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( Jae Won Byun ),( Kyung Hyun Lee ),( Ha Young Kim ),( Soon Seek Yoon ),( Ji Youl Jung1 ),( Woo Seog Jeong1 ),( Jae Ku Oem ),( Jong Soo Lim ),( Myoung Heon Lee ),( You Chan Bae ) 한국예방수의학회(구 한국수의공중보건학회) 2013 예방수의학회지 Vol.37 No.1
Nine cattle among 18 in a native Korean herd died or were euthanized within 3 days. The affected cattle showed cowshed. The pigs and dogs had been fed leftover food originating from nearby restaurants, and the cattle could presumably reach the contaminated food in the pig troughs. Necropsy revealed a few chicken bones and red pepper pieces as well as large amounts of grain and rice straw hay mixed in the rumen. Botulism type D was isolated in the ruminal contents of one of the cattle. We speculated that the outbreak was associated with the cattle incidentally eating presumably contaminated leftover food from the pig trough.
Carnosine Promotes Exhaustive Swimming Capacity in Mice
Jong-Soo Kim, Ki Nam Lee, Jin-Joo Hue, Jun-Hyeong Kim, Bong Soo Kang, Sang Yoon Nam, Young Won Yun, Jae-Hwang Jeong2, Beom Jun Lee 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
To investigate the effect of carnosine on exhaustive exercise, swimming tests were conducted weekly with loads corresponding to 5% of body weight attached to the tails of mice, and the swimming time to exhaustion was measured. Eighty male ICR mice were divided into four groups, to which carnosine was administered at doses of 0 (control), 10, 50, and 250 mg/kg/day, respectively, for a period of four weeks. At the end of swimming exercise challenges, serum biochemistry, oxidative stress enzyme activity, and antioxidant enzyme activity in tissues were determined. Treatment with 250 mg/kg carnosine resulted in a significant increase in swimming times to exhaustion, compared to the control group in the first (P<0.01) and third week (P<0.05). Significantly lower serum lactate levels were observed after the swimming exercise in the carnosine-treated groups (10 and 250 mg/kg), compared with the control (P<0.01). Malondialdehyde levels in the liver (10 and 50 mg/kg carnosine treated groups) and skeletal muscle (250 mg/kg carnosine treated group) were significantly lower, compared with the control (P<0.05). Significantly lower protein carbonyl levels in skeletal muscle were observed in the 50 and 250 mg/kg carnosine treated groups, compared with the control (P<0.01). Superoxide dismutase and glutathione peroxidase activities in skeletal muscle did not differ significantly among the groups. These results indicate that carnosine may improve swimming exercise capacity by attenuating production of lactate and reducing oxidative stress in mice.
Jeong, Gil-Jae,Byun, Hyang-Min,Kim, Jung Mogg,Yoon, Ho,Choi, Han-Gon,Kim, Won-Ki,Kim, Sun-Jae,Oh, Yu-Kyoung Elsevier 2007 Journal of controlled release Vol.118 No.1
<P><B>Abstract</B></P><P>Polyethylenimine (PEI) has been studied as an efficient and versatile <I>in vitro</I> and <I>in vivo</I> gene delivery agent. Here, we report the <I>in vivo</I> fate, tissue expression duration, and safety after the intravenous injection of plasmid DNA complexed to various PEIs under different conditions. Murine interleukin-2 plasmid DNA was complexed with branched PEI2Kd, 25Kd, or linear PEI25Kd at different <I>N</I>/<I>P</I> ratios. The mean residence time of plasmid DNA was found to be prolonged after delivery in PEI, evidencing the highest values in branched PEI25Kd. As compared to branched PEI25Kd, linear PEI25Kd at the same <I>N</I>/<I>P</I> ratio provided mRNA expression levels orders of magnitude higher in the lung over an 8-day period. In the branched PEI2Kd/DNA complexes, the <I>N</I>/<I>P</I> ratio of 80:1 evidenced higher gene expression efficiency in the kidney and spleen than the normal <I>N</I>/<I>P</I> ratio of 10:1. The generation of proinflammatory chemokine receptors was induced by branched PEI25Kd, but not by other PEIs. The complexes of DNA with linear 25Kd PEI or branched PEI2Kd exhibited no histological changes after repeated administrations. These results indicate that the structure, molecular weight, and <I>N</I>/<I>P</I> ratios of PEIs must be collectively considered and modulated for organ-targeted plasmid DNA delivery.</P>
Jeong-Won Yoon,Bo-In Noh,Seung-Boo Jung IEEE 2010 IEEE transactions on components and packaging tech Vol.33 No.1
<P>The solid-state interfacial reactions of Pb-free solders (Sn-3.5Ag, Sn-3.5Ag-0.7Cu, and Sn-0.7Cu) with electroless nickel-immersion gold (ENIG)-plated Cu substrate, and the growth of interfacial intermetallic compound (IMC) layers were investigated and compared during aging at 200<SUP>°</SUP>C for up to 1000 h. The Sn-3.5Ag-0.7Cu solder exhibited a higher IMC growth rate and a higher consumption rate of the Ni(P) layer than the other two Pb-free solders. The interfacial reaction of the Sn-0.7Cu/ENIG-plated Cu system during aging was the slowest among the three kinds of solder joint. The thickness of the interfacial IMCs were ranked in the order Sn-3.5Ag-0.7Cu > Sn-3.5Ag > Sn-0.7Cu. The higher melting temperature of the Sn-0.7Cu solder and the presence of Cu element within the solder suppressed the growth of the interfacial IMC layer and the consumption of the Ni(P) layer, resulting in the superior interfacial stability of the solder joint at high temperature of 200°C.</P>
Graphene Oxide Thin Films for Flexible Nonvolatile Memory Applications
Jeong, Hu Young,Kim, Jong Yun,Kim, Jeong Won,Hwang, Jin Ok,Kim, Ji-Eun,Lee, Jeong Yong,Yoon, Tae Hyun,Cho, Byung Jin,Kim, Sang Ouk,Ruoff, Rodney S.,Choi, Sung-Yool American Chemical Society 2010 Nano letters Vol.10 No.11
<P>There has been strong demand for novel nonvolatile memory technology for low-cost, large-area, and low-power flexible electronics applications. Resistive memories based on metal oxide thin films have been extensively studied for application as next-generation nonvolatile memory devices. However, although the metal oxide based resistive memories have several advantages, such as good scalability, low-power consumption, and fast switching speed, their application to large-area flexible substrates has been limited due to their material characteristics and necessity of a high-temperature fabrication process. As a promising nonvolatile memory technology for large-area flexible applications, we present a graphene oxide based memory that can be easily fabricated using a room temperature spin-casting method on flexible substrates and has reliable memory performance in terms of retention and endurance. The microscopic origin of the bipolar resistive switching behavior was elucidated and is attributed to rupture and formation of conducting filaments at the top amorphous interface layer formed between the graphene oxide film and the top Al metal electrode, via high-resolution transmission electron microscopy and in situ X-ray photoemission spectroscopy. This work provides an important step for developing understanding of the fundamental physics of bipolar resistive switching in graphene oxide films, for the application to future flexible electronics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2010/nalefd.2010.10.issue-11/nl101902k/production/images/medium/nl-2010-01902k_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl101902k'>ACS Electronic Supporting Info</A></P>
GUIDELINE : Severe influenza treatment guideline
( Won Suk Choi ),( Ji Hyeon Baek ),( Yu Bin Seo ),( Sae Yoon Kee ),( Hye Won Jeong ),( Hee Young Lee ),( Byung Wook Eun ),( Eun Ju Choo ),( Ja Cob Lee ),( Young Keun Kim ),( Joon Young Song ),( Seong 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1
Jeong Won Lee,Jong Hoon Lee,Jun-Gi Kim,Seong Taek Oh,Hyuk Jun Chung,Myung Ah Lee,Hoo Geun Chun,Song Mi Jeong,Sei Chul Yoon,Hong Seok Jang 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.3
Purpose: To evaluate the treatment outcomes of preoperative versus postoperative concurrent chemoradiotherapy (CRT) on locally advanced rectal cancer. Materials and Methods: Medical data of 114 patients with locally advanced rectal cancer treated with CRT preoperatively (54 patients) or postoperatively (60 patients) from June 2003 to April 2011 was analyzed retrospectively. 5-Fluorouracil (5-FU) or a precursor of 5-FU-based concurrent CRT (median, 50.4 Gy) and total mesorectal excision were conducted for all patients. The median follow-up duration was 43 months (range, 16 to 118 months). The primary end point was disease-free survival (DFS). The secondary end points were overall survival (OS), locoregional control, toxicity, and sphincter preservation rate. Results: The 5-year DFS rate was 72.1% and 48.6% for the preoperative and postoperative CRT group, respectively (p = 0.05, the univariate analysis; p = 0.10, the multivariate analysis). The 5-year OS rate was not significantly different between the groups (76.2% vs. 69.0%, p = 0.23). The 5-year locoregional control rate was 85.2% and 84.7% for the preoperative and postoperative CRT groups (p = 0.98). The sphincter preservation rate of low-lying tumor showed significant difference between both groups (58.1% vs. 25.0%, p = 0.02). Pathologic tumor and nodal down-classification occurred after the preoperative CRT (53.7% and 77.8%, both p < 0.001). Acute and chronic toxicities were not significantly different between both groups (p=0.10 and p = 0.62, respectively). Conclusion: The results confirm that preoperative CRT can be advantageous for improving down-classification rate and the sphincter preservation rate of low-lying tumor in rectal cancer.
Yoon Seo Lee,Hyelin Jeon,Yang-Mi Her,Da Eun Lee,Yong Joon Jeong,Eun Jeong Kim,Tae Hwan Choe,Hee Ju Suh,Seung-Yeon Shin,Dae Won Park,Yeong-Geun Lee,Se Chan Kang 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.6
BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1β, and -6, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.
Development of Analytical Method of Biotin in Complex Drugs and Dietary Supplements Using HPLC-UV
( Yoon Young Huh ),( Yun Pyo Kang ),( Yong Seok Choi ),( Jeong Hill Park ),( Sung Won Kwon ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.1
Recently, Korean Food and Drug Administration (KFDA) has focused on developing quality control guidelines for all commercial products in Korea to enforce regulations, improve the quality control, and protect consumers by developing prevalently used and efficient analytical tools to determine and quantify target compounds. Because the Korean Pharmacopeia (KP) presents microbiological assays for biotin, which is laborious and time-consuming, this study is focused on applying HPLC-UV to detect and quantify biotin in complex drugs and dietary supplements like multi-vitamin. Biotin in complex drugs was extracted from methanol and analyzed using mobile phase with 10 mM potassium phosphate (monobasic, pH=3.0) in distilled water and acetonitrile. Gradient condition was used to successfully detect and quantify biotin within 20 minutes. Validation result for linearity was significant that average r(2) was 0.999 (n=3) and its relative standard deviation (RSD) was 0.0578% which was less than 2%. Using this method, quantification of biotin in complex drugs was completed successfully and recovery tests were finished that recovery percentage greater than 95% with relative standard deviation less than 2%.