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Park, Eun-Kyung,Park, Mi Jung,Lee, Seong-Hee,Li, Ying Chun,Kim, Jungeun,Lee, Jae-Seon,Lee, Jung Weon,Ye, Sang-Kyu,Park, Jong-Wan,Kim, Chul-Woo,Park, Byung-Kiu,Kim, Yong-Nyun John Wiley Sons, Ltd. 2009 The Journal of pathology Vol.218 No.3
<P>Caveolae (lipid rafts), microdomains of the plasma membrane, are known to contain various signalling molecules and consequently are involved in the regulation of many biological functions. To investigate the role of the caveolae in cell survival and adhesion, we disrupted the caveolae by depletion of cholesterol, a major lipid component of the caveolae, with methyl-β cyclodextrin (MβCD) treatment of A431 cells. We found that cholesterol depletion induced an anoikis-like cell death involving actin reorganization, resulting in a decrease in cell spreading and an increase in cell detachment, which was reversed by cholesterol addition. Disruption of caveolae led to the down-regulation of FAK, Src activation, tyrosine phosphorylation of caveolin-1 and mobilization of caveolae markers, GM1 and caveolin-1, from the cell surface to the cytoplasm, which were also recovered by cholesterol addition. The expression of dominant-active FAK was able to delay caveolae internalization and apoptosis and attenuated Akt inactivation by MβCD, whereas dominant-negative FAK expression resulted in enhanced apoptosis. Moreover, FAK down-regulation by si-RNA resulted in Akt inactivation and thus increased cell death by MβCD treatment. Our results suggest that the cholesterol content and/or surface levels of the caveolae affect the activity of FAK, which in turn regulates caveolae internalization and cell survival. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>
Park Gaeun,Jang Wooyoung Eric,Kim Seoyeon,Gonzales Edson Luck,Ji Jungeun,Choi Seunghwan,Kim Yujin,Park Ji Hwan,Mohammad Hazara Begum,Bang Geul,Kang Minkyung,Kim Soobin,Jeon Se Jin,Kim Jin Young,Kim Kw 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired social behavior and communication, repetitive behaviors, and restricted interests. In addition to genetic factors, environmental factors such as prenatal drug exposure contribute to the development of ASD. However, how those prenatal factors induce behavioral deficits in the adult stage is not clear. To elucidate ASD pathogenesis at the molecular level, we performed a high-resolution mass spectrometry-based quantitative proteomic analysis on the prefrontal cortex (PFC) of mice exposed to valproic acid (VPA) in utero, a widely used animal model of ASD. Differentially expressed proteins (DEPs) in VPA-exposed mice showed significant overlap with ASD risk genes, including differentially expressed genes from the postmortem cortex of ASD patients. Functional annotations of the DEPs revealed significant enrichment in the Wnt/β-catenin signaling pathway, which is dysregulated by the upregulation of Rnf146 in VPA-exposed mice. Consistently, overexpressing Rnf146 in the PFC impaired social behaviors and altered the Wnt signaling pathway in adult mice. Furthermore, Rnf146-overexpressing PFC neurons showed increased excitatory synaptic transmission, which may underlie impaired social behavior. These results demonstrate that Rnf146 is critical for social behavior and that dysregulation of Rnf146 underlies social deficits in VPA-exposed mice.
The Complete Plastome Sequence of an Antarctic Bryophyte <i>Sanionia uncinata</i> (Hedw.) Loeske
Park, Mira,Park, Hyun,Lee, Hyoungseok,Lee, Byeong-ha,Lee, Jungeun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.3
<P>Organellar genomes of bryophytes are poorly represented with chloroplast genomes of only four mosses, four liverworts and two hornworts having been sequenced and annotated. Moreover, while Antarctic vegetation is dominated by the bryophytes, there are few reports on the plastid genomes for the Antarctic bryophytes. <I>Sanionia uncinata</I> (Hedw.) Loeske is one of the most dominant moss species in the maritime Antarctic. It has been researched as an important marker for ecological studies and as an extremophile plant for studies on stress tolerance. Here, we report the complete plastome sequence of <I>S</I>. <I>uncinata</I>, which can be exploited in comparative studies to identify the lineage-specific divergence across different species. The complete plastome of <I>S</I>. <I>uncinata</I> is 124,374 bp in length with a typical quadripartite structure of 114 unique genes including 82 unique protein-coding genes, 37 tRNA genes and four rRNA genes. However, two genes encoding the <I>α</I> subunit of RNA polymerase (<I>rpoA</I>) and encoding the cytochrome b<SUB>6/f</SUB> complex subunit VIII (<I>petN</I>) were absent. We could identify nuclear genes homologous to those genes, which suggests that <I>rpoA</I> and <I>petN</I> might have been relocated from the chloroplast genome to the nuclear genome.</P>
Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women
Park Jungeun,Son Mi Kyoung,Park Hyun-Young 대한의학회 2023 Journal of Korean medical science Vol.38 No.31
Background: Adverse lipid profiles are observed in postmenopausal women. However, there is insufficient evidence of the association between lipids and reproductive aging in Korean women. We aimed to characterize lipid changes with respect to timing relative to menopause in Korean middle-aged women. Methods: This study included 1,436 premenopausal women who had a natural menopause during the follow-up period (median = 15.76 years) from the Korean Genome and Epidemiology Study (KoGES) Ansan and Anseong cohort. Lipid levels were measured every 2 years, and the magnitudes of annual lipid changes and differences in the changes by premenopausal body mass index were estimated using piecewise linear mixed-effects models. Results: All lipid levels increased greatly from 3 or 5 years before menopause to 1 year after menopause in all women, regardless of their premenopausal body mass index. During the period, high-density lipoprotein cholesterol (HDL-C) levels increased at 0.42 mg/dL per year (95% confidence interval [CI], 0.29 to 0.55 mg/dL). Nevertheless, non-HDL-C levels simultaneously increased at 3.42 mg/dL per year (95% CI, 3.11 to 3.72 mg/dL), and an annual change in the non-HDL-C to HDL-C ratio was 0.05 (95% CI, 0.04 to 0.06). One year after menopause, changes in all lipid parameters significantly slowed down, except for the nonHDL-C to HDL-C ratio (P < 0.001 for all). The ratio continued to increase until 3 years after menopause, but thereafter, the change leveled off. Conclusion: Women experienced remarkable increases in lipid levels during menopausal transition, highlighting the need for early intervention strategies for cardiovascular disease prevention in women.
Accuracy of Horse-Riding Energy Consumption according to Accelerometer Wearing Location
( Jungeun Park ),( Hanju Ahn ),( Seungyun Shin ),( Mihyun Lee ) 한국스포츠정책과학원(구 한국스포츠개발원) 2015 International Journal of Applied Sports Sciences Vol.27 No.2
The purpose of this study is to verify the accuracy of energy consumption per wearing location (waist, wrist, ankle) of uniaxial accelerometer (GT1M) during horse-riding exercise (normal-walking, fast-walking, running). The study subjects were conveniently sampled from 11 males in their 20s from Shorse-riding course who have over 3 years of experience in horse-riding and are licensed as leisure sports instructors (horse-riding), and the following conclusion was drawn. For normal-walking, there was no significant difference of standard energy consumption among waist, wrist, and ankle, and all three locations showed confidence interval with small deviation in Bland-Altman Plot. On the other hand, for fast-walking and running, only wrist showed no significant difference, where only wrist location showed low-deviation confidence interval in Bland-Altman Plot. According to such results, the accuracy was relatively high for wrist-wearing when predicting horse-riding activity energy consumption using accelerometer. Therefore, the wearing location must be considered when predicting horse-riding activity energy consumption with accelerometer on site.