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      • KCI등재
      • Contact and Fumigant Toxicity of Hiba Oil Constituents and Efficacy of Spray Formulations Containing the Oil to American House Dust Mite and Copra Mite

        Jun-Ran Kim,Haribalan Perumalsamy,Min Jung Kwon,Hyung Wook Kwon,Young-Joon Ahn 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

        An assessment was made of the toxicity of hiba, Thujopsis dolabrata var. hondai, oil and 24 oil constituents and control efficacy of four experimental spray formulations containing the oil (0.5. 1, 2, and 3% sprays) to adult American house dust mite (AHDM), Dermatophagoides farinae, and copra mite (CM), Tyrophagus putrescentiae. Results were compared with those of three conventional acaricides benzyl benzoate, N,N-diethyl-3-methylbenzamide (deet), and permethrin. Based on 24 h LC50 values, (–)-thujopsene was the most toxic constituent against AHDM (9.82 μg/cm2) and CM (10.92 μg/cm2) and the toxicity of the compound was nearly identical to that of benzyl benzoate (9.33 and 10.14 μg/cm2). High toxicity was also observed with (–)-(E)-pinocarveol, carvacrol, (+)-terpinen-4-ol, β-thujaplicin, cedrol, α-terpineol, (+)-ledene, thymol, and 2,4-di-tert-butylphenol against both mite species (LC50, 11.92–19.19 and 12.49–22.97 μg/cm2). These constituents were more toxic than deet (LC50, 35.53 and 38.42 μg/cm2). Hiba applied as 2 and 3% sprays provided >95% mortality against both mite species, whereas permethrin (cis:trans, 25:75) 2.5 g/L spray treatment resulted in ca 11% mortality. Global efforts to reduce the level of highly toxic synthetic acaricides in indoor environments justify further studies on hiba oil preparations containing the constituents described as potential contact-action fumigants or lead molecules for the control of mite populations.

      • KCI등재

        산전 진찰주 초음파진단으로 발견된 선미골부기형종 1 예

        김혜영(HY Kim),전영우(YW Jun),윤경식(KS Youn),박승보(SB Park) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.9

        산전 진찰주 초음파진단으로 발견된 선미골부기형종 1 예 The frequency of antental diagnosis of fetal abnormalities is increasing rapidly and is certainly one of the most challenging aspects of the ultrasound imaging at the present time We present a case of sacrococcygeal teratoma, which was diagnosed by ultrasonography The brief summary and pertinent articles were presented.

      • SCOPUSKCI등재

        감마선조사에 의한 돈육의 위생화 및 유전독성학적 안전성 평가

        강일준(Il-Jun Kang),윤정한(Jung-HY Park),강영희(Young-Hee Kang),이효구(Hyo-Ku Lee),변명우(Myung-Woo Byun) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.28 No.5

        감마선 조사에 의한 돈육의 위생화 및 저장성 향상을 목적으로 조사 선량에 따른 돈육의 미생물 생육 억제능을 측정함과 동시에 단기검색법을 이용한 유전독성시험을 통하여 이들 시료의 안전성을 평가하고자 하였다. 돈육은 3 kGy의 감마선 조사로 초기 미생물 오염도를 검출한계 이하로 감소시킬 수 있었다. 냉장저장 (-5℃) 8주 동안 호기성 전세균 및 저온성 미생물을 제외한 병원성 세균의 생육을 검출한계 이하로 억제를 위해서는 3 kGy 이상의 선량이 요구되었다. 30 kGy 조사돈육의 S. typhimurium TA98, TA100, TA1535 및 TA1537에 대한 복귀변이 집락수를 조사한 결과, 대사활성계 도입 및 부재시 모두, 시험적용 농도인 0.1~8.3㎎g/plate의 범위에서 복귀변이 집락수의 농도 의존적인 증가 혹은 감소를 보이지 않았다. 또한, 포유류 배양세포를 이용한 염색체 이상시험 및 설치류 망상적혈구를 이용한 소핵시험에서도 감마선 조사돈육(30 kGy)은 시험적용 용량에서 염색체이상 유발능이 없었으며, 소핵을 가진 망상적혈구의 출현율이 음성 대조군과 유의한 차이를 나타내지 않음을 확인하였다. Gamma irradiation was applied to pork for improving its hygienic quality and evaluating its possible genotoxicity. The effective dose of irradiation was 3 kGy in pork for the sterilization of all contaminated microorganisms tested. After 8 weeks of storage at 5℃, no growth of microorganisms except for psychrophile and total aerobic bacteria was observed in the more than 3 kGy irradiated pork. The genotoxicity of high dose irradiated pork(30 kGy) was evaluated by Salmonella typhimurium reversion assay, chromosomal aberration test and in vivo micronucleus assay. The results were negative in the bacterial reversion assay with S. typhimurium TA98, TA100, TA1535, TA1537. In chromosomal aberration tests with GHL cells and in vivo mouse micronucleus assay, no significant difference in the incidences of chromosomal aberration and micronuclei was seen between nonirradiated and 30 kGy irradiated porks. These results indicate that 30 kGy irradiated pork did not show any genotoxic effects under these experimental conditions.

      • KCI등재
      • SCOPUSKCI등재

        간 : 최근 2년간 발생한 급성 A형간염의 임상 특성에 관한 연구

        이응준 ( Eung Jun Lee ),권소영 ( So Young Kwon ),서태호 ( Tae Ho Seo ),윤현성 ( Hyun Sung Yun ),조한수 ( Han Su Cho ),김병국 ( Byung Kook Kim ),최원혁 ( Won Hyeok Choe ),이창홍 ( Chang Hong Lee ),김진남 ( Jin Nam Kim ),임형준 ( Hy 대한소화기학회 2008 대한소화기학회지 Vol.52 No.5

        목적: A형간염은 미감염자의 연령층이 점차 증가하면서 현증 급성 A형간염 환자의 발생이 증가하고 있고, 심한 간염의 임상 경과를 보이는 예들도 점차 증가하고 있다. 최근 18개월 동안 서울지역과 안산지역에서 산발적으로 발생한 급성 A형간염 환자의 임상, 혈청학적인 특성을 조사하였다. 대상 및 방법: 2005년 8월부터 2007년 3월까지 서울의 건국 대학교병원과 안산의 고려대학교안산병원에서 급성 A형간염으로 진단된 총 222예를 대상으로 간염 발생의 양상 및 임상 경과를 후향 분석하였다. 결과: 대상 환자의 나이 중앙값은 28세(3-50세)였고, 남녀 비는 129:93이었다. 연령별 분포는 15-20세가 17예(7.6%), 21-25세가 56예(25.2%), 26-30 세가 76예(34.2%), 31-35세가 44예(19.8%), 36세 이상이 29예(13.6%)였다. 월별 환자 분포는 6월에 10월 사이에 발생 빈도가 비교적 높았으나 유의한 차이를 보이지는 않았다. 경과 중 혈청 creatinine 수치가 1.5 mg/dL 이상의 신기능 장애를 보인 환자는 14예(6.3%), 담즙정체 간염이 2예(0.8%), 재발 간염이 4예(1.8%), ALT 수치가 3개월 이상 정상 범위를 초과한 지속 간염이 13예(5.8%)였고, 전격 간염은 없었다. 평균 최고 AST와 ALT는 각각 1,778±1,645 IU/L, 2,340±1,802 IU/L이었고, 평균 최고 총 빌리루빈은 6.88±5.04 mg/dL이었다. 복부초음파검사의 44.4%에서 정상 소견이었고, 비장 종대와 지방간 소견이 흔하게 관찰되었다. 내원 당시 IgManti-HAV가 음성이었으나 추적 검사 후 양성으로 진단된 경우가 15예(6.7%)였으며, 이들 환자는 내원 당시 IgM anti-HAV 양성 환자들에 비하여 발열, 오심, 구토 등의 임상 증상이 더 빈번하였다. 기저 질환으로서는 만성 B형간염 병력을 가진 환자는 8예(3.6%), 당뇨 병력을 가진 환자는 3예(1.3%)였으나 기저 질환에 따른 간염의 중증도 차이는 없었다. 결론: 급성 A형간염은 대부분에서 심각한 합병증 없이 회복되지만, 과거에 비하여 발병 연령이 높아지고 계절에 관계없이 산발적으로 발생하였다. 대부분의 환자는 심각한 합병증 없이 회복되지만, 비전형적인 임상 경과를 보이는 경우도 적지 않았다. 간염의 초기에 내원한 일부 환자에서는 IgM anti-HAV가 검출되지 않을 수 있으므로, A형간염이 임상적으로 의심된다면 항체 추적 검사가 필요하다. Background/Aims: The purpose of this study was to characterize the clinical features of acute hepatitis A in Seoul and Gyeonggi province during the recent 2 years. Methods: We reviewed the medical records of 222 patients who were diagnosed as acute hepatitis A between August 2005 and March 2007 at the Konkuk University Hospital and Korea University, Ansan Hospital. The clinical manifestation, serological tests, and image findings were analyzed. Results: Median age of the patients was 28.1 years and the age groups of highest incidence were the second and third decade. The frequent symptoms were anorexia (66.4%), fatigue (49.2%), fever (47.7%), and abdominal discomfort (42.5%). Fourteen cases (6.3%) showed renal insufficiency, and hemodialysis was performed in one. Cholestatic hepatitis in 2 cases, relapsing hepatitis in 4 cases and prolonged hepatitis in 13 cases were observed. However, there was no case of fulminant hepatitis or death. The underlying diseases including chronic hepatitis B, diabetes mellitus and thyroid disorder did not affect the disease severity of hepatitis A. IgM anti-HAV was not detected initially in 6.7% of the patients. Anti-HEV (IgM) was detected simultaneously in 3 of 150 patients. Conclusions: The age of patients with acute hepatitis A has been increased in the recent years. Most patients recovered uneventfully. However, unusual patterns of severe hepatitis and renal insufficiency occurred in considerable number of cases. Follow-up serologic test for IgM anti-HAV is needed in seronegative cases with hepatitis A. (Korean J Gastroenterol 2008;52:298-303)

      • KCI등재

        흉부 유합중복기형아 1 예

        전영우(YW Jun),김혜영(HY Kim),류빈수(BS Liu),박승보(SB Park) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.9

        Diagnosis of conjoined twin antepartum is very difficult Although twin may be known, conjoining is not usually identified until diffculty is encountered in attempting delivery At times by development of diagnostic equipment these twins may be suspected and possibly diagnosed prior to the onset or labor A case of 37th week of gestaion thoracopagus delivered by cesarean section is reported with a brief review of the related iliteratures.

      • KCI등재

        《소문(素門),열론(熱論)》 육경분증(六經分證)과 《상한론(傷寒論)》 육경변증(六經辨證)의 상관성(相關性)에 대(對)한 연구(硏究)

        이동희 ( Dong Hy Lee ),이준범 ( Jun Beom Lee ),황만섭 ( Min Seob Hwang ),윤종화 ( Jong Hwa Yoon ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.4

        Objective: The following study was undertaken in order to seek the acupuncture operation method of 《Sang Han Lun(傷寒論)》 Liu-Jing-Bian-Zheng(六經辯證). Methods: Based on the documents quoted in 《Sang Hang Za Bing Lun·Xu Wen(傷寒雜病論·序文)》 of "Zhang, Zhong-Jing(張仲景)", the relativity of the theory of Jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence. Results: 1. 《Sang Han Lun》 Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) of 《Su Wen·Re Lun(素問·熱論)》. 2. Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫려)and Zabing(雜病). 3. Most commentators of 《Sang Han Lun》 in the Song, Ming and Ching Dynasties of 《Sang Han Lun》 interpreted the Liu-Jing-Bing in physiological and pathological aspects of Rong-Wei(榮衛).

      • KCI등재

        다발성 선천성 기형1예

        고행조(HJ Ko),정행용(HY Chung),전현권(HK Jun) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.6

        A very rare case of multiple congenital anomalies consisting of anencephaly, meningocele, anophthalmia, cleft lip, cleft palate, facial cleft, gastroschisis, club hand deformity, Syndactylism, and lordosis is presented with brief review of the literatures.

      • SCIESCOPUSKCI등재

        이성체쌍의 열중성자포획단면적비 측정

        박혜일,김헌준,이철,Park, Hy-Eil,Kim, Heon-Jun,Lee, Chul 한국원자력학회 1972 Nuclear Engineering and Technology Vol.4 No.4

        Isomeric ratios were measured for the capture of thermal neutron by $^{79}$ Br, $^{80}$ Se, $^{103}$ Rh, $^{115}$ In and $^{133}$ Cs as well as those of epi-cadmium neutron by $^{79}$ Br, $^{80}$ Se and $^{l33}$Cs. The measurements were performed by analysing decay curves obtained by ${\gamma}$-ray spectrometry after irradiation. The counting efficiency curve was determined by using the calibrated standard sources with overall uncertainties of about 1%. Isomeric ratios, given in $\sigma$ high spin/($\sigma$ high spin + $\sigma$ low spin), of $^{80, 80m}$Br, $^{81,81m}$Se, $^{014, 104m}$Rh, $^{116,116m}$In and $^{134, 134m}$Cs produced by thermal neutron activation were found to be 0.21$\pm$0.01, 0.14$\pm$0.02, 0.12$\pm$0.02, 0.69$\pm$0.07 and 0.058$\pm$0.004, respectively, Those values of $^{80, 80m}$Br, $^{81,81m}$Se, and $^{134, 134m}$Cs Produced by epi-cadmium neutron were found to be 0.19$\pm$0.02, 0.29$\pm$0.02 and 0.074$\pm$0.011, respectively. The experimental values obtained were compared with the theoretical values deduced from the statistical model. There were the general agreements between the theory and the experiment.t.

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