27CG+CC genotype was associated with a significantly increased risk for overall lung cancer compared to the –27GG genotype (adjusted OR = 1.97, 95% CI 1.22–3.17, p = 0.005). The other 6 polymorphisms were not significantly associated with overall risk of lung cancer. When lung cancer cases were categorized by tumor histology, the –371AA genotype was associated with a significantly increased risk of squamous cell carcinoma compared to the combined –371GG and GA genotype (adjusted OR = 2.08, 95% CI 1.09–4.00, p = 0.03). The PAT–/+, IVS11-5C→A and Lys939Gln polymorphisms were associated with a significantly decreased risk of small cell carcinoma (SM) under a dominant model for the polymorphic allele (adjusted OR = 0.49, 95% CI 0.29–0.82, p = 0.006; adjusted OR = 0.60, 95% CI 0.36–1.00, p = 0.05; and adjusted OR = 0.58, 95% CI 0.35–0.97, p = 0.04, respectively). Consistent with genotyping analyses, haplotype 4 (1112222) containing the PAT+/IVS11-5A/939Gln alleles was associated with a significantly decreased risk of SM (adjusted OR = 0.56, 95% CI 0.37–0.85, p = 0.007 and Bonferroni-corrected p = 0.049), whereas haplotype 5 (1122111) containing the –27C allele was associated with a significantly increased risk of SM (adjusted OR = 2.88, 95% CI 1.41–5.87, p = 0.004 and Bonferroni-corrected p = 0.028). These results suggest that XPC polymorphisms/haplotypes may contribute to genetic susceptibility for lung cancer. © 2005 Wiley-Liss, Inc.</P>

Effects of elevated CO2 on mineralizaion of organic C , N and P in two forest soils , Mt. Jumbong , Korea

Lee, Do Won,Koo, Hee Seung,Yoo, Ga Young 경북대학교 환경과학연구소 1995 環境科學硏究所論文集 Vol.9 No.1

In addition to increasing atmospheric COz, ecosystems experience various levels of COz. For example, levels of COz must be heterogeneous in soil matrices as expected from spatial variation of denitrification rates (Parkin 1987). The patchy distribution of particulate organic matter may lead to highly variable levels of COz through microbial consumption of Oz in soil air, when isolation of air pocket due to poor aeration in soil pores impedes diffusive transport of gases. The isolation may occur at micropores inside soil aggregates and at macropores between aggregates. In particular, many confined air pockets may be distributed in poorly drained soils and even in general soils during and just after a period of rainfall. Two sandy loam soils were taken from in the south- and north-facing slopes. respectively, located at a local area of forest floors in Mt. Jumbong. After the soils were incubated for 6 weeks under five different environments of COa (final levels ranged from 0.00 to 1.95), available and microbial pools and mineralization of C. N, and P were determined. Overall. COz enrichment lowered pool of NHa-N and enlarged that of N03 -N in the soils, indicating that it stimulated nitrification, enlarged the ratio of microbial C/N, inhibited mineralization of organic C, and stimulated mineralization of N. Effect of COz enrichment on mineralization of organic C has not been identified

Significance of Aspect and Understory Type to Leaf Litter Redistribution in a Temperate Hardwood Forest

Lee, Do-Won,Yoo, Ga-Young,Oh, Sung-Jin,Shim, Jee H.,Kang, Sin-Kyu The Korean Society for Integrative Biology 1999 Korean journal of biological sciences Vol.3 No.2

Annual production and redistribution of leaf litter were compared among three distinct understory patches in a temperate hardwood forest dominated by Quercus mongolica, Kalopanax pictus, Acer pseudo-sieboldianum, and Carpinus cordata. Two patches were located on a southwest-facing slope: one with an understory dominated by herbaceous plants (Patch S), and the other covered with evergreen dwarf bamboo, Sasa borealis (patch SS). The third patch was on the opposite slope with an understory dominated by herbaceous plants (Patch N). Annual leaf litterfall was averaged 330 g m$^{-2} yr$^{-2}$ in the three patches from 1994 to 1998. From mid-September 1996 to mid-September 1997, net transport of leaf litter over patch bound-aries was 1,824g m$^{-1}$ from Patch S to SS, 1,465g m$^{-1}$ from Patch S to N, and 886 g m$^{-1}$ from Patch SS to N. The amounts moving downslope out of Patch S, SS, and N were 2,548, 471, and 588g m$^{-1}$, respectively. When a mass balance approach was employed for the data of leaf litter transport, the results were relatively consistent with 216, 631, and 724g m$^{-2}$ of leaf litter stores in Patch S, SS, and N, respectively, in April 1997. This study suggests that leaf litter redistribution is largely regulated by aspect and understory type and exerts a significant effect on carbon processes in the forest ecosystem.

Tunable emission from blue to white light in single-phase Na(0.34)Ca(0.66-x-y)Al(1.66)Si(2.34)O8:xEu2+,yMn2+ (x = 0.07) phosphor for white-light UV LEDs.

Lee, Ga-yeon,Im, Won Bin,Kirakosyan, Artavazd,Cheong, Sang Hoon,Han, Ji Yeon,Jeon, Duk Young Optical Society of America 2013 Optics express Vol.21 No.3

<P>A series of single-phased emission-tunable Na(0.34)Ca(0.66)Al(1.66)Si(2.34)O(8):Eu(2+),Mn(2+) phosphors were successfully synthesized by a wet-chemical synthesis method. Photoluminescence excitation (PLE) spectra indicate that the phosphor can be efficiently excited by UV radiation from 250 to 420 nm. Also, NCASO:Eu(2+),Mn(2+) phosphor exhibit a broad blue emission band at 440 nm and an orange emission band at 570 nm, which originate from Eu(2+) and Mn(2+) ions, respectively. Therefore, overall emission color can be tuned from blue to white by increasing the concentration of Mn(2+) ions in the host lattice utilizing energy transfer from Eu(2+) to Mn(2+) ions. This energy transfer phenomenon was demonstrated to be a resonant type through dipole-dipole interaction determined with the help of PL spectra, decay time measurement, and energy transfer efficiency of the phosphor. These results indicate that NCASO:Eu(2+),Mn(2+) can be a promising single-phased white-emitting phosphor for white-light UV LEDs.</P>

Effects of Herbal treatment for In-patients with Mild Fever: Retrospective Clinical Study

Lee, Sun-Ju,Han, In-Sik,Oh, Hyun-Suk,Lee, Dong-Jin,Yoon, Jeung-Won,Choi, Ga-Young,Hong, Sun-Gi,Lee, Won-Chul,Sun, Seung-Ho The Society of Korean Medicine 2011 대한한의학회지 Vol.32 No.6

Objectives: This study was designed to investigate the effect of herbal extract medicines for inpatients with fever symptoms in an oriental medicine hospital. Methods: Medical records of inpatients who experienced over $38^{\circ}C$ of fever from July 2010 to August 2011 has been requested with deleted personal identifiable information. The requested data were analyzed by patients' general characteristics, administrated western/herbal medicines, and changes in the body temperature of four administration groups (group 1, herbal extract medicine only; group 2, western medication(antibiotics/antipyretics) only; group 3, combination of herbal extract medicine and western medication; group 4, no medication control). The SPSS 19.0 was used for statistical analysis and p-value of less than 0.05 was regarded significant. Results: The body temperature has significantly dropped over time in the herbal extract medicine only group (p<0.001) along with the antibiotics/antipyretics only group. When both treatments were combined, stronger antipyretic effect was shown compared to the sole treatment of herbal extract medicine or antibiotics/antipyretics. Conclusion: The use of herbal extract medicines may be effective in alleviation of fever.

Preparation of Novel T-Type Nonlinear Optical Polyimide with High Thermal Stability of Second Harmonic Generation

Lee, Ga-Young,Jang, Han-Na,Jung, Won-Taek,Lee, Ju-Yeon The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.8

Optimization of N:P Ratio of BG 11 Medium for the Phototrophic Lipid Production of Chlorella sp. HS2

Ga Hyeon LEE,Jin-kyu LIM,Won-Kun PARK 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Thyroid dysfunction in very low birth weight preterm infants

Lee, Ji Hoon,Kim, Sung Woo,Jeon, Ga Won,Sin, Jong Beom The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.6

Purpose: Thyroid dysfunction is common in preterm infants. Congenital hypothyroidism causes neurodevelopmental impairment, which is preventable if properly treated. This study was conducted to describe the characteristics of thyroid dysfunction in very low birth weight infants (VLBWIs), evaluate risk factors of hypothyroidism, and suggest the reassessment of thyroid function with an initially normal thyroid-stimulating hormone (TSH) as part of a newborn screening test. Methods: VLBWIs (January 2010 to December 2012) were divided into two groups according to dysfunction-specific thyroid hormone replacement therapy, and associated factors were evaluated. Results: Of VLBWIs, 246 survivors were enrolled. Only 12.2% (30/246) of enrolled subjects exhibited thyroid dysfunction requiring thyroid hormone replacement. Moreover, only one out of 30 subjects who required thyroid hormone treatment had abnormal thyroid function in the newborn screening test with measured TSH. Most of the subjects in the treatment group (22/30) exhibited delayed TSH elevation. Gestational age, Apgar score, antenatal steroids therapy, respiratory distress syndrome, patent ductus arteriosus, sepsis, intraventricular hemorrhage, postnatal steroids therapy, and duration of mechanical ventilation did not differ between the two groups. Birth weight was smaller and infants with small for gestational age were more frequent in the treatment group. Conclusion: Physicians should not rule out suggested hypothyroidism, even when thyroid function of a newborn screening test is normal. We suggest retesting TSH and free thyroxine in high risk preterm infants with an initially normal TSH level using a newborn screening test.