http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jihoon Shin,Shinae Park,Jung‑Shin Lee,Eun‑Jin Lee,Hong‑Duk Youn 한국유전학회 2020 Genes & Genomics Vol.42 No.3
Background Streptomyces seoulensis has contributed to the discovery and initiation of extensive research into nickel superoxide dismutase (NiSOD), a unique type of superoxide dismutase found in actinomycetes. Still so far, there is no information about whole genome sequence of this strain. Objective To investigate complete genome sequence and perform bioinformatic analyses for genomic functions related with nickel-associated genes. Methods DNA was extracted using the Wizard Genomic DNA Purification Kit then sequenced using a Pacific Biosciences SMRT cell 8Pac V3 DNA Polymerase Binding Kit P6 with the PacBiov2 RSII platform. We assembled the PacBio longreads with the HGAP3 pipeline. Results We obtained complete genome sequence of S. seoulensis, which comprises a 6,339,363 bp linear chromosome. While analyzing the genome to annotate the genomic function, we discovered the nickel-associated genes. We observed that the sodN gene encoding for NiSOD is located adjacent to the sodX gene, which encodes for the nickel-type superoxide dismutase maturation protease. In addition, several nickel-associated genes and gene clusters-nickel-responsive regulator, nickel uptake transporter, nickel–iron [NiFe]-hydrogenase and other putative genes were also detected. Strain specific genes were discovered through a comparative analysis of S. coelicolor and S. griseus. Further bioinformatic analyses revealed that this strain encodes at least 22 putative biosynthetic gene clusters, thereby implying that S. seoulensis has the potential to produce novel bioactive compounds. Conclusion We annotated the genome and determined nickel-associated genes and gene clusters and discovered biosynthetic gene clusters for secondary metabolites implying that S. seoulensis produces novel types of bioactive compounds.
글루탐산 생산을 위한 Lactococcus lactis HY7803 균주의 대두 발효 적용
Lee Jungmin,Heo Sojeong,Choi Jihoon,Pyo Eunji,Lee Myounghee,Shin Sangick,Lee Jaehwan,Lee Junglyoul,정도원 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.1
The glutamic acid producing strain for development savory taste enhancing foods was identified the possibility through application into soybean fermentation. To check the effects on glutamic acid production during soybean fermentation, Lactococcus lactis HY7803 was introduced as a starter. The soybean samples were analyzed on days 0, 7, 14 and 21. The numbers of bacteria decreased gradually, while the content of amino-type nitrogen increased during fermentation in the soybean with L. lactis HY7803. Glutamic acid content in soybeans with L. lactis HY7803 increased from 114.99 ± 9.37 pmol/ul on day 0 to 138.14 ± 1.76 pmol/ul on day 21, showing an overall higher amino acid content than soybeans without L. lactis HY7803 and similar content to soybeans with Aspergillus oryzae SNU-G. It was clearly distinguished through principal component analysis. Consequently, our results indicate that L. lactis HY7803 is available as a fungus replacement and may be a good starter strain for enhancing savory taste in vitro as well as soybean fermentation.
Wavelength-Switchable Erbium-Doped Fiber Ring Laser Using Inline Fiber Bragg Grating Filter
Lee, Seul-Lee,Park, Kyongsoo,Jo, Songhyun,Choi, Sungwook,Jeong, Jun Hyeok,Jeong, Sun Jae,Christian, Nouaze Joseph,Kim, Jihoon,Lee, Yong Wook American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.10
<P>Here, we propose a wavelength-switchable erbium-doped fiber (EDF) ring laser by harnessing the unique switching feature of an inline fiber Bragg grating (FBG) filter based on a polarization-diversified loop. The inline filter consists of a four-port polarization beam splitter, three quarter-wave plates (QWPs), and two FBGs with different Bragg wavelengths. By adjusting the orientation angles of the three QWPs, this inline filter can select one of the two different resonances of the two FBGs. The proposed laser is composed of EDF pumped by a 980 nm laser diode, a wavelength-division multiplexing coupler, an optical isolator, a 3 dB optical coupler, and the inline FBG filter. At a special combination of the orientation angles of the three QWPs, one of the two reflection spectra of two FBGs could be chosen and thus the lasing wavelength of the proposed laser, which corresponds to the Bragg wavelength of the selected FBG, could be switched by adjusting the QWP angles. The fabricated ring laser accomplished stable and uniform lasing at each Bragg wavelength or switching operation between two wavelengths at proper QWP angle sets.</P>
Jihoon Oh(Jihoon Oh),Sekye Jeon(Sekye Jeon),Tae Hyon Ha(Tae Hyon Ha),Woojae Myung(Woojae Myung),Seung-Hwan Lee(Seung-Hwan Lee),Young-Hoon Ko(Young-Hoon Ko),Do Hoon Kim(Do Hoon Kim),Hwa-Young Lee(Hwa-Y 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Although the effects and safety of transcranial direct current stimulation (tDCS) treatment in depressive patients are largely investigated, whether the self-administration of tDCS treatment at patient’s home is comparable to clinic-based treatment is still unknown. Methods: In this single-arm, multi-center clinical trial, 61 patients with mild to moderate major depressive disorder were enrolled. tDCS treatment was delivered at the patient’s home once a day, 5 to 7 times a week for 6 weeks, and each session lasted for 30 minutes. The primary outcome was a total Beck-Depression Inventory-II score, and no concurrent antidepressants were used. Results: The remission rates in both Full-Analysis (FA) (n = 61) and Per-Protocol (PP) (n = 43) groups were statistically significant (FA: 57.4% [0.44−0.70], PP: 62.8% [0.47−0.77]; percent [95% confidence interval]). The degree of depression- related symptoms was also significantly improved in 2, 4, and 6 weeks after the treatment when compared with baseline. There was no significant association between treatment compliance and remission rate in both FA and PP groups. Conclusion: These results suggest that acute treatment of patient-administered tDCS might be effective in improving the subjective feeling of depressive symptoms in mild to moderate major depressive disorder patients.
구치부 반대교합을 동반한 성인 구순구개열 환자의 MARPE를 사용한 치험례
Jihoon Kim(Jihoon Kim),Ji-Hyun Lee(Ji-Hyun Lee),Chooryung J. Chung(Chooryung J. Chung),Kyung-Ho Kim(Kyung-Ho Kim) 연세대학교 치과대학 두개안면기형연구소 2023 연세임상교정 Vol.30 No.1
목적: 구순구개열로 인해 상악골의 횡적, 전후방적 성장 결핍과 열 부위 치아 결손을 동반한 환자에서 MARPE를 사용하여 악궁 확장을 시행한 증례를 보고하고자 한다. 임상 증례: 본 증례는 21세 남환으로 이가 반대로 물리며 치열을 가지런하게 하고싶다는 주소로 내원하였다. 환자는 구순구개열에 의한 상악의 성장 부전으로 인해 III급 골격 관계를 갖고 있었으며, 열 부위인 상악 좌측 측절치 결손 상태였다. 환자는 유아기 구순구개열 수술과 골 결손부위 2차 치조골 이식술, 성장기 교정 치료를 진행했으며, 성인이 된 후 치아배열 및 2차교정을 위해 본과 내원했다. 본과에서는 구순구개열에 의한 상악 열성장을 해결하기 위해 수술교정을 권하였으나, 환자분의 요구대로 비수술적 치료를 하게 됐고, 따라서 MARPE를 사용한 상악궁 확장과 전후방적 치아 이동을 통한 절충치료를 진행했다. 결론: 구순구개열을 치료하기 위해서는 출생 시부터 성장이 완료될 때까지 여러 과들의 협진을 통해 진행되며, 각 시기에 필요한 치료를 순서대로 진행하여 성인이 된 후 구순구개열을 성공적으로 치료할 수 있다. 특히 교정적 접근은 결손된 치아 및 부정교합의 회복을 위해 필수적이며, 성장기 교정치료와 더불어 악골 성장이 완료되는 시기에 최종적인 교합의 완성을 위한 치료를 진행한다. 대다수의 구순구개열 환자는 악골의 전후방적 부조화 및 횡적 부조화를 보이며, 이에 따라 치료과정이 더 복잡해지기 때문에 치료계획을 수립함에 있어 환자의 교정적 문제점을 파악하는 데 중점을 두어야 한다. 본 증례는 상악골의 횡적, 전후방적 성장 결핍과 열 부위 치아 결손을 동반한 구순구개열 환자에서 악궁의 회복 및 결손 부위의 공간확보를 통해 양호한 교합을 형성하였고 심미와 기능의 개선을 얻을 수 있었다. Purpose: We report the successful treatment of a patient with cleft lip and palate and anterior-posterior and transverse deficiency of the maxilla using MARPE. Clinical Case: A 21-year-old man presented with the chief complaints of multiple teeth in crossbite and crowding. He had cleft lip and palate in the past, skeletal Class III malocclusion due to growth deficiency of the upper jaw, and a missing upper left lateral incisor. For the treatment of cleft lip and palate, the patient underwent lip and palate surgeries in infancy, secondary alveolar bone graft, and phase I orthodontic treatment. We recommended surgical correction to solve the maxillary deficiency due to cleft lip and palate, but nonsurgical treatment was performed as requested by the patient. Orthopedic treatment through maxillary arch expansion using MARPE along with camouflage treatment through anterior and posterior tooth movement was performed. Conclusion: It is necessary to carry out treatment of cleft lip and palate patients in multiple stages from birth to adulthood through collaboration with various medical and dental departments. Orthodontic approach is essential for the recovery of malocclusion. Treatment for the completion of the final occlusion is performed after growth cessation, while orthodontic treatment also takes place during the growth period.
이지훈(Lee, Jihoon),이주희(Lee, Joohee),정석훈(Chung, Seockhoon),강솔비(Kang, Solbi),서수연(Suh, Sooyeon),이상하(Lee, Sangha) 한국재활심리학회 2021 재활심리연구 Vol.28 No.4
COVID-19 팬데믹(pandemic)은 등교 중지 및 원격수업 등의 형태로 학교 교육에 큰 영향을 주었고 교사들의 부담을 가중시켰다. 본 연구는 COVID-19로 인해 변화된 학교 현장에서 공립 교사들이 경험하는 심리적 고통과 소진 요인을 탐색하는 것을 목적으로 하였다. 이를 위해 현재 서울 소재 학교에서 근무하고 있는 9명의 교사를 대상으로 표적집단면접(Focus Group Interview, FGI)을 진행하였다. FGI에서 수집된 질적 정보들을 주제별로 나누어 분석하였고, 개방코딩을 통해 중복되는 개념을 제거한 후 초점코딩으로 하위 주제와 최종 주제를 개념화하였다. 그 결과, 국내 공립 학교에서 직면한 COVID-19의 문제는 ‘활력이 없는 학교’, ‘소모적인 온라인 수업’, ‘[힘 없는] 중간자인 교사’의 세 가지로 분류되었다. 본 연구는 COVID-19 기간 동안 학교 현장에서 교사, 학생, 학부모 간의 역학관계와 더불어 교사의 위치와 책임에 관한 인식을 파악했다는 것에 의의가 있다. 연구결과를 바탕으로 추후 교사들을 위한 심리적 지원에 대한 제언과 더불어 연구의 한계점을 논하였다. The COVID-19 pandemic has resulted in an increase in psychological distress, burnout, and workloads among public school teachers. This study aimed to explore the teachers experiences regarding the impact of the pandemic on their mental health and burnout. Nine teachers who were currently working in public schools in Seoul, South korea were invited to participate in focus group interviews (FGI). Data from FGIs were combined and analyzed thematically. The open codes were grouped and categorized by identifying and classifying the overlapping concepts into focused codes, which were then conceptualized into sub-themes and final themes. The analysis revealed three main themes of the COVID-19 pandemic-related challenges across public schools in Seoul. 1) Schools have no vitality; 2) Online classes are energy-consuming; and 3) Teachers are vulnerable middlemen. The results of this study offer insight into teachers perceptions of the unique position in which they are in to support students and their parents during the COVID-19 pandemic. Limitations of the study and implications for future research were also discussed.