화학사고 후 주민복귀 및 피해복구 시점 결정을 위한 인체지표 개발

양준용(JunYong Yang),허정무(JeongMoo Heo),이현석(HyunSeok Lee),이준상(JunSang Lee),조용성(YongSung Cho),김호현(HoHyun Kim),박상희(SangHee Park) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.5

Objectives: Human indices were developed to determine returning point of residents and damage restoration after the chemical accident Methods: To determine the returning point of residents after the chemical accident, a new concept, the standard man model was introduced as a human index, in which both H-code and its acute effects were main idea. To evaluate the applicability, a hydrogen fluoride leakage accident in Gumi was applied. The returning point were suggested as the conservative remission period of acute effects among relevant hazard effects and compared with actual returning point. The coverage of each age group were considered with reflecting average daily dose expected for actual residents. In addition, a relief-index as a social-scientific approach was reflected as well to apply the damage restoration Results: Actual returning point of residents in Gumi was 88 days; and that of standard man model suggested was 84 days. The expected amount of exposure at aged 12 or under was at least 2.35 times greater than that of this model, 40s, theoretically. However, their population ratio was less than 1%, so 99% of residents could be applied when the standard man model was applied. The relief-index was as an objective and quantitative methodology to apply the qualitative aspect. Conclusions: Although evaluated as a relatively positive result, there was a limitation such as the number of accident applied to the verification of standard man model. The relief index was also considered, but further research should be carried out to find threshold level for the relief.

Analysis of First-line Target Therapy on EGFR Mutant NSCLC Patients with Brain Metastasis Using Common Data Model

( Junyong Jang ),( So-my Koo ),( Ki-up Kim ),( Hyeon-jong Yang ),( Suyeon Park ),( Sangyoung Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background There is limited head-to-head comparative studies on the effects of EGFR-TKIs used in advanced EGFR mutant non-small cell lung cancer (NSCLC). The purpose of this study is to analyze the real-world clinical data of the target therapies (afatinib, erlotinib, gefitinib, and osimertinib) as a first-line treatment in patients with NSCLC with brain metastasis. Method The data were retrospectively collected from patients who were diagnosed with advanced NSCLC within 60 days prior to receiving EGFR-TKIs using common data model (CDM) from four Soonchunhyang University hospital. Primary outcome was the time to treatment failure, and secondary outcome was overall survival and adverse drug reaction (ADR) : leukopenia, neutropenia, anemia, thrombocytopenia, hepatitis, and kidney injury. The time to treatment failure was defined as the duration of EGFR-TKI treatment as first-line treatment. Result In total of 437 patients were included (afatinib, 88 [20.1%]; erlotinib, 80 [18.3%]; gefitinib, 245 [56.0%]; Osimertinib, 24 [5.5%]). The median time to treatment failure was 164.0 days (interquartile range [IQR], 52.5 to 382.5 days) in afatinib group, 83.5 days (IQR, 24.5 to 279.8 days) in erlotinib group, 171.0 days (IQR, 42.0 to 411.0 days) in gefitinib group, and 139.5 days (IQR, 59.8 to 212.0 days) in Osimertinib group. Of the 437 patients, 104 patients had brain metastasis. Among patients with brain metastasis, gefitinib also showed the longest median time to treatment failure (201.0 days [IQR, 42.0 to 420.0 days]). Anemia was more common in the gefitinib group (n = 89, 40.3%). Thrombocytopenia is more common in erlotinib group (n=28, 35%) and osimertinib (n=9, 37.5%). Creatinine increase was more common in gefitinib (n=67, 27.4%) and osimertinib (n=6, 25.0%). Conclusion As the first-line treatment for advanced EGFR mutant NSCLC, gefitinib showed the longest treatment duration. There are limitations to analyzing survival of patients with CDM, and further studies are needed.

The role of senescence of bone marrow cells in acute kidney injury

( Junyong Lee ),( Yoon Sook Ko ),( Hee Young Lee ),( Jihyun Yang ),( Sewon Oh ),( Sang-kyung Jo ),( Wonyong Cho ),( Myung-gyu Kim ) 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.1

Background: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes. This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. Methods: Female 7-week-old C57BL/6 mice were irradiated and treated with BM cells from either 48-week-old or 8-week-old male mice. Ischemia-reperfusion injury (IRI) was induced, and their functional deterioration, histological tubular damage, and inflammatory responses were compared. For the in-vitro study, lipopolysaccharide (LPS)- stimulated cytokine production by BM cells from old and young mice were examined. Results: At 24 hours after IRI, there was no significant difference in the number of circulating immune cells between the mice transplanted with old or young BM cells. However, the mice with old BM cells showed less functional deterioration and histological tubular injury than those with young BM cells. Moreover, macrophage infiltration and renal cytokine interleukin (IL)-12 levels were lower in the mice with old BM cells at 24 hours post-IRI. Consistently, the in vitro study showed that LPS-induced production of cytokines interferon-γ, monocyte chemoattractant protein-1, and IL-10 was attenuated in cultured old BM cells, suggesting that age-related functional changes in these cells may lead to reduced inflammation in IRI. Conclusion: Immunosenescence could affect the susceptibility and response to renal IRI. Further studies specifically addressing age-related alterations can help in the development of treatment strategies for elderly patients with AKI.

시계열 분석법을 이용한 도시지역 토지피복형태에 따른 지하수위와 강수량의 상관관계 분석

허준용 ( Junyong Heo ),김태용 ( Taeyong Kim ),박혜민 ( Hyemin Park ),하태정 ( Taejung Ha ),강형빈 ( Hyungbin Kang ),양민준 ( Minjune Yang ) 대한원격탐사학회 2021 大韓遠隔探査學會誌 Vol.37 No.6

최근 도시화로 인한 토지피복의 변화로 불투수층이 증가함에 따라, 강수의 자연적인 지하수 함양이 방해되어 도시홍수와 같은 재난 문제가 발생하고 있다. 따라서 토지피복의 변화에 따른 강수와 지하수위 간 상관관계를 규명하기 위해 본 연구는 소규모 도심지역인 부산광역시 연제구를 대상으로 교차상관분석(Cross-correlation function, CCF) 및 이동평균분석(Moving average method, MA)을 통해 강수와 지하수위간 지연시간을 산정하였다. 지연시간을 산정하기 위해 자기상관분석, 교차상관분석, 이동평균분석을 수행하였으며 피어슨 상관함수를 목적함수로 설정하여 강수량과 지하수위 간 가장 높은 상관계수를 가지는 시차 값을 지연시간으로 결정하였다. 관측공 반경 250 m 내 토지피복형태와 지형은 토지피복지도와 수치지형도를 이용하여 Arc-GIS를 통해 분석하였다. 연구결과 토지피복형태가 도심영향이 많은 불투수층으로 이루어진 GW01, GW03, GW05 (Urban: 71-96%)의 경우 지연시간이 길게 나타났으며(CCF: 42-71일, MA: 148-161일) 식생영향이 많은 투수층으로 이루어진 GW04 (Urban: 35%)는 짧은 지연시간(CCF: 4일, MA: 67일)을 보였다. 토지경사도에 따른 지연시간의 차이는 보이지 않았으며 이는 토지피복형태가 강수와 지하수위 간 지연시간에 영향을 강하게 미치는 요소이기 때문에 토지경사도에 따른 영향이 작용하지 못한 것으로 판단된다. 본 연구를 통해 부산 연제구의 토지 이용에 따른 지하수위와 강수량의 지연시간을 규명함으로써 도시 내 강수의 자연적인 지하수 함양을 위한 도시 녹지공간 조성과 수문학적 재난 예방을 위한 관리계획의 자료로 활용될 수 있을 것으로 기대된다. Land-use/cover change caused by rapid urbanization in South Korea is one of the concerns in flood risk management because groundwater recharge by precipitation hardly occurs due to an increase in impermeable surfaces in urban areas. This study investigated the hydrologic effects of land-use/cover on groundwater recharge in the Yeonje-gu district of Busan, South Korea. A statistical time series analysis was conducted with temporal variations of precipitation and groundwater level to estimate lag-time based on correlation coefficients calculated from auto-correlation function (ACF), cross-correlation function (CCF), and moving average (MA) at five sites. Landform and land-use/cover within 250 m radius of the monitoring wells (GW01, GW02, GW03, GW04, and GW05) at five sites were identified by land cover and digital map using Arc-GIS software. Long lag-times (CCF: 42-71 days and MA: 148-161 days) were calculated at the sites covered by mainly impermeable surfaces (GW01, GW03, and GW05) while short lag-times (CCF: 4 days and MA: 67 days) were calculated at GW04 consisting of mainly permeable surfaces. The results suggest that lag-time would be one of the good indicators to evaluate the effects of land-use/cover on estimating groundwater recharge. The results of this study also provide guidance on the application of statistical time series analysis to environmentally important issues on creating an urban green space for natural groundwater recharge from precipitation in the city and developing a management plan for hydrological disaster prevention.

LDA 모델을 이용한 학술지 자원환경지질의 연구 동향 분석

허준용(Junyong Heo),김태용(Taeyong Kim),양민준(Minjune Yang) 대한지질학회 2020 대한지질학회 학술대회 Vol.2020 No.10

Switching-like event-triggered control of nonlinear networked systems under DoS attacks using predictor-based observer

Meng Yang,Junyong Zhai 제어로봇시스템학회 2023 제어로봇시스템학회 국제학술대회 논문집 Vol.2023 No.10

한양방결합치료로 장기간 생존하고 있는 교모세포종 증례 보고

양주노(Juno Yang),윤영주(Youngju Yun),홍진우(Jinwoo Hong),한창우(Changwoo Han),권정남(Jungnam Kwon),이인(In Lee),박성하(Seongha Park),김소연(Soyeon Kim),최준용(Junyong Choi),이혜윤(Hyeyoon Lee) 대한한의학회 2018 대한한의학회지 Vol.39 No.1

An Improved Predictive Functional Control with Minimum-Order Observer for Speed Control of Permanent Magnet Synchronous Motor

Shuang Wang,Junyong Fu,Ying Yang,Jian Shi 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.1

In this paper, an improved predictive functional control (PFC) scheme for permanent magnet synchronous motor (PMSM) control system is proposed, on account of the standard PFC method cannot provides a satisfying disturbance rejection performance in the case of strong disturbances. The PFC-based method is first introduced in the control design of speed loop, since the good tracking and robustness properties of the PFC heavily depend on the accuracy of the internal model of the plant. However, in orthodox design of prediction model based control method, disturbances are not considered in the prediction model as well as the control design. A minimumorder observer (MOO) is introduced to estimate the disturbances, which structure is simple and can be realized at a low computational load. This paper adopted the MOO to observe the load torque, and the observations are then fed back into PFC model to rebuild it when considering the influence of perturbation. Therefore, an improved PFC strategy with torque compensation, called the PFC+MOO method, is presented. The validity of the proposed method was tested via simulation and experiments. Excellent results were obtained with respect to the speed trajectory tracking, stability, and disturbance rejection.

다중채널 이미지 분석법을 활용한 형광 추적자의 확산 농도분포 추정

김창민(Changmin Kim),허준용(Junyong Heo),양민준(Minjune Yang) 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10

본 연구에서는 세 종류의 점토(kaolinite, montmorillonite, bentonite)를 사용한 배치 흡착 실험과 유동챔버 실험을 통해 저투수성 매체 내 형광 추적자의 농도 분포 추정을 위한 다중채널 이미지 분석법의 적용 가능성을 평가하였다. 배치 흡착 실험은 0~2000 mg/L농도의 형광 추적자 용액과 각 종류의 점토를 혼합하여 아크릴 박스에 옮긴 뒤, 사진을 촬영하여 각 점토에서 RGB (Red, Green, Blue) 채널의 색강도를 측정하였다. 측정된 RGB 색강도의 표준편차(SD)와 변동계수(CV)를 기준으로 확산 농도분포 추정을 위한 색상의 타당성을 평가하고 용질 농도와 색강도 간 상관관계를 수식화 하였다. 유동 챔버 실험은 glass bead로 이루어진 대수층 상부에 점토층을 쌓아 구성하였으며, 2000 mg/L의 형광 추적자를 대수층을 통해 유입시켰다. 형광 추적자가 저투수성 매체로 이동하는 동안 사진을 촬영하였으며, 배치 흡착 실험결과를 통해 농도 분포를 추정하여 이를 확산해석해와 비교하여 이미지 분석법의 타당성을 평가하였다. 배치 실험 결과, kaolinite의 경우 추적자 농도가 0에서 1785 mg/L로 증가할 때 B채널의 강도가 0.8284에서 0.1583으로 감소하였으며, 표준편차와 변동계수 모두 가장 낮게 나타났다. Montmorillonite의 경우, 추적자 농도가 2.39에서 174.2 mg/L로 증가할 때 G채널의 강도가 0.8053에서 0.3101로 감소하여 측정 농도범위에서 가장 단계적인 강도 변화를 나타내었다. Bentonite의 경우, 추적자 농도 0-414 mg/L에서는 B채널의 색강도가 0.362에서 0.004로 감소하였으나, 414 mg/L이상의 범위에서 색강도의 변화가 미비하였다. 하지만 414-1748 mg/L 농도 범위에서 G채널의 색강도가 0.758에서 0.658로 감소하여, 두 색강도를 동시에 활용한 이미지 분석법이 필요할 것으로 판단되었다. 유동 챔버 실험결과, kaolinite와 montmorillonite의 경우 B채널과 G채널을 각각 적용한 농도분포 추정값이 확산 초기(31.1, 54.6 PVs)와 후기(97.9, 93.9 PVs)에 확산해석해와 높은 일치도를 보였다(E > 0.97). Bentonite의 경우, B, G 채널을 동시에 활용한 농도분포 추정값(EB+G=0.98, 0.98)이 확산 초기(6.71, 29.7 PVs)와 후기(89.1 PVs)에서 모두 단일 채널을 적용한 추정값(EB = 0.56) 보다 높은 일치도를 보였다. 따라서, kaolinite와 montmorillonite는 B채널과 G채널을 각각 이용한 농도분포 추정이 적용되어야 하며, bentonite는 농도범위에 따라 B채널과 G채널을 복합적으로 적용한 이미지 분석방법이 필요할 것으로 사료된다.

An Improved Predictive Functional Control with Minimum-Order Observer for Speed Control of Permanent Magnet Synchronous Motor

Wang, Shuang,Fu, Junyong,Yang, Ying,Shi, Jian The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.1

In this paper, an improved predictive functional control (PFC) scheme for permanent magnet synchronous motor (PMSM) control system is proposed, on account of the standard PFC method cannot provides a satisfying disturbance rejection performance in the case of strong disturbances. The PFC-based method is first introduced in the control design of speed loop, since the good tracking and robustness properties of the PFC heavily depend on the accuracy of the internal model of the plant. However, in orthodox design of prediction model based control method, disturbances are not considered in the prediction model as well as the control design. A minimum-order observer (MOO) is introduced to estimate the disturbances, which structure is simple and can be realized at a low computational load. This paper adopted the MOO to observe the load torque, and the observations are then fed back into PFC model to rebuild it when considering the influence of perturbation. Therefore, an improved PFC strategy with torque compensation, called the PFC+MOO method, is presented. The validity of the proposed method was tested via simulation and experiments. Excellent results were obtained with respect to the speed trajectory tracking, stability, and disturbance rejection.