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Junbo Wu,Kang Sun Park,Lili Zhuang,Dong Eon Kim,Eun Do Lee,Chi Sun Yun,Eun Ji Lee,Beom Sik Kim,Min Kyu Kim 한국수정란이식학회 2017 한국수정란이식학회 학술대회 Vol.2017 No.05
Somatic cell nuclear transfer (SCNT) is the technique which generates embryos by transferring diploid nucleus into an enucleated oocyte, it has produced specific animals successfully in a variety of species. However, the developmental capacity of SCNT embryos is still relatively lower than that of embryos produced in vivo. Oocyte is a kind of lipid rich cells, its quality limits the efficiency of embryo production. L-carnitine is a co-enzyme facilitating the transportation of long chain fatty acids across the inner mitochondria membrane where fatty acids are used for generating adenosine triphosphate (ATP) via beta-oxidation. It also has antioxidant actions which may protect mitochondrial membranes and DNA against damage induced by reactive oxygen species (ROS). Whether L-carnitine is functional in bovine SCNT embryos are unknown. Therefore, the objective of this study was to examine the effects of L-carnitine on oocyte maturation and developmental competence of subsequent SCNT embryos. L-carnitine was supplemented during IVM, then intracellular ROS and GSH levels, mitochondrial activity, gene expression of COCs were analyzed at the end of IVM. SCNT embryos were produced subsequently, apoptosis detection and gene expression evaluation were performed in blastocysts. In the results, treatments with 1.5 mM and 3 mM L-carnitine significantly improved maturation rates (P<0.05). Treatments with 3 mM L-carnitine effectively induced improvement in nuclear maturation, intracellular GSH levels and mitochondrial activity, as well as a reduction in intracellular ROS levels (P<0.05). mRNA levels of CPT1A, ACAA1, ACAA2, AREG, EREG, SOD1, GPX4, GLUT1 and CDC2 transcripts were effectively up-regulated by 3 mM L-carnitine treatments (P < 0.05). Similarly, 3mM L-carnitine induced an increase in blastocyst developmental rates and an improvement in blastocyst quality (P<0.05). Our study indicates that L-carnitine treatment during IVM improves oocyte nuclear maturation and subsequent SCNT embryo development.
RGB 및 열화상 이미지 퓨전을 활용한 야간 보행자 검출 네트워크
장준보(Junbo Jang),김희광(Heegwang Kim),박찬영(Chanyeong Park),이지윤(Jiyoon Lee),백준기(Joonki Paik) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6
This paper proposes an optical/thermal image fusion network based on YOLOX to improve pedestrian object detection performance in night situations. The proposed network was trained and validated using the LLVIP dataset, an open benchmark for pedestrian detection under dark lighting conditions. There are two methods proposed in this paper; 1) the optical/thermal image is passed through each backbone network, and the Fusion Backbone Network (SFRM) using the Semantic Feature Receiving Module proposed in this paper is delivered to the last stage of the PAN to highlight the objects Feature Network. When performing a performance evaluation on the pedestrian object detection network in night situations, the proposed network is mAP 0.97, which is superior to other optical/thermal image fusion networks. Accurate and fast pedestrian object detection using the proposed method can reduce casualties in night autonomous driving situations because the outline of the object is not clear due to lack of lighting or light reflection.
PMSG Wind Turbine Simulation under the consideration of real characteristics
심준보(Sim, Junbo),김명호(Kim, Myungho),박기현(Park, Kihyeon),한경섭(Han, Kyungseop) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.11
A various algorism has been studied to extract possibly every energy from a wind turbine in conjunction with the increase of concern about wind power system. In order to verify these control algorism, it is essential to make the most similar conditions to the real wind turbine's environment. Therefore, using separately excited DC motor a wind turbine the most similar to the real turbine is simulated. Tower shadow effect and Wind shear effect are considered as well as inertia emulation. For the control of Back-to-Back Converter Vector current control methods and space vector pulse width modulation are used and for reducing THD of grid current LCL filter is considered. This simulation results verified the energy produced by wind all flows into the utility under the consideration of the characteristics of a wind turbine. The result of this paper is expected to be used as a basic material for analyzing the characteristics of the wind turbine generator.
박준성(Joon Sung Park),윤준보(Junbo Yun),이주(Ju Lee) 한국조명·전기설비학회 2016 조명·전기설비학회논문지 Vol.30 No.9
Over the last decade, there has been a growing interest in renewable energy. As one of the renewable energy resources, wind power is attracting considerable attention and becoming most developing renewable energy resources. Especially, offshore wind power generation system can generate higher power than onshore wind power generator system due to strong wind. The size of windmill and the capacity of the converter have been also increasing from the economical point of view. In this paper, the authors developed and evaluated MV class power stack by considering their influence on the performance. Experiment performed with developed power stack.
( Byung Su Yoo ),( Jin Joo Park ),( Dong Ju Choi ),( Seok Min Kang ),( Juey Jen Hwang ),( Shing Jong Lin ),( Ming Shien Wen ),( Jian Zhang ),( Junbo Ge ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.4
Background/Aims: Hyponatremia is a well-known risk factor for poor outcomes in Western studies of heart failure (HF) patients. We evaluated the predictive value of hyponatremia in hospitalized Asian HF patients. Methods: The Clinical Characteristics and Outcomes in the Relation with Serum Sodium Level in Asian Patients Hospitalized for Heart Failure (the COAST) study enrolled hospitalized patients with systolic HF (ejection fraction < 45%) at eight centers in South Korea, Taiwan, and China. The relationship between admissionsodium level and clinical outcomes was analyzed in 1,470 patients. Results: The mean admission sodium level was 138 ± 4.7 mmol/L, and 247 patients (16.8%) had hyponatremia defined as Na+ < 135 mmol/L. The 12-month mortality was higher in hyponatremic patients (27.9% vs. 14.6%, p < 0.001), and hyponatremia was an independent predictor of 12-month mortality (hazard ratio, 1.72; 95% confidence interval, 1.12 to 2.65). During hospital admission, 57% of hyponatremic patients showed improvement without improvement in their clinical outcomes (p = 0.620). The proportion of patients with optimal medical treatment was only 26.5% and 44.2% at admission and discharge, respectively, defined as thecombined use of angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker and β-blocker. Underuse of optimal medical treatment was more pronounced in hyponatremic patients. Conclusions: In hospitalized Asian HF patients, hyponatremia at admission is common and is an independent predictor of poor clinical outcome. Furthermore, hyponatremic patients receive less optimal medical treatment than their counterparts.