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Im, Jihoon,Lim, Gunpyo,Park, Chanwook,Choi, Yohan,Kim, Seunghan,Chang, Byunghoon Korea Electric Power Corporation 2016 KEPCO Journal on electric power and energy Vol.2 No.1
KEPCO has completed the installation and demonstration of a 52 MW battery energy storage system (BESS) for frequency regulation. Especially, 24 MW BESS is for Automatic Generation Control (AGC) in Shin-Yongin substation. Recently, KEPCO Research Institute has operated it connected to EMS of KPX. This paper discussed the operation strategy of EMS through a study on using 24 MW BESS in AGC operation and propose the improvement of AGC target. It is expected that this paper helps a safe and reliable operation and control of ESS for AGC through its continuous update.
Differential Cytotoxic Effects of Jaspine B in Various Cancer Cells
Jihoon Lee(이지훈),Kwangik Choi(최광익),Mihwa Kwon(권미화),Dongjoo Lee(이동주),Min-Koo Choi(최민구),Im-Sook Song(송임숙) 한국생명과학회 2016 생명과학회지 Vol.26 No.12
Jaspine B는 석회해면류에서 추출된 sphingosine유도체로 인간 암세포에서의 항암활성이 보고되었다. 그러므로 본 연구는 다양한 인간 암세포주에서 항암활성을 비교하고, 암세포주에서의 Jaspine B의 농도를 측정하여 항암활성과의 연관성을 확인하고자 하였다. 항암활성은 MTT 방법을 이용하여 측정하였고, EC50 값으로 표현하였다. 암세포주내 Jaspine B의 농도는 LC-MS/MS를 이용하여 분석하였다. 항암활성은 세포주마다 다양하게 나타났는데, 유방암과 흑색종 세포주에서 항암활성이 높게 나타났으며(EC50 각각 2.3 μM과 2.6 μM), 신장암세포주에서는 EC50 값이 29.4 μM이었다. 암세포주에서의 EC50 값은 동일한 세포에서의 Jaspine B 농도와 높은 상관성을 나타내었으며(r=0.838), 암세포내 약물농도를 조절하는 것으로 잘 알려진 P-glycoprotein과 breast cancer resistance protein 등의 배출수송계와는 관련이 없음을 확인하였다. 이상의 결과는 세포내 약물농도를 높게 유지하는 것이 항암활성에 매우 중요하며, 세포내 약물농도가 암세포주에 따라 다른 약효를 보이는 원인으로 사료된다. Jaspine B is an anhydrophytosphingosine that is isolated from a marine sponge. Because of its structural similarity to sphingosine, it shows anti-cancer effects in human carcinomas. Therefore, this study aims to investigate its anti-proliferative effect on various cancer cells and to correlate its association with the intracellular accumulation of Jaspine B in relevant cancer cells. The anti-proliferative effect of Jaspine B in various cancer cells was determined by a cell viability test, and the intracellular concentration of Jaspine B in relevant cancer cells was determined using mass spectrometry coupled with liquid chromatography. The correlation coefficient and p value between the cytotoxicity and the cell accumulation of Jaspine B were determined using SPSS 16.1. The cytotoxicity of Jaspine B varied depending on the type of cancer cell when compared the EC50 values of Jaspine B. Breast and melanoma cancer cells were susceptible to Jaspine B, whereas renal carcinoma cells were resistant. The intracellular concentrations of Jaspine B had a reciprocal correlation with the EC50 values in the same cells (r = 0.838). The results suggested that the anti-proliferative effect of Jaspine B was associated with the cellular accumulation of this compound. However, Jaspine B was not a substrate for P-glycoprotein and breast cancer resistance protein, as major efflux pumps caused multidrug resistance. The maintenance of a high intracellular concentration is crucial for the cytotoxic effect of Jaspine B; however, efflux pumps may not be a controlling factor for Jaspine B-related resistance in cancer cells.
표면거칠기와 절삭력을 고려한 Al7075-T0 선삭가공 최적화
정지훈(Jihoon Jeong),김정석(Jeongsuk Kim),김평호(Pyeongho Kim),구준영(Joonyoung Koo),임학진(Hakjin Im),이종환(Jonghwan Lee) 한국생산제조학회 2012 한국생산제조학회지 Vol.21 No.5
The Response Surface Method(RSM) is used as optimal design technique of experimental conditions. In Al7075-T0 turning operation, the principle cutting force and the Center-line averaged roughness are measured to optimize machining process. In variation of feed, depth of cut and cutting speed, three cutting parameters are evaluated. The optimal cutting conditions of Al7075-T0 turning are suggested by RSM. As a main result, feed is the dominant cutting parameter in this turning process considering surface roughness and cutting force.