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RISS 인기검색어
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- 저자 : Hyeon Nam Do (검색결과 158 건)
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서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.
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편도현(Do Hyeon Pyeon),이윤상(Yun Sang Lee),남진현(Jin Hyeon Nam),이준협(Jun Hyeop Lee),최기권(Gee Gwon Choi),조평곤(Pyong Kon Cho) 대한CT영상기술학회 2012 대한CT영상기술학회지 Vol.14 No.2
목적 CT 환자누적선량 관리를 위해서 검사 후 환자에게 영향을 미치는 유효선량 및 흡수선량을 관리하여 일정기간 동안의 누적선량을 분기 혹은 연간 권고치와 비교하여, 권고량 이상일 경우 의사처방 단계 및 CT검사 시 방사선량 주의 표시를 의료정보시스템과 연계할 수 있는 프로그램을 개발하여, CT 검사 시 표준 프로토콜 및 선량 저감화 프로토콜을 누적선량에 따라 선택적으로 적용함으로써, 환자 피폭선량 저감화에 기여할 수 있는 프로그램을 제안한다. 대상 및 방법 CT 환자누적선량 관리를 위해서 CT 장비에서 제공되는 CTDIvol과 DLP값의 신뢰도를 평가하기 위해서 본원의 임상조건을 적용하여 두부 및 전신용 팬텀과 ImPACT 프로그램을 이용한 선량측정 방법을 통해서 흡수선량과 유효선량을 비교하였고, 성인 및 소아의 연령대별 변환 인자를 DLP값에 대입하는 방법을 통해 유효선량을 비교 평가하였다. 결과 임상조건을 적용한 두부용 팬텀에서의 선량측정은 CTDIvol 35.8mGy, DLP 537mGyㆍcm, 복부용 팬텀에서는 CTDIvol 15.4mGy, DLP 616mGyㆍcm, ImPACT 프로그램에서는 두부에서 CTDIvol 41.1 mGy, DLP 617mGyㆍcm, 복부에서는 CTDIvol 18.8 mGy, DLP 752 mGyㆍcm, CT장비 표시 선량은 두부는 CTDIvol 42.0mGy, DLP 649 mGyㆍcm, 복부는 CTDIvol 17.2 mGy, DLP 951 mGyㆍcm로 나타났다. 또한, 유효선량 값은 두부용 팬텀에서는 1.12 mSv, ImPACT에서는 1.4mSv, CT장비는 1.36 mSv, 복부용 팬텀에서는 9.24 mSv, ImPACT에서는 12 mSv, CT장비에서는 14.2 mSV로 나타났다. 결론 본 연구의 CT환자누적선량관리 프로그램을 통해서 선량 저감화를 위한 적극적인 자세와 노력을 한다면 누적선량관리 프로그램의 효용성은 높을 것으로 생각한다. I. Purpose The purpose of this study is to propose a program that can manage the patient radiation dose of CT for active reduction in the radiation exposure of patient by devising a program where effective dose and absorbed dose that influence the patient are controlled after conducting the test far the management of patient radiation dose of CT, accumulated dose for certain period is compared with the recommended dose per quarter or year, and alert for radiation dose can be carried out in accordance with the medical information system in the stage of doctor’s prescription and CT test in case it has exceeded the recommended dose and selectively applying the standard protocol and radiation dose reduction protocol in accordance with the accumulated dose when conducting CT test. II. Meterial and Methods Materials and Method: In order to evaluate the reliability of CTDIvol and DLP value provided by CT equipment for the management of patient radiation dose of CT, absorbed dose and effective dose were compared through radiation dose measurement using head and whole body phantom and ImPACT program applying clinical conditions. Also, comparative evaluation of effective dose was carried out through method that substitutes conversion factors for each age group of adult and child to DLP value. III. Result In regards to dose measurement with the use of head phantom applying clinical conditions, CTDIvol of 35.8 mGy, DLP of 537 mGyㆍcm were displayed. In addition, CTDIvol of 15.4 mGy and DLP of 616 mGyㆍcm were displayed with the use of whole body phantom, In regards to ImPACT program, CTDIvol of 41.1 mGy and DLP of 617mGyㆍcm for head and CTDIvol of 18.8mGy and DLP of 752 mGyㆍcm for abdomen were displayed, In regards to CT modality, CTDIvol of 42.0mGy and DLP of 649mGyㆍcm for head and CTDIvol of 17.2mGy and DLP of 951 mGyㆍcm for abdomen were displayed Also, effective dose of head CT was revealed to be 1.12 mSv for phantom, 1.4 mSv for ImPACT, and 1.36 mSv for CT equipment and effective dose for Abdomen CT was revealed to be 9.24mSv for phantom, 12mSv for ImPACT, and 14.2mSv for CT equipment. IV. Conclusions Conclusion: Although no precise degree of danger or standard regarding the radiation exposure has been proposed through PDIS of CT in this study, I believe that the efficiency of PDIS for the reduction in radiation dose will be high when there is the willingness and effort to reduce the radiation dose with any means available.
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소아 흉ㆍ복부 CT 검사 시 소아 체적을 고려한 합리적 선량 권고기준 확립을 위한 연구
남진현(Jin Hyeon Nam),최기권(Gee Gwon Choi),편도현(Do Hyeon Pyoen),홍수연(Su Yeon Hong),이성현(Sung Hyun Lee),이현우(Hyeon Woo Lee) 대한CT영상기술학회 2013 대한CT영상기술학회지 Vol.15 No.1
목적 : 10세 이하 소아 흉ㆍ복부 CT검사 시 팬텀 직경 변화에 따른 선량 평가를 통해 각 나이별 흉ㆍ복부 직경에 따른 가중치를 체계적으로 세분화하여 합리적인 권고기준을 확립하는데 있어 도움이 되고자 한다. 대상 및 방법 : CT장치는 Siemens사의 somatom Definition 128MSCT, Philips사의 Brilliance 64MDCT, Toshiba사의 Aquilion ONE 640MSCT를 사용하였다. 선량측정은 16, 21, 24, 27, 32cm 아크릴 팬텀과 형광유리선량계를 이용하여 CTDIvol값을 측정하였으며, 각 팬텀 직경별 증감률을 구해 소아 피폭선량 측정 시 나이별 가중계수를 계산하였다. 결과 : 소아검사의 프로토콜 환경에 따른 CTDIvol값의 결과 Siemens사의 경우 16 cm 아크릴 팬텀 환경에서 측정한 CTDIvol값이 32cm 아크릴 팬텀 환경에서 측정한 CTDIvol값보다 97.6%, Philips사의 경우 108.7%, Toshiba사의 경우 102% 증가하였다. 각 장비에서 팬텀 직경에 따른 CTDIvol 증가율의 평균값은 32 cm과 27 cm에서 22.8% (p=0.18), 32cm과 24cm에서 42.4% (p=0.082), 32cm과 21cm에서 60.9% (p=0.102), 32cm과 16cm에서 102.4% (p=0.162)로 나왔다. 결론 : 본 연구에서 제안한 소아 나이별 흉ㆍ복부 직경에 따른 세분화된 가중계수는 소아 체적을 고려한 합리적인 소아 선량 권고기준 확립에 도움이 될 것으로 사료된다. Purpose : This study tries to give help in establishing reasonable recommended standards by systematically subdividing the weight depending on the chest and abdominal diameter by each age through dose assessment according to the variation of phantom diameter in chest and abdominal CT of pediatric under the age of 10. Materials and Methods : For CT device, Siemens’ somatom Definition 128MDCT, Philips’ Brilliance 64MDCT and Toshiba’s Aquilion one 640MDCT were used. For dosimetry, CTDIvol value was measured by using 16, 21, 24, 27, 32 cm acryl phantom and PLD and weighting factor by age was calculated when measuring pediatric exposure dose by finding variation rate by each phantom diameter. Results : The result of CTDIvol value according to the protocol environment of pediatric examination showed that in case of Siemens, CTDIvol value measured in 16 cm acryl phantom environment increased 97.6% more than CTDIvol value measured in 32 cm acryl phantom environment and in case of Philips, 108.7% more and in case of Toshiba, 102% more. The average value of CTDIvol increase rate depending on the phantom diameter of each device turned out to be 22.8% at 32 cm and 27 cm (p=0.18), 42.4% at 32 cm and 24 cm (p=0.082), 60.9% at 32 cm and 21 cm (p=0.102) and 102.4% at 32 cm and 16 cm (p=0.162). Conclusion : Subdivided weighting parameter depending on the chest and abdominal diameter by pediatric age proposed in this study is considered to be helpful in establishing reasonable international recommended standards considering pediatric volume.
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Do, Jeong Hyeon,Jeon, Chang Woo,Nam, Duk Hyun,Kim, Choong Nyun Paul,Song, Young Bum,Lee, Sung Hak Trans Tech Publications, Ltd. 2010 Materials science forum Vol.654 No.-
<P>This study aimed at investigating the ballistic performance of Zr-based bulk metallic glass/Ti surface composites fabricated by high-energy electron-beam irradiation. The ballistic impact test was conducted on surface composite plates to evaluate the ballistic performance. Since the surface composite layers were observed to block effectively a fast traveling projectile, while many cracks were formed in the composite layers, the surface composite plates were not perforated. The surface composite layer containing ductile β dendritic phases showed the better ballistic performance than the one without containing dendrites because dendritic phases could hinder the propagation of shear bands or cracks.</P>
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Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Do-Geun Kim,Hyeon-Joong Kim,Sun-Hye Choi,Sung Min Nam,Hyoung-Chun Kim,Hyewhon Rhim,Ik-Hyun Cho,Man Hee Rhee,Seung-Yeol Nah 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.3
Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor. Recently, we reported that systemic administration of gintonin increases blood-brain barrier (BBB) permeability via the paracellular pathway and its binding to brain neurons. However, little is known about the influences of gintonin on in vivo neuron morphology and migration in the brain. Materials and methods: We examined the effects of gintonin on in vitro migration and morphology using primary hippocampal neural precursor cells (hNPC) and in vivo effects of gintonin on adult brain neurons using real time microscopic analysis and immunohistochemical analysis to observe the morphological and locational changes induced by gintonin treatment. Results: We found that treating hNPCs with gintonin induced morphological changes with a cell rounding following cell aggregation and return to individual neurons with time relapses. However, the in vitro effects of gintonin on hNPCs were blocked by the LPA1/3 receptor antagonist, Ki16425, and Rho kinase inhibitor, Y27632. We also examined the in vivo effects of gintonin on the morphological changes and migration of neurons in adult mouse brains using anti-NeuN and -neurofilament H antibodies. We found that acute intravenous administration of gintonin induced morphological and migrational changes in brain neurons. Gintonin induced some migrations of neurons with shortened neurofilament H in the cortex. The in vivo effects of gintonin were also blocked by Ki16425. Conclusion: The present report raises the possibility that gintonin could enter the brain and exert its influences on the migration and morphology of adult mouse brain neurons and possibly explains the therapeutic effects of neurological diseases behind the gintonin administration.
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