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Sung Sil Park,Sung Chan Park,Dong-Eun Lee,Dong Woon Lee,Kiho Yu,Hyoung-Chul Park,Chang Won Hong,Dae Kyung Sohn,Kyung Su Han,Bun Kim,Byung Chang Kim,Jae Hwan Oh 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.2
Purpose: Oral sulfate tablets are abundantly used for bowel preparation before colonoscopy. However, their efficiency and safety for bowel preparation before colorectal surgery remain ill-defined. Herein, we aimed to compare the surgical site infection rates and efficiency between oral sulfate tablets and sodium picosulfate. Methods: We designed a prospective, randomized, phase 2 clinical trial. Patients with colorectal cancer aged 19–75 years who underwent elective bowel resection and anastomosis by minimally invasive surgery were administered oral sulfate tablets or sodium picosulfate. Eighty-three cases were analyzed from October 2020 to December 2021. Surgical site infection within 30 days after surgery was considered the primary endpoint. Postoperative morbidities, the degree of bowel cleansing, and tolerability were the secondary endpoints. Results: Surgical site infection was detected in 1 patient (2.5%) in the oral sulfate tablet group and 2 patients (4.7%) in the sodium picosulfate group, indicating no significant difference between the 2 groups. Postoperative morbidity and the degree of bowel cleansing bore no statistically significant differences. Furthermore, none of the investigated tolerability criteria, namely bloating, pain, nausea, vomiting, and discomfort, differed significantly between the 2 groups. The patients’ willingness to reuse the drug was also not significantly different between the 2 groups. Conclusion: Although we could not establish the noninferiority of oral sulfate tablets to sodium picosulfate, we found no evidence suggesting that oral sulfate tablets are less safe or tolerable than sodium picosulfate in preoperative bowel preparation.
Sung-Ha Lee,Hyeok-Hee Lee,Kiho Sung,Yoosik Youm,Hyeon Chang Kim 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: The adverse health effects of individual-level social isolation (e.g., perceived loneliness) have been well documented in older adults. However, little is known about the impact of collective-level social isolation on health outcomes. We sought to examine the association of group-level segregation with cardiovascular health (CVH) in older adults. METHODS: From the prospective Korean Social Life, Health, and Aging Project database, we identified 528 community-dwelling older adults who were aged ≥60 years or were married to those aged ≥60 years. Participants who belonged to smaller social groups separate from the major social group were defined as group-level-segregated. The CVH score was calculated as the number of ideal non-dietary CVH metrics (0-6), as modified from the American Heart Association’s Life’s Simple 7. Using ordinal logistic regression models, we assessed cross-sectional and longitudinal associations between group-level segregation and CVH. RESULTS: Of the 528 participants (mean age, 71.7 years; 60.0% female), 108 (20.5%) were segregated at baseline. In the cross- sectional analysis, group-level segregation was significantly associated with lower odds of having a higher CVH score at baseline after adjusting for socio-demographic factors and cognitive function (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.43 to 0.95). Among 274 participants who completed an 8-year follow-up, group-level segregation at baseline was marginally associated with lower odds of having a higher CVH score at 8 years (OR, 0.49; 95% CI, 0.24 to 1.02). CONCLUSIONS: Group-level segregation was associated with worse CVH. These findings imply that the social network structure of a community may influence its members’ health status.
Seo, Sang Won,Lee, Jong-Min,Im, Kiho,Park, Jun-Sung,Kim, Sook-Hui,Kim, Sung Tae,Ahn, Joong Hyun,Kim, Min-Jeong,Kim, Geon Ha,Kim, Jong Hun,Roh, Jee Hoon,Cheong, Hae-Kwan,Na, Duk L. Lippincott WilliamsWilkins, Inc. 2012 Alzheimer disease and associated disorders Vol.26 No.2
Cardiovascular risk factors are associated with cognitive impairments. However, the effects of cardiovascular risk factors on the topography of cortical thinning have not yet been studied in patients with mild cognitive impairment (MCI) or dementia. Thus, we aimed to evaluate the topography of cortical thinning related to cardiovascular risk factors and the relationships among cardiovascular risk factors, white matter hyperintensities (WMH), and cortical atrophy. Participants included 226 patients with Alzheimer disease or subcortical vascular dementia and 135 patients with amnestic MCI or subcortical vascular MCI. We automatically measured the volume of WMH and cortical thickness. Hypertension was associated with cortical thinning in the frontal and perisylvian regions, and cortical thinning related to diabetes mellitus (DM) occurred in the frontal region. In path analyses, hypertension accounted for 0.04 of the frontal thinning with the mediation of WMH and 0.16 without the mediation of WMH. In case of DM, it accounted for 0.02 of the frontal thinning with the mediation of WMH and 0.13 without the mediation of WMH. Hypertension and DM predominantly affected frontal thinning both with and without the mediation of WMH, where the effects without the mediation of WMH were greater than those with the mediation of WMH.
Jung, Min-Ho,Song, Min-Cheol,Bae, Kiho,Kim, Han Sung,Kim, Seung Hyun,Sung, Sang Hyun,Ye, Sang Kyu,Lee, Kwang Ho,Yun, Yeo-Pyo,Kim, Tack-Joong Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.4
<P>We investigated the effects of sauchinone, isolated from the root of <I>Saururus chinensis</I>, on muscle disorders and the underlying mechanism of oxidative stress-induced C<SUB>2</SUB>C<SUB>12</SUB> skeletal muscle myoblast damage. To assess the protective effects of sauchinone on oxidative stress-induced C<SUB>2</SUB>C<SUB>12</SUB> skeletal muscle myoblasts, we measured the viability of the cells, showing that sauchinone pre-treatment significantly reduced the decreased cell viability after H<SUB>2</SUB>O<SUB>2</SUB> treatment. We also investigated the mechanism of this protective effect of sauchinone. In Western blot analysis, the heat shock protein (HSP)-70 level increased significantly in the sauchinone-pretreated myoblasts. We used high performance liquid chromatography (HPLC) to examine the level of endogenous ceramide after pre-treatment with sauchinone followed by exposure to H<SUB>2</SUB>O<SUB>2</SUB>. While hydrogen peroxide increased the ceramide content to approximately 166.60±38.93% of the control level, pre-treatment with sauchinone inhibited this increase, maintaining the ceramide content at the control level. We demonstrated that sauchinone regulates intracellular HSP70 expression as well as ceramide levels to protect against oxidative stress-induced C<SUB>2</SUB>C<SUB>12</SUB> muscle myoblast damage. We suggest the potential benefits of herbal medicines in the treatment of oxidative stress-related muscle disorders.</P>