흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

Evaluation of Genetic Resource Traits for the Development into a Horticultural Item of Hungarian ‘Hot Pepper Varieties’

Su Gyeong Jun,Gi Eun Hwang,Gil Su Jang,Oh Hun Kwon,Tae Young Kwon,Ji Hee Kim,Jeung Keun Suh 한국인간·식물·환경학회 2014 인간식물환경학회지 Vol.17 No.1

This study was conducted to evaluate 35 units of genetic resources collected from Hungary in 1999, and identify their horticultural traits and select useful resources. A comparison with ‘Geumdang’ and ‘Superbigarim’, the two varieties of Korean origin now being marketed indicated that the durations of time involved in flowering were largely similar to each other, and that the stem length of the Korean varieties averaged 163 cm, comparing with that of Hungarian varieties that averaged 133 cm. As for the fruit shape, the sweet banana type which was similar to the Korean counterpart accounted for 83%, ranking a top, followed by smaller varieties of which the cherry type accounted for 14% of the total. The hungarian varieties averaged 34.7 g in weight, a level significantly heavier than the Korean counterparts that averaged 25 g. As regards the ASTA value, 9 resources registered 100 or over, and as regards sugar contents, 4 resources reached 15% or over. As for capsaicinoid contents, 69% of the resources reached 10 mg% or lower, and 17% reached 10~40 mg%, followed by the group of 49 mg% or over that accounted for 14%. As a rule, the resources sampled for the current study were relatively less hot in taste. 본 연구는 1999년 헝가리에서 수집한 고추 유전자원 35점을 평가하여 원예적 형질을 조사하고 유용한 자원을 선발하고자 실시하였다. 한국시판 대비 품종 ‘금당’과 ‘슈퍼비가림’과 비교했을 때 개화소요일은 거의 유사하였으며, 초장은 한국 품종이 평균 163cm이었으나 헝가리 자원은 133cm로 작게 조사되었다. 과형은 한국 품종과 유사한 sweet banana형이 83%로 가장 많았고, 소형은 cherry형이 14%였다. 과중은 대체로 한국 품종 25g에 비해 무거워 평균 34.7g이었다. ASTA 값은 100이상이 9자원이었으며, 당함량은 15% 이상이 4자원이었다. Capsaicinoids 함량은 10mg% 이하인 자원이 69%, 10~40mg%가 17%, 40mg% 이상은 14%로 대부분 매운맛 성분이 적은 자원이었다.

Prevalence of Major Methicillin-Resistant <i>Staphylococcus aureus</i> Clones in Korea Between 2001 and 2008

Kang, Gi Su,Jung, Yung Hee,Kim, Hwa Su,Lee, Yeong Seon,Park, Chan,Lee, Kwang Jun,Cha, Jeong Ok The Korean Society for Laboratory Medicine 2016 Annals of Laboratory Medicine Vol.36 No.6

<P><B>Background</B></P><P>Methicillin-resistant <I>Staphylococcus aureus</I> (MRSA) are important pathogens causing nosocomial infections in Korean hospitals. This study aimed to investigate the epidemiological and genetic diversity of clinical <I>S. aureus</I> isolates in healthcare settings from 2001 to 2008.</P><P><B>Methods</B></P><P>Samples and data were obtained from 986 individuals as part of the National Antimicrobial Surveillance Project, involving 10 regions nationwide. Molecular typing studies, including multilocus sequence typing (MLST) and staphylococcal cassette chromosome <I>mec</I> (SCC<I>mec</I>) typing were performed, and a representative clone of Korean MRSA was classified by combinational grouping using a DiversiLab (DL; bioMérieux, France) repetitive element polymerase chain reaction (rep-PCR) system.</P><P><B>Results</B></P><P>Nine Korean MRSA clones (KMRSA-1 to -9) were identified by analysis of genetic backgrounds and molecular characteristics. KMRSA-1 to -3, expressing clonal complex (CC) 5 (carrying SCC<I>mec</I> II), CC8 (carrying SCC<I>mec</I> III), and CC72 (carrying SCC<I>mec</I> IV) were spread nationwide. In contrast, KMRSA-6 was highly prevalent in Gyeongsangnam-do, and KMRSA-4 was highly prevalent in Jeollanam-do and Jeollabuk-do.</P><P><B>Conclusions</B></P><P>Epidemic KMRSA clones were genetically similar to major clones identified from the USA, with the exception of KMRSA-2, which had the SCC<I>mec</I> III type. Our results provide important insights into the distribution and molecular genetics of MRSA strains in Korea and may aid in the monitoring of MRSA spread throughout the country.</P>

헝가리 수집 고추 유전자원의 원예형질 특성평가

전수경(Su Gyeong Jun),황지은(Gi Eun Hwang),장길수(Gil Su Jang),권태영(Tae Young Kwon),원종건(Gong Gen Won),권오훈(Oh Hun Kwon) 한국원예학회 2013 한국원예학회 학술발표요지 Vol.2013 No.5

실물대 실험에 의한 SH합성보 및 H형강 합성보에 지지되는 S-Deck의 부모멘트 성능평가

전수찬(Jun, Su Chan),이철호(Lee, Cheol Ho),배창준(Bae, Chang Jun),이승준(Lee, Seung Jun),최용성(Choi, Young Sung),정기택(Chung, Gi Taek) 한국강구조학회 2023 한국강구조학회 학술대회 발표집 Vol.34 No.6

Non-Alcoholic Fatty Liver Is Associated with Incidence of Dementia: A National Health Cohort Study in Korea

( Gi-ae Kim ),( Han Hee Lee ),( Su Jin Jeong ),( Jin San Lee ),( Key-Chung Park ),( In-hwan Oh ),( Jae-jun Shim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Fatty liver disease and dementia are emerging health problems in many countries. Hepatic steatosis is a feature of abnormal fat metabolism in the body. Fat dysregulation in the brain might also increase risk for dementia. The aim of this study was to investigate whether hepatic steatosis is associated with development of dementia in the middle-aged population. Methods: A nationwide population-based cohort study was conducted using customized data from the National Health Insurance Service of Korea. We identified subjects (40 to 69 years) who conducted two or more health examinations between 2004 and 2007, who were free of chronic viral hepatitis, alcoholic liver disease, cirrhosis, cancers, stroke, and dementia. Fatty liver was defined using hepatis steatosis index (HSI) > 36. Control was defined when all HSIs were less than 30 between 2004 and 2007. Dementia was identified using disease classification codes (F00, F01, F02, F03, G30, G31, or G32) and prescription data of an antidementia drug. Enrolled subjects (n=3,811,942) were observed until 2017 and incidence of dementia was evaluated according to fatty liver. Results: Among the control group (all HSI < 30, n=651,481), dementia was identified in 37,182 persons (5.4%) during follow-up (2007 - 2017). Among subjects with all HSI > 36 (n=439,654), dementia was identified in 36,093 persons (7.59%, P< 0.0001). After adjusting for sex, age, liver enzymes, body mass index, smoking status, diabetes, hypertension, cholesterol, and disability, the multivariate analysis showed non-alcoholic fatty liver (any HSI > 36) was significantly associated with incidence of dementia (adjusted HR 1.08; 95% CI 1.06- 1.10). In subgroup analysis, dementia was not associated with improved fatty liver (initial HSI > 36, last HSI < 30), (adjusted HR 1.05; 95% CI 0.99-1.11). However, aggravated fatty liver (initial HSI < 30, last HSI > 36) was significantly associated with dementia (adjusted HR 1.10; 95% CI 1.03-1.17). Sustained fatty liver (all HSI > 36) was also associated with dementia (adjusted HR 1.03; 95% CI 1.01-1.16). Conclusions: Non-alcoholic fatty liver is associated with development of dementia in middle-aged Korean population.

Altered Thoracic Cage Dimensions in Patients with Chronic Obstructive Pulmonary Disease

( Su Jin Lim ),( Ju-young Kim ),( Seung Jun Lee ),( Gi Dong Lee ),( Yu Ji Cho ),( Yi Yeong Jeong ),( Kyung Nyeo Jeon ),( Jong Deog Lee ),( Jang Rak Kim ),( Ho Cheol Kim ) 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.2

Background: Chronic obstructive pulmonary disease (COPD) may cause changes in the shape of the thoracic cage by increasing lung volume and hyperinflation. This study investigated changes in thoracic cage dimensions and related factors in patients with COPD. Methods: We enrolled 85 patients with COPD (76 males, 9 females; mean age, 70.6±7.1 years) and 30 normal controls. Thoracic cage dimensions were measured using chest computed tomography at levels 3, 6, and 9 of the thoracic spine. We measured the maximal transverse diameter, mid-sagittal anteroposterior (AP) diameter, and maximal AP diameter of the right and left hemithorax. Results: The average AP diameter was significantly greater in patients with COPD compared with normal controls (13.1±2.8 cm vs. 12.2±1.13 cm, respectively; p=0.001). The ratio of AP/transverse diameter of the thoracic cage was also significantly greater in patients with COPD compared with normal controls (0.66±0.061 vs. 0.61±0.86; p=0.002). In COPD patients, the AP diameter of the thoracic cage was positively correlated with body mass index (BMI) and 6-minute walk test distance (r=0.395, p<0.001 and r=0.238, p=0.028) and negatively correlated with increasing age (r=-0.231, p=0.034). Multiple regression analysis revealed independent correlation only between BMI and increased ratio of AP/transverse diameter of the thoracic cage (p<0.001). Conclusion: Patients with COPD exhibited an increased AP diameter of the thoracic cage compared with normal controls. BMI was associated with increased AP diameter in these patients.

Physicochemical Qualities and Consumer Acceptance of Lemon Balm Muffins

Su Min Han,Su Yeon Kim,Nam Gi Kim,Jun Ho Lee 한국산업식품공학회 2021 학술대회 및 심포지엄 Vol.2021 No.05

OB-27 : A prophylactic Meicelin (cefminox sodium) use for elective Cesarean birth at Dongsan Medical Center, Daegu, Korea

( Gi Su Lee ),( Jun Chul Park ),( Jung Ho Rhee ),( Jong In Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

A prophylactic antibiotic is recommended to reduce infection-related complication following Cesarean birth. There is no absolute treatment schedule on the time of prophylactic antibiotic in cesarean birth. We used the intravenous injection of 1g of meicelin as single dose either at pre-incision or after clamping of the umbilical cord at elective Cesarean birth. The incidence of post-cesarean febrile and infection-related morbidity and neonatal outcomes between the two groups was investigated. An opened randomized, controlled clinical trial was done at Dongsan Medical Center, Daegu, South Korea. 200 women in each group received an intravenous injection of 1g of meicelin as single dose either at pre-incision or after clamping of the umbilical cord. There was no significant difference in the incidence of wound infection between the two groups, 5,7% s. 4.9% , p=0.3) Similar number of neonate (11 in each group) was admitted to nursery due to preterm delivery . There were no significant difference in the neonatal jaundice between the two groups, (5.6% vs. 4.84%, p=0.2) There was no perinatal death. There was no difference in the two groups (pre-incision or post-clamping of the umbilical cord) of meicelin as prophylactic for elective cesarean birth.

Position Error Correction Using Homography in Discretized Positioning Circuit for Gamma-Ray Imaging Detection System

Su-Jin Jeon,Jihoon Kim,Myung-Gi Ji,Jun-Hee Park,Young-Wan Choi Professional Technical Group on Nuclear Science 2017 IEEE transactions on nuclear science Vol.64 No.2

<P>A discretized positioning circuit (DPC) based on a resistive network has been developed to reduce the size of a gamma-ray detection system using multi-anode photomultiplier tubes (MA-PMT) in an array, because it can drastically decrease the number of output channels. The output signal from the gamma-ray detection system is a current pulse generated in each tube that contains information about the gamma-ray energy and detecting position in the array. The output current pulse is distributed to four outputs according to the resistance ratio of the resistive network in the DPC, and the detected position is estimated using the height values of the four distributed current pulses. However, owing to parasitic capacitors of MA-PMT connected in parallel to resistors in the resistive network, the four output pulses are affected by the RC time constants. In particular, when the duration of the input signal is not long enough, the height values of the distributed pulses are reduced, and thereby the position error increases significantly. In this paper, we present a new distortion correction method that considers the pulse duration and the RC time constant. In order to correct the position error, we employed homography, which is a coordinate transformation method. The ideal grid was mapped to a new grid for the distorted position. Using this method, error correction was completely achieved, even for short current pulses.</P>