미세각막절개도 헤드의 선택을 통한 맞춤식각막절개방식의 라식

강민호,송유미,강성민,박영숙,최철영,이윤정,이병로.Min Ho Kang. M.D.. Yoo Mi Song. M.D.. Sung Min Kang. M.D.. Young Sook Park. M.D.. Chul Young Choi. M.D.. Yoon Jung Lee. M.D.. Byung Ro Lee. M.D. 대한안과학회 2006 대한안과학회지 Vol.47 No.2

Purpose: To compare the intraoperative and postoperative complication rates and visual outcomes with M2 130 head (thick flap group) and M2 110 head (thin flap group). Methods: One-hundred-ninety-five eyes of 104 patients who underwent LASIK with the Moria M2 microkeratome and Allegretto-wave laser were reviewed retrospectively. Selection of M2 heads was based on preoperative pachymetry and estimated ablation depth. Intraoperative and postoperative flap-related complications, mean postoperative uncorrected visual acuity (UCVA), and mean spherical equivalent (MSE) were evaluated and compared. Results: Mean follow-up was 8.1 months. The number of eyes, preoperative MSE and mean corneal thickness of M2 130 were 115, -4.04±1.63diopter (D) and 549.40±39.16??m, and 85, -6.61±3.43D and 525.16±24.53 ?m, respectively, in the 110 head group. Mean UCVA and MSE at postoperative 1 week, 3 months and 6 months were 1.00±0.18, -0.26±0.49D; 1.07±0.68, -0.40±0.51D; and 1.01±0.22, -0.51±0.50D, respectively, in the 130 head group, and 0.90±0.23, -0.46±1.02D; 0.91±0.23, -0.67±0.79D; 0.85±0.46, -0.75±0.88D, respectively, in the 110 head group. There were no significant differences in intraoperative and postoperative flap-related complication rates between the two groups (p=0.316). There were no statistically significant differences in postoperative mean UCVA or MSE between the two groups (p>0.05), except for MSE at the third and sixth postoperative months (p=0.005, 0.013). Conclusions: Proper selection of M2 heads by preoperative pachymetry allowed for an adequate residual stroma bed with good visual outcome. Utilizing one single microkeratome and switching between two heads was advantageous and cost-effective.

Supplemented vaccination with tandem repeat M2e virus-like particles enhances protection against homologous and heterologous HPAI H5 viruses in chickens

Song, B.M.,Kang, H.M.,Lee, E.K.,Jung, S.C.,Kim, M.C.,Lee, Y.N.,Kang, S.M.,Lee, Y.J. Butterworths ; Elsevier Science Ltd 2016 Vaccine Vol.34 No.5

Highly pathogenic avian influenza (HPAI) H5 viruses derived from A/Goose/Guangdong/1/96 have been continuously circulating globally, severely affecting the public health and poultry industries. The matrix 2 protein ectodomain (M2e) is considered a promising candidate for a universal cross-protective influenza vaccine that provides more effective control over HPAI H5 viruses harboring variant hemagglutinin (HA)-antigens. Here, we evaluated the protective efficacy of a tandem repeat construct of heterologous M2e presented on virus-like particles (M2e5x VLPs) either alone or as a supplement against HPAI H5 viruses in a chicken model. Chickens immunized with M2e5x VLPs alone induced M2e-specific antibodies but were not protected against HPAI H5. The homo- and cross-protective efficacy of M2e5x VLP-supplemented vaccination of chickens was also examined. Importantly, supplementation with M2e5x VLPs induced significantly higher levels of antibodies specific for M2e and different viruses as well as provided improved protection against homologous and heterologous HPAI H5 viruses. Considering the limited efficacy of inactivated vaccines, supplement vaccination with M2e5x VLPs may be an effective measure for preventing outbreaks of HPAI viruses that have the ability to constantly change their antigenic properties in poultry.

Identification of Aggregation-Sex Pheromone of the Korean Monochamus alternatus (Coleoptera: Cerambycidae) Population, the Main Vector of Pine Wood Nematode

Lee, H. R.,Lee, S. C.,Lee, D. H.,Jung, M.,Kwon, J. H.,Huh, M. J.,Kim, D. S.,Lee, J. E.,Park, I. K. Entomological Society of America [etc.] 2018 Journal of economic entomology Vol. No.

<P>We confirmed an aggregation-sex pheromone of the Korean Monochamus alternatus Hope (Coleoptera: Cerambycidae) population, which primarily transmitted the pine wood nematode in Korea. Only the M. alternatus male emitted monochamol which has been previously reported in the Chinese M. alternatus population. In field attraction testing, the monochamol+alpha-pinene+ethanol combination attracted more M. alternatus adult beetles than traps containing only monochamol, ethanol, or alpha-pinene. The bark beetle aggregation pheromone compounds of ipsenol, ipsdienol, and ipsenol+ipsdienol, did not show synergistic effects with the monochamol+alpha-pinene+ethanol combination. No synergistic effects were observed when each host volatile compound of 3-carene, beta-caryophyllene, limonene, myrcene, and beta-pinene was added to traps containing monochamol+alpha-pinene+ethanol. The ratio of female beetles was much higher in traps containing the monochamol+alpha-pinene+ethanol combination than that of the natural population. Our results indicated that pheromone and synergists could be useful for managing the M. alternatus population.</P>

The human AQP4 gene : Definition of the locus encoding two water channel polypeptides in brain

LU, MINGOI,LEE, M.DOUGLAS,SMITH, BARBARA L.,JUNG, JIN SUP,AGRE, PETER,VERDUK, MARIAN A.J.,MERKX, GERARD,RUSS, JOHAN P.L.,DEEN, PETER M.T. 부산대학교 유전공학연구소 1996 분자생물학 연구보 Vol.12 No.-

The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4. Here we report the isolation and characterization of the human AQP4 cDNAs and genomic DNA. Two cDNAs were isolated corresponding to the two initiating methionines (M1 in a 323-aa polypeptide and M23 in a 301-aa polypeptide) previously indentified in rat [Jung, J. S., Bhat, R. V., Preston, G. M., Guggino, W. B. & Agre, P. (1994) Proc. Natl. Acad. Sci. USA 91, 13052-13056]. Similar to other aquaporins, the AQP4 gene is composed of four exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0; the next 11 amino acids and M23 are encoded by exon 1. Transcription initiation sites have been mapped in the proximal promoters of exons 0 and 1. RNase protection revealed distinct transcripts corresponding to M1 and M23 mRNAs, and AQP4 immunoblots of cerebellum demonstrated reactive polypeptides of 31 and 34 kDa. Using a P1 and a λEMBL subclone, the chromosomal site of the human AQP4 gene was mapped to chromosome 18 at the junction of q11.2 and q12.1 by fluorescence in situ hybridization. These studies may now permit molecular characterization of AQP4 during human development and in clinical disorders.

Effects of tungsten and molybdenum on high-temperature tensile properties of five heat-resistant austenitic stainless steels

Jung, S.,Jeon, C.,Jo, Y.H.,Choi, W.M.,Lee, B.J.,Oh, Y.J.,Jang, S.,Lee, S. Elsevier Sequoia 2016 Materials science & engineering. properties, micro Vol.656 No.-

<P>Heat-resistant austenitic stainless steels have been intensively used worldwide for turbo-chargers requiring excellent high-temperature properties to sustain their structures at very high exhaust gas temperatures. Five heat-resistant austenitic stainless steels were fabricated by varying contents of W and Mo, and their high-temperature tensile properties were investigated by analyzing phases (liquid, austenite, ferrite, and carbides) existing at high temperatures. Effects of replacement of expensive alloying element, W, by Mo or reduction in W were also examined. The increase in contents of W and Mo resulted in linearly increased volume fractions of M7C3 and total carbides, while the volume fraction of MC carbide hardly showed any relation, and showed a good correspondence with high-temperature yield and tensile strengths. The steel where 2 wt% of W was replaced by 2 wt% of Mo showed the best 900 degrees C-tensile properties, thereby confirming the successful achievement of partly replacement of W by Mo. In addition, the low-W-containing steels showed excellent 900 degrees C-tensile properties, which also indicated that the reduction in 1-2 wt% of W was accepted for saving costs of alloying elements. (C) 2016 Elsevier B.V. All rights reserved.</P>

Spectral optical properties of long-range transport Asian dust and pollution aerosols over Northeast Asia in 2007 and 2008

Jung, J.,Kim, Y. J.,Lee, K. Y.,-Cayetano, M. G.,Batmunkh, T.,Koo, J.-H.,Kim, J. Copernicus GmbH 2010 Atmospheric Chemistry and Physics Vol.10 No.12

<P>Abstract. As a part of the IGAC (International Global Atmospheric Chemistry) Mega-cities program, aerosol physical and optical properties were continuously measured from March 2007 to March 2008 at an urban site (37.57° N, 126.94° E) in Seoul, Korea. Spectral optical properties of long-range transported Asian dust and pollution aerosols have been investigated based on the year long measurement data. Optically measured black carbon/thermally measured elemental carbon (BC/EC) ratio showed clear monthly variation with high values in summer and low values in winter mainly due to the enhancement of light attenuation by the internal mixing of EC. Novel approach has been suggested to retrieve the spectral light absorption coefficient (babs) from Aethalometer raw data by using BC/EC ratio. Mass absorption efficiency, σabs (=babs/EC) at 550 nm was determined to be 9.0±1.3, 8.9±1.5, 9.5±2.0, and 10.3±1.7 m2 g−1 in spring, summer, fall, and winter, respectively with an annual mean of 9.4±1.8 m2 g−1. Threshold values to classify severe haze events were suggested in this study. Increasing trend of aerosol single scattering albedo (SSA) with wavelength was observed during Asian dust events while little spectral dependence of SSA was observed during long-range transport pollution (LTP) events. Satellite aerosol optical thickness (AOT) and Hysplit air mass backward trajectory analyses as well as chemical analysis were performed to characterize the dependence of spectral optical properties on aerosol type. Results from this study can provide useful information for studies on regional air quality and aerosol's effects on climate change. </P>

DNA 증거의 집단유전학적 분석을 위한 SAS시스템

이효정,이혜승,한길로,이재원,황적준 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

DNA analysis has become one of the most powerful tools in forensic inference for human identification and is now used worldwide. It is used to be statistical technique for the individual identification of a civil and criminal action. The purpose of this article is computerization of the statistical technique for the population study and DNA evidence analysis. The system using SAS/AF and SAS/SCL is the graphic user interface and the correspondence of the changed experimental circumstances

Various shaped-ZnO nanocrystals via low temperature synthetic methods: Surfactant and pH dependence

Jung, H.J.,Lee, S.,Choi, H.C.,Choi, M.Y. Elsevier 2013 Solid state sciences Vol.21 No.-

ZnO nanocrystals, rod-, carnation-, and flower-like structures, have been synthesized in a high yield through low-temperature synthetic methods. Well-aligned ZnO nanorods having hexagonal wurtzite structure were grown on the ZnO thin films assembled by a spin-coating method. The morphologies of ZnO seed films are affected by pHs of sol-gel solutions, resulting smaller sizes and homogeneous roughness at higher pHs and higher number of spin-coating times. The carnation-like structures, average size of about 2-3 μm, were assembled by tens of uniform ZnO nanosheet petals of ~50 nm in thickness when a different volume ratio of the precursory solution was used. ZnO nanocrystals on the facets of the compact ZnO nanorods have grown to linear nanorods having an average diameter of ~500 nm and length of ~2 μm. Furthermore, a noticeable difference in the growth of ZnO nanocrystals in the presence of various surfactants, polyvinylpyrrolidone, polyvinylsulphonic acid, and polyethyleneimine, has been observed and discussed.

Effects of Cr and Nb addition on high-temperature tensile properties in austenitic cast steels used for turbo-charger application

Jung, S.,Sohn, S.S.,Jo, Y.H.,Choi, W.M.,Lee, B.J.,Oh, Y.J.,Kim, G.Y.,Jang, S.,Lee, S. Elsevier Sequoia 2016 Materials science & engineering. properties, micro Vol.677 No.-

<P>In automotive turbo-chargers, excellent high-temperature properties are needed for retaining their structures at extremely high temperature of exhausted gas, and thus austenitic cast steels have been actively developed. In this study, high-temperature tensile properties of austenitic cast steels containing different W, Nb, and Cr were interpreted by deformation and fracture mechanisms related with carbides and austenite matrix. Replacement effects of W by Nb or Cr were also investigated because of expensive alloying cost of W. The high-temperature tensile test results revealed that the Cr-added steel containing many M7C3 carbides showed the higher strength than the Nb-added steel containing hard MC carbides. This was because the strength could be enhanced by distributing carbides having slightly lower hardness such as M7C3 carbides in the strengthened matrix as it could hold hard carbides, like in the Cr-added steel. The Cr-added steel (1 wt% W) also showed the higher strength and elongation at 900 degrees C than the basic-composition steel (2 wt% W), which indicated that the partly replacement of W by Cr was successfully achieved. (C) 2016 Elsevier B.V. All rights reserved.</P>

Distribution of natural and anthropogenic radionuclides in northwest Mediterranean coastal sediments

Lee, Sang-Han,Povinec, Pavel P.,Chisholm, John R.M.,Levy, Isabelle,Miquel, Juan-Carlos,Oh, Jung-Suk Elsevier 2017 JOURNAL OF ENVIRONMENTAL RADIOACTIVITY Vol.172 No.-

<P><B>Abstract</B></P> <P>The distribution of radionuclides in NW Mediterranean coastal sediments, and the processes controlling their abundance were investigated in three cores taken near the island of Porquerolles and one offshore Monaco. The sediments collected near Porquerolles were strongly anoxic due to diagenetic processes involved in the decomposition of organic matter, whereas they transitioned from oxic to anoxic at a depth of 4 cm beneath the seawater interface at Monaco. Organic carbon (OC) was more abundant in sediments at Porquerolles (by about a factor of 3–5) than at Monaco and elsewhere in the coastal NW Mediterranean. Sediment cores collected NE of Porquerolles also possessed elevated uranium concentrations that correlated with high OC content and strong reducing conditions. The <SUP>239,240</SUP>Pu and <SUP>241</SUP>Am activities in surficial sediments ranged from 1 to 5.7 Bq kg<SUP>−1</SUP> and 0.3 to 1 Bq kg<SUP>−1</SUP>, respectively, while the <SUP>137</SUP>Cs activity ranged from 0.3 to 6.2 Bq kg<SUP>−1</SUP>. The mean activity ratios of <SUP>241</SUP>Am/<SUP>239,240</SUP>Pu and <SUP>238</SUP>Pu/<SUP>239,240</SUP>Pu in Porquerolles and Monaco sediments were similar to the global fallout ratios. Sediment inventories of global fallout <SUP>239,240</SUP>Pu (430–800 Bq m<SUP>−2</SUP>) and <SUP>241</SUP>Am (150–285 Bq m<SUP>−2</SUP>) were by about a factor of 5–10 higher at Porquerolles, whereas the inventory of <SUP>137</SUP>Cs (430–1000 Bq m<SUP>−2</SUP>) was substantially lower at the investigated stations than have been reported elsewhere at similar latitudes. Specific local conditions characterised by high OC sediment loads due to the growth and mortality of <I>Posidonia oceanica</I> have been responsible for deposition of large amounts of seagrass tissues at the NE corner of Porquerolles, which have had a profound effect on the distribution of radionuclides in the sediments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Radionuclides in coastal sediments of NW Mediterranean were investigated. </LI> <LI> <SUP>241</SUP>Am/<SUP>239,240</SUP>Pu and <SUP>238</SUP>Pu/<SUP>239,240</SUP>Pu ratios consistent with global fallout ratios. </LI> <LI> <SUP>137</SUP>Cs mostly dissolved, but <SUP>239,240</SUP>Pu and <SUP>241</SUP>Am are particle reactive elements. </LI> <LI> Inventories of <SUP>239,240</SUP>Pu (430–800 Bq m<SUP>−2</SUP>) and <SUP>241</SUP>Am (150–285 Bq m<SUP>−2</SUP>) are high. </LI> <LI> Inventories of <SUP>137</SUP>Cs are significantly lower at all stations investigated. </LI> </UL> </P>