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A retrospective analysis of second-Line chemotherapy in patients with advanced gastric cancer (초)
( Sang Hoon Ji ),( Do Hyoung Lim ),( Min Jae Park ),( Seong Yoon Yi ),( Kyoung Ha Kim ),( Hyo Song Kim ),( Hyun Jung Jun ),( Ji Eun Uhm ),( Jee Yun Lee ),( Se Hoon Park ),( Joon Oh Park ),( Young Suk 대한내과학회 2008 대한내과학회지 Vol.75 No.1S
Yoon, Ji Young,Kwon, Mo Sun,Kang, Jee Hyun,Ahn, Kwang Sung,Kim, So Seob,Kim, Nam-Hyung,Kim, Jin-Hoi,Kim, Teoan,Shim, Hosup Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.2
Human follicle-stimulating hormone (hFSH) is a pituitary glycoprotein that regulates follicular development and ovulation. Clinically, hFSH has been used to induce follicular growth in infertile women. The hormone is composed of heterodimers, including a common ${\alpha}$ subunit among the gonadotropin family and a hormone-specific ${\beta}$ subunit. Since assembly of the heterodimer is a rate-limiting step in the production of functional hFSH, transgenic clone cows carrying a single-chain hFSH transgene may efficiently produce functional hormone. Genes encoding the ${\alpha}$ and ${\beta}$ subunits of hFSH were linked using the C-terminal peptide sequence from the ${\beta}$ subunit of human chorionic gonadotropin. Bovine fetal fibroblasts were transfected with the gene construct, including the goat ${\beta}$-casein promoter and a single-chain hFSH coding sequence. Transfected fibroblasts were transferred into enucleated oocytes, and individual nuclear transfer (NT) embryos developed to the blastocyst stage were analyzed for the transgene by polymerase chain reaction. Seventy eight blastocysts (30.8%) were developed from 259 reconstructed embryos. Among these blastocysts, the hFSH gene was detected in 70.8% (34/48) of the embryos. Subsequent transfer of hFSH-transgenic clone embryos to 31 recipients results in 11 (35.5%) early pregnancies. However, all fetuses were lost before reaching day 180 of gestation. The results from this study demonstrated that bovine NT embryos carrying single-chain hFSH could be produced, and further extensive studies in which NT embryos are transferred to more recipients may give rise to single chain hFSH-transgenic cows for biomedical applications.
The Association between Motor Laterality and Cognitive Impairment in Parkinson’s Disease
Jee-Eun Yoon,김지선,Jae-Young Seo,Jin Whan Cho,Jun-Sang Sunwoo,이경복,노학재,안무영 대한치매학회 2016 Dementia and Neurocognitive Disorders Vol.15 No.4
Background and Purpose The relationship between the side of motor symptoms and cognitive impairment has rarely been reported in Parkinson’s disease (PD). We aimed to estimate the influence of motor laterality on cognition in PD patients. Methods We enrolled 67 patients with PD, and they were divided into two groups according to side of symptom onset or predominant motor symptom presentation (right and left). Right-sided PD (RPD, 40) and left-sided PD (LPD, 27) patients underwent a neuropsychological battery exploring memory, attention/working memory, frontal/executive, visuospatial, and language functions. Student's t-test and Chisquare test have been carried out to compare the clinical and neuropsychological data between two groups. Results There were no significant differences in any neuropsychological test between the RPD and LPD groups, except for digit forward span test. RPD patients scored lower on the digit forward span test than LPD patients (5.43±9.49 vs. 6.15±1.38, p=0.045). Conclusions RPD patients seem to experience more difficulties in attention and working memory than did LPD patients. The laterality of motor symptoms is not a major determinant for cognitive impairment in PD patients but, we should consider differences of cognitive deficits depending on the side of motor symptoms to treat patients with PD.
p53 gene mutations and amplification of c-erbB-2 in breast cancer
Yoon, Keun-young,Mok, Jee-Won,Lee, Min-hyuk,Park, Sung-sup,Park, Kyung-Sook 성신여자대학교 기초과학연구소 2001 基礎科學硏究誌 Vol.19 No.-
유방암은 종양억제 유전자 p53의 돌연변이 또는 기능 상실의 유전적인 요인과 종양유전자 c-erbB-2의 활성화에 의해 일어날 수 있으며, 한국 여성의 암발병율에서 3위를 차지하고 있다. 29명의 한국인 infiltrating ductal 유방암 환자를 대상으로 p53 유전자의 exons 2에서 11까지의 돌연변이를 PCR-Single Strand Conformation Polymorphism법과 직접염기서열분석법으로 분석하고, c-erbB-2의 증폭을 differential PCR로 확인하였다. 연구결과 20.6% (6예)의 p53 돌연변이가 나타났는데, 한개의 점돌연변이 (엑손 7: CD 248 CGG→ CAG)와 다섯개의 격자이동 돌연변이 (엑손 5: CD 181 -G, 엑손 6: CD 196 -G, 엑손 7· CD 234 -C, 엑손 8: CD 291 +A, 엑손 9: CD 316 +GG)로 다섯개의 격자이동 돌연변이가 많이 나타났다. 엑손 2-4 및 10-11에서는 돌연변이가 발견되지 않았다. c-erbB-2 증폭은 3예 (10%)에서 나타났으며, p53 돌연변이와 c-erbB-2 증폭은 유의한 상관관계를 보이지 않았다. 환자의 연령, 병기, 에스트로겐 수용체/프로게스테론 수용체, 종양의 크기, 폐경 및 림프절 전이도, p53 및 c-erbB-2와 관련하여 살펴보았으나 특이한 상관관계는 발견되지 않았다. p53 돌연변이 빈도와 분포는 일본, 미국, 프랑스등에서 보고된 결과와 유사하였으나, 돌연변이 양상은 점돌연변이가 대부분인 타 실험결과와는 달리 격자이동 돌연변이가 83%로 나타났다. 이로써, p53의 돌연변이는 지역이나 인종에 따라차이를 보이며, 유방암의 발병은 p53 종양억제 유전자의 체세포변이에 의함을 알 수 있었다.
Sung-Rak Lee,Seong-Tae Kim,Min Geun Yoon,문명상,Jee-Hyun Heo 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.1
Background:Intertrochanteric fractures of the femur are the most common type of fracture, and are an increasing occurrence due to the aging of the population. The objectives of our study are to predict the fate of intertrochanteric fractures treated with intramedullary hip nails by assessing the postoperative fracture stability utilizing the newly developed scoring system, and to help rehabilitate these patients. Methods: Eighty-two patients with intertrochanteric fractures that were treated with intramedullary hip nails between December, 2004 and January, 2011 were subjected to this study. The patients who could be followed for a minimum of one year postoperatively were enrolled. The immediate postoperative conditions were determined by radiograms: reduction status (3 parameters/4 points: contact accuracy of posteromedial cortex, severity of angulation, and distraction), fixation status (3 parameters/3 points: tip-apex distance, location of tip of the lag screw, entry point of the intramedullary nail), and fracture type (1 parameter/1 point: stable or unstable type by the Kyle’s classification). Postoperative reduction loss and fixation failure were checked by radiograms taken at a minimum 3 months postoperative. Results: Reduction loss and fixation failure were observed in 14 consecutive patients (17%). The fixation failure rate was 100% (2 patients) in score 1, 60% (3 out of the 5 patients) in score 2, 39% (3 out of the 8 patients) in score 3, and 50% (4 out of the 8 patients) in score 4 groups. There were fixation failures only in 1 out of 13 patients with score 5, and in 1 out of 18 patients with score 6. There was no fixation failure in 17 patients with score 7 and 11 patients with score 8. Conclusions: Maintenance of the fracture reduction by the stable fixation in the patient scores over 5 could be predicted by the postoperative radiograms.