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Natural Toxin의 안전성 평가연구 : Ochratoxin A의 면역독성 Immunotoxicity of ochratoxin A
김주일,한형미,정혜주,김형수,김환묵,정승태,박재현,강선경,김진호 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
Ocllratoxin A는 fenicl'flrium과 rtsr☞rgiffus 속 등의 곰팡of가 생성하는 mycotoxin으로서 세포매기성 및 체액성 면역기능에 슨상을 일으키는 것으로 알려져 있다. 본 연구는 OTA가 면역계에 미치는 영향과 OTA의 면역 독성 억제 효과가 있는 물질을 검색하기 위하며 6~7 주령의 Balb/c mice 비장세핀에 T 및 B 세포의 mitogen인 Con A와 LPS로 처리하고 3일간 배양한 후 비장세포의 분화정도를 MTS를 처리하여 관찰하였으며, OTA를 투여한 마우스의 면역장기 형리조직학적 견화를 관찰하였다. 마우스의 비장세포 (2xtD6cel1/rnf)에 OTA(1~6μg/ml)를 상에서 혼합하여 Con A와 LPS로 자극시킨 결과 임파구는 Sfg/mf이상에서 거의 모든 세포가 분화되지 않았다. mice에 OTA (1,5 및 10mg/11g)를 2일 간격으로 6회 복갚 주사한 후 비장세포를 분리하여 Con A와 LPS로 처리한 결과 Smg 투여군에서는 6회 투여 혼에 분화가 억제되었고, 10mg 투여군에서는 3회 및 6회 투여군에서 분화가 억제되었단. Ochratoxin A의 면역독성 억제 효과가 있는 물질을 검색하기 위하여 in vitro 실험에서 마우스의 비장세포 (2×10" cell/mf)에 OTA (3fg/mf)와 L-phenylalanine, indole-3-carbinol, L-ascorbic acid,piroxicaTn, curcumin 및 arethylsalicylic acid를 혼합하고 동일 처리한 결과 L-ascorbic acid, L-phenylala-nine 및 Indole-3-carbinol은 OTA의 면역독성 발현을 운의성 있게 억제하였다. Balt/c mice에 OTA (10mg/kg)와 l'n pifro실험에서 억제효파가 확인된 L-ascorbic acfd, L-phenylalanine 및 indole-3-carbinol을 2일 간격으로 동시에 3회 복강주사하여 관찰한 결과 indote-3-carbine께서 엮제효과를 관찰할수 있었다. Ochratoxin A를 투여할 마우스의 비장 및 홍선에서는 임파구의 빈도가 줄었으며 특히 비장제서는 starry-sky 세포가 증가됨을 관찰할 수 있었다. 이러한 결자로 OTA는 비장세포의 T 및 B 임파구의 분열능을 억제시 키며, 면역장기의 임파구에 손상 야기시키므로서 면역기능을 저하시키고 OTA에 의한 면역독성은 indole-3-carbinol이 경감시킴을 관찰하엿다. Ochratoxin A (OTA) is a Tnyeotoxin produced by several fungal species iBcluded the genera fs4pergiffug and f☞HiciHiHuL and known as one of the major environmental contaminants. Tn thepresent study, the effects of OTA on the imraune system and the prevention of the OTA-inducedimmunosuppression by protective agents were studied in Balb/c rnicf:. Splenocytes were isolated and theproliferative responses to concanavalin A (Con A) and lipopolysaccharide (LPS) were measured in thepreseEce of 1 to 6fg/mf OTA. Sfg/mf OTA completely btocked both Con A and LPS-stimulatedmitogenic responses, causing approximately 50% inhibition at 3fe/mf OTA. This suppression of mitogen-induced proliferative resplonses observed id uifro was reproduced in mice treated with ☞rA in rioafntraperitoneal administration of 5, IDmg/kg OTA 3 to etimes every other day significantly decreasedboth Con A- aud LPS-inttuced mitegenic responses. The effects of possible protective agents on theOTA-induced suppression c)』 mitogenic responses were examined both in uifro and in viua Amoag 6 pos-sible protective agents (1,-phenylalanine, L-ascorbic acid, indole-3- carbinol, curcumin, firoxicam,acethylsaricylic acid) employed in the present study, L-phenylalanine (100ff), L-ascorbic acid (100#M) and iBdote-3-carbinel t 10Df) showed significantly protective effects on the OTA-iBduced suppres-sion of mitogenic responses id uifro. Howeuer, when the protective of·fects of these agents were examinedin rr'ua only indole-3-carbinol showed significantly protective respoases. It has been ebserved that Iyin-phatic cell population in thc spleen and thymus was decreased in raice given OTA by hematoBylin-eosinstaining. These data indicate that OTA suppresses the cell-mediated and humoral immune functioBsand this OTA-iBduced supflression of immune functions can he alleviated by indole-3-carbinol.
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김형묵,이규문 忠北大學校 平生體育硏究所 1996 平生體育硏究所 論文集 Vol.8 No.-
An increase in age is accompanied by structural as well as functional changes in all organs of the human body. A decrease in skeletal muscle mass, however, is one of the most striking features of the aging process. The mechanisms of muscular functional changes with aging are very controversial, such as in muscle total mass, strenghth, number of motor units, specific fiber types, fiber number, oxidative capacity, and hormonal action. Therefore, it was focused and examined on muscle strength and hypertrophy in this study. Eight male subjects(69.9+/-4.13yrs) were participated in weight training for 12 weeks (3 day/week, 3 set/day). After the weight training, their muscle strength, hypertropy and muscle composition were tested. The conclusions were as followings: 1) Before the training after 4,8, and 12 weeks trainings, their strengths were improved: gripping, abdominal, leg, and back strengths. 2) After the training, the muscle mass of midthigh, scanned by CT, was improved on both right and left. 3) After the training, the fat of midthigh, seanned by CT, was decreased on both right and left. 4) The girth of each part of body, scanned by CT, was increased on upperarm, forearm, chest, lowerthigh, and calf, but decreased on upperthigh and midthigh.
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중년여성들의 숙련자와 비숙련자간 수영운동 후 신체조성 비교
김형묵,박관도 청주대학교 학술연구소 2004 淸大學術論集 Vol.4 No.-
The purpose of this study is to analyze 'how swimming' for twelve weeks affects the body development of middle-aged women. An investigation into the body development of thirteen women in a two-month period and a one-year period was performed. Each woman that participated in the swimming trials was asked to continually practice one hour in the morning three times a week before and after the investigation. The study arrived at the following conclusion. 1) The weight after swimming was found to have decreased significantly by 0.7kg in the case of the unskilled group and 0.6kg in the case of the expert group. 2) FAT(%) before and after investigation had similarly decreased by 2% in the case of the unskilled group and by 1.7% in the case of the expert group. FAT percentages(%) of the unskilled group were reduced by more than 0.3% when compared to the expert group. 3) FAT mass(kg) before and after the investigation had similarly decreased by 1.3kg in the case of the unskilled group and by 1.1kg in the case of the expert group. FAT mass(kg) of the unskilled group was reduced by more reduced by more than 0.2kg in comparison with the expert group. 4) The variation of lean body mass(kg) before and after the investigation had increased by 0.8kg in the case of the unskilled group and by 0.5kg in the case of the expert group. Lean body mass(kg) of the unskilled group increased by more than 0.3kg in comparison with the expert group. 5) Total body water before and after the unskilled group and expert group didn't change. In summation, swimming for one hour three times a week was found to reduce the FAT(%) and FAT mass(kg) of middle-aged women.
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