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Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4
Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.
Xin Ji,Chenggen Jin,Ke Ji,Ji Zhang,Xiaojiang Wu,Ziyu Jia,Zhaode Bu,Jiafu Ji 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3
Purpose The aim of the present study was to compare the difference between double tract reconstruction and esophagogastrostomy.Materials and Methods Patients who underwent radical proximal gastrectomy with esophagogastrostomy or double tract reconstruction were included in this study.Results Sixty-four patients were included in this study and divided into two groups according to reconstruction method. The two groups were well balanced in perioperative safety and 3-year overall survival (OS). The rates of postoperative reflux esophagitis in the double tract reconstruction group and esophagogastrostomy group were 8.0% and 30.8%, respectively (p=0.032). Patients in the double tract reconstruction group had a better global health status (p < 0.001) and emotional functioning (p < 0.001), and complained less about nausea and vomiting (p < 0.001), pain (p=0.039), insomnia (p=0.003), and appetite loss (p < 0.001) based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. Regarding the EORTC QLQ-STO22 questionnaire, patients in the double tract reconstruction group complained less about dysphagia (p=0.030), pain (p=0.008), reflux (p < 0.001), eating (p < 0.001), anxiety (p < 0.001), dry mouth (p=0.007), and taste (p=0.001). The multiple linear regression analysis showed that reconstruction method, postoperative complications, reflux esophagitis, and operation duration had a linear relationship with the global health status score.Conclusion Double tract reconstruction could better prevent reflux esophagitis and improve quality of life without scarifying perioperative safety or 3-year OS.
Bin Ji,Xianwu Luo,Yulin Wu,Kazuyoshi Miyagawa 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.7
Unsteady cavitating turbulent flow around a twisted hydrofoil was analyzed to illustrate the physical mechanism of the cavitygeneratedpressure fluctuations. The numerical simulations of cavitating flow were based on the Partially-Averaged Navier-Stokes(PANS) method and a mass transfer cavitation model. The validity of PANS model has been evaluated and confirmed in cavitation simulationsby present authors using three different cases, 2D hydrofoil (Ji et al. 2012 [37]), 3D hydrofoil (Ji et al. 2013 [31]) and marine propeller(Ji et al. 2012 [38]), which shows that the PANS model with fk = 0.2 and fe = 1 can obtain more accurate estimates of unsteadycavitating flows with large-scale fluctuations at a reasonable cost. In present paper we intended to shed light on the physical process responsiblefor the pressure fluctuations excited by cavitation. The cavity volume was analyzed to illustrate the relationship between thecavitation evolution and the pressure fluctuations. The results show that the cavity volumetric acceleration curve tracks remarkably wellwith the main features of the time-dependent pressure fluctuations except for the high frequency component. Thus, the cavity volumetricacceleration is the main source of the excited pressure fluctuations by cavitation. It is noted that the cavitation induced pressure fluctuationsare transmitted along the suction surface of the hydrofoil and are synchronized with those on the pressure surface at the midplane ofthe twisted hydrofoil. Further, the pressure fluctuations on the pressure surface decrease towards the center from both the leading andtrailing edges of the hydrofoil, with a minimum at 60% chord length from the leading edge.
Foreign Bank Penetration, Resource Allocation and Economic Growth: Evidence from Emerging Economies
Ji Wu,전방남,Alina C. Luca 세종대학교 경제통합연구소 2010 Journal of Economic Integration Vol.25 No.1
This paper examines the implications of foreign bank penetration on economic growth from the perspective of resource allocation in host countries. We use aggregate banking data, constructed from bank-level balance sheets and income statement information covering more than 1200 banks in the 35 emerging economies of Asia, Latin America and Eastern and Central Europe for the period from 1996 to 2003. By applying the pooled OLS and fixed-effects models, we present consistent evidence that the effect of gross fixed capital formation on output growth is higher in an economy with a more pronounced level of foreign bank penetration relative to an economy with a lower level of foreign bank penetration. This finding suggests that foreign banks play an important role in allocating capital in a more productive way, thus leading to a higher economic growth rate. One of the main policy implications of our findings in this paper is that foreign banks may serve as a channel in enhancing economic integration of emerging economies with advanced economies that are the home countries of foreign banks.
Synthesis and structures of <i>o</i>-phenylene-bridged Cp/phosphinoamide titanium complexes
Ji Wu, Chun,Hoon Lee, Sang,Yun, Hoseop,Yeoul Lee, Bun Elsevier 2006 Journal of organometallic chemistry Vol.691 No.26
<P><B>Graphical abstract</B></P><P><I>o</I>-Phenylene-bridged Me<SUB>2</SUB>Cp or Me<SUB>3</SUB>Cp/phosphinoamide titanium and zirconium complexes were prepared and the structures of some complexes were determined by X-ray crystallography. They show negligible activity in ethylene polymerization.</P><ce:figure></ce:figure> <P><B>Abstract</B></P><P>Addition of R′<SUB>2</SUB>PCl to anilines substituted with di- or trimethylcyclopentadienyl unit at <I>ortho</I>-position affords <I>ortho</I>-phenylene-bridged Me<SUB>2</SUB>Cp or Me<SUB>3</SUB>Cp/phosophinoamide ligands, 2-(RMe<SUB>2</SUB>C<SUB>5</SUB>H<SUB>2</SUB>)C<SUB>6</SUB>H<SUB>4</SUB>NHPR′<SUB>2</SUB> (R=Me or H; R′=Ph, iPr, or Cyclohexyl). Successive addition of Ti(NMe<SUB>2</SUB>)<SUB>4</SUB> and Me<SUB>2</SUB>SiCl<SUB>2</SUB> to the ligands affords the desired dichlorotitanium complexes, [2-(η<SUP>5</SUP>-RMe<SUB>2</SUB>C<SUB>5</SUB>H)C<SUB>6</SUB>H<SUB>4</SUB>NPR′ <SUB>2</SUB>− <I>κ</I><SUP>2</SUP><I>N</I>,<I>P</I>]TiCl<SUB>2</SUB> (R=H, R′=Ph, <B>9</B>; R=Me, R′=Ph, <B>10</B>; R=H, R′=iPr, <B>11</B>; R=Me, R′=iPr, <B>12</B>; R=H, R′=Cy, <B>13</B>; R=Me, R′=Cy, <B>14</B>). By using Zr(NMe<SUB>2</SUB>)<SUB>4</SUB> instead of Ti(NMe<SUB>2</SUB>)<SUB>4</SUB>, a zirconium complex, [2-(η<SUP>5</SUP>-Me<SUB>3</SUB>C<SUB>5</SUB>H)C<SUB>6</SUB>H<SUB>4</SUB>NP(iPr)<SUB>2</SUB>−<I>κ</I><SUP>2</SUP><I>N</I>,<I>P</I>]ZrCl<SUB>2</SUB> (<B>15</B>) is prepared. Molecular structures of <B>10</B>, <B>14</B> and [2-(η<SUP>5</SUP>-Me<SUB>2</SUB>C<SUB>5</SUB>H<SUB>2</SUB>)C<SUB>6</SUB>H<SUB>4</SUB>NPPh<SUB>2</SUB>− <I>κN</I>]Ti(NMe<SUB>2</SUB>)<SUB>2</SUB> (<B>16</B>) were determined. The metric parameters determined on the X-ray crystallographic studies and the chemical shifts of the <SUP>31</SUP>P NMR signal indicate that the phosphorous atom coordinates to the titanium in the dichloro-complexes <B>9</B>–<B>15</B>. The titanium and zirconium complexes show negligible activity in ethylene and ethylene/1-hexene (co)polymerization when activated with MAO or iBu<SUB>3</SUB>Al/[Ph<SUB>3</SUB>C][B(C<SUB>6</SUB>F<SUB>5</SUB>)<SUB>4</SUB>].</P>
Selective surface functionalization at regions of high local curvature in graphene
Wu, Qingzhi,Wu, Yaping,Hao, Yufeng,Geng, Jianxin,Charlton, Matthew,Chen, Shanshan,Ren, Yujie,Ji, Hengxing,Li, Huifeng,Boukhvalov, Danil W.,Piner, Richard D.,Bielawski, Christopher W.,Ruoff, Rodney S. The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.7
<P>Monolayer graphene was deposited on a Si wafer substrate decorated with SiO<SUB>2</SUB> nanoparticles (NPs) and then exposed to aryl radicals that were generated <I>in situ</I> from their diazonium precursors. Using micro-Raman mapping, the aryl radicals were found to selectively react with the regions of graphene that covered the NPs. The enhanced chemical reactivity was attributed to the increased strain energy induced by the local mechanical deformation of the graphene.</P> <P>Graphic Abstract</P><P>Due to the increased strain energy caused by local mechanical deformation, aryl radicals were found to selectively react with regions of graphene that were curved by underlying SiO<SUB>2</SUB> nanoparticles. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc36747e'> </P>