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제주재래돼지와 듀록 참조축군에서 Melanocortin 4 Receptor (MC4R) 유전자형과 지방산 조성간의 관련성 분석
강용준(Yong-Jun Kang),김상금(Sang-Geum Kim),김수연(Su-Yeon Kim),신문철(Moon-Cheol Shin),우제훈(Jae-Hoon Woo),김남영(Nam-Young Kim),신상민(Sang-Min Shin),최재영(Jae-Young Choi),유지현(Ji-Hyun Yoo),박남건(Nam-Geon Park),양병철(Byoung-C 한국생명과학회 2020 생명과학회지 Vol.30 No.1
본 연구에서는 제주재래돼지와 듀록 품종 사이에서 생산된 F₂ 참조축군에서 melanocortin-4-receptor (MC4R) 유전자형과 지방산 조성간의 관련성을 연구하였다. 전체 290 여두의 F₂ 자손을 이용하여 14개의 지방산 조성을 측정하였다. Taq Ⅰ PCR-RFLP 방법을 이용하여 MC4R c.1426A>G (p.Asp298Asn)의 단일염기다형성(single nucleotide polymorphism, SNP)을 확인하였다. MC4R 세 가지 유전자형(AA, AB, BB)이 모두 발견되었고, 그 빈도는 각각 0.299, 0.542, 0.159로 확인되었다. AA 유전자형을 가진 개체에서 palmitic acid (C16:0, p<0.05), stearic acid (C18:0, p<0.01), eicosenoic acid (C20:1n9, p<0.05), saturated fatty acid (SFA, p<0.01) 함량이 GG 유전자형을 가진 개체보다 더 높은 것으로 확인되었다. 반면에 GG 유전자형을 가진 개체는 linoleic acid (C18:2n6, p<0.001), linolenic acid (C18:3n3, p<0.001), linolenic acid (C18:3n6, p<0.001), arachidonic acid (C20:4n6, p<0.001)과 같은 불포화지방산(unsaturated fatty acid) 함량이 AA 유전자형을 가진 개체보다 더 높은 것을 확인하였다. 제주재래돼지와 듀록 품종 사이에서 생산된 F₂ 참조축군에서 MC4R GG 유전자형이 포화지방산은 낮추고, 불포화지방산은 높이는 것으로 확인되었다. 본 연구 결과 MC4R의 유전적 다형성이 듀록과 제주재래돼지 교배 프로그램에서 육질향상과, 고기내의 지방산 함량을 조절할 수 있는 유전적 표지 인자로 활용될 수 있을 것이라 사료된다. This study was conducted to examine association between melanocortin-4-receptor (MC4R) genotypes and fatty acid (FA) composition in an F₂ intercross between Duroc and Jeju (South Korea) Native pigs (JNP). Fourteen FA composition traits were measured in more than 290 F₂ progeny population produced between Duroc and JNP. All experimental pigs were successfully genotyped for the MC4R c.1426A>G (p.Asp298Asn) single nucleotide polymorphism (SNP) by using Taq Ⅰ PCR-RFLP methods. We detected three MC4R genotypes, AA, AG, and GG with 0.299, 0.542, and 0.159 genotype frequencies, respectively. The MC4R AA genotype animals showed higher levels in palmitic acid (C16:0, p<0.05), stearic acid (C18:0, p<0.01), eicosenoic acid (C20:1n9, p<0.05), saturated fatty acid (SFA, p<0.01) than GG homozygotes, respectively. Whereas MC4R GG genotype showed higher values in linoleic acid (C18:2n6, p<0.001), linolenic acid (C18:3n3, p<0.001), linolenic acid (C18:3n6, p<0.001), arachidonic acid (C20:4n6, p<0.001) and unsaturated fatty acid (USFA, p<0.01) than AA pigs, respectively. The MC4R GG genotype was associated with increasing USFA and decreasing SFA in the F₂ progeny population produced between Duroc and JNP. Our finding suggests that the MC4R polymorphisms can be used as a valuable genetic marker for Duroc and JNP breeding programs to improve meat quality and to control FA compositions.
Yang Jeong Hun,Park C. Hyung Keun,Rhee Sang Jin,Kang Dae Hun,Kim Min Ji,Lee Hyun Jeong,Lee Sang Yeol,Shim Se-Hoon,Moon Jung-Joon,Cho Seong-Jin,Kim Shin Gyeom,Kim Min-Hyuk,Lee Jinhee,Kang Won Sub,Yoo J 대한의학회 2024 Journal of Korean medical science Vol.39 No.31
Background: Despite a plethora of research on the topic, there is still no solid evidence that pharmacological treatment actually reduces the risk of suicide in patients with mental illness. In this study, we aimed to assess the effect of psychotropic medications on suicidal ideation in patients with major depressive disorder (MDD) and bipolar disorder (BPD) in two age groups: less than 25 years and 25 years and older. Methods: We analyzed 312 patients with mood disorders with current suicidal thoughts or recent suicide attempts. We followed the participants from baseline for 6 months and assessed changes in suicidal ideation with Columbia-Suicide Severity Rating Scale (C-SSRS). The effect of psychotropic drug administration on suicidal ideation over time was analyzed using a linear mixed model. Results: In patients aged 25 years and older with mood disorders, suicidal ideation was more severe when using psychotropic drugs than when not using them. However, suicidal ideation decreased rapidly over time. The time-dependent reduction in suicidal ideation was accelerated when using antidepressants and sedatives/hypnotics in adult MDD, and when using mood stabilizers in adult BPD. However, this effect was not observed in participants aged less than 25 years. Conclusion: Adequate psychotropic medication may reduce suicidal ideation in patients with mood disorders aged 25 years and older. Additional research on psychotropic drugs is needed to effectively reduce the risk of suicide among children and adolescents with mood disorders.
두개골 척색종의 임상소견과 다형태 치료 : Clinical Presentation and Multimodality Treatment
오석관,김정훈,나영신,김창진,권양,임승철,이정교,권병덕,황충진 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.5
Cranial chordomas are rare and generally slow growing malignant neoplasms of presumed notochordal origin. They seldome metastasize, but are difficult to manage because of their locally invasive nature and their proximity to critical structures. The clinical presentation and results of operative treatment, radiation therapy. and radiosurgery in a series of 10 patients with cranial chordomas seen at our hospital, between June 1989 and December 1994. are analysed. There were 4 men and 6 women with a mean age of 37.5 years. The most common presenting symptoms were visual loss. motor weakness and diplopia. and the most common presenting sign was visual field defect. The mean interval between symptom onset and initial treatment was 4.8(1-17) months. Three tumors classified as the chondroid type showed better clinical course. Extent of tumor resection included biopsy in 1patient and subtotal or greater in 9. Four patients received postoperative radiation therapy and 4 patients stereotactic radiosurgery using Leks디l gamma unit. Among them 1 patient showed tumor progression after radiation therapy but none after radiosurgery. One patient died dug to tumor recurrence and two patients due to postopsrative complications. At the time of analysis 7 patients were alive. The average length of follow-up for the alive patients was 34 months. The results of this study suggest that multimodality treatment using surgical debulking. radiation therapy and stereotactic radiosurgery is necessary for the optimal managment of chordoma.
Stability of graphene band structures against an external periodic perturbation: Na on graphene
Hwang, C. G.,Shin, S. Y.,Choi, Seon-Myeong,Kim, N. D.,Uhm, S. H.,Kim, H. S.,Hwang, C. C.,Noh, D. Y.,Jhi, Seung-Hoon,Chung, J. W. American Physical Society 2009 Physical review. B, Condensed matter and materials Vol.79 No.11
난소를 적출한 Rats에서 우울증, 불안장애, 식이섭취에 대한 석류추출물의 효과
안기훈 ( Ki Hoon Ahn ),이경욱 ( Kyong Wook Yi ),박현태 ( Hyun Tae Park ),신정호 ( Jung Ho Shin ),허준용 ( Jun Young Hur ),김영태 ( Young Tae Kim ),김선행 ( Sun Haeng Kim ),이규완 ( Kyu Wan Lee ),김승희 ( Seung Hee Kim ),배춘식 ( C 대한폐경학회 2010 대한폐경학회지 Vol.16 No.1
연구목적: 난소를 적출한 폐경모델 rats에서 석류추출물이 우울증, 불안장애, 식이섭취에 대해 효과가 있는지 알아보고자 하였다. 연구재료 및 방법: 79마리의 암컷 Sprague-Dawley rats을 이용하였다: A, 난소 적출하지 않고 약물 투여하지 않은 군; B, 가장수술 후 증류수투여군; C, D, E, F는 각각 난소적출 후 증류수, 10%, 20%, 40% 석류 투여군. 약물투여 4주째에 우울증 및 불안장애검사를 시행하였다. 24시간 먹이섭취량를 매일, 몸무게를 일주일에 한 번 측정하였다. 결과: 불안장애검사에서 10% 석류추출물이 % 폐쇄구역횟수를 유의하게 감소시켰다. 우울증검사에서는 석류추출물의 용량과 비례하여 immobility 시간의 감소를 보여주었다. 석류추출물의 투여가 난소 적출과 관련한 식이섭취의 증가 및 몸무게의 증가를 억제하지는 못하였다. 결론: 석류추출물은 난소를 적출한 폐경모델 rats에서 우울증 및 불안장애를 개선시켰다. Objectives: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. Methods: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST). Results: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain. Conclusion: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats. (J Korean Soc Menopause 2010;16:39-45)
Lim, Soo,Kang, Seon Mee,Shin, Hayley,Lee, Hak Jong,Won Yoon, Ji,Yu, Sung Hoon,Kim, So-Youn,Yoo, Soo Young,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak C. American Diabetes Association 2011 Diabetes care Vol.34 No.2
<P><B>OBJECTIVE</B></P><P>To improve quality and efficiency of care for elderly patients with type 2 diabetes, we introduced elderly-friendly strategies to the clinical decision support system (CDSS)-based ubiquitous healthcare (u-healthcare<B>)</B> service, which is an individualized health management system using advanced medical information technology.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We conducted a 6-month randomized, controlled clinical trial involving 144 patients aged >60 years. Participants were randomly assigned to receive routine care (control, <I>n</I> = 48), to the self-monitored blood glucose (SMBG, <I>n</I> = 47) group, or to the u-healthcare group (<I>n</I> = 49). The primary end point was the proportion of patients achieving A1C <7% without hypoglycemia at 6 months. U-healthcare system refers to an individualized medical service in which medical instructions are given through the patient’s mobile phone. Patients receive a glucometer with a public switched telephone network-connected cradle that automatically transfers test results to a hospital-based server. Once the data are transferred to the server, an automated system, the CDSS rule engine, generates and sends patient-specific messages by mobile phone.</P><P><B>RESULTS</B></P><P>After 6 months of follow-up, the mean A1C level was significantly decreased from 7.8 ± 1.3% to 7.4 ± 1.0% (<I>P</I> < 0.001) in the u-healthcare group and from 7.9 ± 1.0% to 7.7 ± 1.0% (<I>P</I> = 0.020) in the SMBG group, compared with 7.9 ± 0.8% to 7.8 ± 1.0% (<I>P</I> = 0.274) in the control group. The proportion of patients with A1C <7% without hypoglycemia was 30.6% in the u-healthcare group, 23.4% in the SMBG group (23.4%), and 14.0% in the control group (<I>P <</I> 0.05).</P><P><B>CONCLUSIONS</B></P><P>The CDSS-based u-healthcare service achieved better glycemic control with less hypoglycemia than SMBG and routine care and may provide effective and safe diabetes management in the elderly diabetic patients.</P>
Do, Sook Kyung,Choi, Sun Ha,Lee, Shin Yup,Choi, Jin Eun,Hong, Mi Jeong,Kang, Hyo-Gyoung,Lee, Won Kee,Lee, Eung Bae,Shin, Kyung Min,Jeong, Ji Yun,Lee, Yong Hoon,Seo, Hyewon,Yoo, Seung Soo,Lee, Jaehee,C Elsevier 2019 Gene Vol.703 No.-
<P><B>Abstract</B></P> <P>This study was conducted to explore whether polymorphisms of glucose transporter 3 (<I>GLUT3</I>) gene affect the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Four single nucleotide polymorphisms (SNPs) in <I>GLUT3</I> were investigated in a total of 782 patients with NSCLC who underwent curative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) was analyzed. Among the four SNPs investigated, <I>GLUT3</I> rs7309332C>T was significantly associated with OS and DFS in multivariate analyses. The SNP was associated with significantly worse OS (adjusted hazard ratio [aHR] = 1.62, 95% confidence interval [CI] = 1.04–2.53, <I>P</I> = 0.03, under recessive model), and worse DFS (aHR = 1.64, 95% CI = 1.18–2.29, <I>P</I> = 0.003, under recessive model). When stratified by tumor histology, the association between the <I>GLUT3</I> rs7309332C>T and OS/DFS was not limited to either squamous cell carcinoma (SCC) or adenocarcinoma (AC), although the significant association remained only in AC for OS (<I>P</I> = 0.40 for SCC and <I>P</I> = 0.04 for OS) and only in SCC for DFS (<I>P</I> = 0.03 for SCC and <I>P</I> = 0.08 for OS). When AC patients were stratified according to <I>EGFR</I> mutation status, the SNP was significantly associated with DFS in patients with <I>EGFR</I> mutant tumors (aHR = 2.47, 95% CI = 1.15–5.30, <I>P</I> = 0.02, under recessive model), but not in those with <I>EGFR</I> wild-type tumors. This study suggests that genetic variation in <I>GLUT3</I> may be useful in predicting survival of patients with early stage NSCLC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>GLUT3</I> variant was significantly associated with survival of NSCLC after surgery. </LI> <LI> The association was not limited to either squamous cell carcinoma or adenocarcinoma. </LI> <LI> The SNP may help identify patients at high risk of poor outcome in early stage NSCLC. </LI> </UL> </P>
C. Hyung Keun Park,Jae Won Lee,Jungjoon Moon,Dong-Wook Jeon,Sang Yeol Lee,Se-Hoon Shim,Shin Gyeom Kim,Jeewon Lee,백종우,Seong-Jin Cho,Min-Hyuk Kim,Sungeun You,전홍진,Sang Jin Rhee,Min Ji Kim,Junghyun Kim,Yo 대한의학회 2021 Journal of Korean medical science Vol.36 No.10
Background: Evidence continues to accumulate that the presence or absence of early trauma (ET) implies unique characteristics in the relationships between suicidal ideation and its risk factors. We examined the relationships among recent stress, depressive symptoms, anxiety symptoms, and suicidal ideation in Korean suicidal women with or without such a history. Methods: Using data on suicidal adult females, 217 victims and 134 non-victims of ET, from the Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior, we performed structural equation modeling to investigate the contribution of recent stress, depressive symptoms, and anxiety symptoms on suicidal ideation within each group according to the presence or absence of a history of ET. Results: Structural equation modeling with anxiety and depressive symptoms as potential mediators showed a good fit. Recent stress had a direct effect on both depressive symptoms and anxiety symptoms in both groups. Only anxiety symptoms for victims of ET (standardized regression weight, 0.281; P = 0.005) and depressive symptoms for non-victims of ET (standardized regression weight, 0.326; P = 0.003) were full mediators that increased suicidal ideation. Thus, stress contributed to suicidal ideation by increasing the level of anxiety and depressive symptoms for victims and non-victims, respectively. Conclusion: Tailored strategies to reduce suicidal ideation should be implemented according to group type, victims or non-victims of ET. Beyond educating suicidal women in stress-management techniques, it would be effective to decrease anxiety symptoms for those with a history of ET and decrease depressive symptoms for those without such a history.
The effect of an APOE polymorphism on cognitive function depends on age
Shin, Min-Ho,Kweon, Sun-Seog,Choi, Jin-Su,Lee, Young-Hoon,Nam, Hae-Sung,Park, Kyeong-Soo,Kim, Hee N.,Song, Hye-Rim,Kim, Byeong C.,Choi, Seong-Min,Oh, Sun-Young,Jeong, Seul-Ki Springer-Verlag 2014 Journal of neurology: Zeitschrift für Neurolo Vol.261 No.1