Slide Session : OS-RES-07 ; Oncology : Progastrin-Releasing Peptide as a Diagnostic and Therapeutic Biomarker of Small Cell Lung Cancer

( Hyuong Ju Oh ),( Hong Jun Shin ),( Chul Kyu Park ),( Bo Ram Lee ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Kyu Sik Kim ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Duck Cho ),( S 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Progastrin-releasing peptide (proGRP) is a recently identifi ed biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement as a tumor marker for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients who visit for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT® proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1830.4 ± 2706.7 pg/mL) than in NSCLC (74.0 ± 365.4 pg/mL) and other diseases (61.7 ± 271.7 pg/mL, p<0.001). Among the cancer group, the sensitivity of proGRP was 85.6% (89/104) in SCLC and 12.2% (26/213) in NSCLC. The specifi city was 87.8%, positive predictive value was 77.4%, and negative predictive value was 92.6% at 63 pg/mL in SCLC patients. The mean proGRP was higher in extensive disease (2166.8 ± 2999.5 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC who could be followed, the mean proGRP levels of 23 responders were signifi cantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not significantly different between before and after chemotherapy (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.

호남 지역의 중추 신경계 종양의 현황

윤경식,조규용,김형일,김태영,조경기,신호,강삼석,우정현 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.7

The authors analized statistically 635 cases of pathologically confirmed central nervous system tumors in the Chonnam and Chonbuk provinces from 1987 to 1989. The results were as follows : 1) Of the 635 cases, 327 cases(51.5%) were male and 308 cases(48.5%) were female. 2) Intracranial tumors were 518 cases(81.6%), spine and intraspinal tumors 94(14.8%), scalp and skull tumors 23(3.6%). 3) Average incidence rate of tumors was 3.5/year/100,000 population, 3.1 for Chonnam province, 4.4 for Chonbuk province. 4) Among the brain tumors, glial tumors were the most common(28.4%), and followed by meningiomas(18%), pituitary tumors(15.2%), metastatic tumors(8.9%), Among the intraspinal tumors, neurinomas and neurofibromas were found most frequently(41.5%), and rests were metastatic tumors(23.4%), meningiomas(9.5%) in order. 5) Sexual predilection of tumors was as follows : male preponderance was noted for oligodendrogliomas(9: 1), metastatic tumors(2.3:1), glioblastomas multiforme(GM)(1.8:1) cysticercoses(1.6:1), and female preponderance for meningiomas(1:3.2), pituitary tumors(1:2), paragonimiases(1:1.5). 6) The incidence rate of brain tumors in children below 15 years was 11.8% and that which occurred infratentorially was 47.5%. 7) The brain tumors were found mainly in cerebral hemispheres, in which area most of tumors were meningiomas, astrocytomas in order. In sellar, parasellar most of tumors were meningiomas, astrocytomas in order. In sellar, parasellar and suprasellar region, the majority of tumors were pituitary tumors and meningiomas. 8) Cysticercoses showed a predilection for the sixth and seventh decades, meningiomas, metastatic tumors, neurinomas for sixth decade, GM and supratentorial astrocytomas for fourth, fifth and sixth decades, oligodendroliomas for fifth decade, infratentorial astrocytomas, medulloblastomas and craniopharyngiomas for first and second decades. 9) In the spinal tumors, the favorable site was thoracic region and majority of them were located intradural extramedullarily and extradurally in similar incidence.

Morphologic Variability of the Shoulder between the Populations of North American and East Asian

Andres F. Cabezas,Kristi Krebes,Michael M. Hussey,Brandon G. Santoni,Hyuong Sik Kim,Mark A. Frankle,Joo Han Oh 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.3

Background: The aim of this study was to determine if there were significant differences in glenohumeral joint morphology between North American and East Asian populations that may influence sizing and selection of shoulder arthroplasty systems. Methods: Computed tomography reconstructions of 92 North American and 58 East Asian patients were used to perform 3-dimensional measurements. The proximal humeral position was normalized in all patients by aligning it with the scapular plane utilizing anatomic landmarks. Measurements were performed on the humerus and scapula and included coronal and axial humeral head radius, humeral neck shaft and articular arc angles, glenoid height and width, and critical shoulder angle. Glenohumeral relationships were also measured and included lateral distance to the greater tuberosity and acromion, abduction lever arm, and acromial index. Parametric and nonparametric statistical analyses were used to compare population metrics. Results: East Asian glenohumeral measurements were significantly smaller for all linear metrics (p < 0.05), with the exception of acromial length, which was greater than in the North American cohort (p < 0.001). The increase in acromial length affected all measurements involving the acromion including abduction lever arms. No difference was found between the neck shaft and articular angular measurements. Conclusions: The East Asian population exhibited smaller shoulder morphometrics than their North American cohort, with the exception of an extended acromial overhang. The morphologic data can provide some additional factors to consider when choosing an optimal shoulder implant for the East Asian population, in addition to creating future designs that may better accommodate this population.

기관지 천식 환자의 기관지폐포세척액내 T 세포 아형과 임상양상간의 관계

이숙영,박성학,이상학,문화식,김석찬,송정섭,윤형규,김관형,신윤 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.6

Background and Objective : T cells play a pivotal role in initiating and orchestrating bronchial inflammation in asthma. However, little is known about changes in T cell subset in the airways. Our objective was to study whether the proportion of CD4+ or CD8+ T cells in the bronchoa1veolar lavage fluid (BALF) of bronchial asthma is different from normal subjects, and whether it is associated with clinical characteristics. Methods : We examined the percentage of CD4+ and CD8+ cells in the BALF of 37 patients with bronchial asthma and 14 normal controls by flow cytometry. Bronchial asthma was classified as mild, moderate and severe according to bronchial hyperresponsiveness. Skin prick test and pulmonary function tests were performed. Results : The percentage of CD4+ cells in BALF did not differ between asthmatics and controls, however, the percentage of CD8+ cells was significantly higher in asthmatics than contro1s, In asthmatics, the percentage of CD4+ cells and CD8+ cells did not differ between atopic and nonatopic asthmatics. The percentage of CD8+ cells in addition to CD4+ cells was correlated with the percentage of eosinophils in BALF, and the percentage of CD8+ cells also showed negative correlation with FEV₁and FEF_(25-75%) Conclusion : These results suggest that CD8+ cells as well as CD4+ cells are associated with airway inflammation in bronchial asthma.