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- 저자 : Jinbo Ma (검색결과 3 건)
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PRIAM: Privacy Preserving Identity and Access Management Scheme in Cloud
( Jinbo Xiong ),( Zhiqiang Yao ),( Jianfeng Ma ),( Ximeng Liu ),( Qi Li ),( Jun Ma ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.1
Each cloud service has numerous owners and tenants, so it is necessary to construct a privacy preserving identity management and access control mechanism for cloud computing. On one hand, cloud service providers (CSP) depend on tenant`s identity information to enforce appropriate access control so that cloud resources are only accessed by the authorized tenants who are willing to pay. On the other hand, tenants wish to protect their personalized service access patterns, identity privacy information and accessing newfangled cloud services by on-demand ways within the scope of their permissions. There are many identity authentication and access control schemes to address these challenges to some degree, however, there are still some limitations. In this paper, we propose a new comprehensive approach, called Privacy pReserving Identity and Access Management scheme, referred to as PRIAM, which is able to satisfy all the desirable security requirements in cloud computing. The main contributions of the proposed PRIAM scheme are threefold. First, it leverages blind signature and hash chain to protect tenant`s identity privacy and implement secure mutual authentication. Second, it employs the service-level agreements to provide flexible and on-demand access control for both tenants and cloud services. Third, it makes use of the BAN logic to formally verify the correctness of the proposed protocols. As a result, our proposed PRIAM scheme is suitable to cloud computing thanks to its simplicity, correctness, low overhead, and efficiency.
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Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application
Lei Zhang,Wen Xu,Xi Ma,XiaoJing Sun,JinBo Fan,Yang Wang 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.1
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and effective immune stimulators and play important roles in vaccine development because of their intrinsic immunogenicity to induce cellular and humoral immune responses. In the design of antiviral vaccine, VLPs based vaccines are appealing multifunctional candidates with the advantages such as self-assembling nanoscaled structures, repetitive surface epitopes, ease of genetic and chemical modifications, versatility as antigen presenting platforms, intrinsic immunogenicity, higher safety profile in comparison with live-attenuated vaccines and inactivated vaccines. In this review, we discuss the mechanism of VLPs vaccine inducing cellular and humoral immune responses. We outline the impact of size, shape, surface charge, antigen presentation, genetic and chemical modification, and expression systems when constructing effective VLPs based vaccines. Recent applications of antiviral VLPs vaccines and their clinical trials are summarized.
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Hongwei Li,Xingzhuang Zhu,Wei Zhang,Wenjie Lu,Chuan Liu,Jinbo Ma,Rukun Zang,Yipeng Song 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4
Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (ESCC). In this study, we compared the expression of MTFR2 in 6 ESCC tumors and relative normal tissues by immunohistochemistry (IHC). To assess the effect of MTFR2 expression on clinicopathologic characteristics and survival, 115 paraffin embedded ESCC tissue samples were assessed by IHC staining. Furthermore, the association between clinicopathological properties and MTFR2 expression in patients with ESCC was examined. The survival analysis was performed using the Cox regression models. We found that MTFR2 expression was significantly increased in ESCC tumors compared with normal esophageal epithelial cells. IHC analysis of 115 paraffin embedded ESCC tumor specimens of the patients showed that the expression of MTFR2 was significantly associated with clinical stage (P < 0.001), tumor classification (P < 0.001), histological grade (P < 0.001), and other clinicopathological characteristics. Both univariate and multivariate analyses showed that MTFR2 expression was inversely correlated with the survival of ESCC patients. In conclusion, the expression of MTFR2 is significantly associated with clinicopathologic characteristics and prognosis of ESCC. Thus, MTFR2 expression could serve as a potentially important prognostic biomarker and clinical target for patients with ESCC. Key Words MTFR2, Esophageal squamous cell carcinoma, Immunohistochemistry, Prognosis
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