Evacuation of Nursing Home Based on Massmotion: Effect of the Distribution of Dependent Elderly

Jia Li,Jinghong Wang,Bowei Jin,Yan Wang,Youran Zhi,Zhirong Wang 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.4

As dramatically increased elderly population, China is entering a society of deep aging. Due to the decline of physical functions, the elderly move slowly and have difficulty in escape. Hence, enough attention should be paid on pedestrian crowds’ evacuation in a nursing home. This paper takes Chinese old-age care institutions as the research object. Using the Massmotion based on the social force to establish the evacuation model and setting the parameters according to the movement characteristics of the elderly, this paper studied the influence of the dependent elderly on evacuation efficiency when they are distributed to the higher floors of the nursing home in different proportions. The results show that the evacuation time is significantly prolonged with the increase of the proportion of dependent elderly, and there is a controllable critical value for the proportion of dependent elderly. Aspeed-up phenomenon is observed when the old man enters the landing from the stairway, and meanwhile, with the increase of the proportion of dependent elderly, the acceleration position is gradually advanced, while the instantaneous speed declines. The results of this study can provide references in properly arranging the distribution of elderly accommodation and safe evacuation of the aged care institutions.

Characterization of the Stress-optic Properties of Ceramics by Terahertz Time-domain Spectroscopy

Zhi Qiang Wang,Wen Jia Ren,Gui Ying Zhang,Zhi Yong Wang 한국광학회 2024 Current Optics and Photonics Vol.8 No.3

This paper introduces a rapid measurement technique for the stress-optic coefficient, using terahertz time-domain spectroscopy. First we propose a design combining a four-point bending device with a scanning stage to streamline the loading process. Then we detail the measurement principle and outline the signal-processing algorithm. The experiments are carried out on Al 2 O 3 , a representative ceramic material. The experimental data reveal that the refractive index of Al 2 O 3 exhibits a linear decrease with increasing stress. This work supplies an efficient method for stress measurement rooted in the stress-optic effect. This paper introduces a rapid measurement technique for the stress-optic coefficient, using terahertz time-domain spectroscopy. First we propose a design combining a four-point bending device with a scanning stage to streamline the loading process. Then we detail the measurement principle and outline the signal-processing algorithm. The experiments are carried out on Al 2 O 3 , a representative ceramic material. The experimental data reveal that the refractive index of Al 2 O 5 exhibits a linear decrease with increasing stress. This work supplies an efficient method for stress measurement rooted in the stress-optic effect.

Characterization of the Stress-optic Properties of Ceramics by Terahertz Time-domain Spectroscopy

Zhi Qiang Wang,Wen Jia Ren,Gui Ying Zhang,Zhi Yong Wang 한국광학회 2024 Current Optics and Photonics Vol.8 No.3

Enantioselective Esterification of Ibuprofen by a Novel Thermophilic Biocatalyst: APE1547

Zhao Dan-tong,Xun Er-na,Wang Jia-xin,Wang Ren,Wei Xiao-fei,Wang Lei,Wang Zhi 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.4

The enantioselective esterification of ibuprofen catalyzed by a novel thermophilic esterase (APE1547)from the archaeon Aeropyrum pernix K1 was successfully conducted in organic solvents. The effects of acyl acceptor,substrate ratio, organic solvent, temperature, and water activity were investigated. Under optimum conditions, the highest enantioselectivity (E = 38.1) was obtained with a higher enzyme activity (216.5 μmol/g/h). Celites were added into the reaction mixture to remove the water produced in the esterification. The reaction achieved its equilibrium in approximately 96 h with a conversion of 57 and 99%(ee) of the un-reacted (S)-ibuprofen obtained.

Research Articles : Molecular Cloning and Characterization of a Muscle-Specific Lipase from the Bumblebee Bombus ignitus

( Zhi Gang Hu ),( Dong Wang ),( Wei Lu ),( Zheng Cui ),( Jing Ming Jia ),( Hyung Joo Yoon ),( Hung Dae Sohn ),( Doh Hoon Kim ),( Byung Rae Jin ) 한국잠사학회 2008 International Journal of Industrial Entomology Vol.17 No.1

A muscle-specific lipase gene of the bumblebee Bombus ignitus was cloned and characterized. This gene, which we named Bi-Lipase, consists of seven exons encoding 317 amino acid residues. Bi-Lipase possesses all the features of lipases, including GXSXG consensus motif and Ser-Asp-His catalytic triad. Expressed as a 37-kDa polypeptide in baculovirus-infected insect Sf9 cells, recombinant Bi-Lipase showed an optimal pH of 9.0 and exhibited its highest catalytic activity at 40℃. Furthermore, through the addition of tunicamycin to the recombinant virus-infected Sf9 cells, recombinant Bi-Lipase was found to be N-glycosylated. Northern and western blot analyses indicated that Bi-Lipase was expressed in the wing, thorax, and leg muscles. These results show that Bi-Lipase is a muscle-specific lipase, suggesting a possible role of Bi-Lipase in the utilization of lipids for muscular activity in B. ignitus.

Comparison of Liver Transplantation and Liver Resection for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Type I and Type II

Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1

Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.

Angiotensin I Converting Enzyme (ACE) Inhibitory Activity and Antihypertensive Effects of Grass Carp Peptides

Wang Shen,Lin Li-mei,Wu Yong-ning,Fang Min,Yu Ya-qin,Zhou Jia,Gong Zhi-yong 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.5

In vitro and in vivo antihypertensive effects ofgrass carp peptides (GCP) were investigated. The aminoacid composition and the angiotensinconverting enzymeinhibitory activity were evaluated using HPLC. GCP wasadministrated to spontaneously hypertensive rats (SHRs)and Wistar Kyoto rats (WKY) by single and long-termadministration before blood pressure measurements. Plasma levels of angiotensin II (Ang II), rennin (RA), nitricoxide (NO), and plasma angiotensin I converting enzyme(ACE) activity were measured. The GCP molecular weightwas between 725 and 1,228 Da with high levels of Leu,Asp, Phe, Gly, and Pro. The in vitro IC50 value was 0.23mg/mL. GCP lowered SHR blood pressure dose and timedependently. Little change occurred in WKY. The plasmalevel of Ang II and the ACE activity decreased. SHR RAand NO concentrations in plasma increased. Theantihypertensive effect of GCP was associated with NOregulation and the rennin-angiotensin system.

New Safrole Oxide Derivatives: Synthesis and in vitro Antiproliferative Activities on A549 Human Lung Cancer Cells

Wang, Li-Ying,Wang, Xiu-Hua,Tan, Jia-Lian,Xia, Shuai,Sun, Heng-Zhi,Shi, Jin-Wen,Jiang, Ming-Dong,Fang, Liang,Zuo, Hua,Dupati, Gautam,Jang, Kiwan,Shin, Dong-Soo Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.11

A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.

Computed Tomography Arteriography for Detecting the Origin of the Inferior Pyloric Artery in Patients with Gastric Cancer

Zhi-Long Wang,Ru-Lin Miao,Chao Gao,Lei Tang,Zi-Yu Li,Ying-Shi Sun,Jia-Fu Ji 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.3

Objective: To analyze the detection rate of the inferior pyloric artery (IPA) in patients with gastric cancer by computed tomography arteriography (CTA). Materials and Methods: Fifty-four patients (48 males and 6 females; mean age, 59.0 ± 1.5 years) who had undergone radical gastrectomy for gastric cancer from September 2016 to July 2017 at our institution were recruited prospectively. Patients underwent abdominal contrast-enhanced CT scans and CTA imaging reconstruction before the operation. The origin of the IPA in all cases was determined by a radiologist based on CTA images and verified by the surgeon. The accuracy of CTA in diagnosing the origin of the IPA was calculated. Dominant vessels of the origin were analyzed. Results: IPAs were detected by CTA in 51 patients (94.4%). Among these, IPAs originated from the right gastroepiploic artery (RGEA) (24 cases), the gastroduodenal artery (GDA) (4 cases), and the anterior superior pancreaticoduodenal artery (ASPDA) (20 cases). In the remaining 3 cases, the IPAs contained two branches originating from the RGEA and ASPDA, respectively. During surgery, in 2 (3.7%) of the 54 cases of gastric cancer, IPAs could not be detected; the IPAs originated from the RGEA (22 cases), GDA (5 cases), and ASPDA (24 cases). One case had an IPA originating from both the RGEA and the GDA. Finally, the accuracy of CTA in diagnosing the origin artery of the IPA was 85.2% (46/54). Conclusion: CTA can detect the origin of the IPA accurately, which can aid surgeons while performing pylorus-preserving operations.

A Simplified GBR Treatment and Evaluation of Posterior Seibert Class I Ridge Defects via Bio-collagen and Platelet-Rich Fibrin: A Retrospective Study

Wang Zhi,Zheng Yafeng,Xu Jiaqi,Jia Qi,Jiang Heng Bo,Lee Eui-Seok 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.6

Background: Classical guided bone regeneration (GBR) treatments can achieve favorable clinical results for ridge defects. However, extensive bone augmentation in the non-esthetic area in the posterior region for minor ridge defects is unnecessary. Therefore, this study used a collagen and Platelet-rich fibrin (PRF) mixture for bone augmentation on minor posterior ridge defects and evaluated the effects. Methods: 22 Seibert Class I ridge defects were treated with BC and covered with a PRF membrane (simplified guided bone regeneration, simplified GBR) and other 22 were treated with Bio-Oss and covered with Bio-Gide (classical GBR). Cone-beam computed tomography imaging was conducted 6 months post-surgery to compare the ridge’s horizontal width (HW) and buccal ridge’s horizontal width to assess the osteogenic effect. In addition, the buccal ridge contour morphology was studied and classified. Results: The buccal ridge contour of simplified GBR was Type A in 14 cases, Type B in 7 cases, and Type C in 1 case and it of classical GBR was Type A in 11 cases, Type B in 8 cases, and Type C in 3 cases. The mean HW significantly increased by 1.50 mm of simplified GBR treatment, while it increased by 1.83 mm in classical GBR treatment. Conclusion: The combined use of BC and PRF had a significant effect on bone augmentation and this treatment exhibited promising clinical results for correcting posterior Seibert Class I ridge defects. The morphological classification of the reconstructive effect in this study can be utilized in future clinical work. Background: Classical guided bone regeneration (GBR) treatments can achieve favorable clinical results for ridge defects. However, extensive bone augmentation in the non-esthetic area in the posterior region for minor ridge defects is unnecessary. Therefore, this study used a collagen and Platelet-rich fibrin (PRF) mixture for bone augmentation on minor posterior ridge defects and evaluated the effects. Methods: 22 Seibert Class I ridge defects were treated with BC and covered with a PRF membrane (simplified guided bone regeneration, simplified GBR) and other 22 were treated with Bio-Oss and covered with Bio-Gide (classical GBR). Cone-beam computed tomography imaging was conducted 6 months post-surgery to compare the ridge’s horizontal width (HW) and buccal ridge’s horizontal width to assess the osteogenic effect. In addition, the buccal ridge contour morphology was studied and classified. Results: The buccal ridge contour of simplified GBR was Type A in 14 cases, Type B in 7 cases, and Type C in 1 case and it of classical GBR was Type A in 11 cases, Type B in 8 cases, and Type C in 3 cases. The mean HW significantly increased by 1.50 mm of simplified GBR treatment, while it increased by 1.83 mm in classical GBR treatment. Conclusion: The combined use of BC and PRF had a significant effect on bone augmentation and this treatment exhibited promising clinical results for correcting posterior Seibert Class I ridge defects. The morphological classification of the reconstructive effect in this study can be utilized in future clinical work.