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Wound healing potential of antibacterial microneedles loaded with green tea extracts
Park, S.Y.,Lee, H.U.,Lee, Y.C.,Kim, G.H.,Park, E.C.,Han, S.H.,Lee, J.G.,Choi, S.,Heo, N.S.,Kim, D.L.,Huh, Y.S.,Lee, J. Elsevier 2014 Materials Science and Engineering C Vol.42 No.-
This study evaluates the utility of an antibacterial microneedle composed of green tea (GT) extract and hyaluronic acid (HA), for the efficient delivery of GT. These microneedles have the potential to be a patient-friendly method for the conventional sustained release of drugs. In this study, a fabrication method using a mold-based technique to produce GT/HA microneedles with a maximum area of ~50mm<SUP>2</SUP> with antibacterial properties was used to manufacture transdermal drug delivery systems. Fourier transform infrared (FTIR) spectrometry was carried out to observe the potential modifications in the microneedles, when incorporated with GT. The degradation rate of GT in GT/HA microneedles was controlled simply by adjusting the HA composition. The effects of different ratios of GT in the HA microneedles were determined by measuring the release properties. In HA microneedles loaded with 70% GT (GT70), a continuous higher release rate was sustained for 72h. The in vitro cytotoxicity assays demonstrated that GT/HA microneedles were not generally cytotoxic to Chinese hamster ovary cells (CHO-K1), human embryonic kidney cells (293T), and mouse muscle cells (C2C12), which were treated for 12 and 24h. Antimicrobial activity of the GT/HA microneedles was demonstrated by ~95% growth reduction of gram negative [Escherichia coli (E. coli), Pseudomonas putida (P. putida), and Salmonella typhimurium (S. typhimurium)] and gram positive bacteria [Staphylococcus aureus (S. Aureus) and Bacillus subtilis (B. subtilis)], with GT70. Furthermore, GT/HA microneedles reduced bacterial growth of infected wound sites in the skin and improved wound healing process of skin in rat model.
뇌로 전이된 인세포암(Signet-Ring Cell Carcinoma) 1례 보고
허양옥,이동화,박응범,이유복,정헌화,김헌주,김상철,정상섭,이헌재 中央醫學社 1975 中央醫學 Vol.28 No.4
The metastatic carcinoma of the brain comprises about 15 to 25 per cent of total brain tumors and most of them originate from the lung. Additional primary sites such as the breast, kidney, large intestine, prostate are rare and the stomach as primary site is very rare. We experienced a case of metastatic signet-ring cell carcinoma to the brain originated from the stomach, which was thought as subdural hematoma at the time of admission.
객체 지향형 프로그램에 의한 유한 요소법 코드 개발에 관한 연구
사종엽,채은미,이철욱,성윤제,허준성,편상욱,강태영 嶺南大學校 工業技術硏究所 1994 工業技術硏究所論文集 Vol.22 No.1
A computer code of finite element method is developed by using the ?? programming language. The concept of class, inheritance, and polymorphism in ?? improves the modularity and the flexibility(such as potability, implantability, and expandability) of engineering software. The graphic user interface (GUI) is designed by using the MFC(Microsoft Foundation Class) based on ??, and combined successfully with the main code of FEM solver. This study shows the superior of OOP(Object-Oriented programming) such as ?? to other progamming languages when applied to complicated engineering problems.
가스분무 및 분무성형법에 의한 Al-Pb 베아링 제조에 관한 연구 (1)
양영석,성장현,박신성,정철민,허태녕,정은 대한금속재료학회(대한금속학회) 1990 대한금속·재료학회지 Vol.28 No.9
Spray Forming technology has been developed at the Department of Materials Science and Engineering, Univ. of Ulsan, for the fabrication of tube, billet and plate of Al-12%Pb alloys. Spray Forming Process involves atomizing a stream of molten metals and collecting the droplets on a substrate before they have solidified, The effects of geometry(orifice diameter and tip design) and position of the metal delivery orifice in atomization device on the pressure characteristics at the tip of orifice have been studied. Mathematical model has been developed to predict the velocity and temperature profiles of the droplets as a function of their flight distances. Microstructural characteristics of Al-12%Pb hyper-monotectic alloys by spray forming process were examined. Dense (~99. 4%) material with fine-grained equiaxed microstructure was spray-formed using nitrogen as the atomizing gas. It was found that lead(Pb) particles existing in the microstructure were homogeneously distributed in the aluminium matrix and along the grain boundaries. The shape of lead particle were approximately spherical and the mean particle size was about 3-4㎛.
새로 국내에서 밝혀진 균주(R19)와 전통적 균주를 이용하여 혈청학적으로 진단된 쯔쯔가무시병의 임상상 및 항체반응 양상
이수기,이은경,허충,임병욱,김용림,강재승,이진관,조준탁,박동철,박경현 대한감염학회 1991 감염 Vol.23 No.1
From September to December 1989, eighteen cases of tsutsugamushi disease were diagnosed by indirect immunofluorescent antibody test in Ulsan-Ulchu area. Their clinical features and patterns of antibody response to R. tsutsugamuschi were analyzed. It was most prevailing in female over 30 years old. Most of patients (16 patients) were rural inhabitants. Two patients in urban area had reaped the rice in the rice field at several days before onset of the disease. It occurred between September and November with a peak in October. Chief complaints of patients were febrile sensation with or without chills or headache. All patients had fever and chills. Headache and myalgia were common. In one patient, delirium with visual hallucination was seen. The major physical findings were skin rash (83%), eschr (78%), lymphadenopathy (11%). The skin rash appeared on whole body or on the trunk. The eschar appeared on the chest or abdomen or in the genial region. The antobody titer to R 19 that had been newly isolated strain in Korea was universally high. There often were anemia (31%), leukocytosis (23%). Microscopic hematuria and pyuria were also seen in routine urinalysis. Liver function tests showed eleveted aminotransferases and LDH. There were erythrophagocytic histiocytes in the bone marrows of six patients among the ten patients whose bone marrow had been aspirated. Chloramphenicol had been used in all patients. The mean time to alleviation of fever was 2.5 days. All patients were cured.
Huh, J.E.,Jung, I.T.,Choi, J.,Baek, Y.H.,Lee, J.D.,Park, D.S.,Choi, D.Y. North-Holland ; Elsevier Science Ltd 2013 european journal of pharmacology Vol.698 No.1
We investigated the effect of galangin, a natural flavonoid, on osteoclastic bone destruction in collagen-induced arthritis and examined the molecular mechanisms by which galangin affects osteoclastogenesis in bone marrow derived macrophages. In mice with collagen-induced arthritis, administration of galangin significantly reduced the arthritis clinical score, edema and severity of disease without toxicity. Interestingly, galangin treatment during a later stage of collagen-induced arthritis, using mice with a higher clinical arthritis score, still significantly slowed the progression of the disease. Extensive cartilage and bone erosive changes as well as synovial inflammation, synovial hyperplasia and pannus formation were dramatically inhibited in arthritic mice treated with galangin. Furthermore, galangin-treated arthritic mice showed a significant reduction in the concentrations of IL-1β, TNF-α and IL-17 . We found that galangin inhibited osteoclastogenic factors and osteoclast formation in bone marrow-derived macrophages and osteoblast co-cultured cells, and increased osteoprotegerin (OPG) levels in osteoblasts. Galangin and NF-κB siRNA suppressed RANKL-induced phosphorylation of the c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), but not AKT and extracellular signal-regulated kinase ½ (ERK½). Also, the JNK inhibitor SP600125 and p38 inhibitor SB203580 reduced RANKL-induced expressions of phospho-c-Jun, c-fos and NFATc1 genes during osteoclast development. In addition, galangin suppressed RANKL-induced phosphorylation of NF-κB, phospho-IκBα, inflammatory cytokines and osteoclast formation in bone marrow-derived macrophages. Our data suggest that galangin prevented osteoclastic bone destruction and osteoclastogenesis in osteoclast precursors as well as in collagen-induced arthritis mice without toxicity via attenuation of RANKL-induced activation of JNK, p38 and NF-κB pathways.