반도체 산업에서의 Enterprise Document Management Architecture 구현에 관한 연구

장현성,이영중,송하석,한영준,안정삼 한국경영과학회 2001 한국경영과학회 학술대회논문집 Vol.- No.2

A systematic construction and re-use of technology related to the product development and production has been the most important for the semiconductor industry dependent on process and equipment Therefore, numerous outputs in the form of paper has been produced in the process of information management ranging from the creation to recycling and disposal of technologies. In this research, the technology and documents necessary for the business management in the field of semiconductor manufacturing were classified in an effort to solve problems while the modeling of document management architecture at the enterprise level was performed by properly setting up the security system to prevent the unauthorized disclosure of the product development technology to the third parties. Especially, the product and process specification are designed in such a way as to ensure a real-time response in interface with the production system in order to shorten the development lead-time and improve the productivity. This paper is to discuss the modeling approach, the strategy to construct the system and its results.

악골에 발생한 Florid Osseous Dysplasia의 치험례

장현석 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

This is case report of florid osseous dysplasia occurred in the entire maxilla and mandible of 47-year-old female. Florid osseous dysplasia is an expansile, exuberant asymptomatic form of benign fibro-osseous disease of the periodontal ligament, often associated with jaw cysts and to be though as an abnormal reaction of bone to irritation or stimulation. The treatment was performed with removal of the necrotic bone, bone curretage and hyperbaric oxygen therapy. The patient did not well postoperatively and has shown sign of persistant infection with pus discharge.

악안면골절의 임상적고찰

장현석,장명진 대한안악면성형재건외과학회 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

With the increase of population, dramatic urbanization, traffic, leisure and sports, the number of maxillofacial injury has increased markedly. Subsequently the number of motor vehicle accident, sports accident and industrial accident were increased and the number of oral and maxilllofacial trauma patients were also markedly increased. A clinical study on 177 patients with facial bone fracture who visited Kangnam General Hospital during 4 years(1992-1995) was done by analysing sex, cause, fracture site, treatment method, complication and involvement of other body part. The results obtained were as follows : 1. The occurrence was more frequent in male than in female with the ratio of 4.2 : 1 and most frequently in twenties. 2. Violence was the most common cause of facial bone fracture. 3. Mandible was the most frequently occurred site and there were more cases of simple fracture(81.9%) than cases of compound fracture. 4. Simple fracture was most frequently occurred(44.0%). 5. In mandible fracture, simple fracture was 86.1%, fracture site was average 1.5 sites, most frequently in symphysis. 6. As treatment methods, open reduction(78.5%) was used more frequently than closed reduction(21.5%). 7. Post-operative complication occurred in 29.4% of the cases. 8. Other injuries that were related to maxillofacial fracture occurred in 28.2%.

악하부종괴에 대한 임상적 연구

장현석,유준영 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

There are many kind of diagnostic entities in submandibular or neck masses, and we can set up treatment plan and estimate treatment result, prognosis by accurate diagnosis. By reasoning medical and dental history, physical examination, anatomical consideration of masses in submandibular or neck area, location of masses, laboratory and radiographic studies, we can formulate a clinical diagnosis or differential diagnosis. Although a clinical diagnosis might suffice in some instances, a definitive(microscopic) diagnosis is frequently required for proper treatment. In order to get some information about making accurate diagnosis and setting up appropriate treatment plan, we did clinical study and histopathologic classification of 82 patients who visited and were operated for sudmandibular masses at Department of Oral and Maxillofacial Surgery in Seoul National University Hospital from 1988 to 1992. The result were as follows: 1. Submandibular masses occured most frequently in forties and fifties, and there was no sex predilection. 2. Chief complaints were in order of mass, swelling, pain and consistency were sofe mass, mobile hard mass, firm mass, diffuse swelling in descending order. 3. Most frequent pathologic finding was lymphadenitis. 4. Site of submandibular masses were submandible, neck, submental, retromandible in descending order, and there was no predilection between left and right side. 5. Accuracy rate between clinical impression and result was 51.2%.

퍼지시스템과 진화알고리즘 기반 지역부하예측 시스템개발

張右晳,指眩旻,姜渙一 명지대학교 산업기술연구소 2006 産業技術硏究所論文集 Vol.25 No.-

This paper proposes a time series prediction method for the nonlinear system using the fuzzy system and the evolutionay strategy and the genetic algorithm. At first, we obtain the optimal fuzzy membership function using the evolutionary strategy or genetic algorithm. With the optimal fuzzy rules and its input differences, a better time prediction series system may be obtained. We obtain a good result for the time prediction of the regional electric load. In addition we implement the graphic user interface for the proposed algorithms.

이익관리연구에 관한 개관 : 1980-1990년대 연구를 중심으로

장석오,노현섭 한국세무회계학회 2003 세무회계연구 Vol.12 No.-

본 연구는 이익관리에 대한 증거와 그 증거가 회계연구자들에 대한 함의를 검토하고 이익관리에 대한 가능한 미래연구 분야를 개관한다. 전반적으로, 대부분의 선행연구들은 이익관리가 존재하는지의 여부와 이익관리가 행해지는 이유에 대해서만 초점을 맞추고 있다. 선행연구의 결과는 이익관리가 주식시장의 인지에 영향을 미치기 위하여, 경영자의 보상을 증가시키기 위하여, 차입계약의 위반가능성을 감소시키기 위하여, 그리고 규제적 개입을 회피하기 위한 목적 등을 포함한 다양한 동기에서 수행되고 있다는 것을 시사해 준다. 본 연구의 검토결과가 갖는 한가지 함의는 이익관리의 존재여부에 대한 보다 강력한 검정으로부터 얻어질 가능성은 적은 반면, 회계상의 재량이 이익관리에 얼마나 빈번하게 사용되는지 그리고 이러한 행위가 이익에 얼마나 많은 영향을 미치는지에 대한 연구에서 미래의 공헌점이 얻어질 것으로 생각된다. 또한, 경제에서 이익관리가 주가와 자원배분에 미치는 영향에 대한 상반된 결과를 더욱 일치시키는 것이 필요할 것으로 생각된다.

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

Squalene Adjuvant를 이용한 단백질 항원의 세포성 면역반응 유도

도현주,김성열,안종성,하영주,이승찬,오재택,장명호,정홍석,문홍모,박해준 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

To investigate the role of adjuvant for cytotoxic T lymphocytes (CTL) induction, squalene-based adjuvant was studied its capability eliciting to the induction of cellular immunity as well as humoral immunity to exogeneous proteins. Ovalbumin (OVA) was used as model proteins. It was demonstrated that antigen formulation consisted of metabolizable oil squalene mixed with Tween 80 and pluronic L121 (S/TJ121) could induced the antigen specific CTL responses and antibodies irrespective of immunization routes in mice. We also demonstrated that this antigen formulation was a inducer of CD8+, major histocompatibility complex(MHC) class I-restricted, and antigen-specific C;1'Ls. These data suggest that the squalene-based emulsion system is a potent adjuvant inducing cellular immunity as well as humoral immunity.

항원의 말단 아미노산이 T 임파구 자극에 미치는 영향의 분석

강현석,장용석 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

Immune responsiveness has been known to be determined by the type of individual's major histocompatibiiity complex (MHC). For example, H-2k or H-2a haplotype-bearing mice are high-responders to hen egg-white lysozyme (HEL) antigen, while H-2b or H-2d haplotype-bearing mice are low- or non-responders to HEL. When HEL is injected to the high-responder C3H (H-2k) mice, most of the T lymphocytes recognize the HEL 46-61 epitope region. However, HEL 46-61 specific T lymphocytes are hardly detected in HEL injected low-responder C57BL/6 (H-2') mice. Previously, as an initial step to understand the mechanisms involved in unresponsiveness of HEL low-responder mice to an HEL 46-61 epitope, the antigen recognition pattern of an HEL 46-61 region specific T hybridoma clone originated from C57BL/6 mice was analyzed. The minimal epitope region recognized by the T hybridoma clone was HEL 51-60 and shifted one amino acid from that of high-responder C3H mice. In addition, the arginine at position 61 has an inhibitory effect for T hybridoma cell stimulation by. inhibiting the binding of the epitope peptide with MHC class-II molecules mainly due to the large size of the side chain of the amino acid. In this study, we found that the same characteristics of the arginine are essential for stimulation of C3H T hybridoma clone, 3A9. In order to confirm the influence of arginine on T cell stimulation in T lymphocyte population of HEL high- and low-responder mice, we performed the lymph node cell proliferation assay after HEL injection. In low-responder C57BL/6 mice, the presence of arginine exerts the similar influence on T cell stimulation as shown in T hybridoma cell stimulation experiment. Interestingly however, patterns of lymph node cell proliferation assay in HEL high-responder C3H mice are somewhat different from those of T hybridoma cell stimulation experiment. For example, all the peptides containing the substitutions at position 61 with various amino acids is able to stimulate the T lymphocytes efficiently, although the peptide containing tryptophan at position 61 is the most efficient for T lymphocyte stimulation. Based on these results, possible mechanisms involved in low-responsiveness of C57BL/6 mice to an HEL 46-61 epitope region is discussed.

웨이브렛변환을 적용한 얼굴영상분할

김장원,박현숙,김창석 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

In this study, we proposed the image segmentation algorithm for facial region segmentation. The proposed algorithm separates the mean image of low frequency band from the differential image of high frequency band in order to make a boundary using HWT, and then we reduce the isolation pixels, projection pixels, and overlapped boundary pixels from the low frequency band. Also the boundaries are detected and simplified by the proposed boundary detection algorithm, which are cleared on the thinning process of 1 pixel unit. After extracting facial image boundary by using the proposed algorithm, we make the mask and segment facial image through matching original image. In the result of facial regiion segmentation experiment by using the proposed algorithm, the successive facial segmentation have 95.88% segmentation value.