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Nitrite Scavenging Effect by Flavonoids and Its Structure-Effect Relationship
Choi, Jae-Sue,Park, Si-Hyang,Choi, Jin-Ho The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.1
Nineteen flavonoids, five phenolics, two coumarins, maltol and L-ascorbic acid were tested as scavenger of nitrite which is believed to participate in the formation of N-nitroso compounds. Many were found to be potent scavenger and the five most potent ones were (+)-catechin, (-)-epicatechin, phloroglucinol, caffeic acid and L-ascorbic acid. The nitrite scavenging effect was higher at pH 1.2 than pH 3.0 and increased when the incubation time was longer. The possible relationship of structures to scavenging effect of the flavonoids tested was discussed.
Flavonoids from the leaves of rhododendron brachycarpum
Choi, Jae-Sue,Young, Han-Suk,Park, Jong-Cheol,Choi, Jin-Ho,Woo, Won-Sick The Pharmaceutical Society of Korea 1986 Archives of Pharmacal Research Vol.9 No.4
The flavonoids isolated form the leaves of rhododendron brachycarpum were identified as quercetin, avicularin, quercitrin and hyperin.
Phytochemical Study on Prunus davidiana
Choi, Jae-Sue,Woo, Won-Sick,Young, Han-Suk,Park, Jong-Hee The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.4
From the stem of Prunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, dihydrokaempferol, kaempferide glucoside, hesperetin glucoside, quercetin glucoside, d-catechin and $\beta$-sitosterol glucoside were isolated.
A Preliminary Study on Hypocholesterolemic and Hypoglycemic Activities of Some Medicinal Plants
Jae Sue Choi,Hae Young Chung,Han Suk Young 한국생약학회 1990 생약학회지 Vol.21 No.2
Total cholesterol level in mice with hypercholesterolemia was determined after intraperitoneal administration of the methanolic extract of some medicinal plants. From the data obtained, it was suggested that the methanolic extract of Elaeagnus crispa, Ixeris dentata, Prunus daroidiana, Eriobotrya japonica, Aralia elata and Phragmites communis produced a significant hypocholesterolemic effect. In the case of the extract of Saussurea diamantiaca, on the other hand, the total cholesterol level was markedly increased. The methanolic extract of Ixeris dentata, Prunus davidiana and Phragmites communis also decreased the level of blood glucose in alloxan-diabetic male albino mice while that of Eriobotrya japonica, Allium tuberosum, Houttuynia cordata and Eucommia japonica did not produce this effect.
Hypolipemic and Hypoglycemic Activities of Prunus davidiana in High Fat-Fed Rats
Choi, Jae-Sue,Suh, Suk-Soo,Young, Han-Suk,Park, Hee-Juhn The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.1
Blood lipid levels in rats with high fat-fed hyperlipemia were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems. Administration of the methanolic extract for 6 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. In addition to the hypolipemic effect, the methanolic extract was also shown to be effective in reducing an elevated level of glucose in rats with hyperlipemia resulting from high-fat feeding. On the other hand, blood triglyceride and total cholesterol in rats fed with stock diet were not affected by administration of the methanolic extract even if there was a tendency to decrease. No significant change was also found in the level of glucose. Thus, it is suggested that this methanolic extract probably may increase the metabolic utilization only when fed with excess fat.
Jae Sue CHOI,Hyun Ah Jung,Himanshu Kumar Bhakta,Hajime Fujii,민병선,Chan Hum Park,Takako Yokozawa 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.3
Oligonol is a low-molecular-weight form of polyphenol that is derived from lychee fruit extract and contains catechin-type monomers and oligomers of proanthocyanidins. This study investigates the anti-diabetic activities of oligonol via a-glucosidase and human recombinant protein tyrosine phosphatase 1B (PTP1B) assays, as well as its anti-Alzheimer activities by evaluating the ability of this compound to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and b-site amyloid precursor protein cleaving enzyme 1 (BACE1). Oligonol exhibited potent concentration-dependent anti-diabetic activities by inhibiting a-glucosidase and PTP1B with IC50 values of 23.14 lg/mL and 1.02 lg/mL, respectively. Moreover, a kinetics study revealed that oligonol inhibited a-glucosidase (Ki = 22.36) and PTP1B (Ki = 8.51) with characteristics typical of a mixed inhibitor. Oligonol also displayed potent concentration-dependent inhibitory activity against AChE and BChE with IC50 values of 4.34 lg/mL and 2.07 lg/mL, respectively. However, oligonol exhibited only marginal concentrationdependent BACE1 inhibitory activity with an IC50 value of 130.45 lg/mL. A kinetics study revealed mixed-type inhibition against AChE (Ki = 4.65) and BACE1 (Ki = 58.80), and noncompetitive-type inhibition against BChE (Ki = 9.80). Furthermore, oligonol exhibited dosedependent inhibitory activity against peroxynitrite (ONOO-)-mediated protein tyrosine nitration. These results indicate that oligonol has strong preventative potential in diabetes mellitus and in Alzheimer’s disease.