PREPARATION OF N-(3-BROMO-2,4,6-TRIMETHYLACETANILIDE)IMINODIACETIC ACID AND ITS ${99M}^TC$-COMPLEX FOR HEPATOBILIARY IMAGING

CHOI OK-JA,HONG YOUNG-DON,GWON HUI-JEONG,CHOI SANG-MU,CHOI SUN-JU Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.4

N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of $SnCl_2$. To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with $^{99m}Tc-BrTIDA$ revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared $^{99m}Tc-BrTIDA$ can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.

수소로 환원시킨 니켈도프된 α형 산화철상에서의 일산화탄소 산화반응메카니즘

최재시,오응주,전종호,원휘준,김돈,최찬유 연세대학교 자연과학연구소 1983 學術論文集 Vol.11 No.-

수소로 환원시킨 니켈도프된 α-Fe_2O_3의 촉매성이 CO산화반응을 통하여 150~250℃에서 연구되었다. CO의 산화속도는 CO에 대하여 1차이며 O_2에 대하여 0.5차 반응이었다. O_2는 수소환원에 의하여 생성된 산소공위에 흡착되고 CO는 흡착된 산소와 반응함을 확인하였다. 전기전도도 데이타는 산소의 흡착이 전기전도전자를 제거한다는 사실을 보여주었고, CO와 흡착된 O_2와의 반응이 전체 반응의 율속단계임을 규명하였다. The catalytic activity of "Hydrogen-Reduced" Ni-doped α-Fe_2O_3 has been investigated the oxidation of carbon monoxide at 150 to 250℃. The oxidation rates have been related with 1.5 order kinetics; first order with respect to CO and 1/2 with respect to O_2. Oxygen is adsorbed on oxygen vacancy that formed through H_2 reducing, on the other hand CO seems to react with already adsorbed oxygen. The conductivities show that adsorption of O_2 on oxygen vacancy withdraws the conduction electron from the vacancy and the reaction of CO with adsorbed oxygen is rate determining step for overall reaction.

Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy

Kwang-Hui Kim,Beom-Kyu Choi,Young-Ho Kim,Chungyong Han,Ho-Sik Oh,Don-Gil Lee,Byoung-Se Kwon 한국실험동물학회 2017 한국실험동물학회 학술발표대회 논문집 Vol.2017 No.2

PREPARATION OF N-(3-BROMO-2,4,6-TRIMETHYLACETANILIDE)IMINODIACETIC ACID AND ITS99MTC-COMPLEX FOR HEPATOBILIARY IMAGING

OK-JA CHOI,최선주,YOUNG-DON HONG,HUI-JEONG GWON,SANG-MU CHOI 한국원자력학회 2005 Nuclear Engineering and Technology Vol.37 No.4

N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of SnCl2. To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with 99mTc-BrTIDA revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared 99mTc-BrTIDA can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.

학생반응으로 살펴본 문제바탕학습 교육과정의 질적 평가

김주희(Ju-Hui Kim),김지영(Ji Young Kim),손희정(Hee Jung Son),최윤호(Yoon-Ho Choi),홍경표(Kyung-Pyo Hong),안병헌(Byung-Heon Ahn),엄대용(Dae-Yong Uhm),진영은(Young Eun Chin),서정돈(Jung-Don Seo) 한국의학교육학회 2004 Korean journal of medical education Vol.16 No.2

Purpose: Recently established in 1997, Sungkyunkwan University School of Medicine was the first medical school in Korea to adopt problem-based learning (PBL) as a core curriculum from the very beginning. The purpose of this study was to evaluate the PBL curriculum from the viewpoint of the medical students. Methods: This study used a qualitative approach to understand students perceptions of the positive aspects of PBL. A total of 22 second-year medical students at Sungkynkwan medical school were surveyed. Student perceptions were obtained from questionnaire and face-to-face interviews. The interview was designed to evoke more personal and in-depth responses. Results: Students perceptions of the effects of PBL were found to be very favorable. Most students showed positive responses on the issues of more active learning attitude, self-directed learning, motivation to study, improved problem solving, and integrated learning. Conclusion: The results of this study demonstrated that the students had a good understanding of PBL and experienced its positive aspects of PBL approach. It might be concluded that PBL was successfully implemented into the curriculum and specific and expected effects of PBL accomplished.

노인의료복지시설 조직문화와 조직유효성관계 : 요양보호사의 감정노동전략과 자기효능감의 매개효과를 중심으로

박정희 ( Park Jeong Hui ),최효돈 ( Choi Hyo-don ) 한국장기요양학회 2018 장기요양연구 Vol.6 No.2

본 연구는 노인의료복지시설에서 종사하는 요양보호사들이 지각하는 조직문화요인이 조직유효성에 미치는 영향을 분석하고, 감정노동전략과 자기효능감의 매개효과에 대한 검증을 통하여 사회 복지적 실천적 방안을 제시하기 위해 수행되었다. 본 연구는 경기 남서부지역 노인의료복지시설에서 근무하는 요양보호사 354명을 연구대상으로 하였으며, 확인적 요인분석을 실시하여 조직문화와 조직유효성의 관계에서 자기효능감과 감정노동전략의 매개효과의 적합성을 평가하고, 각 변수간의 경로와 직·간접 효과를 알아보기 위해서 구조방정식 모형을 설정하고 분석을 실시하였다. 연구결과 첫째, 노인의료복지시설 조직문화는 내부지향, 통합의 중심보다는 융통성과 안정성을 중심으로 하는 외부지향의 차이를 중시하는 개발문화와 합리문화가 조직유효성에 긍정적으로 영향을 미치는 것으로 나타났으며, 자기효능감 요인에서는 자기조절효능감과 과제난이도선호가 강할수록 조직유효성은 강해지는 것으로 분석되었다. 감정노동전략의 요인으로는 심층행위와 진심행위의 전략을 사용할수록 조직유효성은 강해지는 것으로 분석되었다. 둘째, 노인의료복지시설 종사자가 지각하는 조직문화와 조직유효성의 관계에서 자기효능감과 감정노동전략이 매개변수로 투입될 때, 자기효능감은 조직유효성에 직접적인영향을 미칠 뿐 아니라 감정노동전략을 통해 간접적으로 조직유효성에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 결과를 기초로 하여 노인의료복지시설의 인적자원관리를 위한 대안을 모색하였다는 점에서 본 연구의 의의가 있다. The purpose of this study is to analyze the effects of organizational culture factors perceived by nursing care workers in elderly medical welfare facilities on organizational effectiveness and to propose social welfare practical ways through verifying the mediating effects of emotional labor strategy and self - efficacy. The purpose of this study was to investigate 354 caregivers working in the elderly medical welfare facilities in the southwestern part of Gyeonggi. The results of this study are as follows: First, the validity of the mediator effect of emotional labor strategy and self, In order to investigate the direct and indirect effects of each variable, a structural equation model was set up and analyzed. The results of this study are summarized as follows. First, the development culture and rational culture putting a premium on a difference of flexible and stable outgoing-oriented organization culture and inner-oriented and integrated organization exert its positive influence on culture-efficiency. In the factors of self-efficiency, more preferring to challenge difficult job, the self- efficiency is tightened up. The emotional labor strategy - in depth and sincere behavior strateges - of elderly medical welfare facility workers makes organizational effectiveness strengthen. Second, the more positive organizational culture perceived by workers in medical welfare facilities for the elderly is, the higher the organizational effectiveness is, the more the self - efficacy and emotional labor strategy are positively influenced. Based on these results, a proposal for human resource management of the elderly medical welfare facility was conducted.

Screening for Korean Vegetables with Anticarcinogenic Enzyme Inducing Activity Using Cell Culture System

Su-Mi Kim,Seung Hee Ryu,Hui-Don Choi,Sung-Su Kim,Jeong-Hwan Kim,Jong-Sang Kim 한국식품영양과학회 1998 Preventive Nutrition and Food Science Vol.3 No.3

There is extensive evidence suggesting the protective role of fruits and vegetables against chemically induced carcinogenesis. We have tested the ability of a representative range of Korean vegetables to act as blocking agents against neoplastic initiation by determining the induction level of quinone reductase, an anticarcinogenic marker enzyme, in hepa1c1c7 cells exposed to vegetable extracts. Among thirty vegetables tested, Arctium lappa (Burdock), Brassica juncea (Mustard leaf), Pteridium aguilinum (Bracken) and Chrysanthemum coronarium (Crown daisy) caused a significant induction of quinone reductase activity with a limited increase in arylhydrocarbon hydroxylase activity. Combination of crown daisy with burdock had synergistic effect on quinone reductase induction. Quinone reductase-inducing activity was found mostly in hexane and ethylacetate fractions of MeOH extract of crown daisy while it was not detected in n-butanol and water fractions. Animal study using SD rats demonstrated that crown daisy intake induced quinone reductase activity in liver, kidney, lung, and small intestine, confirming the presence of potent QR inducer(s) in crown daisy. These data suggest that some vegetables including crown daisy induced QR merits further investigation as a potential cancer preventive agent in human.

Metal artifact 감소를 위한 CT simulator 영상 재구성의 유용성 평가

최지훈,박진홍,최병돈,원희수,장남준,구장현,홍주완,Choi, Ji Hun,Park, Jin Hong,Choi, Byung Don,Won, Hui Su,Chang, Nam Jun,Goo, Jang Hyun,Hong, Joo Wan 대한방사선치료학회 2014 대한방사선치료학회지 Vol.26 No.2

목 적 : CT simulation 시 고 밀도 인공물에 의해 발생된 metal artifact는 주변조직의 관찰능력 감소 및 CT number 변화에 영향을 미치게 된다. 본 연구에서는 CT 촬영 시 Metal Artifact Reduction for Orthopedic implants(O-MAR)의 유용성을 평가해 보고자 한다. 대상 및 방법 : CT simulator를 이용하여 Gammex phantom과 Rando phantom의 original 영상, 고 밀도 인공물을 삽입 후 획득한 non O-MAR 영상과 O-MAR 적용 영상을 획득하였다. CT 영상 평가를 위해 Gammex phantom CT 영상 내 5개 조직과 artifact 영향을 직접 받는 3개 지점에 관심영역(region of interest, ROI)을 각각 설정하고, CT number와 노이즈(standard deviation, SD)를 평균값으로 비교, 분석하였다. 고 밀도 인공물 주변조직의 CT number 변화에 따른 선량변화 확인을 위해 전산화치료계획시스템 Eclipse를 이용하여 Rando phantom CT 영상 3곳에 원기둥 체적을 형성하였다. 치료계획은 6 MV 광자선, 7개 조사면, 조사야 $15{\time}15cm$, 1회당 처방선량 100 cGy를 적용하여 수립하고 평균선량을 비교, 분석하였다. 두 실험 모두 original 영상을 기준으로 분석하였다. 결 과 : Gammex phantom을 이용한 영상평가 실험에서 각 영상별 5개 조직의 CT number 차이는 작았으며, artifact 영향을 직접 받는 3개 지점은 O-MAR 적용 시 original 영상과 유사하게 나타났다. 그리고 O-MAR 적용 시 8개 지점의 SD는 non O-MAR 영상보다 모두 감소되었다. Rando phantom을 이용한 선량변화 실험 또한 O-MAR 적용 시 original 영상과 유사하게 나타났다. 결 론 : O-MAR 적용 시 고 밀도 인공물 artifact로 인한 영상 왜곡 및 SD 감소로 영상의 질이 향상되었으며 CT number 보정에 유용하였다. 이는 체표윤곽도(contour) 생성 및 치료계획 수립에 이점이 있을 것이라 사료된다. Purpose : This study presents the usefulness assessment of metal artifact reduction for orthopedic implants(O-MAR) to decrease metal artifacts from materials with high density when acquired CT images. Materials and Methods : By CT simulator, original CT images were acquired from Gammex and Rando phantom and those phantoms inserted with high density materials were scanned for other CT images with metal artifacts and then O-MAR was applied to those images, respectively. To evaluate CT images using Gammex phantom, 5 regions of interest(ROIs) were placed at 5 organs and 3 ROIs were set up at points affected by artifacts. The averages of standard deviation(SD) and CT numbers were compared with a plan using original image. For assessment of variations in dose of tissue around materials with high density, the volume of a cylindrical shape was designed at 3 places in images acquired from Rando phantom by Eclipse. With 6 MV, 7-fields, $15{\time}15cm2$ and 100 cGy per fraction, treatment planning was created and the mean dose were compared with a plan using original image. Results : In the test with the Gammex phantom, CT numbers had a few difference at established points and especially 3 points affected by artifacts had most of the same figures. In the case of O-MAR image, the more reduction in SD appeared at all of 8 points than non O-MAR image. In the test using the Rando Phantom, the variations in dose of tissue around high density materials had a few difference between original CT image and CT image with O-MAR. Conclusion : The CT images using O-MAR were acquired clearly at the boundary of tissue around high density materials and applying O-MAR was useful for correcting CT numbers.

Investigation of reportable communicable diseases and parasitic diseases in freshwater wild fish and crustacean in Soyang Lake

Hyun-Kyu Kim,Seong-Hee Mun,Seo-Hui Gwon,Hyun-Ji Oh,Se-Ryun Kwon,Hye-Sung Choi,Sung-Don Hwang,Jeong-Ho Lee,Maeng-hyun Son,Joon-Yeong Kwon 한국수산해양기술학회(구 한국어업기술학회) 2017 한국수산해양기술학회 학술발표대회 Vol.2017 No.11

Comparison of Volumes between Four-Dimensional Computed Tomography and Cone-Beam Computed Tomography Images using Dynamic Phantom

김성은,원희수,홍주완,장남준,정우현,최병돈,Kim, Seong-Eun,Won, Hui-Su,Hong, Joo-Wan,Chang, Nam-Jun,Jung, Woo-Hyun,Choi, Byeong-Don Korean Society for Radiation Therapy 2016 대한방사선치료학회지 Vol.28 No.2

목 적 : Computerized imaging reference systems 동적팬텀을이용한 cone-beamcomputed tomography(CBCT) 영상과 four-dimensionalcomputed tomography(4DCT) 영상의 체적을 비교분석 하고자 한다. 대상 및 방법 : 동적팬텀 내에 직경 1, 2, 3 cm 노드를 각각 삽입하고, CT simulator와 TruebeamSTx X-ray Imaging system을 이용하여 4DCT 영상과 CBCT 영상을 얻었다. 4DCT 영상은 maximum intensity projection(MIP), minimum intensity projection(MinIP), 그리고 average intensity projection(AVG)영상으로 재구성 하고 노드의 체적은 Eclipse system의 CT ranger tool로 CT number를 설정하여 측정하였다. 결 과 : CBCT를 기준으로 노드1, 2, 3 cm의 체적을 비교하였을 때 4DCT의 MIP는 0.54~2.33, 5.16~8.06, 9.03~20.11 ml, MinIP는 0.00~1.48, 0.00~8.47, 1.42~24.85 ml, AVG는 0.00~1.17, 0.00~2.19, 0.04~3.35 ml의 차이를 보였다. 결 론 : 노드의 체적을 비교한 결과 CBCT 영상은 4DCT의 AVG 영상과 유사한 것으로 확인되었다. Purpose : The aim of this study was to compare the differences between the volumes acquired with four-dimensional computed tomography (4DCT)images with a reconstruction image-filtering algorithm and cone-beam computed tomography (CBCT) images with dynamic phantom. Materials and Methods : The 4DCT images were obtained from the computerized imaging reference systems (CIRS) phantom using a computed tomography (CT) simulator. We analyzed the volumes for maximum intensity projection (MIP), minimum intensity projection (MinIP) and average intensity projection (AVG) of the images obtained with the 4DCT scanner against those acquired from CBCT images with CT ranger tools. Results : Difference in volume for node of 1, 2 and 3 cm between CBCT and 4DCT was 0.54~2.33, 5.16~8.06, 9.03~20.11 ml in MIP, respectively, 0.00~1.48, 0.00~8.47, 1.42~24.85 ml in MinIP, respectively and 0.00~1.17, 0.00~2.19, 0.04~3.35 ml in AVG, respectively. Conclusion : After a comparative analysis of the volumes for each nodal size, it was apparent that the CBCT images were similar to the AVG images acquired using 4DCT.