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The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study
Hyeji Kwon,Song Hwa Chae,Hyo Jin Jung,Hyeon Min Shin,O-Hyun Ban,Jungwoo Yang,Jung Ha Kim,Ji Eun Jeong,Hae Myung Jeon,Yong Won Kang,Chan Kum Park,Daeyoun David Won,Jong Kyun Lee 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.5
Purpose: Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this study was to evaluate change in microbiota composition after-probiotics supplementation and assessed the efficacy of probiotics in improving quality of life (QOL) in postoperative cancer patients. Methods: Stool samples were collected from 30 cancer patients from February to October 2020 before (group I) and after (group II) 8 weeks of probiotics supplementation. We performed 16S ribosomal RNA gene sequencing to evaluate differences in gut microbiota between groups by comparing gut microbiota diversity, overall composition, and taxonomic signature abundance. The health-related QOL was evaluated through the EORTC Quality of life Questionnaire Core 30 questionnaire. Results: Statistically significant differences were noted in group II; increase of Shannon and Simpson index (P = 0.004 and P = 0.001), decrease of Bacteroidetes and Fusobacteria at the phylum level (P = 0.032 and P = 0.014, retrospectively), increased of beneficial bacteria such as Weissella (0.096% vs. 0.361%, P < 0.004), Lactococcus (0.023% vs. 0.16%, P < 0.001), and Catenibacterium (0.0% vs. 0.005%, P < 0.042) at the genus level. There was a significant improvement in sleep disturbance (P = 0.039) in group II. Conclusion: Gut microbiota in cancer patients can be manipulated by specific probiotic strains, result in an altered microbiota. Microbiota modulation by probiotics can be considered as part of a supplement that helps to increase gut microbiota diversity and improve QOL in cancer patients after surgery.
A pilocarpine-induced animal model for pathogenesis and treatment of Temporal Lobe Epilepsy
Hyeji Yang,Minjae Kim,Jin A Park,Young Namkung,Donghun Hyun,Sunghoi Hong 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Epileptic seizure disorders are characterized by unpredictable abnormal electrical discharge, loss of consciousness, and convulsions. 60% of adult patients are Temporal lobe epilepsy(TLE), and 60% of them have hippocampal sclerosis. TLE patients have a poor prognosis and, in particular, when hippocampal sclerosis is accompanied, the cure rate decreases to less than 20%. The pilocarpine rodents model exhibiting hippocampal sclerosis is commonly used in TLE research and has been well known. However, it is difficult to establish a modeling protocol due to the very high mortality rate and the low efficiency with which spontaneous recurrent seizures(SRS) is observed. In this study, we constructed a suitable rodent model for epilepsy studies by our well established protocol using pilocarpine. We used C57BL/6J mice to inject various concentrations of pilocarpine, and established a pilocarpine-induced TLE model by optimizing the effective concentrations for seizure induction. We also investigated the mechanisms of epileptogenesis and characterized the neuropathology. Importantly, hippocampal neurons were damaged in pilocarpine injected mice, and gliosis was confirmed with an increase in the number of astrocytes. Furthermore, we identified the increased mRNA levels at various receptors, including the glutamic acid receptor in the hippocampus. These results show that our protocol to construct a rodent TLE model is well established, which suggests that the TLE model animals could be used to evaluate the effects of the various therapeutic drugs such as the small molecules or the genes or the stem cells. This work was supported by the Ministry of Science and ICT (2019M3E5D5065399) of the government of Korea.
Park, Hyeji,Hong, Kicheol,Kang, Jin Soo,Um, Teakyung,Knapek, Michal,Miná,rik, Peter,Sung, Yung-Eun,Má,this, Kristiá,n,Yamamoto, Akiko,Kim, Hyun-Kyung,Choe, Heeman Elsevier 2019 Materials Science and Engineering C Vol.97 No.-
<P><B>Abstract</B></P> <P>We synthesized Fe foams using water suspensions of micrometric Fe<SUB>2</SUB>O<SUB>3</SUB> powder by reducing and sintering the sublimated Fe oxide green body to Fe under 5% H<SUB>2</SUB>/Ar gas. The resultant Fe foam showed aligned lamellar macropores replicating the ice dendrites. The compressive behavior and deformation mechanism of the synthesized Fe foam were studied using an acoustic emission (AE) method, with which we detected sudden localized structural changes in the Fe foam material. The evolution of the deformation mechanism was elucidated using the adaptive sequential <I>k</I>-means (ASK) algorithm; specifically, the plastic deformation of the cell struts was followed by localized cell collapse, which eventually led to fracturing of the cell walls. For potential biomedical applications, the corrosion and biocompatibility characteristics of the two synthesized Fe foams with different porosities (50% vs. 44%) were examined and compared. Despite its larger porosity, the superior corrosion behavior of the Fe foam with 50% porosity can be attributed to its larger pore size and smaller microscopic surface area. Based on the cytotoxicity tests for the extracts of the foams, the Fe foam with 44% porosity showed better cytocompatibility than that with 50% porosity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Iron foam synthesized from water suspension of Fe<SUB>2</SUB>O<SUB>3</SUB> powder under 5% H<SUB>2</SUB>/Ar gas. </LI> <LI> Compressive deformation mechanism of iron foam is analyzed using an acoustic emission. </LI> <LI> Not porosity but pore size is a dominant factor for corrosion behavior of iron foams. </LI> <LI> Concentration released Fe<SUP>n+</SUP> controls cytotoxicity of iron foam extracts. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>