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      • Mobile Robot Obstacle Avoidance Algorithms Based on Information Fusion of Vision and Sonar

        Hongwei Gao,Qiuyang Wei,Yang Yu,Jinguo Liu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.8

        In view of the problem of AS-R autonomous wheeled mobile robot obstacle avoidance, a rapid convergence of sonar and binocular stereovision sensor distance information in order to detect and avoid obstacle algorithm is proposed in this paper. The algorithm first uses binocular camera (CCD) to get three-dimensional image of the real environment, through the stereo matching and V-disparity method which is used to calculate disparity map, then obstacles is extracted by Hough lines detection algorithm, finally we will get information about obstacles and sonar return information with T-S fuzzy neural network fusion, then it will output walking controlled decisions. Experimental results proved that the algorithm is effective and practical.

      • KCI등재

        miR-140 inhibits porcine fetal fibroblasts proliferation by directly targeting type 1 insulin-like growth factor receptor and indirectly inhibiting type 1 insulin-like growth factor receptor expression via SRY-box 4

        Hongwei Geng,Linlin Hao,Yunyun Cheng,Chunli Wang,Wenzhen Wei,Rui Yang,Haoyang Li,Ying Zhang,Songcai Liu 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.10

        Objective: This study aimed to elucidate the effect of miR-140 on the proliferation of porcine fetal fibroblasts (PFFs) and identify the target genes of miR-140 in PFFs. Methods: In this study, bioinformatics software was used to predict and verify target genes of miR-140. Quantitative polymerase chain reaction and western blot were used to detect the relationship between miR-140 and its target genes in PFFs. Dual luciferase reporter gene assays were performed to assess the interactions among miR-140, type 1 insulin-like growth factor receptor (IGF1R), and SRY-box 4 (SOX4). The effect of miR-140 on the proliferation of PFFs was measured by CCK-8 when PFFs were transfected with a miR-140 mimic or inhibitor. The transcription factor SOX4 binding to promoter of IGF1R was detected by chromatin immunoprecipitation assay (ChIP). Results: miR-140 directly targeted IGF1R and inhibited proliferation of PFFs. Meanwhile, miR-140 targeted transcription factor SOX4 that binds to promoter of porcine IGF1R to indirectly inhibit the expression of IGF1R. In addition, miR-140 inhibitor promoted PFFs proliferation, which is abrogated by SOX4 or IGF1R knockdown. Conclusion: miR-140 inhibited PFFs proliferation by directly targeting IGF1R and indirectly inhibiting IGF1R expression via SOX4, which play an important role in the development of porcine fetal.

      • SCOPUSKCI등재

        Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis

        Wei, Feng,Lyu, Hongwei,Wang, Shuoer,Chu, Yan,Chen, Fengyuan The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.4

        Purpose: To identify the potential therapeutic role of postoperative radiotherapy (RT) in patients with locally advanced (stage II and stage III) gastric signet ring cell carcinoma (SRC). Materials and methods: Patients with locally advanced gastric SRC from the Surveillance, Epidemiology, and End Results program database between 2004 and 2012 were included in our study. Univariate and multivariate Cox proportional models were performed, and survival curves were generated to evaluate the prognostic effect of postoperative RT and surgery alone on SRC patients. Propensity score matching (PSM) was used to avoid selection bias among the study cohorts. Results: We found that patients with postoperative RT had better probability of survival compared with those who did not receive RT (overall survival [OS], P<0.001; cancer-specific survival [CSS], P<0.001). After PSM, analysis of both overall and CSS showed that patients who underwent postoperative RT had better prognosis than those receiving surgery alone in the matched cohort (OS, P=0.00079; CSS, P=0.0036). Multivariate Cox proportional model indicated that postoperative RT had better effect on prognosis compared with surgery alone with respect to both overall (hazard ratio [HR], 0.716; 95% confidence interval [95% CI], 0.590-0.87; P=0.001) and CSS (HR, 0.713; 95% CI, 0.570-0.890; P=0.003). Conclusions: Postoperative RT had better prognosis compared with surgery alone for both overall and CSS for patients with locally advanced gastric SRC.

      • KCI등재

        Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

        Hongwei Li,Xingzhuang Zhu,Wei Zhang,Wenjie Lu,Chuan Liu,Jinbo Ma,Rukun Zang,Yipeng Song 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4

        Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (ESCC). In this study, we compared the expression of MTFR2 in 6 ESCC tumors and relative normal tissues by immunohistochemistry (IHC). To assess the effect of MTFR2 expression on clinicopathologic characteristics and survival, 115 paraffin embedded ESCC tissue samples were assessed by IHC staining. Furthermore, the association between clinicopathological properties and MTFR2 expression in patients with ESCC was examined. The survival analysis was performed using the Cox regression models. We found that MTFR2 expression was significantly increased in ESCC tumors compared with normal esophageal epithelial cells. IHC analysis of 115 paraffin embedded ESCC tumor specimens of the patients showed that the expression of MTFR2 was significantly associated with clinical stage (P < 0.001), tumor classification (P < 0.001), histological grade (P < 0.001), and other clinicopathological characteristics. Both univariate and multivariate analyses showed that MTFR2 expression was inversely correlated with the survival of ESCC patients. In conclusion, the expression of MTFR2 is significantly associated with clinicopathologic characteristics and prognosis of ESCC. Thus, MTFR2 expression could serve as a potentially important prognostic biomarker and clinical target for patients with ESCC. Key Words MTFR2, Esophageal squamous cell carcinoma, Immunohistochemistry, Prognosis

      • KCI등재

        A Three-phase Hybrid Power Flow Algorithm for Meshed Distribution System with Transformer Branches and PV Nodes

        Hongwei Li,Huabing Wu,Biyu Jiang,Anan Zhang,Wei Fang 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

        Aiming at analyzing the power flow of the distribution systems with distribution transformer (DT) branches and PV nodes, a hybrid three-phase power flow methodology is presented in this paper. The incidence formulas among node voltages, loop currents and node current injections have been developed based on node-branch incidence matrix of the distribution network. The method can solve the power flow directly and has higher efficiency. Moreover, the paper provides a modified method to model DT branches by considering winding connections, phase shifting and off-nominal tap ratio, and then DT branches could be seen like one transmission line with the proposed power flow method. To deal with the PV nodes, an improved approach to calculate reactive power increment at each PV node was deduced based on the assumption that the positive-sequence voltage magnitude of PV node is fixed at a given value. Then during calculating the power flow at each iteration, it only needs to update current injection at each PV node with the proposed algorithm. The process is very simple and clear. The results of IEEE 4 nodes and the modified IEEE 34 nodes test feeders verified the correctness and efficiency of the proposed hybrid power flow algorithm.

      • SCIESCOPUSKCI등재

        A Three-phase Hybrid Power Flow Algorithm for Meshed Distribution System with Transformer Branches and PV Nodes

        Li, Hongwei,Wu, Huabing,Jiang, Biyu,Zhang, Anan,Fang, Wei The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

        Aiming at analyzing the power flow of the distribution systems with distribution transformer (DT) branches and PV nodes, a hybrid three-phase power flow methodology is presented in this paper. The incidence formulas among node voltages, loop currents and node current injections have been developed based on node-branch incidence matrix of the distribution network. The method can solve the power flow directly and has higher efficiency. Moreover, the paper provides a modified method to model DT branches by considering winding connections, phase shifting and off-nominal tap ratio, and then DT branches could be seen like one transmission line with the proposed power flow method. To deal with the PV nodes, an improved approach to calculate reactive power increment at each PV node was deduced based on the assumption that the positive-sequence voltage magnitude of PV node is fixed at a given value. Then during calculating the power flow at each iteration, it only needs to update current injection at each PV node with the proposed algorithm. The process is very simple and clear. The results of IEEE 4 nodes and the modified IEEE 34 nodes test feeders verified the correctness and efficiency of the proposed hybrid power flow algorithm.

      • KCI등재

        Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets

        Hua Hongwei,Xu Xiao,Tian Wei,Li Pei,Zhu Huiling,Wang Wenjun,Liu Yulan,Xiao Kan 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.6

        Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury. Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected. Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver. Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis. Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury.Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected.Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver.Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis.

      • SCOPUSKCI등재SCIE
      • KCI등재

        Extraction of microbial transglutaminase from Amycolatopsis sp. fermentation broth using aqueous two-phase system

        Nan Shi,Hongwei Xu,Kaiyuan Guo,Chunyu Kang,Wei Zhang,Yingying Zhang,Liping Zhang,Jianxin Tan 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.8

        Partitioning of microbial transglutaminase (MTG) from Amycolatopsis sp. in the polyethylene glycol (PEG)/salt-based ATPS was investigated for the first time. The key parameters such as the molecular weight of PEG (PEG 600-6000), the type and concentration of phase-forming salt (ammonium sulfate or phosphates), the pH of system (pH 5.0-8.5), and the concentration of neutral salt (0-6% NaCl, w/w) were determined. The partition coefficient of the enzyme was not linear with PEG molecular weight; PEG1000 gave better yield than others. The concentration of PEG1000, ammonium sulfate and NaCl, and the system pH showed effects with different extents on specific activity (SA) and yield of the enzyme. In the ATPS of 26% w/w PEG 1000 and 19% w/w ammonium sulfate in the presence of 5% w/w NaCl and at pH 6.0, MTG was partitioned into the PEG-rich phase with a maximum yield of 86.51% and SA was increased to 0.83. The results of SDS-PAGE showed the MTG produced by the test strain differed from the enzymes reported before. Thus, this study proves that ATPS can be used as a preliminary step for partial purification of MTG from Amycolatopsis sp. fermentation broth.

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