응급실 내원시 예상치 못한 사망 환자의 예측 인자

김욱진,서정필,정성필,황태식,이한식 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Unexpected deaths of the patients at ED are surprising to the medical staffs as well as the families. It may also increase the possibilities of medico-legal problems. This study was conducted to review the unexpected death in ED and find the predictive factors leading patients to unexpected death. Methods: A retrospective study with reviewing available medical records of 183 patients who were expired at Ed of Shinchon Severance Hospital from Mar. 1997 to Feb. 1998 and 103 patients of Youngdong Severance Hospital from Mar. 1996 to Feb. 1998 was done. Analyses were done on 30 variables of physical findings, laboratory results, procedures and therapies. We used univariate analysis such as t-test and x²-test and multiple logistic regression analysis. Results: Of the total 286 deaths in Ed, 153 cases were enrolled in this analysis. The number of unexpected deaths were 76. Age, mental status, fraction of neutrophil count, BUN level, whether endotracheal intubation was done, use of inotropics were the factors with statistical significance on the univariate analysis, but only comatose mentality, endotracheal intubated case, and use of the inotropics were significant on logistic regression analysis. The longer the ED length of stay, the higher the rate of mortality and unexpected death. Conclusion: This result suggest that medical attention is needed on the patients with comatose decreased mental status, endotracheally intubated case and needing inotropic agents to prevent unexpected deaths shortening the ED length of stay may also be a factor for decrease the unexpected death rate.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

Magneto-rheological accumulator for temperature compensation in hydropneumatic suspension systems

Seo, Jeong-Uk,Yun, Young-Won,Park, Myeong-Kwan 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.6

Hydro-pneumatic suspension systems consist of two fluids acting upon each other, usually gas over oil. In these systems, a compressible gas such as nitrogen is used as the springing medium, while a hydraulic fluid is used to convert the pressure to force. One of the problems associated with hydro-pneumatic systems is the effect of temperature change on the spring characteristics, which results in a variation in the spring rate and ride height. The important characteristics of a gas chamber filled with gas or air are to maintain the setting pressure, with very small variations, even for long strokes. This paper presents a magneto-rheological (MR) accumulator that can adjust the pressure of the gas chamber through the use of an MR device. To analyze the characteristics of the gas chamber, mathematical modeling based on the energy equation for a gas in a closed container is carried out. Further, a prototype of the MR device is designed and manufactured, and its performance is evaluated. The theoretical results are validated by conducting experiments in the laboratory environment. It is demonstrated that the MR accumulator can effectively compensate for the pressure variations caused by an increase in the gas temperature. Moreover, this research provides new information about the applicability of the MR accumulator to devices that use conventional accumulators.

Distribution Characteristics of Dioxins in Soils under Different Land Use in Busan, Korea

Jeong, Tae-Uk,Seo, Dong-Cheol,Jeong, Seung-Ryul,Cho, Jeong-Gu,Yoo, Pyung-Jong,Kim, Gi-Gon,Cho, Ju-Sik,Heo, Jong-Soo Korean Society of Soil Science and Fertilizer 2011 한국토양비료학회지 Vol.44 No.4

In this study, distribution characteristics of dioxins in soils in Busan, Korea were investigated regarding different land use types. Soil sampling sites that distributed through the Busan city showed dioxin concentration ranging from 0.489 to $322.736pg-TEQ\;g^{-1}$ dry weight with a mean value of $26.257pg-TEQ\;g^{-1}$ dry weight. The mean dioxin concentrations of investigated soils ranged from 1.554 to $50.357pg-TEQ\;g^{-1}$ dry weight in consideration of each land use type. That in metal refinery sites with $50.357pg-TEQ\;g^{-1}$ dry weight was higher than any other sites, followed by waste incinerator sites with $44.285pg-TEQ\;g^{-1}$ dry weight. The majority of soil samples had the same dioxin congener profiling despite the different range of dioxin concentration. Octa-CDD was the major contributor among seventeen dioxin congeners with the range from 29.5 to 70.1% in real values. In contrast to real values, dioxin congener profiles in TEQ values were dominated by 2,3,4,7,8-PeCDF which contributed about 35.3~43.8% to the total dioxin concentrations. It was judged by these results that penta-CDF was the major contributor of soil samples in Busan city. The mean ratio of PCDFs/PCDDs in real values was about 0.71, but that in TEQ values was, in contrast to it, approximately 3.03.

Enhancing Tumor Perfusion Using Orally Active Heparin to Improve the Efficacy of Immunotherapy

Jeong Uk CHOI,Na Kyeong LEE,Hyungseok SEO,Seung Woo CHUNG,Taslim A. AL-HILAL,Seho KWEON,Sang Kyoon KIM,Seohyun AHN,Uk-Il KIM,Jin Woo PARK,Chang-Yuil KANG,In-San KIM,Kyungjin KIM,Youngro BYUN 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.4

ZnTe and ZnTe/C nanocomposite: a new electrode material for high-performance rechargeable Li-ion batteries

Seo, Jeong-Uk,Park, Cheol-Min The Royal Society of Chemistry 2014 Journal of materials chemistry. A, Materials for e Vol.2 No.47

<P>Zinc telluride (ZnTe) and a nanostructured ZnTe/C composite were prepared by a simple solid-state synthetic route, and their potential as electrode materials for rechargeable Li-ion batteries was investigated. The electrochemical conversion/partial recombination reactions between ZnTe and Li were determined using<I>ex situ</I>X-ray diffraction and extended X-ray absorption fine structure analysis. X-ray diffraction and high-resolution transmission electron microscopy confirmed that the ZnTe/C nanocomposite consisted of ZnTe nanocrystallites that were uniformly distributed within an amorphous carbon matrix. The nanostructured ZnTe/C composite electrode exhibited excellent electrochemical properties with a high capacity (1st charge: 530 mA h g<SUP>−1</SUP>), cycling durability (over 200 cycles), and fast rate capability (1 C:<I>ca.</I>550 mA h g<SUP>−1</SUP>, 3 C:<I>ca.</I>504 mA h g<SUP>−1</SUP>).</P>

Anti-inflammatory Effect of Columbianetin on Activated Human Mast Cells

Jeong, Hyun-Ja,Na, Ho-Jeong,Kim, Su-Jin,Rim, Hong-Kun,Myung, Noh-Yil,Moon, Phil-Dong,Han, Na-Ra,Seo, Jae-Uk,Kang, Tae-Hee,Kim, Jae-Joong,Choi, Youngjin,Kang, In-Cheol,Hong, Seung-Heon,Kim, You-Ah,Seo, Pharmaceutical Society of Japan 2009 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.32 No.6

<P>In the present study, we extracted <I>Corydalis heterocarpa</I> with various solvents in order to find the bioactive constituents that demonstrated anti-inflammatory effects. We isolated the active compound, Columbianetin. Anti-inflammatory effect of Columbianetin has been reported but the precise effects of Columbianetin in experimental models have remained unknown. In the present study, we investigate the effect of Columbianetin on the production of histamine, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α and expression of cyclooxygenase-2 (COX-2) by using the human mast cell line (HMC-1). Various concentrations of Columbianetin were treated before the activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore, A23187. PMA plus A23187 significantly increased IL-1β, IL-6, IL-8, and TNF-α production compared with media control (<I>p</I><0.05). We also show that the increased cytokines IL-1β, IL-6, IL-8, and TNF-α level was significantly inhibited by Columbianetin in a dose-dependent manner (<I>p</I><0.05). Maximal inhibition rates of IL-1β, IL-6, IL-8, and TNF-α production by Columbianetin were about 102.6%, 101.1%, 95.8%, and 103.9%, respectively. Columbianetin inhibited expression of COX-2. In addition, the effect of Columbianetin was investigated on the histamine release from HMC-1 stimulated by substance P, which promotes histamine release. Columbianetin also inhibited the histamine release by substance P. In conclusion, these results indicate that Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses.</P>

Distribution Characteristics of Dioxins in Marine Sediment from Busan Port in Korea

Jeong, Tae-Uk,Seo, Dong-Cheol,Jeong, Seung-Ryul,Song, Bok-Joo,Cho, Jeong-Gu,Yoo, Pyung-Jong,Kim, Gi-Gon,Cho, Ju-Sik,Heo, Jong-Soo Korean Society of Soil Science and Fertilizer 2012 한국토양비료학회지 Vol.45 No.1

Eight marine sediments from Busan port in Korea were annually analyzed to examine the concentration distribution of dioxins from 2006 to 2010. Yearly mean concentration of dioxins ranged from 186.3 to $383.3pg\;g^{-1}$ in real values and 5.087 to 8.541 pg-TEQ (Toxicity equivalency) based on dry weight of samples. The dioxin concentration at the site near fishing market was the highest concentration among all sampling sites. Also the dioxin concentration at the sites with various pollutant sources such as large ships, sewage influx and thermal power station as well as fishing market was higher than that of the sites without specific pollutant sources. Another main factor that affects the dioxin concentration is topography characteristics of the bay. The bay has relatively high dioxin concentration because of the lack of the pollutant diffusion. This study demonstrated that the dioxin concentration in the site with pollutant sources and the lack of the pollutant diffusion was relatively high as compared with the other sites. As a result of contribution ratio of dioxin congeners, OCDD (Octachlorodibenzodioxin) in all sites was major contributor in real value, in contrast, dioxin congeners in TEQ values were dominated by 2,3,4,7,8-PeCDF.

Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts

Seo, Jeong Kyun,Kim, Su Hyun,Lee, Sang Hyub,Park, Joo Kyung,Woo, Sang Myung,Jeong, Ji Bong,Hwang, Jin-Hyeok,Ryu, Ji Kon,Kim, Jin-Wook,Jeong, Sook-Hyang,Kim, Yong-Tae,Yoon, Yong Bum,Lee, Kuhn Uk,Kim, S Lippincott Williams Wilkins, Inc. 2010 European journal of gastroenterology & hepatology Vol.22 No.8

BACKGROUND: Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are often confused with other intrahepatic cystic diseases. AIMS: The aims of this study were to investigate predictive factors of biliary cystic tumor (BCT) and clinical characteristic of BCAC. METHODS: We retrospectively reviewed preoperative diagnoses, overall characteristics and postoperative outcome of 20 BCTs and 19 cystadenoma-mimicking simple cysts that were pathologically confirmed. RESULTS: Comparing with atypical simple cysts, symptoms, left-lobe cyst, thick wall, septation, mural nodule, bile duct dilatation and an increase of serum alkaline phosphatase were associated with BCTs. However, on multivariate analysis, mural nodule, left-lobe cyst, and an increase of serum alkaline phosphatase were significantly frequent in BCTs with odds ratios of 75.5, 13.8, and 33.0, respectively. Among the 20 BCTs, seven BCACs were diagnosed. The characteristics of BCACs were mural nodule (P<0.01), intrahepatic cyst debris (P<0.01), and bile duct dilation (P=0.04). Cystic fluid analysis provided no significant differences between BCT and simple cyst. After fine needle aspiration cytology of BCTs, all except one BCAC with atypical cell showed nonspecific findings. After complete surgical excision (97.4% of patients), only one patient with BCAC had recurrence during 29 months of follow-up period. CONCLUSION: In hepatic cysts with mural nodule, left-lobe cyst or increment of serum alkaline phosphatase seem to be indicative of BCTs in the diagnosis of suspicious hepatic cyst. Intracystic debris, bile duct dilation, and mural nodule may be suggestive clinical features of malignancy in BCTs.

地方自治團體의 事務에 관한 現行法의 問題點과 立法論的 考察

서정욱(Seo Jeong-Uk) 한국비교공법학회 2007 公法學硏究 Vol.8 No.1

지방자치란 일정한 지역적 사무를 지역주민의 의사에 기하여 국가로부터 독립된 법인인 지역적 단체가 자주적으로 처리하는 것을 말한다. 즉 지방자치는 각 지방의 주민생활에 밀접한 관련이 있는 공공사무를 지방주민의 의사와 책임에 기하여 자주적으로 처리 하게하는 지방행정의 방식이라 할 수 있다. 우리 헌법 제117조는 ‘지방자치단체는 주민의 복리에 관한 사무를 처리하고 재산을 관리하며, 법령의 범위 안에서 자치에 관한 규정을 제정할 수 있다(제1항)’고 규정하고 있고, 또한 ‘지방자치단체의 종류는 법률로 정한다(제2항)’라고 규정하여 지방자치제도를 헌법적 제도로 보장하고 있다. 한편 지방자치단체의 사무라 함은 지방자치단체가 사무의 관리주체가 되는 사무를 말한다. 지방자치단체의 사무에 대하여 지방의회가 원칙적으로 개입할 수 있으며 사무처리의 효과는 지방자치단체에 귀속된다. 지방자치단체의 사무에는 자치사무와 단체위임사무가 있다. 기관위임사무는 지방자치단체의 장이 처리하지만 그 성질은 국가의 사무이며 지방자치단체의 사무는 아니다. 따라서, 기관위임사무의 처리효과는 국가에 귀속된다. 지방자치법 제9조 제1항은 ‘지방자치단체는 그 관할구역의 자치사무와 법령에 의하여 지방자치단체에 속하는 사무를 처리한다.’라고 규정하고 있는데, ‘법령에 의하여 지방자치단체에 속하는 사무’라 함은 단체위임사무를 말한다. 본고에서는 오늘날 한 국가에서의 중앙집권과 지방분권의 문제는 세계화와 지방화라는 두개의 목표를 동시에 달성하기 위하여 그 조화로운 실현이 요구되며, 특히 지방자치가 활성화되기 위하여 정부가 움켜지고 있는 권한을 과감하게 지방으로 이양하여야 한다는 지방화의 관점에서 현행법의 여러 문제점을 살펴보고 이에 대한 입법론적 대안을 제시해 보도록 하겠다. The local autonomy means the local organization which is an independent body from the State autonomously handling regional affairs according to the opinions of local residents. Therefore, the local autonomy is a method of local administration which enables to handle autonomously the public affairs that are closely related to the living of local residents based on the local residents' opinions and responsibilities. The local autonomy system is protected by the constitutional system which is shown by the clause 1 of the Article 117 of the Constitution of the Republic of Korea which states that the local government handles the affairs relating to the public welfare, deals with the properties and enacts law in regards to autonomy within the limit of law and by the clause 2 which states that the type of a local government is decided based on the law. The affairs of a local government mean affairs that a local government acts as a managing authority. The local council is able to intervene in principle with respect to the affairs of a local government and the effects of conducting affairs belong to a local government. The affairs of a local government consist of autonomous affairs and collective delegated affairs. The head of a local government deals with the agency delegated affairs which are treated as the state affairs, not the affairs of a local government. Therefore, the effects of conducting the agency delegated affairs belong to the State. The Article 9.1 of the Local Autonomy Act states that a local government handles the autonomous affairs within its jurisdiction and the affairs which belong to a local government in accordance with the statue. The affairs which belong to a local government in accordance with the statue mean collective delegated affairs. This article presents controversial issues with the law in force and suggest legislative proposals dealing with the issues that the centralization and decentralization of powers in a country should be realized harmoniously to achieve the goals of globalization and localization, especially by examining from a localization point of view which states that the powers of a central government should be turned over resolutely to a local government.