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Sim, Yeomoon,Park, Gunhyuk,Eo, Hyeyoon,Huh, Eugene,Gu, Pil Sung,Hong, Seon-Pyo,Pak, Youngmi Kim,Oh, Myung Sook Elsevier 2017 NEUROSCIENCE Vol.340 No.-
<P><B>Abstract</B></P> <P>Parkinson’s disease (PD) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (SNpc) and the striatum. Recent studies have demonstrated that the nuclear receptor-related 1 protein (Nurr1) is critical of dopaminergic phenotype induction in mesencephalic dopaminergic neurons. Further, Nurr1 engages in synthesizing and storing dopamine through regulating levels of tyrosine hydroxylase (TH), dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). The aim of this study was to investigate the protective effects of a herbal extract combination, consisting of <I>Bupleurum falcatum</I>, <I>Paeonia suffruticosa</I>, and <I>Angelica dahurica</I> (MABH), on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD-like symptoms and to elucidate possible mechanisms of action focusing on Nurr1. In a subacute mouse model of MPTP-induced PD, MABH treatment resulted in recovery from movement impairments. MABH prevented dopamine depletion and protected against dopaminergic neuronal degradation induced by MPTP. Additionally, MABH increased Nurr1 expression in the SNpc of mice. To evaluate the effects of MABH on Nurr1 expression, we measured the protein levels of Nurr1 and its regulating factors using Western blot analysis in PC12 cells. MABH treatment induced the phosphorylation of extracellular signal-regulated kinase protein via increasing the protein expression levels of Nurr1 and ultimately the levels of TH, VMAT2, and DAT. These results indicate that MABH has protective effects on dopaminergic neurons in a mouse model of PD by regulating Nurr1.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MABH improved MPTP-induced movement impairments in mice. </LI> <LI> MABH prevented dopamine depletion and protected against MPTP-induced dopaminergic neuron damage in mice. </LI> <LI> MABH increased Nurr1 expression in the SNpc of mice. </LI> <LI> MABH increased TH, DAT, and VMAT2 expressions by upregulating Nurr1 via phosphorylation of ERK in PC12 cells. </LI> </UL> </P>
Hong, Seung Han,Yoo, Wook Jae,Shin, Sang Hun,Sim, Hyeok In,Kim, Seon Guen,Jeon, Hye Su,Jang, Jae Seok,Kim, Jae Seok,Kwon, Gu Won,Jang, Kyoung Won,Lee, Bong Soo Trans Tech Publications, Ltd. 2015 Advanced materials research Vol.1083 No.-
<P>We developed a fiber-optic beta/gamma imaging detector that can obtain the scintillating images for beta-or gamma-ray emitted from the radioisotope. To evaluate spatial resolution of proposed imaging detector, we obtained the optical images using USAF 1951 resolution target. And then, a modulation transfer function curve of the optical image was calculated. Also, we measured the scintillating images of Tl-204 and Cs-137 with information respecting the beta-and gamma-rays distribution. Finally, the intensities of scintillating light as a function of radioactivity were analyzed from the region of interest in the scintillating image.</P>
비소세포폐암에서 Survivin, HSP 및 Bcl-2 발현에 관한 면역조직화학적 분석
홍현주 ( Hong Hyeon Ju ),홍석균 ( Hong Seog Gyun ),이계영 ( Lee Gye Yeong ),김우호 ( Kim U Ho ),이춘택 ( Lee Chun Taeg ),유철규 ( Yu Cheol Gyu ),한성구 ( Han Seong Gu ),심영수 ( Sim Yeong Su ),김영환 ( Kim Yeong Hwan ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.5
심종성 ( Jongsung Sim ),한만엽 ( Manup Han ),오흥섭 ( Hong-seob Oh ),김정구 ( Jung-gu Kim ) 한국구조물진단유지관리공학회 1997 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.1 No.1
T-typed piers are predominately found in urban settings because they are both attractive and occupy a minimum of space. But, these piers were often failed to be cause by human error. In this study, collapse reason of a T-typed pier was searched on the basis of real failure. To find the failure reason, design procedure were reviewed and non - destructive test on the collapsed pier was performed.
가성낭을 동반한 만성 췌장염 환자에서 발생한 비장경색 및 비장파열 1 예
조용구(Yong Gu Cho),임영찬(Young Chan Lim),한병호(Beoung Ho Han),김충기(Chung Kee Kim),임홍섭(Hong Seub Lim),심영웅(Young Woong Sim),송갑영(Gap Young Song) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, portal hypertension, splenic torsion, septicemia and drugs, etc. Splenic infarction accompained by chronic pancreatitis is most likely due to splenic vein thrombosis, surrounding tissue fibrosis accompanied with splenic vessel occlusion, and intrasplenic penetration of pancreatic pseudocyst. Recently, we experienced a case of splenic infarction and rupture in a 46-year-old male who had been diagnosed as chronic pancreatitis with pseudocyst. (Korean J Gastroenterol 2001;38:457-460)