저충실성 급성백혈병의 분석-1987년부터 1996년사이의 고려대학병원의 경험-

윤수영,김일태,서인범,조윤정,서재홍,김병수,김준석,김영기,이갑노 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.1

Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration

Kim, Jeongah,Jang, Sangwon,Choi, Mijung,Chung, Sooyoung,Choe, Youngshik,Choe, Han Kyoung,Son, Gi Hoon,Rhee, Kunsoo,Kim, Kyungjin Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.8

Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that $REV-ERB{\alpha}$, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that $REV-ERB{\alpha}$ may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of $REV-ERB{\alpha}$ affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. $REV-ERB{\alpha}$ deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The $REV-erb{\alpha}$ knockout mice showed prolonged microglial activation in the SN along with the over-production of interleukin $1{\beta}$, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of $REV-ERB{\alpha}$ can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.

Two Case Reports of Chronic Inflammatory Demyelinating Polyneuropathy After COVID-19 Vaccination

Kim Sooyoung,Lee Eun Kyoung,손은희 대한의학회 2023 Journal of Korean medical science Vol.38 No.8

The occurrence of chronic inflammatory demyelinating polyneuropathy (CIDP) related to coronavirus disease 2019 (COVID-19) has rarely been reported. We describe two patients who were diagnosed with CIDP after COVID-19 vaccination. A 72-year-old man presented with a progressive tingling sensation and weakness below both knees for two weeks. He had been vaccinated against COVID-19 (mRNA-1273 vaccine) a month before the appearance of symptoms. Demyelinating polyneuropathy was observed in the nerve conduction studies (NCS). Intravenous immunoglobulin (IVIg) was administered under the diagnosis of GuillainBarré syndrome (GBS), and his symptoms were improved. However, his symptoms relapsed at 10 weeks from the onset. Oral prednisolone, azathioprine, and IVIg were administered as treatment. The second case was a 50-year-old man who complained of a bilateral leg tingling sensation and gait disturbance lasting four weeks. He had received the Ad26.COV2.S vaccine against COVID-19 five weeks prior. Demyelinating polyneuropathy was observed in the NCS. He was treated with oral prednisolone, azathioprine, and IVIg for CIDP because his symptoms had lasted for more than 12 weeks from the onset. A causal relationship has not been established between COVID-19 vaccination and CIDP; however, CIDP may follow COVID-19 vaccination. As CIDP treatment is different from that for GBS, clinicians should closely monitor patients diagnosed with GBS associated with COVID-19 whether they deteriorate after initial treatment.

Neurolymphomatosis in patients with mantle cell lymphoma diagnosed by FDG PET-CT

Sooyoung Kim,Hakyeu An,Yoon Seok Choi,Kee Hong Park,Eun Hee Sohn 대한임상신경생리학회 2020 Annals of Clinical Neurophysiology Vol.22 No.1

Neurolymphomatosis (NL) is characterized by the infiltration of malignant lymphoma cells into peripheral nerves, nerve roots, plexuses, or cranial nerves. This is a very rare complication of mantle-cell lymphoma. Diagnosing NL is made difficult by cerebrospinal fluid cytology and bone-marrow biopsy results often being negative. NL can appear as the only sign of recurrence in a patient with a previous diagnosis of lymphoma. Here we present two cases of NL in patients with mantle-cell lymphoma diagnosed by positron emission tomography with deoxy-fluoro-D-glucose integrated with computed tomography.

Five Social Issues Facing the Korean Steel Industry: A Corporate Citizenship Perspective

( Sooyoung Kim ) 포스코경영연구원 2019 Asian Steel Watch Vol.7 No.-

Error Performance for Satellite Communications

Sooyoung Kim,Sung-Moon Yeo,Dongseok Shin 대한전자공학회 2006 ITC-CSCC :International Technical Conference on Ci Vol.2006 No.1

Evaluation of Cooperative Diversity Techniques Using STC for Future S-DMB Services

KIM, Sooyoung,PARK, Unhee,KIM, Hee-Wook,AHN, Do-Seob The Institute of Electronics, Information and Comm 2009 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.92 No.11

<P>This paper presents an evaluation of various cooperative diversity techniques applied to future satellite digital multimedia broadcasting (S-DMB) systems. The increasing importance of hybrid and/or integrated satellite and terrestrial networks is associated with the utilization of spatial diversity techniques such as antenna diversity using space-time coding. The space-time coding schemes can be expected to result in more diversity gain as the number of transmit antennas are increased. However, we cannot design a rate-1 scheme that achieves full diversity for more than two transmit antennas. To overcome this limitation, quasi-orthogonal schemes were proposed, at the expense of the decoder complexity and diversity gain. In this paper, we introduce an efficient quasi-orthogonal space time coding scheme, and evaluate various aspects associated with the application of the proposed scheme to satellite systems. The proposed scheme in this paper provides the full rate as well as maximum-likelihood decoding via simple linear detection.</P>

A Study on the determination of the optimal resolution for the application of the distributed rainfall-runoff model to the flood forecasting system – focused on Geumho river basin using GRM

Kim Sooyoung,Yoon Kwang Seok 한국수자원학회 2019 한국수자원학회논문집 Vol.52 No.2

한국에서 현재 사용되고 있는 홍수예보모형은 집중형 강우-유출모형을 적용하여 유역의 유출을 계산하고 하도 및 저수지 추적모형 등을 활용하여 하천의 수위를 예측한다. 집중형 모형은 유역을 동질의 배수구역으로 가정한다. 따라서 유역내의 다양한 공간적 특성을 고려하지 못한다는 단점이 있다. 또한, 사용되는 강우자료도 지점강우를 활용하기 때문에 공간적인 분포를 자세히 고려하지 못한다는 한계가 있다. 따라서 홍수예보모형에 분포형 모형을 적용하기 위한 연구가 다양하게 진행되고 있다. 본 연구에서는 GRM모형을 한국 홍수예보시스템에 적용하기 위해 모형의 다양한 해상도에 따른 유역유출의 결과의 차이를 분석하여 최적의 해상도를 결정하고자 한다. 모형의 격자가 너무 조밀한 경우 계산시간이 과다하게 되어 홍 수예보모형에 적용하기에는 적합하지 않다. 너무 성길 경우에도 분포형 모형을 적용하여 공간적인 분포를 파악하고자 하는 목적에 맞지 않게 된다. 본 연구의 결과로 유역유출 예측의 정확성을 만족시키고 홍수예보에 적합한 계산속도가 나올 수 있는 최적 해상도를 제시하였다. 유출량 예측의 정 확도는 Nash-Sutcliffe model efficiency coefficient (NSE) 값의 비교를 통해 분석하였다. 본 연구에서 도출된 최적해상도 산정 결과는 분포형 유 역유출모형을 홍수예보모형에 적용하기 위한 기초자료로 활용될 것이다. The flood forecasting model currently used in Korea calculates the runoff of basin using the lumped rainfall-runoff model and estimates the river level using the river and reservoir routing models. The lumped model assumes homogeneous drainage zones in the basin. Therefore, it can not consider various spatial characteristics in the basin. In addition, the rainfall data used in lumped model also has the same limitation because of using the point scale rainfall data. To overcome the limitations as mentioned above, many researchers have studied to apply the distributed rainfall-runoff model to flood forecasting system. In this study, to apply the Grid-based Rainfall-Runoff Model (GRM) to the Korean flood forecasting system, the optimal resolution is determined by analyzing the difference of the results of the runoff according to the various resolutions. If the grid size is to small, the computation time becomes excessive and it is not suitable for applying to the flood forecasting model. Even if the grid size is too large, it does not fit the purpose of analyzing the spatial distribution by applying the distributed model. As a result of this study, the optimal resolution which satisfies the accuracy of the bsin runoff prediction and the calculation speed suitable for the flood forecasting was proposed. The accuracy of the runoff prediction was analyzed by comparing the Nash-Sutcliffe model efficiency coefficient (NSE). The optimal resolution estimated from this study will be used as basic data for applying the distributed rainfall-runoff model to the flood forecasting system.

Signal Quality Estimation for QAM System

Sooyoung Kim,Shan Gao,Dongseok Shin,Sang-seob Song 대한전자공학회 2006 ITC-CSCC :International Technical Conference on Ci Vol.2006 No.1

Nonlinear Color-Metallicity Relations of Globular Clusters. VII. Nonlinear Absorption-line Index versus Metallicity Relations and Bimodal Index Distributions of NGC 5128 Globular Clusters

Kim, Sooyoung,Yoon, Suk-Jin American Astronomical Society 2017 The Astrophysical Journal Vol.843 No.1

<P>Spectroscopy on the globular cluster (GC) system of NGC 5128 revealed bimodality in absorption-line index distributions of its old GCs. GC division is a widely observed and studied phenomenon whose interpretation has depicted host galaxy formation and evolution such that it harbors two distinct metallicity groups. Such a conventional view of. GC bimodality has mainly been. based on photometry. The recent GC photometric data, however, presented an alternative perspective in which the nonlinear metallicity-to-color transformation is responsible for color bimodality of GC systems. Here we apply the same line of analysis to the spectral indices and examine the absorption-line index versus metallicity relations for the. NGC 5128 GC system. NGC 5128 GCs display nonlinearity in the metallicity-index planes, most prominently for the Balmer lines and by a. non-negligible degree for the metallicity-sensitive magnesium line. We demonstrate that the observed spectroscopic division of NGC 5128 GCs can be caused by the nonlinear nature of the metallicity-to-index conversions and thus one does not need to resort to two separate GC subgroups. Our analysis incorporating this nonlinearity provides a. new perspective on the structure of NGC 5128's GC system, and a further piece to the global picture of the formation of GC systems and their host galaxies.</P>