마산연안지역의 국지풍 순환 및 대기오염물질 확산에 관한 연구

김유근,이화운,문윤섭,김해동,원경미,정우식,오인보 부산대학교 환경문제연구소 1997 環境硏究報 Vol.15 No.1

To investigate a horizontal windrose and the mixing height in Masan coastal area, a local atmospheric flow and the concentration of air pollutants were analyzed by abserved data from AWS, airsonde and air sampler. The land-sea breeze model and the ISCST2 model of U. S. EPA(Environmental Protection Agency) were used to predict the concentration of air pollutants such as SO2 and TSP. As a result, during spring the principal wind direction in the Masan region is mainly represented by windrose of the WNW and NW, which can be induced by land breeze and the SE and SSW of sea breeze even if weak wind speed. The mixing height during the measurement was marked with the range from 400 m(0900 LST) to 1450 m(1500 LST), and the height of an inverse layer was presented as the range from 30 m(2100 LST) to 150 m(0300 LST). It is very important to cosider the local wind field for the accurate diffusion and movement of air pollutants in coastal urban area. The atmospheric flow was simulated by the two-dimensional local wind model upon considering the orographic characteristics such as land-sea contrast, mountain valley and urban building. The result of air quality simulated by ISCST2 support that the dispersion pattern of the pollutants in that area was followed as local circulation system in coastal urban area.

全北地域農業活性化方案과 食品加工産業育成戰略

朴正根,申東禾,康昌植 全北大學校 1993 論文集 Vol.36 No.-

This paper attempts to suggest an alternative regional policy of agricultural restructuring and strategies for food processing industry support in Chonbuk. Chonbuk is on the threshold of serious restructuring against the trade liberalization. The increasing pressure of agricultural import liberalization from abroad has given great burden to Chonbuk agricultural sector which has lagged behind the average growth of national agriculture. The challange is to find an orderly process of restructuring that will achieve a more improvement of productivity and stability. This study suggests diversification out of rice monoculture into a multicrop enterprise system as an essential component of agricultural restructuring, induced by the changing relative profitability of rice and nonrice enterprise. The potential for diversification out of rice depends on both physical and economic factors. The profitability of diversification is constrained by both markets and physical infrastructure. Successful transition from rice monoculture to a rice based farming system in Chonbuk should be induced by market forces. The Korean dietary pattern has been changed drastically in parallel with economic growth and the share of processed foods in the daily diet has been increasing over the last decade. Thus, the Chonbuk local government should encourage the growth of the food industry which is projected to continue to grow in the comming years. The structure of the food industry in Korea is lather unique in that small-sized firms produce a greater part of the total output. One major problem facing the small firms in the food industry is that they are often too small to exploit economies of scale in production and marketing. Some small-sized companies are being gradually phased out of business due to shortage of labor and high cost seructure. The expansion of export market is expected to accelerate the development of food industry. In order to keep ahead of competition in export markets, Chonbuk local government should undertake an important role in establishing food combinat to adopt a restructuring and upgrading strategies for food processing industry support.

부산연안역에서의 대기오염기상 예보시스템 개발에 관한 연구 : 고농도 오존일의 예측을 중심으로 Centering around Forecast of Ozone Episode Day

김유근,이화운,전병일,홍정혜,문윤섭 한국환경과학회 1996 한국환경과학회지 Vol.5 No.4

Pusan is the largest coastal city with a population of about four million in Korea. Because of increased and confused traffic, photochemical air pollution become a major urban environmental problem recently. The photo-chemical air pollution weather forecasting method preciser than existing air pollution forecast method has been developed to forecast ozone episode days with meteorological conditions using the data measured at 7 air quality continuous monitoring stations from June to September using 2 years (1994, 1995). The method developed in present study showed higher percentage correct and skill score than existing air pollution forecasting in KMA (Korea Meteorological Administration).

연안부근 복잡지형의 대기유동장 수치실험 1 : 선형이론을 이용한 국지순환모형의 타당성 검토 A Verification of Propriety of Local Circulation Model Using the Linear Theory

이화운,김유근,정우식 한국환경과학회 1999 한국환경과학회지 Vol.8 No.5

A sea/land breeze circulation system and a regional scale circulation system are formed at a region which has complex terrain around coastal area and affect to the dispersion and advection of air pollutants. Therefore, it is important that atmospheric circulation model should be well designed for the simulation of regional dispersion of air pollutants. For this, Local Circulation Model, LCM which has an ability of high resolution is used. To verify the propriety of a LCM, we compared the simulation result of LCM with an exact solution of a linear theory over a simple topography. Since they presented almost the same value and pattern of a vertical velocity at the level of 1 ㎞, we had a reliance of a LCM. For the prediction of dispersion and advection of air pollutants, the wind field should be calculated with high accuracy. A numerical simulation using LCM will provide more accurate results over a complex terrain around coastal area.

거대 점오염원이 주변 대기질에 미치는 영향에 관한 연구

김유근,이화운,전병일,장은숙,홍정혜,문윤섭,원경미,송정희 부산대학교 환경문제연구소 1996 環境硏究報 Vol.14 No.1

In order to show the effect of a vast point pollutant source on air quality of Pusan Thermoeletric Power Plant and its surrounding area, air quality around Pusan Thermoeletric Power Plant was simulated by ISCLT-2 which was supplied by EPA. For this purpose the emission amount of SO_2, NO_2 and TSP was calculated and atmospheric stability was classified for a recent decade(1985~1994) in Pusan. A result of the emission amount showed that much amount of NO_2, NO_2 and TSP are emitted from industrial area. It was clear that NO_2 is much emitted from line source and industrial area. And as a result of classification of atmospheric stability, neutral, stable and unstable state were 58%, 24.1% and 17.9%, respectivly. The result of ai quality simulation by ISCLT-2 showed that Pusan Thermoeletric Power Plant is affecting on the increse of 2.0ppb, 3.0ppb and 5.0㎍/㎥, SO_2, NO_2, and TSP respectively at its surrounding area, site A-3 which was located westward 2.2㎞ distance from Plant

부산광역시의 대기질 변화경향 및 특성에 관한 연구

이화운,김유근,원경미,홍정혜,문윤섭,장난심,정우식 부산대학교 환경문제연구소 1997 環境硏究報 Vol.15 No.1

Secular Trends in Ischemic Stroke Characteristics in a Rapidly Developed Country : Results From the Korean Stroke Registry Study (Secular Trends in Korean Stroke)

Jung, Keun-Hwa,Lee, Seung-Hoon,Kim, Beom Joon,Yu, Kyung-Ho,Hong, Keun-Sik,Lee, Byung-Chul,Roh, Jae-Kyu Ovid Technologies Wolters Kluwer -American Heart A 2012 Circulation. Cardiovascular quality and outcomes Vol.5 No.3

<P>A dynamic change in industry, lifestyle, and healthcare structure brings a corresponding change in disease patterns. Limited data exist with respect to secular trends in stroke epidemiology in Korea, a rapidly developed country.</P>

Anthricin Isolated from <i>Anthriscus sylvestris</i> (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting Akt/mTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition

Jung, Chang Hwa,Kim, Heemun,Ahn, Jiyun,Jung, Sung Keun,Um, Min Young,Son, Kun-Ho,Kim, Tae Wan,Ha, Tae Youl Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-

<P>Anthricin (deoxypodophyllotoxin) is a natural product isolated from <I>Anthriscus sylvestris</I> (L.) Hoffm. (Apiaceae). Here, we investigated the effect of anthricin on autophagy and mammalian target of rapamycin (mTOR) signaling as anticancer actions in breast cancer cells. Many studies have supported the contention that the phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway is considerably deregulated in breast cancer and that autophagy plays important roles in the development of this type of cancer, although the exact underlying mechanisms remain unknown. Our data confirmed that anthricin markedly induced apoptosis in 2 breast cancer cell lines, MCF7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor, progesterone receptor, and Her2/Neu receptor negative). Anthricin treatment decreased the levels of phosphorylated Akt and mTORC1, followed by inhibition of cell growth. Interestingly, blockage of autophagy by a pharmacological inhibitor or genetic deletion of ULK1 and Atg13 accelerated anthricin-induced apoptosis, suggesting that autophagy has cytoprotective effects. Taken together, our results indicate that anthricin is an inhibitor of mTOR and that a combination of an autophagy inhibitor and anthricin may serve as a new promising strategy for the treatment of breast cancer cells.</P>

Region-specific plasticity in the epileptic rat brain: A hippocampal and extrahippocampal analysis

Jung, Keun-Hwa,Chu, Kon,Lee, Soon-Tae,Kim, Jin-Hee,Kang, Kyung-Muk,Song, Eun-Cheol,Kim, Se-Jeong,Park, Hee-Kwon,Kim, Manho,Lee, Sang Kun,Roh, Jae-Kyu Blackwell Publishing Ltd 2009 Epilepsia Vol.50 No.3

<P>Summary</P><P><U>Purpose:</U> </P><P>Recent evidence suggests that aberrant neuro/gliogenesis and/or inflammation play critical roles in epileptogenesis. Although the plastic and inflammatory changes have been described in the postseizure hippocampus, little data is available concerning extrahippocampal regions, notably in the piriform and entorhinal cortices, amygdala, and parts of the thalamus. In this study, we examined histological changes in whole epileptic rat brain, with respect to cell death, cell genesis, and inflammation.</P><P><U>Methods and Results:</U> </P><P>Experimental status epilepticus (SE) was induced using a lithium-pilocarpine injection. Neuronal death was evident in the amygdala, piriform, and entorhinal cortices, as well as the subfields of hippocampus. Microglial activation was observed in more extended limbic areas, such as, the hippocampus, entorhinal, perirhinal and piriform cortices, amygdala, thalamus, and hypothalamus, and a robust increase of cell genesis was noted in these damaged areas. The majority of newly generated cells in extrahippocampal areas proliferated in situ, and differentiated mainly into astrocytes or oligodendrocytes. In addition, stromal cell-derived factor-1α was found to be induced in close temporal and anatomical association with seizure-induced plasticity.</P><P><U>Discussion:</U> </P><P>These findings indicate that neuronal death, inflammation, and cell genesis are substantially associated throughout the entire brain and that they may influence the epileptogenic process and clinical manifestations.</P>

Naringenin targets ERK 2 and suppresses UVB ‐induced photoaging

Jung, Sung Keun,Ha, Su Jeong,Jung, Chang Hwa,Kim, Yun Tai,Lee, Hoo‐,Keun,Kim, Myoung Ok,Lee, Mee‐,Hyun,Mottamal, Madhusoodanan,Bode, Ann M.,Lee, Ki Won,Dong, Zigang John Wiley and Sons Inc. 2016 Journal of Cellular and Molecular Medicine Vol.20 No.5

<P><B>Abstract</B></P><P>A number of natural phytochemicals have anti‐photoaging properties that appear to be mediated through the inhibition of matrix metalloproteinase‐1 (MMP‐1) expression, but their direct target molecule(s) and mechanism(s) remain unclear. We investigated the effect of naringenin, a major flavonoid found in citrus, on UVB‐induced MMP‐1 expression and identified its direct target. The HaCaT human skin keratinocyte cell line and 3‐dimensional (3‐D) human skin equivalent cultures were treated or not treated with naringenin for 1 hr before exposure to UVB. The mechanism and target(s) of naringenin were analysed by kinase assay and multiplex molecular assays. Dorsal skins of hairless mice were exposed to UVB 3 times per week, with a dose of irradiation that was increased weekly by 1 minimal erythema dose (MED; 45 mJ/cm<SUP>2</SUP>) to 4 MED over 15 weeks. Wrinkle formation, water loss and water content were then assessed. Naringenin suppressed UVB‐induced MMP‐1 expression and AP‐1 activity, and strongly suppressed UVB‐induced phosphorylation of Fos‐related antigen (FRA)‐1 at Ser265. Importantly, UVB irradiation‐induced FRA1 protein stability was reduced by treatment with naringenin, as well as with a mitogen‐activated protein kinase (MEK) inhibitor. Naringenin significantly suppressed UVB‐induced extracellular signal‐regulated kinase 2 (ERK2) activity and subsequently attenuated UVB‐induced phosphorylation of p90<SUP>RSK</SUP> by competitively binding with ATP. Constitutively active MEK (CA‐MEK) increased FRA1 phosphorylation and expression and also induced MMP‐1 expression, whereas dominant‐negative ERK2 (DN‐ERK2) had opposite effects. U0126, a MEK inhibitor, also decreased FRA1 phosphorylation and expression as well as MMP‐1 expression. The photoaging data obtained from mice clearly demonstrated that naringenin significantly inhibited UVB‐induced wrinkle formation, trans‐epidermal water loss and MMP‐13 expression. Naringenin exerts potent anti‐photoaging effects by suppressing ERK2 activity and decreasing FRA1 stability, followed by down‐regulation of AP‐1 transactivation and MMP‐1 expression.</P>