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허진,최원혁,조진혁,함영희,홍정범,정성규,김현,허동 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Two men were admitted to hospital with flank pain, hematuria, which was diagnosised as ureteral stone. Elevation of aspartate aminotransferase (AST) without typical pattern of toxic hepatitis was observed. Careful history taking, several laboratory tests, abdominal and pelvis computered tomography was done. Findings from theses examinations supported the clinical diagnosis of ureteral stone complicated of exercised induced rabdomyolysis. Early recognization of rhabdomyolysis in clinical setting is important, because clinical manifestations have ranged from asymtomatic elevation of creatine kinase to acute renal failure which is a life threating medical emergency. Authors report two cases of exercised induced rhabdomyolysis initially admittied as ureteral stone managed with hydration
위선암에 병발된 혈액학적 합병증 1예 : 백적아구증, 파종성 혈관내 응고, 미세 맥관성 용혈성 빈혈
정혜경,김희진,이선영,최진혁,이순남,이홍수,정화순,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.2
Among the hematologic complications of solid tumors, leukoerythroblastosis, DIO and MAHA have been known to be clinically significant According to the recent increasing incidence of cancer, these hematologic complications have been reported frequently. However, the simutaneous developement of such manifestations is rare. Recently, we have experienced a patient with gastric adenocarcinoma in which case severe bleeding tendency were observed and laboratory studies including bone marrow examination demonstrated the findings of leukoerythroblastosis, DIC and MAHA. She died of upper gastrointestinal bleeding despite the supportive care such as vlood transfusions. We should give attention to the findings of peripheral golld smear for the patient with malignancy and it is mandatory for therapeutic plan to perform bone marrow examination if the above mentioned hemorrhagic complications are suspected.
Choi, Jaewon,Hwang, Yu Kyeong,Choi, Young Jin,Yoo, Ki Eun,Kim, Jeong Han,Nam, Seok Jin,Yang, Jung Hyun,Lee, Sang Jin,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Im, Young-Hyuck The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22//SUP No.-
<P>Neuronal apoptosis inhibitory protein (NAIP) is a recently identified inhibitor of apoptosis protein. However, the clinical relevance of NAIP expression is not completely understood. In an attempt to determine the clinical relevance of NAIP expression in breast cancer, the levels of NAIP and survivin expression were measured in 117 breast cancer samples and 10 normal breast tissues using quantitative reverse-transcriptase-polymerase chain reaction. While there was no evidence of NAIP expression in the normal breast tissue, NAIP was expressed in all breast cancer samples. The level of NAIP expression in breast cancer was significantly higher (257 times) than in the universal tumor control. There was a strong correlation between the level of NAIP expression and the level of survivin expression (<I>p</I>=0.001). The level of NAIP expression in patients with a large tumor (≥T2) and patients with an unfavorable histology (nuclear grade III) was significantly higher than in those patients with a small tumor (T1) and patients with a favorable histology (nuclear grade I, II) (<I>p</I>=0.026 and <I>p</I>=0.050, respectively). Although the level of NAIP expression was higher in patients with other unfavorable prognostic factors, it was not significant. The three-year relapse-free survival rate was not significantly the patients showing high NAIP expression and patients showing low NAIP expression (86.47±4.79% vs. 78.74±6.57%). Further studies should include the expressions of NAIP in a larger number of patients and for a longer period of follow-up to evaluate correlation with metastasis and treatment outcome. In conclusion, NAIP is overexpressed in breast cancer patients with unfavorable clinical features such as stage and tumor size, suggesting that NAIP would play a role in the disease manifestation.</P>
Choi, Jin-sil,Choi, Hyuck Jae,Jung, Dae Chul,Lee, Joo-Hyuk,Cheon, Jinwoo Royal Society of Chemistry 2008 Chemical communications Vol.2008 No.19
<P>Co@Pt–Au nanoparticles, which have enhanced magnetism and high stability in aqueous media, are utilized in conjunction with MRI to monitor the structural evolution of Aβ assemblies, especially Aβ protofibrils in the early reversible stages.</P> <P>Graphic Abstract</P><P>Co@Pt–Au nanoparticles, which have enhanced magnetism and high stability in aqueous media, are utilized in conjunction with MRI to monitor the structural evolution of Aβ assemblies, especially Aβ protofibrils in the early reversible stages. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b803294g'> </P>
( Jin Yong Choi ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Jae-won Joh ),( Gyu-seong Choi ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Advanced HCC with portal vein tumor thrombus (PVTT) patients are excluded for liver transplantation (LT), according to the Milan criteria. But after the development of conformal RT, there have been several trials on RT as a bridge or downstaging management approach to LT. The purpose of our study is to evaluate the value of living donor liver transplantation (LDLT) following RT in PVTT patients. Methods: This study took place between May 1996 and March 2013; a, total of 1360 patients were treated by LT in our institution, and 5 of those recipients had RT due to PVTT. To confirm the value of LDLT following RT in PVTT, we did a propensity-matched study retrospectively. Results: There were no statistically significant differences in the clinical characteristics of the two groups. All LT was done by LDLT with duct to duct anastomosis and the mean operation time was 588 minutes. During the follow-up periods, in the LDLT following RT group, two recipients exhibited disease progression, but in the RT alone group, all patients had tumor ingrowths or either intra- or extra- hepatic metastasis. The OS for the LDLT following RT group was 1055 days and that of the RT alone group was 367 days, and there was a statistically significant difference. Conclusions: LDLT following RT can be the treatment of choice for PVTT in select patients and when bile duct anastomosis was performed in RT recipients, a hepaticojejunostomy was recommended to prevent biliary complications.