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Won, Hoyoun,Kim, Jung-Sun,Shin, Dong-Ho,Kim, Byeong-Keuk,Ko, Young-Guk,Choi, Donghoon,Jang, Yangsoo,Hong, Myeong-Ki Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-
<P><I>Purposes</I>. The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT). <I>Methods</I>. Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries. <I>Results</I>. In BMS-implanted lesions, neointimal volume decreased from 7.3 mm<SUP>3</SUP> to 6.9 mm<SUP>3</SUP> and 6.4 mm<SUP>3</SUP> at 1, 3, and 6 months follow-up without statistical significance (<I>P</I> = 0.369). At the time points of 1, 3, and 6 months, neointimal tissue appearance was mainly a homogeneous pattern (80.0%, 93.3%, and 100%, resp.), while the other pattern was layered. In contrast, in EES-implanted lesions, neointimal volume significantly increased from 4.8 mm<SUP>3</SUP> to 9.8 mm<SUP>3</SUP> between 1 and 3 months but significantly decreased to 8.6 mm<SUP>3</SUP> between 3 and 6 months (<I>P</I> < 0.001). Between 1 and 3 months, the layered pattern of neointimal tissue increased from 26.7% to 66.7% but decreased to 20.0% between 3 and 6 months. <I>Conclusions</I>. EES had a biphasic pattern of neointimal amounts that correlated with changes in neointimal morphology.</P>
Gwang Sil Kim,Young-Guk Ko,Yongsung Suh,Hoyoun Won,Sung-Jin Hong,Chul-Min Ahn,Jung-Sun Kim,Byeong-Keuk Kim,Donghoon Choi,Myeong-Ki Hong,Yangsoo Jang 대한심장학회 2020 Korean Circulation Journal Vol.50 No.11
Background and Objectives: The effectiveness of angiotensin II receptor blockers (ARBs) compared with angiotensin converting enzyme inhibitors (ACEIs) in patients with acute myocardial infarction (AMI) has not been established. We investigated the effects of ARBs on clinical outcomes after percutaneous coronary intervention (PCI) in AMI patients. Methods: Patients receiving ACEIs or ARBs after AMI treated with PCI between January 2005 and December 2014 were selected from the Korean National Health Insurance Service database. The primary endpoint was major cardiovascular adverse event (MACE; all-cause death, myocardial infarct [MI], or stroke). Results: We included patients regularly taking ACEIs (n=22,331) or ARBs (n=28,533) (medication possession ratio ≥80%). Compared with the ACEI group, the ARB group contained more females (31% vs. 18%), were older (mean, 63 vs. 60 years), and had more comorbidities, including hypertension (62.8% vs. 44.8%), diabetes (33.9% vs. 26.4%), congestive heart failure (7.9% vs. 4.3%), chronic obstructive pulmonary disease (25.5% vs. 18.9%), and end-stage renal disease (1.3% vs. 0.4%) (p<0.001 for all). After propensity score–matching, ARBs were associated with a 23% lower risk of MACE (hazard ratio [HR], 0.774; 95% confidence interval [CI], 0.715–0.838; p<0.001) than ACEIs. ARB use was also associated with a significantly reduced risk of death (HR, 0.741; 95% CI, 0.659–0.834; p<0.001), MI (HR, 0.731; 95% CI, 0.638–0.837; p<0.001), and revascularization (HR, 0.816; 95% CI, 0.773–0.861; p<0.001). Conclusions: ARB use was associated with a lower risk of MACE, MI, and revascularization than ACEIs in our retrospective analysis of AMI patients who underwent PCI.
텅스텐 CMP에서 디싱 및 에로젼 결함 감소에 관한 연구
박범영(Boumyoung Park),김호윤(Hoyoun Kim),김구연(Gooyoun Kim),김형재(Hyoungjae Kim),정해도(Haedo Jeong) Korean Society for Precision Engineering 2005 한국정밀공학회지 Vol.22 No.2
Chemical mechanical polishing(CMP) has been widely accepted for the planarization of multi-layer structures n semiconductor fabrication. But a variety of defects such as abrasive contamination, scratch, dishing, erosion md corrosion are occurred during CMP. Especially, dishing and erosion defects increase the metal resistance because they decrease the interconnect section area, and ultimately reduce the life time of the semiconductor. Due to this reason dishing and erosion must be prohibited. The pattern density and size in chip have a significant influence on dishing and erosion occurred by over-polishing. The fixed abrasive pad(FAP) was applied and tested o reduce dishing and erosion in this paper. The abrasive concentration decrease of FAP results in advanced pattern selectivity which can lead the uniform removal in chip and declining over-polishing. Consequently, reduced dishing and erosion was observed in CMP of tungsten pattern wafer with proposed FAP and chemicals.
박범영(Boumyoung Park),김호윤(Hoyoun Kim),김형재(Hyungjae Kim),김구연(Gooyoun Kim),정해도(Haedo Jeong) Korean Society for Precision Engineering 2004 한국정밀공학회지 Vol.21 No.7
As a result of high integration of semiconductor device, the global planarization of multi-layer structures is necessary. So the chemical mechanical polishing(CMP) is widely applied to manufacturing the dielectric layer and metal line in the semiconductor device. CMP process is under influence of polisher, pad, slurry, and process itself, etc. In comparison with the general CMP which uses the slurry including abrasives, fixed abrasive pad takes advantage of planarity, resulting from decreasing pattern selectivity and defects such as dishing & erosion due to the reduction of abrasive concentration especially. This paper introduces the manufacturing technique of fixed abrasive pad using hydrophilic polymers with swelling characteristic in water and explains the self-conditioning phenomenon. And the tungsten CMP using fixed abrasive pad achieved the good conclusion in terms of the removal rate, non-uniformity, surface roughness, material selectivity, micro-scratch free contemporary with the pad life-time.
Min Jae Cha,William D Kim,Hoyoun Won,Jaeeun Joo,Hasung Kim,In-Cheol Kim,Jin Young Kim,Seonhwa Lee,Iksung Cho 대한심장학회 2022 Korean Circulation Journal Vol.52 No.11
Background and Objectives: Real-world trends in the utility and type of gatekeeping studies in invasive coronary angiography (ICA) requires further investigation. Methods: We identified outpatients who underwent noninvasive cardiac tests or directly ICA for suspected coronary artery disease (CAD) from the nationwide Korea Health Insurance Review and Assessment Service-National Patient Sample database between 2012 and 2018. Results: Among 71,401 patients, the percentage of patients who were evaluated for suspected CAD was 34.7% for treadmill test (TMT), 4.2% for single-photon emission computed tomography (SPECT), 24.2% for coronary computed tomography angiography (CCTA), 1.6% for multiple gatekeepers, and 32.3% for directly ICA without noninvasive studies. The proportion of CCTA as a gatekeeper showed linear increase, (18.6% in 2012 and 28.8% in 2018; p<0.001), while those of TMT, SPECT, and direct ICA have decreased (p<0.001, p=0.03, and p<0.001, respectively). The overall incidence of downstream ICA after gatekeeper was 13.8% (6,662/48,346), and SPECT showed higher ICA rate in pairwise comparison with TMT and CCTA (p<0.001). Patients who performed gatekeepers before ICA showed higher rate of subsequent PCI (34.7% vs. 32.3%; p<0.001) and CABG (3.5% vs. 1.0%; p<0.001), compared to those who directly underwent ICA, and CCTA was associated with higher revascularization rate after ICA in pairwise comparison with TMT and SPECT (p<0.001). Conclusions: Nationwide database demonstrated that CCTA is utilized increasingly as a gatekeeper for ICA and is associated with high revascularization rate after ICA in outpatients with suspected CAD.
Gyu Tae Park,Moonki Jung,Young Kim,Iksung Cho,Hoyoun Won,Seung Yong Shin,Wang-Soo Lee,Kwang Je Lee,Sang-Wook Kim,Tae Ho Kim,김치정 한국지질동맥경화학회 2017 지질·동맥경화학회지 Vol.7 No.2
Objective: Previous studies have shown that fenofibrate therapy increases serum creatinine level and that there is a returnof serum creatinine to baseline level after the discontinuation of the drug. We evaluated the effect of long-term fenofibratetherapy on creatinine levels and its reversibility in patients with hypertension and hypertriglyceridemia. Methods: This retrospective study enrolled 54 hypertensive and hypertriglyceridemic patients taking fenofibrate for 3-6years (Fenofibrate group) and 30 control patients with similar age, sex, follow-up duration, and creatinine levels (Controlgroup). In 23 patients taking fenofibrate with low triglyceride level and/or with high creatinine levels, fenofibrate was discontinued,and creatinine levels were measured after 2 months. Results: Creatinine levels increased in both the fenofibrate group (from 0.91±0.18 mg/dL to 1.09±0.23 mg/dL, p<0.001)and the control group (from 0.94±0.16 mg/dL to 0.98±0.16 mg/dL, p=0.04) compared to baseline. However, the elevationwas more pronounced in the fenofibrate group than in the control group (21.1±15.4% vs. 4.5±11.3%, p<0.001). Thediscontinuation of fenofibrate lowered creatinine levels (from 1.39±0.32 mg/dL to 1.15±0.24 mg/dL, p<0.001) whichwere still higher than pre-treatment levels (p=0.013). Conclusion: Long-term fenofibrate therapy significantly increased creatinine levels in hypertensive and hypertriglyceridemicpatients. The effect of fenofibrate on creatinine level was partially reversible. This finding suggests that follow-up creatininelevel is necessary with fenofibrate therapy. (J Lipid Atheroscler 2017 December;6(2):89-96)
Five-Year Clinical Outcomes of Copeptin in patient with ST elevation Acute Myocardial I nfarction
( Moon Ki Jung ),( Jee Eun Kwon ),( Seong Hyeop Hyeon ),( Young Kim ),( Hoyoun Won ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je Lee ),( Sang Wook Kim ),( Tae Ho Kim ),( Chee Jeong Kim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
We collected 111 coronary arterial blood samples at the coronary artery ostium during primary percutaneous coronary intervention(PCI) in STEMI and assessed the clinical outcomes depending on Copeptin. We evaluated cardiac biomarkers[CK, CK-MB, troponin-I, CRP] and additionally measured the recently introduced biomarkers [Copeptin(C-terminal Provasopressin), N-terminal pro-B-type natriuretic peptide(NT-proBNP)]. Intravascular ultrasound (IVUS) imaging was performed before and after stent implantation during primary PCI. Results: Pt age was 59±12 yrs and 86% were male. STEMI pts had a higher copeptin level than normal pts(243.31±169.68 pmol/L in vs 18.14±6.17 pmol/L, p=0.010). NT-proBNP was not correlated with copeptin (r=0.183, p=0.085). IVUS analysis of the culprit lesion showed the ruptured plaque in 47%(40/86 pts). VH-TCFA was identified in 36 patients, however, the mean copeptin level was similar compared to non-VH-TCFA pts(292.62±199.77 pmol/L vs 240.78±189.46 pmol/L, p=0.328). In hospital death occurred in 7 pts who showed higher Copeptin level than survivors. All were due to cardiogenic shock after primary PCI. The level of Copeptin was higher in-hospital death group than survivor(382.7±263 pmol/L vs. 211.3±127 pmol/L, p=0.0001). The clinical outcomes was worse in pts with Copeptin ≥300 pmol/L during five years follow up (p=0.046). Conclusions: Stress stimulated Copeptin might be one of the prognostic marker in long-term outcomes of STEMI. Thepotential role of Copeptin deserves to confirm with a further study.