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- 저자 : Junghyun Kim (검색결과 858 건)
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Junghyun Kim(Junghyun Kim),Dae-Eun Kim(Dae-Eun Kim),Eunseok Park(Eunseok Park),Dae-Jin Kim(Dae-Jin Kim),Hwanhee Kim(Hwanhee Kim) 한국보건의료윤리학회 2023 한국보건의료윤리학회지 Vol.2 No.1
Background: The purpose of this study is to provide basic data on the necessity and direction of education to establish a desirable bioethics view by identifying bioethics awareness of the Life-sustaining Treatment Decision Act among biomedical laboratory science student and nursing students attending K University. Methods: From October 30 to November 5, 2022, the final 279 people (144 in biomedical laboratory science and 135 in nursing) were analyzed through a structured survey of 29 questions. Results: As a result of comparing the presence or absence of learning and the degree of awareness of the life-sustaining treatment decision act, the presence or absence of learning p<.001. There was a statistically significant difference in cognitive degree p<.001. Conclusion: It is suggested that continuous research should be conducted to confirm the perception of biomedical ethics of Biomedical laboratory science students and nursing students and to find the need and direction of education to establish a desirable bioethics.
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Subsequent platinum based re-treatment of platinum-resistant ovarian cancer: 7 cases review
( Junghyun Kim ),( Jina Yun ),( Ah Reum Chun ),( Se Hun Kim ),( Se Hyung Kim ),( Seong Kyu Park ),( Dae Sik Hong ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Patients who relapse within 6 months after completion of therapy are thought to be “platinum-resistant"(Pt-R) and felt to have a worse prognosis. Currently, Single agent such as topotecan, liposomal doxorubicin, vinorelbine, docetaxel and gemcitabine is used as second line setting for patients with Pt-R ovarian cancer. But, some articles have been reported that patients who have Pt-R ovarian cancer may still benefit from re-treatment with platinum compounds after an interval of treatment with nonplatinum agents. The purpose of our study was to review our experience with subsequent platinum based re-treatment in women with Pt-R ovarian cancer. We studied seven patients who had relapsed within six months of their recent exposure to platinum. They were treated with platinum based combination with topotecan, irinotecan, or docetaxel. The median age was 52 years, six patients was received paclitaxel and carboplatin combination chemotherapy prior to re treatment with platinum compounds. They received a median number of six cycles as first line chemotherapy. Two patients achieved complete respons (CR) and 5 had stable disease(SD). The median time to progression(TTP) of 1st line treatment was 8.5 months (95% CI 7.8-9.3) and the median platinum free interval was 4.6 months. All of them had good performance status(ECOG 0) before 2nd line treatment. Four patients received docetaxel-carboplatin and 3 had topotecan/irinotecan-cisplatin combination regimen. A median number of 6 cycles as re treatment with platinum compounds was received. One patient achieved CR, one patient achieved partial response, while 5 patients achieved SD. The median TTP for these seven patients after re-treatment with platinum compounds was 7.3 months (95% CI 5.1-9.4). Four patients had progressive disease and received further salvage therapy with another regimen. The median overall survival from the time deemed to be Pt-R is 22.8 months (95% CI 18.8-26.8). Our small retrospective series suggest that the Pt-R category is still less clear. Patients who have been deemed Pt-R may still benefit from subsequent platinum based re-treatment.
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( Junghyun Kim ),( Chan-sik Kim ),( Young Sook Kim ),( Ik Soo Lee ),( Jin Sook Kim ) 한국운동영양학회 2016 Physical Activity and Nutrition (Phys Act Nutr) Vol.20 No.4
[Purpose] Advanced glycation end products (AGEs) have been implicated in the patho genesis of diabetes and other age-related diseases. AGE inhibitors or breakers, such as aminoguanidine and alagebrium, have been proposed as therapeutic agents for AGE-re- lated disorders. Jakyakgamcho-tang (JGT) is a well-known traditional herbal formula, which consists of the radix of Paeonia lactiflora Pallas (PR) and the radix and rhizome of Gly cyrrhiza uralensis Fisch (GR). The purpose of this study was to evaluate the inhibitory and breaking activities of JGT, PR, and GR against AGEs. [Methods] JGT, PR, and GR extracts were prepared in hot water. We performed in vitro assays to evaluate their inhibitory activity against glycation of bovine serum albumin (BSA) by high glucose and their ability to break the already formed AGEs. [Results] In the in vitro AGE formation as say, JGT and PR dose-dependently inhibited AGE-BSA formation (half-maximal inhibitory concentration, IC<sub>50</sub>, = 41.41 ± 0.36 and 6.84 ± 0.09 μg/mL, respectively). In the breakdown assay of the preformed AGE-BSA-collagen complexes, JGT and PR exhibited potent breaking activities (IC<sub>50</sub> = 6.72 ± 1.86 and 7.45 ± 0.47 μg/mL, respectively). However, GR showed a weaker inhibitory activity and no breaking activity against AGEs. [Conclusion] This study suggests that JGT and PR could be valuable drug candidates for treatment of AGE-related diseases by reduc ing AGE burden.
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Kim, Junghyun,Kang, Hyojin,Park, Jeongmoo,Kim, Woohyun,Yoo, Janghyun,Lee, Nayoung,Kim, Jaewook,Yoon, Tae-young,Choi, Giltsu American Society of Plant Biologists 2016 The Plant cell Vol.28 No.6
<P>The bHLH transcription factor PHYTOCHROME INTERACTING FACTOR1 (PIF1) binds G-box elements in vitro and inhibits light-dependent germination in Arabidopsis thaliana. A previous genome-wide analysis of PIF1 targeting indicated that PIF1 binds 748 sites in imbibed seeds, only 59% of which possess G-box elements. This suggests the G-box is not the sole determinant of PIF1 targeting. The targeting of PIF1 to specific sites could be stabilized by PIF1-interacting transcription factors (PTFs) that bind other nearby sequence elements. Here, we report PIF1 targeting sites are enriched with not only G-boxes but also with other hexameric sequence elements we named G-box coupling elements (GCEs). One of these GCEs possesses an ACGT core and serves as a binding site for group A bZIP transcription factors, including ABSCISIC ACID INSENSITIVE5 (ABI5), which inhibits seed germination in abscisic acid signaling. PIF1 interacts with ABI5 and other group A bZIP transcription factors and together they target a subset of PIF1 binding sites in vivo. In vitro single-molecule fluorescence imaging confirms that ABI5 facilitates PIF1 binding to DNA fragments possessing multiple G-boxes or the GCE alone. Thus, we show in vivo PIF1 targeting to specific binding sites is determined by its interaction with PTFs and their binding to GCEs.</P>
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Kim, Junghyun,Lee, Yun Mi,Jung, Wookwon,Park, Su-Bin,Kim, Chan-Sik,Kim, Jin Sook Oxford University Press 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P> Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50mg/kg/day) and CA (25 and 50mg/kg/day) were administered intraperitoneally for 5 days (P12-P16). Retinal flat mounts were prepared tomeasure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1-10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner.The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA. </P>
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Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
Kim, Junghyun,Sohn, Eunjin,Kim, Chan-Sik,Lee, Yun Mi,Jo, Kyuhyung,Kim, Jin Sook Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>KIOM-79, a herbal mixture of parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix, and Euphorbiae radix, has a strong inhibitory effect on advanced glycation end products (AGEs) formation. We investigated the beneficial effects of KIOM-79 on cardiac fibrosis in Zucker diabetic fatty (ZDF) rats. KIOM-79 (50 or 500 mg/kg/day) was orally administered for 13 weeks. AGEs formation and collagen expression in the myocardium were assessed by immunohistochemistry. The expression levels of the receptor for AGEs (RAGE), transforming growth factor-<I><I>β</I></I>1 (TGF-<I><I>β</I></I>1), collagen IV, fibronectin, urotensin II, and urotensin II receptor were examined in the myocardial tissue of ZDF rats. KIOM-79 treatment at 500 mg/kg inhibited the accumulation of AGEs, reduced RAGE mRNA and protein expression, and reduced the upregulation of cardiac fibrogenic factors, such as fibronectin and collagen IV, in heart of ZDF rats. Additionally, KIOM-79 ameliorated urotensin II/receptor gene expression in the cardiac tissue of ZDF rats. Our findings indicate that KIOM-79 diminishes cardiac fibrosis in ZDF rats by preventing AGEs accumulation and RAGE overexpression and by modulating the cardiac urotensin II/receptor pathway, which decreases the amount of profibrotic factors, such as TGF-<I><I>β</I></I>1, fibronectin, and collagen in cardiac tissue.</P>
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( Junghyun Kim ),( Woo Jin Kim ),( Bom Kim ),( So Hyeon Bak ),( Yeon-mok Oh ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) has proposed heterogeneity according to the sources of inflammation characterized in COPD. This study tried to evaluate COPD phenotypes for specific dust exposure. Method This study was designed to compare characteristics and clinical outcomes with radiological findings between the two prospective COPD cohorts representing a distinguishing region in the Korea; COPD in Dusty Area (CODA) and the Korean Obstructive Lung Disease (KOLD) cohort. A total of 733 participants (n=186 for CODA, and n=547 for KOLD, for each) were included in the final analysis. Multivariate analysis for the comparison of lung function and CT measurements of both study groups after adjusting for age, gender, education, body mass index, smoking status, pack-year, charlson comorbity index, and the frequency of exacerbation were done entering the level of FEV1(%), biomass exposure and COPD medication into the model in stepwise. Result There was no differences in mean wall area (70.2±1.26 in CODA vs. 67.07±0.90 in KOLD, p=0.121). KOLD, where the COPD subjects from urban and metropolitan area, showed higher emphysema index (6.07±3.06 in CODA vs. 20.0±2.21 in KOLD, p<0.001, respectively). This significance in emphysema index was consistent even after further adjustment for FEV1 (6.12±2.88 in CODA vs. 17.3±2.10 in KOLD, p=0.002, respectively). Mean wall area was also found to be significantly lower in KOLD (70.2±1.21 in CODA vs. 66.8±0.88 in KOLD, p=0.028) after including FEV1 into the model. However, there was no difference in lung density between the two groups (p=0.077). Additional adjustment for biomass parameter and medication for COPD did not alter the statistical significance after entering into the analysis with COPD medication. Conclusion Higher mean wall area and lower emphysema index were observed in dust exposure region. These Results suggest that imaging phenotype of COPD is influenced by the environmental exposure.
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Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats
Kim, Junghyun,Lee, Yun Mi,Kim, Chan-Sik,Sohn, Eunjin,Jo, Kyuhyung,Shin, So Dam,Kim, Jin Sook Hindawi Publishing Corporation 2013 Journal of diabetes research Vol.2013 No.-
<P>Pyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes. Apoptosis of the retinal vascular cell that was stimulated by the intravitreal injection of MGO was evidently attenuated by the EP treatment. EP exerts inhibitory effect on MGO-induced vascular cell apoptosis by blocking oxidative injury. In addition, EP treatment prevented MGO-induced BRB breakage and the degradation of occludin, an important tight junction protein. These observations suggest that EP acts through an antioxidant mechanism to protect against oxidative stress-induced apoptosis in retinal vessels.</P>
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Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Kim, Jin Sook SPANDIDOS PUBLICATIONS 2016 MOLECULAR MEDICINE REPORTS Vol. No.
<P>The aim of the present study was to assess the involvement of the high-mobility group box-1 (HMGB1) protein, receptor for advanced glycation end products (RAGE) and nuclear factor (NF)-κB signaling pathway in the development of diabetic retinopathy. Rat primary retinal pericytes were exposed to 25 mmol/l D-glucose for 48 h. Diabetic retinal vessels were prepared from streptozotocin-induced diabetic rats 12 weeks following the induction of diabetes. The expression of HMGB1 was detected using immunofluorescence staining. The expression of RAGE and the activity of NF-κB were analyzed using western blot and electrophoretic mobility shift assays, respectively. The results showed that HMGB1 was translocated to the cytoplasm of the high glucose-treated pericytes and diabetic retinal pericytes, whereas, in the control cells and the normal retinas, HMGB1 was expressed in the cell nuclei only. The expression of RAGE, a potential receptor for HMGB1, and the activity of NF-κB were also increased in the high glucose-treated pericytes, compared with the normal control cells. In addition, high glucose increased the binding of NF-κB to the RAGE promoter. These findings suggested that the cytoplasmic translocation of HMGB1 may be caused by diabetes and high glucose in retinal pericytes, and that the pathogenic role of HMGB1 may be dependent on the expression of RAGE and activation of NF-κB.</P>
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