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Jin, Mei Hua,Hong, Chang Hee,Lee, Hye Young,Kang, Hyo Jin,Han, Sang Won Wiley Subscription Services, Inc., A Wiley Company 2010 Environmental toxicology Vol.25 No.1
<P>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent endocrine disruptor compound and induces multiple organ dysfunctions. The effect of TCDD exposure both in adults and in utero has been well established. However, little is known about the effects of TCDD acquired through mother's milk on the development of the male reproductive system. The aim of this study was to investigate the effects and mechanisms of TCDD from lactational exposure. TCDD (1 μg/kg) was administered to C57BL/6 mouse mothers for 4 days from the day of delivery. On postnatal day 30 (PND 30) and postnatal day 60 (PND 60), body weight, body length, and anogenital distance (AGD) of male offspring were measured. The weights of the testes and epididymides were also measured. Epididymides were used for sperm counts, and testes were used to measure the activity of antioxidant enzymes (SOD, CAT, GPX, GR), the parameters of oxidative stress (hydrogen peroxide, MDA), and testosterone. In addition, expression of p53 and the proapoptotic protein, Bax, were analyzed by Western blot. TCDD exposure decreased body weight, body length, and AGD in both PND 30 and PND 60 groups compared with the control group. The activity of all antioxidant enzymes at PND 60 was decreased after TCDD treatment. TCDD treatment decreased testicular testosterone levels in both the PND 30 and PND 60 groups. The expression of p53 and Bax were also upregulated by TCDD and did not return to normal levels by PND 60. These data suggest that TCDD affects development of male offspring when the mother is exposed to TCDD during lactation. In addition, oxidative stress is a major mediator of TCDD-induced adverse effects, and p53 may play an important role in this mechanism. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2010.</P>
Hong, Jin-Long,Qu, Zhi-Rong,Ma, Hua-Jun,Wang, Gai-Gai,Zhao, Hong Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.5
Two new complexes with 5-methyl-1-(pyridine-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (Hmptc) ligand: [$Cd(mptc)_2(H_2O)_4$] (1) and $[Cu(mptc)_4{\cdot}2H_2O]_n$ (2) were prepared and their crystal structures were determined by single crystal X-ray diffraction analyses. In complex 1, the Cd(II) ions coordinates with the pyridyl nitogen atom from the Hmptc ligand, forming a mononuclear Cd(II) compound. Complex 2 exhibits a novel two-dimensional (2D) polymer in which four Hmptc ligands stabilize the Cu(II) atom. And the coordination involves one nitrogen atom of the triazole, one oxygen atom of the carboxylic acid and the pyridyl nitrogen atom. In addition, FT-IR and solid-state fluorescent emission spectroscopy of two compounds have been determined.
Jin-Long Hong,Zhi-Rong Qu,Hua-Jun Ma,Gai-Gai Wang,Hong Zhao 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.5
Two new complexes with 5-methyl-1-(pyridine-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (Hmptc) ligand: [Cd(mptc)2(H2O)4] (1) and [Cu(mptc)4·2H2O]n (2) were prepared and their crystal structures were determined by single crystal X-ray diffraction analyses. In complex 1, the Cd(II) ions coordinates with the pyridyl nitogen atom from the Hmptc ligand, forming a mononuclear Cd(II) compound. Complex 2 exhibits a novel twodimensional (2D) polymer in which four Hmptc ligands stabilize the Cu(II) atom. And the coordination involves one nitrogen atom of the triazole, one oxygen atom of the carboxylic acid and the pyridyl nitrogen atom. In addition, FT-IR and solid-state fluorescent emission spectroscopy of two compounds have been determined.
Melanogenesis inhibitory pregnane glycosides from <i>Cynanchum atratum</i>
Jin, Qinghao,Han, Xiang Hua,Yun, Cheong-Yong,Lee, Chul,Lee, Jin Woo,Lee, Dongho,Lee, Mi Kyeong,Jung, Sang-Hun,Hong, Jin Tae,Kim, Youngsoo,Hwang, Bang Yeon Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.7
<P><B>Abstract</B></P> <P>Bioassay-guided fractionation of the methanolic extract from the roots of <I>Cynanchum atratum</I> has resulted in the isolation of three new pregnane glycosides (<B>1</B>–<B>3</B>) along with four known compounds (<B>4</B>–<B>7</B>). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds <B>4</B>–<B>7</B> dose-dependently inhibited the melanin production with the IC<SUB>50</SUB> values ranging from 4 μM to 33 μM.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
RFID 시스템에서 리더기들간의 협업을 이용한 태그 인식 알고리즘
김홍화 ( Hong-hua Jin ),박숙영 ( Sook-young Park ),이상규 ( Sang-kyu Lee ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.2
본 논문에서는 단일리더기가 아닌 멀티리더기를 이용하여 리더기들간의 상호 협동작업을 통하여 일정한 속도로 이동하는 태그를 최대한 많이 읽을 수 있는 멀티리더기들간의 협업을 이용한 향상된 태그인식 알고리즘을 제안하였다. 즉, 두 개의 리더기를 사용하여 많은 양의 태그가 서로 다른 이동 속도로 리더기를 지나 갈 때, 첫 번째 리더기가 저장해 놓은 태그정보를 두 번째 리더기가 이어받아 계속하여 나머지 태그를 인식하는 알고리즘을 개발한다. 시뮬레이션 결과 멀티리더기를 이용하면 단일리더기의 단점을 극복하여 보다 향상된 태그 인식 결과를 얻어내어 좀 더 안정적이고 효율적인 알고리즘을 제안하였다.
Micrococcus endophyticus sp. nov., isolated from surface-sterilized Aquilaria sinensis roots.
Chen, Hua-Hong,Zhao, Guo-Zhen,Park, Dong-Jin,Zhang, Yu-Qin,Xu, Li-Hua,Lee, Jae-Chan,Kim, Chang-Jin,Li, Wen-Jun Society for General Microbiology 2009 International journal of systematic and evolutiona Vol.59 No.5
<P>A Gram-positive bacterial strain, designated YIM 56238(T), was isolated from plant roots (Aquilaria sinensis), and characterized by using a polyphasic approach. Strain YIM 56238(T) grew optimally at pH 7.0-8.0 and at 28 degrees C. Analysis of the 16S rRNA gene sequence of strain YIM 56238(T) indicated that it belongs to the genus Micrococcus. Chemotaxonomic data strongly supported the classification of this strain within the genus Micrococcus: the cell-wall peptidoglycan contained lysine, glutamic acid, alanine and glycine; the predominant menaquinones were MK-8(H(2)) (63.6 %) and MK-7(H(2)) (21.1 %); the phospholipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol and an unknown ninhydrin-negative phospholipid; and the major cellular fatty acids were iso-C(15 : 0) (30.95 %) and anteiso-C(15 : 0) (53.75 %). The G+C content of the genomic DNA was 72.9 mol%. A number of physiological features were found that clearly distinguished strain YIM 56238(T) from recognized species of the genus Micrococcus. DNA-DNA hybridization studies suggested that the novel strain represents a separate genomic species. On the basis of the data, therefore, strain YIM 56238(T) represents a novel species of the genus Micrococcus, for which the name Micrococcus endophyticus sp. nov. is proposed. The type strain is YIM 56238(T) (=DSM 17945(T)=KCTC 19156(T)).</P>
The Bacterial Surface Expression of SARS Viral Epitope using Salmonella typhi Cytolysin A
Piao, Hong-Hua,Seong, Ji-Hyoun,Song, Man-Ki,Kim, Youn-Uck,Shin, Dong-Jun,Choy, Hyon-E,Hong, Yeong-Jin The Korean Society for Microbiology 2009 Journal of Bacteriology and Virology Vol.39 No.2
The cytolysin A (ClyA) is a 34 kDa pore-forming cytotoxic protein and expressed by some enteric bacteria including Salmonella typhi. This toxin is transported on the bacterial surface and secreted without posttranslational modification. Using the surface display of ClyA, the expression vectors for 193-aa immunogenic antigen of spike protein (termed S1E) from severe acute respiratory syndrome coronavirus (SARS-CoV) were constructed. The vectors carried a gene encoding S. typhi ClyA conjugated to S1E at the C terminus (termed ClyA-S1E) and asd gene in pGEM-T and pBR322, named pGApLCS1E and pBApLCS1E, respectively. An asd-mutated E. coli transformed with these vectors could grow without diaminopimelic acid (DAP), indicating that they were stably maintained in such mutants. ClyA-S1E recombinant proteins from these vectors were expressed on the surface of the attenuated S. typhimurium deficient of global virulence gene regulator, ppGpp. However, they did not show the hemolytic activity on the blood agar plate and cytotoxicity against HeLa cells. To examine whether bacteria expressing ClyA-S1E induced the immune response against S1E, S. typhimurium deficient of ppGpp and Asd was transformed with these vectors and orally immunized in mice. In the western blotting against GST-conjugated S1E using the immunized mouse sera, it was shown that the significant band was detected in the mouse serum by the bacteria transformed with pGApLCS1E but not with pBApLCS1E. It indicates that the immune response producing antibody was dependent on the expression level of ClyA-S1E. Therefore, ClyA delivery system can be used for SARS vaccine development.