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RISS 인기검색어
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- 저자 : Hua Hongwei (검색결과 3 건)
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Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets
Hua Hongwei,Xu Xiao,Tian Wei,Li Pei,Zhu Huiling,Wang Wenjun,Liu Yulan,Xiao Kan 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.6
Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury. Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected. Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver. Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis. Objective: The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury.Methods: Thirty-two piglets were assigned by a 2×2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected.Results: Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver.Conclusion: These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis.
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Xingjiang Li,Ya Liu,Ying Yang,Hua Zhang,Hualin Wang,Yue Wu,Min Zhang,Ting Sun,Jieshun Cheng,Xuefeng Wu,Lijun Pan,Shaotong Jiang,Hongwei Wu 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.3
The microbial fermentation of malic acid,which is one of the most important organic acid platformsused widely in food and chemical engineering, hasattracted considerable interest. A malate production strainwas isolated, a mutation was induced, and regulation of themetabolic network was then conducted. The identificationresults showed that the malic acid production strain, HF-119, belonged to Rhizopus delemar. An analysis of themetabolic pathway showed that the malic acid flux of thisstrain occurred through three main pathways, and manybyproducts, such as succinic acid, fumaric acid andethanol, were produced. Although corn straw hydrolytewas used, the metabolism of xylose was not as rapid as thatof glucose. Subsequently, breeding of the strains andregulation of the metabolic network resulted in an increasein malate yield, and the strain HF-121 produced more than120 g/L malic acid within 60 h. The ability to producemalic acid from biomass hydrolyte highlights the industrialdevelopment potential of this strain.
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Huizhou Liu,Jian Yang,Fei Qu,Hua Zhang,Hongwei Gu 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.4
In research on YBa2Cu3O7 coated conductors, the development of buffer layers for epitaxial growth of YBa2Cu3O7 is very important. In our work, epitaxial buffer layers of Y2O3 have been deposited on biaxially textured Ni and NiW substrates using a continuous electron beam evaporation technique. The surface morphology and texture of Y2O3 buffer layers were characterized using SEM and XRD. The results show a sharp (2 0 0) orientation distribution and a smooth surface. Textured, crack-free, continuous Y2O3 buffer layers were obtained on moving tape using electron beam evaporation. In research on YBa2Cu3O7 coated conductors, the development of buffer layers for epitaxial growth of YBa2Cu3O7 is very important. In our work, epitaxial buffer layers of Y2O3 have been deposited on biaxially textured Ni and NiW substrates using a continuous electron beam evaporation technique. The surface morphology and texture of Y2O3 buffer layers were characterized using SEM and XRD. The results show a sharp (2 0 0) orientation distribution and a smooth surface. Textured, crack-free, continuous Y2O3 buffer layers were obtained on moving tape using electron beam evaporation.
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