http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
콩 및 당의 종류의 달리한 매실 콩아이스크림의 품질특성
이숙영,김아영,유지영,이중기,이향섭 중앙대학교 생활과학연구소 2003 생활과학논집 Vol.17 No.-
The purpose of this experiment was to compare the quality characteristics of soy ice creams prepared with soy protein isolate(SPI) or Jinpum-soybean, and different kinds of sweeteners of maltitol and sucrose, xylitol+sucrose, or malitiol. The viscosity of the ice cream mix containing xylitol+sucrose appeared the highest, and that from Jinpum-soybean was higher than that from SPI. The overrun of soy ice creams containing xylitol+sucrose was the highest, and the next was the samples containing maltitol+sucrose. The overrun values of Jinpum-soybean samples appeared higher than those of SPI samples. As for the case of the SPI samples, the melt-down percent was the highest in the sample of maltitol addition, and the next were maltitol+sucrose addition, xylitol+sucrose addition in order. The melt-down percent of Jinpum-soybean was the highest in the sample of maltitol+sucrose addition, and the next were maltitol addition, xylitol+sucrose addition in order. The higher the viscosity of samples, the lower the melt-down percent. In sensory characteristics, the beany flavor, flavor, mouthfeel, overall quality of Jinpum-soybean samples were evaluated better than those of SPI in general. The samples containing xylitol+sucrose evaluated better in beany flavor, mouthfeel, icy feel, and overall quality. The quality characteristics of the samples prepared with Jinpum-soybeans and xylitol+sucrose were evaluated the best.
Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome
( Ji Young Oh ),( Ji Ah Lee ),( Hye Jin Lee ),( Jee Young Oh ),( Yeon Ah Sung ),( Hye Won Chung ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.4
Background/Aims: Serum levels of highly sensitive C-reactive protein (hsCRP), a vascular inflammatory marker, may predict the development of cardiovascular disease (CVD) and type 2 diabetes. Women with polycystic ovary syndrome (PCOS) are at greater risk for type 2 diabetes and CVD. The aim of this study was to compare hsCRP levels between normal weight women with PCOS and controls with a normal menstrual cycle and to determine the factors associated with serum hsCRP levels. Methods: Thirty-nine lean PCOS patients and 24 healthy, regular cycling women were enrolled in this study. We performed anthropometric measurements, fat computed tomography (CT), and blood sampling to determine blood chemistry and levels of hsCRP, gonadotropins, testosterone, and sex-hormone binding globulin. We also conducted 75-g oral glucose-tolerance test and euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Results: Serum hsCRP concentrations were higher in women with PCOS than in women with regular mensturation. However, this difference was no longer significant after adjusting for body mass index (BMI). hsCRP levels were correlated with waist circumference (r=0.46, p<0.01), BMI (r=0.46, p<0.01), visceral fat area (r=0.45, p<0.01), and systolic (r=0.42, p<0.05) and diastolic blood pressure (r=0.39, p<0.05). hsCRP also tended to be negatively associated with insulin-mediated glucose uptake (IMGU) (r=-0.31, p=0.07). A multiple regression analysis revealed that BMI (β=0.29, p<0.05), systolic blood pressure (β=0.39, p<0.01), and IMGU (β=-0.31, p<0.05) predicted serum hsCRP levels in women with PCOS. Conclusions: PCOS by itself does not seem to be associated with increased hsCRP levels, whereas known CVD risk factors affect serum hsCRP levels in PCOS. (Korean J Intern Med 2009;24:350-355)
Ha, Young Mi,Kim, Jin-Ah,Park, Yun Jung,Park, Daeui,Choi, Yeon Ja,Kim, Ji Min,Chung, Ki Wung,Han, Yu Kyeong,Park, Ji Young,Lee, Ji Yeon,Moon, Hyung Ryong,Chung, Hae Young Royal Society of Chemistry 2011 MedChemComm Vol.2 No.6
<P>In this study, we describe the synthesis and tyrosinase inhibitory activity of a new family of hydroxybenzylidenyl pyrrolidine-2,5-dione compounds. Among them, compound 3f (HMP) exhibited the highest inhibition, 83.87%, at a concentration of 20 μM, on the <SMALL>L</SMALL>-DOPA oxidase activity of mushroom tyrosinase. We also predicted the tertiary structure of tyrosinase, simulated its docking with HMP and confirmed that HMP strongly interacts with tyrosinase residues. This result suggested that the binding activity of HMP with tyrosinase could be high. Based on these results, we determined the IC<SUB>50</SUB> value for HMP inhibition of mushroom tyrosinase activity. HMP inhibited mushroom tyrosinase with an IC<SUB>50</SUB> value of 2.23 ± 0.44 μM, which is more potent than the anti-tyrosinase activity of kojic acid (IC<SUB>50</SUB> = 20.99 ± 1.80 μM), a well-known tyrosinase inhibitor. Kinetic analysis of tyrosinase inhibition revealed that HMP is a competitive inhibitor (<I>K</I><SUB>i</SUB> = 4.24 × 10<SUP>−7</SUP> M at 1.25 μM and <I>K</I><SUB>i</SUB> = 1.82 × 10<SUP>−6</SUP> M at 20 μM). HMP also inhibited melanin production and tyrosinase activity in B16F10 melanoma cells (B16 cells). These data strongly suggest that HMP can suppress the production of melanin <I>via</I> the modulation of tyrosinase activity.</P> <P>Graphic Abstract</P><P>Computational structure prediction for mushroom tyrosinase and docking simulation with compound HMP. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00234h'> </P>
Ah Rang Cho(조아랑),Jin Kyung Park(박진경),Jong Woo Kim(김종우),Ji Young Song(송지영),Joo Ho Chung(정주호),Geon Ho Bahn(반건호) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.1
목적 : Dopamine beta-hydroxylase(DBH) 유전자는 정신병적 증상과 관련하여 정신분열병의 후보유전자 중의 하나이다. 본 연구는 DBH 유전자 내 새로운 단일염기다형성의 유전자형을 확인하고 정신분열병과의 유전적 연관성을 알아보고자 하였다. 연구대상 및 방법 : DSM-Ⅳ에 의해 정신분열병으로 진단된 입원환자 89명과 정신질환의 과거력과 가족력이 없는 대조군 109명을 대상으로 하였다. DBH 유전자의 네 번째 엑손 부위를 다중효소중합연쇄반응(Polymerase Chain Reaction, PCR)으로 증폭하여 DNA sequencing 기법으로 유전자형을 확인하고 연관성을 알아보기 위한 통계 분석을 시행하였다. 결과 : DBH 유전자 내 4개의 단일염기다형성(DBH5818G/A, DBH5990G/A, DBH6153C/T, DBH6259A/G)을 확인하였다. 이 4개의 단일염기다형성 모두에서 정신분열병 환자군과 정상 대조군 간 유전자형 분포와 대립유전자 빈도 및 일배체형 빈도에서의 유의한 차이는 없었다. DBH와의 관련성이 보고된 양성 정신병적 증상이 두드러지는 편집형 정신분열병 환자군과 정상 대조군 간 일배체형 빈도에서도 유의한 차이는 보이지 않았다. 결론 : DBH5818G/A, DBH5990G/A, DBH6153C/T, 그리고 DBH6259A/G 다형성은 한국 정신분열병 환자군과 유전적 관련성이 없을 것으로 추정된다.
Predictors of HCC Recurrence beyond MILAN Criteria after Primary Liver Resection
( Chung Gyo Seo ),( Yoo Ra Lee ),( Han Ah Lee ),( Sun Young Yim ),( Tae Hyung Kim ),( Hyung Joon Yim ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Soon Ho Um ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: There is a controversy whether to undergo liver resection or transplantation at early stage HCC. Thus, we aimed to find factors that reliably predict HCC recurrence beyond MILAN criteria which could help prioritizing transplantation as initial therapy. Methods: This is a retrospective study including patients who were diagnosed with HCC within MILAN criteria and had liver resection as initial treatment from year 2002 to 2016. In total, 152 patients were enrolled for analysis. The primary endpoint of this study is to find factors that enable prediction of HCC recurrence beyond MILAN criteria at the time of first recurrence. Secondary endpoints were factors associated with recurrence and recurrence free survival. Cox regression model was employed to select factors associated with recurrence. Results: Out of 152 patients, 56 patients developed HCC recurrence. Out of 56 patients 12 patients (21.5%) showed HCC recurrence beyond MILAN criteria at the initial time of recurrence. Time to recur was significantly shorter in patients out of MILAN criteria compared to those recur within MILAN (14±10 vs 28±23 months, P=0.005). HCC recurrence was independently associated with increased baseline tumor size, ALT levels (>35 IU/L) and degree of AFP decrease after resection (all, P<0.05). Factors associated with HCC recurrence beyond MILAN criteria were greater tumor number, higher child pugh score, and increased baseline serum ALT levels (all, P<0.05). Lastly, independent factors associated with recurrence free survival rate were recurrence beyond MILAN criteria, remote recurrence from resection site and degree of AFP decrease (all, P<0.05). Conclusions: HCC recurrence pattern (within versus beyond MILAN) has significant impact in the recurrence free survival even when patients are cured at early stage. Therefore, to prolong survival, prediction of patients who would lead to HCC recurrence beyond MILAN criteria is important and early liver transplantation could be an alternative treatment in this group.