Composite hydrogels filled with inclusion complexes made from β-cyclodextrins with poly(propylene glycol) bisamine

Huaiqing Yu,Hongliang Wei,Dandan Hou,Ai-ying Zhang,Zeng-guo Feng 한국물리학회 2007 Current Applied Physics Vol.7 No.s1

A novel kind of composite hydrogel lled with inclusion complexes (ICs) made fromb-cyclodextrins (b-CDs) with amine-terminatedpoly(propylene glycol) (PPG-BA) was prepared by copolymerization of methacryloyl end-capped poly(L-lactide)-poly(ethylene glycol)-poly-(L-lactide) macromer (DMPEGL) with acrylic acid (AA) in water under UV irradiation. Owing to the hydrogen bonding interactionof COOH in AA on the network backbones with NH2 and OH in ICs embedded in the crosslinked network, the composite hydrogelsmechanical properties being signicantly improved. The mass loss test conducted in water indicates that they degrade by following a dualdegradation mechanism, that is, not onlyb-CDs slipping from the polymer axles and then escaping out of the hydrogel network, but alsothe bulk hydrogel network hydrolyzing itself to lose the weight. These composite hydrogels show potential to be used as biomaterials fortissue engineering scaolds and carriers of drugs with controlled release.

Study on Anomalous Codeposition Phenomenon of CoNi Magnetic Films

Yundan Yu,Guoying Wei,Hongliang Ge,Li Jiang,Lixia Sun 한국자기학회 2017 Journal of Magnetics Vol.22 No.2

CoNi alloy films prepared from electrolytes with various concentrations of cobalt ions were studied in the paper. Influences of different cobalt ions concentrations on electrochemistry processes, components, microstructures, surface morphologies and magnetic properties of CoNi films were investigated. It was found that CoNi film plating was a kind of anomalous codeposition process. The percentage of cobalt content in CoNi films was higher than that of in the electrolyte. Moreover, with the rise of cobalt ions concentrations, the percentage of cobalt content in the samples increased gradually. CoNi films possessed crystal structures with four stronger diffraction peaks. However, CoNi films prepared from bath with higher cobalt ions possessed hcp structures which contributed to dendrite structures resulting in the increase of coercivity.

Degradation Characteristics and Metabolic Pathway of 17β-estradiol (E2) by Rhodococcus sp. DS201

Qingmiao Yu,Ping Wang,Dongbo Liu,Ruixia Gao,Huanhuan Shao,Hongyan Zhao,Zhe Ma,Dan Wang,Hongliang Huo 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.6

In this study an E2-degrading bacterium was isolated from the activated sludge of a municipal treatment plant that treats the waste from a contraceptive medicineprocessing factory in Beijing, China. Using the observed morphological and physiological features of the bacterium and 16S rRNA sequence analysis, this bacterial strain was identified as Rhodococcus sp. DS201. Using single-factor experiments and orthogonal tests, it was demonstrated that, when strain DS210 bacteria were inoculated into MM medium at an initial concentration of 1 mg/L with an initial pH of 7 and an inoculum amount of 1%, complete degradation of E2 by this strain was achieved within 3 days at 30oC. After strain DS201 had degraded the E2, several E2 metabolites were detected in the culture extracts using high-performance liquid chromatography (HPLC); they were then further identified using HPLC with tandem mass spectrometry (LC-MS/MS). Mass spectrum analysis of the E2 degradation identified the following products: pent- 4-enoic acid; 2-ethyl-3-hydroxy-6-methylcyclohexane-1- carboxylic acid; 3-(7a-methyl-1,5-dioxooctahydro-1H-inden- 4-yl) propanoic acid; and 5-hydroxy-4-(3-hydroxypropyl)- 7a-methyloctahydro-1H-inden-1-one. These products have not previously been reported as parts of a mechanism for microbial E2 degradation and were suspected to be new metabolite products. Therefore, the E2 degradation pathway by strain DS201 is proposed herein.

Triaxial Test Research on Mechanical Properties and Permeability of Sandstone with a Single Joint Filled with Gypsum

Jin Yu,Xu Chen,Yan-yan Cai,Hongliang Liu 대한토목학회 2016 KSCE Journal of Civil Engineering Vol.20 No.6

In this study, the mechanical properties and permeability variation in single joint rock samples filled with a gypsum layer were investigated. In order to simulate the inclined infilled joint, the solid cylinders were saw-cut at the dip angles of 90°, 60°, 45°, 30° or 0° with respect to the samples’ axes, and then joined together with gypsum. Triaxial compression experiments with permeability measurements were then performed using these prepared samples. The results indicated that the peak strength and failure modes change with the inclined angles. In comparison with the theoretical analysis of rock with a clean joint, infilling has a marked influence on the mechanical properties to some extent. In regards to the initial permeability, the results showed decreases of approximately two orders of magnitude with the increasing of the prefabricated joint angle, and the initial permeability of the samples with a prefabricated joint were all larger than the intact sample. The evolutionary trends of the permeabilities in triaxial compression in the sandstone samples were shown to be varied with a joint filled with gypsum at different angles, due to the fact that the changes of the inner structure are quite different during the loading process.

Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress

Duan, Hongliang,Lee, Jae Wook,Moon, Sung Won,Arora, Daleep,Li, Yu,Lim, Hui-Ying,Wang, Weidong American Chemical Society 2016 Journal of medicinal chemistry Vol.59 No.17

<P>Pancreatic insulin-producing beta-cell dysfunction and death plays central roles in the onset and progression of both type 1 and type 2 diabetes. Current antidiabetic drugs cannot halt the ongoing progression of beta-cell dysfunction and death. In diabetes, a major cause for the decline in beta-cell function and survival is endoplasmic reticulum (ER) stress. Here, we identified quinazoline derivatives as a novel class of beta-cell protective agents against ER stress-induced dysfunction and death. A series of quinazoline derivatives were synthesized from dichloroquiazoline utilizing a sequence of nucleophilic reactions. Through SAR optimization, 2,4-diaminoquinazoline compound 9c markedly protects beta-cells against ER stress-induced dysfunction and death with 80% maximum rescue activity and an EC50 value of 0.56 mu M. Importantly, 9c restores the ER stress-impaired glucose-stimulated insulin secretion response and survival in primary human islet beta-cells. We showed that 9c protects beta-cells by alleviating ER stress through the suppression of the induction of key genes of the unfolded protein response and apoptosis.</P>

Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA

Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1

Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.

Tri-metal-based hollow nanorods-on-microrod arrays as efficient water splitting electrocatalysts

Jianzhi Wang,Hongliang Yu,Xianming Wang,Chen Chen,Shuaijie Li,Ning Cai,Weimin Chen,Yanan Xue,Hui Li,Faquan Yu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

Constructing ordered hierarchical porous electrocatalysts while maintaining their high efficiency and stabilityfor oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is highly desirable butstill remains challenging. Herein, hierarchical tri-metal-based hollow nano/micro rod-on-rod array structures,including hydroxides and phosphates, are vertically grown on Cu foam by the cation-exchangingand anion exchanging approaches. Such ordered porous architecture, providing multi metal center, regularinterconnection of macropore channel, large electrochemical surface area, small charge-transferresistance, efficient mass transport and electron transfer for overall water splitting in alkaline media. These obtained hydroxide OER catalysts (CoMn LDH@Cu(OH)2/CF) and phosphide HER catalysts(CoMnP@Cu3P/CF) exhibited low onset potential, low Tafel slope, and prominent durability. Such excellentperformance, ordered porous structure and simple preparation methods indicate that this study providesa new strategy for assembling promising catalysts for water splitting and other applications.

Multi-strategy augmented Harris Hawks optimization for feature selection

Zhao Zisong,Yu Helong,Guo Hongliang,Chen Huiling 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.3

In the context of increasing data scale, contemporary optimization algorithms struggle with cost and complexity in addressing the feature selection (FS) problem. This paper introduces a Harris hawks optimization (HHO) variant, enhanced with a multi-strategy augmentation (CXSHHO), for FS. The CXSHHO incorporates a communication and collaboration strategy (CC) into the baseline HHO, facilitating better information exchange among individuals, thereby expediting algorithmic convergence. Additionally, a directional crossover (DX) component refines the algorithm's ability to thoroughly explore the feature space. Furthermore, the soft-rime strategy (SR) broadens population diversity, enabling stochastic exploration of an extensive decision space and reducing the risk of local optima entrapment. The CXSHHO's global optimization efficacy is demonstrated through experiments on 30 functions from CEC2017, where it outperforms 15 established algorithms. Moreover, the paper presents a novel FS method based on CXSHHO, validated across 18 varied datasets from UCI. The results confirm CXSHHO's effectiveness in identifying subsets of features conducive to classification tasks.

Synthesis of N-doped Carbon Spheres Using Extended Stöber Method for SO2 Adsorption

Yunqian Li,Yifeng Yu,Lei Liu,Hongliang Zhang,Guoxu Wang,Aibing Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1

SO2 is one of the major pollutants in the atmosphere. N-doped microporous carbon spheres (NCS) have been demonstrated to be effective for SO2 adsorption. Here we report the synthesis of monodispersed NCS by the extended Stöber method with urea resorcinol-formaldehyde resins as carbon source, urea as nitrogen source and ammonia as catalyst in an ethanol-water mixed solvent. The obtained carbon spheres show a uniform diameter of around 550 nm, specific surface area of 476 m2 g-1, micropores pore volume of 0.20 cm3 g-1 and nitrogen doping. The NCS manifest special performance for SO2 capture with capability of 75.34 mg g-1 and good cycling stability, due to the large surface area, abundant micropores and nitrogen functionality.

Simultaneous Impact of Multiple Droplets on Liquid Film

Gangtao Liang,Tianyu Zhang,Haibing Yu,Hongliang Chen,Shengqiang Shen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-

Multiple droplets impinging on a thin liquid film simultaneously is numerically studied using a three-dimensional model with an implement of a random disturbance subjected to Gaussian distribution. This model is very effective to predict droplet splashing under relatively high impingement momentum. Interface evolutions and field distributions are addressed after droplets impact. Besides, a geometric model is built up to demarcate the impact region into two semicircular regions and a series of rectangular regions during simultaneous impact, further to discuss the variations of area and residual film thickness in each region as well as the total area and average film thickness.